Clinical trials: BDNF
Cervicogenic Headache, Sleep Disturbance
Effect of Isometric Neck Exercises on Cervicogenic Headache Symptoms, Cortisol and BDNF Levels Among Smart Phone Users
Cervicogenic headache (CGH) is a secondary headache type caused due to refereed pain arising from the cervical spine in the forehead, sometimes in temporal region.
- Conditions
- Cervicogenic Headache, Sleep Disturbance, Stress
- Trial name
- NCT07354776
- Testing
- Isometric Neck Exercise Program, Usual Care
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Epilepsy
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy
Epilepsy is a common neurological condition that affects people of all ages.Recent studies found that epilepsy is associated with several chromosomal regions, where mutations in these regions cause neurological dysfunction.
- Trial name
- NCT05096871
- Testing
- Genotyping by Real Time PCR
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sohag University
Depression Disorder, Anxiety
Impact of Nut Consumption on Mental Health in Young Adults
Nuts have a high nutrient density, and numerous studies have reported their cardiometabolic benefits. Although observational studies in adults have indicated a potential link between nut consumption and improved mental health…
- Conditions
- Depression Disorder, Anxiety, Mental Health, Stress
- Trial name
- NUTS4BRAIN-RCT (NCT07292610)
- Testing
- mixed nuts. Group A, mixed nuts. Group B, control group
- Where
- Spain
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Healthy
Indole-3-PROpionic Acid Clinical Trials - a Pilot Study Part 2
The goal of this trial is to investigate the biological effects of oral supplementation with indole-3-propionic acid (IPA) taken twice daily in healthy adults.
- Trial name
- iPROACT-pilot2 (NCT07105514)
- Testing
- Indole-3-propionic acid (IPA)
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Psychotic Disorders, Depressive Disorder
Genetics of Symptomatology and Treatment Response in Psychotic Major Depression
We hope to learn more about the biology of psychiatric illness with the hope of improving the diagnosis and treatment of such psychiatric conditions as major depression.
- Conditions
- Psychotic Disorders, Depressive Disorder, Depressive Disorder, Major
- Trial name
- NCT00691535
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy Volunteers
Anti-Platelet Drugs and Brain-derived Neurotrophic Factor (BDNF) in Human Serum and Plasma
The impact of anti-platelet drugs on the concentrations of Brain-derived neurotrophic factor (BDNF) in human plasma and serum is unknown.
- Trial name
- NCT01264640
- Testing
- Aspirin and Clopidogrel
- Where
- Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Rostock
Brain Concussion
The Effect of Exercise on Neurorecovery Following Mild Traumatic Brain Injury
The study is a "proof-of-principle" project to examine the safety and feasibility of implementing a 1-week aerobic exercise program in the post-acute phase after mild traumatic brain injury (mTBI).
- Trial name
- NCT02276079
- Testing
- Aerobic Exercise, Non-Aerobic Exercise
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Florida
Stroke
Exercise and Genotype in Sub-acute Stroke
This study will investigate the impact of cardiovascular exercise on brain plasticity among patients in sub-acute stages after stroke, and whether genotype modulates the response to this intervention.
- Trial name
- NCT05076747
- Testing
- Cardiovascular training, Standard Therapy
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- McGill University
Sleep, Sleep Restriction
Effects of Sleep Restriction on Female Soccer Players: Physical Performance, Muscle Damage, Inflammation, and BDNF Levels.
This research aims to investigate the interplay between menstrual cycles, sleep patterns, and athletic performance. Before experimental sessions, participants will maintain menstrual diaries for three months and complete…
- Trial name
- NCT06251362
- Testing
- Sleep restriction
- Where
- 2 sites in Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University School of Physical Education, Krakow, Poland
BDNF, Small Side Game
Comparing Touch-Limited and Free-Play 4v4 Small-Sided Games (SSGs)
This study aimed to compare acute serum BDNF and cognitive performance following touch-limited versus free-play 4v4 small-sided games (SSGs) in male soccer players.
- Conditions
- BDNF, Small Side Game, Football Players
- Trial name
- TOUCH-BDNF (NCT07395765)
- Testing
- SSGf, SSGr
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Aksaray University Training and Research Hospital
Acute Physical Exercise
Effect of Acute Physical Exercise on Memory
An increasing amount of studies show the beneficial effect of regular exercise on cognitive and brain functions and especially in the memory domain.
- Trial name
- SPEMO (NCT04680494)
- Testing
- moderate intensity physical exercise, high intensity physical exercise, rest
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Memory
BDNF Levels After Bacopa
Brain-derived neurotrophic factor (BDNF) is a well-known neurotrophic factor important for learning, memory, and synaptogenesis.
- Trial name
- NCT03974399
- Testing
- Bacopa Monnieri
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Roskamp Institute Inc.
Exercise
Expression of BNDF Through Stretching and Recovery
The phenomena of biological adaptation and overtraining are closely related terms, that is why in sport it is possible to identify two types of overtraining.
- Trial name
- BDNF&Exe (NCT04059120)
- Testing
- Experimental group whit specific stretching, Control group whit out specific stretching
- Where
- Mexico
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Universidad de Colima
Aerobic Exercise, Anaerobic Exercise
The Effect of Physical Activity on the Brain
Physical activity is thought to increase overall body functions and to decrease cardiovascular and stroke risk factors. Now the question arose, wether enhanced exercise could also exert positive influence on cognition in the…
- Conditions
- Aerobic Exercise, Anaerobic Exercise, Unchanged Condition
- Trial name
- NCT01475396
- Testing
- exercise
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Borderline Personality Disorder
Methylation Status of BDNF Gene After Dialectical Behavior Therapy in BPD
Borderline personality disorder (BPD) is a chronic and debilitating syndrome associated with considerable morbidity, mortality, and high rates of medical and psychiatric utilization services.
- Trial name
- NCT02134223
- Testing
- Dialectical behavior therapy, Treatment as Usual: any other drug or psychotherapy offered to participants, except DBT
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
BDNF, Lactate
Determination of BDNF Peak Time in Different Types of Exercises
Purpose The purpose of this study was to determine the peak point of BDNF following exercises of different intensities. Method This randomized crossover controlled trial aimed to examine the acute effects of three experimental…
- Conditions
- BDNF, Lactate, Exercise Intensity, Healthy
- Trial name
- BDNF Kinematic (NCT07175831)
- Testing
- Low-Intensity Continuous Training, Moderate intensity Interval training, High-Intensity Interval Training
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Aksaray University Training and Research Hospital
Quality of Life
Effects of Genetic Variation on the Efficacy of Aerobic Exercise
This study investigates whether, after six weeks of exercise, a genetic variant (Val66Met) in the gene that makes a molecule (BDNF) important for brain health and function, influences the beneficial effects of a further session…
- Trial name
- NCT03670186
- Testing
- High-Intensity Interval Training (HIIT)
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cognition, Sodium Bicarbonate
Exercise-Induced Lactate and Cognitive Function (ExLBC)
A single bout of exercise can rapidly improve cognitive functions including memory, attention, and executive functions, which help us navigate through everyday life.
- Conditions
- Cognition, Sodium Bicarbonate, Lactate, Exercise
- Trial name
- NCT06817681
- Testing
- Sodium Bicarbonate (NaHCO3)
- Where
- 2 sites in Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- McMaster University
Healthy
Explore the Nature Factors Relevant to Learning-Pioneering Natural Factors That Influences Science Learning II
Genetic research has provided the most exciting breakthroughs in neuroscience and cognitive science. Partially genetically determined cognitive impairments have been described in people with COMT, 5HT6, BDNF (Swillen et al.…
- Trial name
- NCT00713570
- Where
- Taiwan
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cognitive Dysfunction, Glucose Metabolism
Brain-derived Neurotrophic Factor and Cogntive Function
Individuals with type 2 diabetes have an increased risk of developing cognitive dysfunction followed by dementia in late life. Obesity, physical inactivity and "systemic low-grade inflammation" are strong risk factors and play a…
- Conditions
- Cognitive Dysfunction, Glucose Metabolism, Low-grade Inflammation, Bodycomposition
- Trial name
- NCT01390688
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet