Clinical trials: Avenanthramides
Inflammation
Single and Multiple Ascending Oral Doses of Avenanthramide
Avenanthramides (AVA) are di-phenolic compounds found only in oats and are of interest due to suggested bioactivities, including antioxidant and anti-inflammatory effects in vitro and in vivo.
- Trial name
- AvenActive (NCT06101784)
- Testing
- Avenanthramide
- Where
- Canada
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Inflammation
Effects of Avenanthramide-enriched Oats on Inflammation
The objective of this randomized, double-blinded, placebo-controlled, parallel trial is to determine whether consuming avenanthramide-enriched oats daily for 8 weeks on can improve biomarkers of inflammation in older, obese…
- Trial name
- NCT01527604
- Testing
- Avenanthramide-enriched oats, Refined flour absent avenanthramides
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Tufts University
Bioavailability, Metabolism
Bioavailability and Metabolism of Avenanthramide: a Novel Oat Phytochemical
The purpose of the study is to examine whether orally ingested oat avenanthramides (AVA) in oat flour cookies are bioavailable in humans by measuring plasma and urine concentrations of AVAs and their potential metabolites after…
- Conditions
- Bioavailability, Metabolism, Avenanthramides
- Trial name
- NCT02415374
- Testing
- Avenanthramides
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Healthy
Phenolic-rich Oats and Artery Improvement
In this proposed human trial, the investigators aim to establish whether consumption of one portion of phenolic acid-rich oats leads to acute improvements (i.e.
- Trial name
- PROGRAIN2 (NCT02731755)
- Testing
- Oat, Control
- Where
- 2 sites in United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Reading
Human Health, Polyphenols
Avenanthramide and Saponin Bioavailability in Oat Bran
Avenanthramides and saponins are types of chemical compounds found naturally in oats. Avenanthramides have anti-oxidant properties, anti-atherosclerotic, anti-inflammation, and anti-proliferative effects on cancer cells in vitro.
- Conditions
- Human Health, Polyphenols, Pharmacokinetics
- Trial name
- NCT04335435
- Testing
- Oat Bran Consumption
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- North Carolina Agriculture & Technical State University
Avenanthramides
Avenanthramides and Exercise
The aim of the proposed study is to examine whether long-term dietary supplementation (8 weeks) of an oat flour cookie rich in avenanthramides (AVA) could enhance blood antioxidant capacity and reduce blood inflammatory markers…
- Trial name
- NCT02584946
- Testing
- Avenanthramides
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Healthy
Chronic Cardiovascular and Gut-bacteria Effects of Phenolic Rich Oats in Adults With Above Average Blood Pressure
In this proposed human trial, the investigators aim to establish whether 4 weeks of daily consumption of beta-glucan matched meals providing either a high dose or a moderate dose of oat avenanthramides and phenolic acids leads to…
- Trial name
- NCT02847312
- Testing
- High avenanthramide, phenolic acid, Low avenanthramide, medium phenolic acid, Control
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Reading
Healthy
Bioavailability of Avenanthramide-Enriched Oats in Healthy Older Adults
This is a placebo-controlled, crossover study investigating the pharmacokinetic bioavailability of avenanthramides from avenanthramide-enriched oats and their in vivo metabolites in a cohort of healthy, older adults.
- Trial name
- NCT01055717
- Testing
- Avenanthramide-enriched oats
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Tufts University