Clinical trials: Autoimmune Encephalitis
Autoimmune Encephalitis
CPI Combination Therapy for Autoimmune Encephalitis
Corticosteroids, intravenous immunoglobulin (IVIG), and plasma exchange (PE) are the first-line therapies for autoimmune encephalitis (AE) patients, but optimal first-line treatment strategy for different AE patients remains…
- Trial name
- CPI (NCT03542279)
- Testing
- Plasma exchange (PE), intravenous immunmoglobulin (IVIG), intravenous methylprednisolone (IVMP)
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Xuanwu Hospital, Beijing
Autoimmune Encephalitis
Clinical Characteristics of Patients With Anti-Collapsin Response Mediator Protein 2 Antibodies in Encephalitis or Encephalomyelitis
Autoimmune encephalitis (AE) is an important autoimmune neurological disease, and its clinical manifestations, treatment and prognosis are closely related to the type of pathogenic antibodies.
- Trial name
- NCT07036042
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Leucine-Rich Glioma Inactivated 1 Autoimmune Encephalitis
A Study to Test the Efficacy, Safety, and Pharmacokinetics of Rozanolixizumab in Adult Study Participants With Leucine-Rich Glioma Inactivated 1 Autoimmune Encephalitis
The purpose of the study is to assess the efficacy of rozanolixizumab as measured by seizure freedom, change in cognitive function, use of rescue medication, onset of seizure freedom and to assess safety and tolerability.
- Trial name
- NCT04875975
- Testing
- Rozanolixizumab
- Where
- 27 sites in United States, Australia and 7 more
- Volunteers
- 12 people
- Sponsor
- UCB Biopharma SRL
Encephalitis, Encephalitis, Viral
Efficacy and Safety of Calculus Bovis Sativus (CBS) for Adult Encephalitis (CBSinEncephalitis)
Based on the records of traditional Chinese medicine, CBS has the functions of purifying the heart, eliminating phlegm, stimulating bile secretion, and soothing the nerves.
- Conditions
- Encephalitis, Encephalitis, Viral, Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody, Autoimmune Encephalitis
- Trial name
- NCT06584045
- Testing
- Calculus bovis sativus (CBS)
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Autoimmune Encephalitis
Neuro-ophthalmology and Autoimmune Encephalitis (NODE)
Autoimmune encephalitis represents a group of rare and heterogeneous neurological disorders. Pathophysiological mechanisms in these diseases are still unknown. Recently, oculomotor and neurovisual disorders have been described.
- Trial name
- NODE (NCT03872284)
- Testing
- oculomotor movement recordings, neurovisual assessment
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Hospices Civils de Lyon
Autoimmune Encephalitis
A Multicentric Cohort of Autoimmune Encephalitis
This study aims to establish an autoimmune encephalitis cohort and observe the prognosis of patients with different subtypes and subgroups (e.g. epilepsy subgroup and teratoma subgroup ).
- Trial name
- NCT06760091
- Testing
- baseline data collection and follow-up
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Severe Autoimmune Encephalitis
Risk Prediction Model for Severe Autoimmune Encephalitis
A prospective study aims to establish a multicenter clinical diagnosis and treatment database for patients with autoimmune encephalitis (AE).
- Trial name
- NCT06697678
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 1,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Optic Neuritis, Transverse Myelitis
Swiss Pediatric Inflammatory Brain Disease Registry (Swiss-Ped-IBrainD)
The Swiss-Ped-IBrainD is a national patient registry that collects information on diagnosis, symptoms, treatment, and follow-up of pediatric patients with an inflammatory brain disease in Switzerland.
- Conditions
- Optic Neuritis, Transverse Myelitis, Acute Disseminated Encephalomyelitis, Multiple Sclerosis
- Trial name
- NCT05017142
- Where
- 13 sites in Switzerland
- Volunteers
- 500 people
- Sponsor
- University of Bern
Autoimmune Diseases, Autoimmune Diseases of the Nervous System
Safety and Efficacy of CT103A Cells for Relapsed/Refractory Antibody-associated Inflammatory Diseases of the Nervous System
Antibody-mediated inflammatory diseases of the nervous system (also known as autoimmune diseases of the nervous system) are autoimmune diseases in which autoimmune cells and immune molecules attack the nervous system as the main…
- Conditions
- Autoimmune Diseases, Autoimmune Diseases of the Nervous System, Neuromyelitis Optica Spectrum Disorder, Myasthenia Gravis
- Trial name
- CARTinNS (NCT04561557)
- Testing
- CT103A cells, Cyclophosphamide and fludarabine
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Tongji Hospital
Autoimmune Encephalitis
Clinical Features and Prognostic Markers in Adult Patients With AE Requiring ICU Treatment
Autoimmune encephalitis (AE) is a potentially life-threatening inflammation of the central nervous system (CNS) and constitutes 20%-30% of encephalitis cases in adults AE often leads to subacute, severe, and debilitating…
- Trial name
- NCT06456736
- Testing
- None, non-interventional study
- Volunteers
- 200 people
- Sponsor
- Central South University
Multiple Sclerosis, NMO Spectrum Disorder
National, Multicentric Registry Study on Neuroimmunological Diseases in China
The aim of this study is to establish a real-world clinical neuroimmune disease research cohort, to follow up and observe the prognosis of patients with different subtypes and subgroups, and to provide support for the treatment…
- Conditions
- Multiple Sclerosis, NMO Spectrum Disorder, Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease, Myasthenia Gravis
- Trial name
- NIDBase (NCT06443333)
- Testing
- Data collection and follow-up observation, Data collection
- Where
- China
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Paraneoplastic Neurological Syndrome, Autoimmune Encephalitis
Metabolic Imaging for Diagnosis and Prognostication of Autoimmune encephalitiS
Autoimmune encephalitis (AE) is a rare neurological disorder mediated by autoimmune antibody response against neuronal cell surface and intraneuronal proteins associated with specific brain areas, resulting in severe inflammation…
- Trial name
- MIDAS (NCT06432803)
- Testing
- PET-Scan analysis
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Hospices Civils de Lyon
Paraneoplastic Neurological Syndromes or Autoimmune Encephalitis
Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis Collection
Numerous neurological disorders affecting the central and peripheral nervous system can be attributed to the immune system through multiple effector mechanisms.
- Trial name
- SNP (NCT05198661)
- Testing
- Collection of biological sample with sera, CSF, buffy coat, PBMC, plasma.
- Where
- 62 sites in France
- Volunteers
- 3,500 people
- Sponsor
- Hospices Civils de Lyon
Autoimmune Encephalitis Associated With Anti-CAPR2 Antibodies
Brain MRI Longitudinal Volumetric Characteristics Associated With Outcomes of CASPR2-Limbic Encephalitis
Anti-CASPR2 limbic encephalitis (CASPR2-LE) is a rare neurological disorder primarily affecting males over the age of 50. It is mediated by an autoimmune antibody response in the central nervous system (CNS) against the cellular…
- Trial name
- C2-MRI (NCT06245447)
- Testing
- Retrospective evaluation of specific brain MRI features
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Hospices Civils de Lyon
Acute Autoimmune Encephalitis
Study of Acute Autoimmune Encephalitis With Positive Antibodies in Eastern France
The number of acute encephalitides diagnosed each year is gradually increasing, reaching approximately 5 to 10/100,000 per year; more than 50% of etiologies currently remain unknown.
- Trial name
- Encephalitis (NCT05605223)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Autoimmune Encephalitis, Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody (Disorder)
Validation of a Diagnostic Score for Encephalitis to Assess the Risk of Autoimmune Origin
The investigators wish to test a diagnostic risk score for autoimmune encephalitis in case of encephalitis, previously validated by two American teams, in a retrospective analysis, according to the clinical and paraclinical data…
- Trial name
- Val-Dia score (NCT05953974)
- Testing
- Clinical score of Granillo and al.
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Hospices Civils de Lyon
Anti-N-Methyl-D-Aspartate Receptor Encephalitis, Autoimmune Encephalitis
Developing Advanced Neuroimaging for Clinical Evaluation of Autoimmune Encephalitis
Autoimmune encephalitis is brain inflammation caused by the immune system mistakenly reacting against proteins in the brain. The commonest form is called NMDAR-antibody encephalitis (N-methyl-D-aspartate receptor antibody…
- Trial name
- DANCE-AE (NCT05280600)
- Testing
- Not applicable - non-interventional study
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- King's College London
Autoimmune Encephalitis, Epilepsy
Acute Sympotomatic Seizure Secondary to Autoimmune Encephalitis and Autoimmune-associated Epilepsy
Previously, scholars called the seizures secondary to autoimmune encephalitis（AE） "autoimmune related epilepsy", but the seizures secondary to AE are usually controlled after the improvement of encephalitis, which does not meet…
- Conditions
- Autoimmune Encephalitis, Epilepsy, Seizures
- Trial name
- NCT05422664
- Testing
- Lacosamide
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Liu Yonghong
Autoimmune Encephalitis
BRIEF TITLE * (in English and Sufficiently Descriptive) Role of MRI in Anti-LGI1 Encephalitis
The term "autoimmune encephalitis" denotes an heterogenous group of diseases commonly associated with autoantibodies targeting neural or glial antigens.
- Trial name
- LGI1-IRM (NCT05825690)
- Testing
- Retrospective evaluation of specific brain MRI features
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Paraneoplastic Neurological Syndrome, Autoimmune Encephalitis
Diagnostic Performance of a Commercial Assay for the Detection of Neuronal Antibodies
Detection of autoantibodies targeting neuronal surface or intracellular antigens is a keystone for the diagnosis and the treatment of auto-immune encephalitis and paraneoplastic neurological syndromes.
- Trial name
- IFINEURO (NCT05783947)
- Testing
- Indirect immunofluorescence assay on tissue slides and cell-based assays with CSF and/or sera
- Where
- 2 sites in France
- Volunteers
- 34 people
- Sponsor
- Hospices Civils de Lyon