Clinical trials: Atypical Endometrial Hyperplasia
Cancer Screening
Endometrial Cancer Screening in High-risk Populations
Endometrial cancer is one of the most common malignancies of the reproductive system. The incidence of endometrial cancer has increased in recent years. No effective, low-cost screening method for populations at high risk exists.
- Trial name
- NCT06125886
- Testing
- transvaginal ultrasound and microscale endometrial sampling biopsy
- Volunteers
- 22,000 people
- Sponsor
- Peking University People's Hospital
Endometrial Cancer
Surgery Plus Medroxyprogesterone in Preventing Endometrial Cancer
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of surgery with or without medroxyprogesterone may be an effective way to prevent the development…
- Trial name
- NCT00003179
- Testing
- medroxyprogesterone
- Where
- 31 sites in United States, Norway
- Volunteers
- 360 people
- Sponsor
- Gynecologic Oncology Group
Endometrial Hyperplasia Without Atypia
Vaginal Micronized Progesterone Versus Levonorgestrel for Treatment of Non-atypical Endometrial Hyperplasia
The purpose of this study is to compare the efficacy of the vaginal micronized progesterone and Levonorgestrel-releasing Intrauterine System for treatment of non-atypical endometrial hyperplasia in premenopausal women.
- Trial name
- NCT03992937
- Testing
- Vaginal Micronized Progesterone, Levonorgestrel-Intrauterine System
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people
- Sponsor
- Kocaeli University
Endometrial Cancer, Endometrial Cancer Stage I
SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer
SHAPE-ENDO is a single-center, open-label, pilot randomized clinical trial conducted at Hospital Universitari de Bellvitge in Barcelona, Spain.
- Conditions
- Endometrial Cancer, Endometrial Cancer Stage I, Atypical Endometrial Hyperplasia and Endometrial Carcinoma Stage I, Atypical Endometrial Hyperplasia
- Trial name
- SHAPE-ENDO (NCT07462663)
- Testing
- GLP-1 Receptor Agonist, Levonorgestrel IUD (Lng-IUD), Oral Progestins
- Volunteers
- 80 people
- Sponsor
- Hospital Universitari de Bellvitge
Atypical Endometrial Hyperplasia
Metformin Plus Megestrol Acetate As a Fertility-sparing Treatment in Patients with Atypical Endometrial Hyperplasia
To verify whether metformin could improve the effect of progestin as fertility-sparing treatment in patients with atypical endometrial hyperplasia(AEH).
- Trial name
- NCT04607252
- Testing
- Metformin plus Megestrol acetate, Megestrol Acetate
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Fudan University
Atypical Endometrial Hyperplasia
Megestrol Acetate Plus LNG-IUS in Young Women With Endometrial Atypical Hyperplasia
To see if megestrol acetate plus Levonorgestrel-releasing intrauterine system (LNG-IUS) will not be inferior to returning the endometrial tissue to a normal state than megestrol acetate or LNG-IUS alone in patients with…
- Trial name
- NCT03241888
- Testing
- Megestrol Acetate, Levonorgestrel-releasing Intrauterine System(LNG-IUS)
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Fudan University
Complex Atypical Hyperplasia, Endometrial Cancer
18-fluorofuranylnorprogesterone (FFNP) PET/MRI as a Potential Biomarker of Response to Progesterone Therapy
Purpose: The purpose of this study is to evaluate FFNP PET/MRI's utility for predicting response to Levonorgestrel-releasing Intrauterine Device (LR-IUD) hormonal therapy for Complex Atypical hyperplasia (CAH) and Endometrial…
- Trial name
- NCT05483023
- Testing
- 18F-fluorofuranylnorprogesterone PET / MRI
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia, Endometrial Carcinoma
Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer
This phase II trial studies the effect of megestrol acetate alone or in combination with metformin in preventing the progression of uterine pre-cancer (endometrial intraepithelial neoplasia) to endometrial cancer.
- Trial name
- NCT04576104
- Testing
- Biopsy Procedure, Extended Release Metformin Hydrochloride, Megestrol Acetate
- Where
- 8 sites in United States
- Volunteers
- 51 people
- Sponsor
- Northwestern University
Atypical Endometrial Hyperplasia, Endometrial Cancer
Intrauterine Injection of Type III Collage in FST of EC/AEH
The goal of this clinical trial is to learn if intrauterine injection of "Recombinant Humanized Type III Collagen Lyophilized Fibers" works to treat endometrial cancer or atypical hyperplasia in patients seeking…
- Trial name
- 2026ColECFerSp (NCT07377734)
- Testing
- Recombinant Humanized Type III Collagen Lyophilized Fibers + High-dose Progestin, High-dose Progestin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Wang Jianliu
Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia, FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma
A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial Cancer
This phase II trial studies whether adding tirzepatide injections to a levonorgestrel intrauterine device (LNG-IUD) improves pathologic response (absence of cancer cells in tissue samples after treatment) in women with…
- Trial name
- NCT07349641
- Testing
- Medical Device Usage and Evaluation, Tirzepatide
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- National Cancer Institute (NCI)
Endometrial Cancer, Endometrial Intraepithelial Neoplasia
A Multi-center Prospective Study on the Oncological and Reproductive Outcomes and Quality of Life in Young Woman After Fertility-sparing Treatment of Endometrial Cancer and Endometrial Intraepithelial Hyperplasia
We will investigate the safety and efficiency of fertility-sapring treatment in ypung women witg endometrial cancer and endometrial intraepithelial hyperplasia
- Conditions
- Endometrial Cancer, Endometrial Intraepithelial Neoplasia, Fertility-sparing Surgery
- Trial name
- PreFerEC/EIN (NCT06745427)
- Volunteers
- 100 people
- Sponsor
- Region Stockholm
Endometrial Cancer, Atypical Hyperplasia
OSCAR ENDO One Stop Assessment of Risk for Endometrial Hyperplasia and Cancer
It is to be achieved that in postmenopausal women through the combination of Hysteroscopy and intraoperative rapid section a positive predictive value (PPV) regarding the objective illness like endometrial cancer or adenomatous…
- Trial name
- NCT01961102
- Testing
- hysteroscopy/curettage in case of suspicious aspect will be done a rapid section
- Where
- Austria
- Volunteers
- 300 people
- Sponsor
- Krankenhaus Barmherzige Schwestern Linz
Atypical Endometrial Polyps, Atypical Endometrial Hyperplasia
Resectoscopic Treatment of Atypical Endometrial Polyps in Fertile Women
The study aims to evaluate the long-term efficacy and prognosis of hysteroscopic resection and coagulation of the base of endometrial polyps with focal atypia in fertile women.
- Trial name
- NCT00490087
- Testing
- Levonorgestrel intrauterine device (IUD)
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- IRCCS Burlo Garofolo
High Grade Squamous Intraepithelial Neoplasia, Stage 0 Uterine Corpus Cancer
Megestrol in Treating Patients With Endometrial Neoplasia or Endometrial Hyperplasia
This randomized phase II trial is studying how well megestrol works in treating patients with endometrial neoplasia or endometrial hyperplasia. Estrogen can cause the growth of endometrial cancer cells.
- Trial name
- NCT00503581
- Testing
- Biopsy, Laboratory Biomarker Analysis, Megestrol Acetate
- Where
- 50 sites in United States
- Volunteers
- 9 people
- Sponsor
- Gynecologic Oncology Group
Endometrial Hyperplasia
Efficacy of LNG-IUS for Treatment of Non-atypical Endometrial Hyperplasia in Perimenopausal Women
The purpose of this study is to compare the efficacy of the Levonorgestrel releasing Intrauterine System (Mirena) and Norethisterone Acetate for treatment of non-atypical endometrial hyperplasia in perimenopausal women.
- Trial name
- NCT01499602
- Testing
- LNG-IUS; Mirena; Bayer Schering Pharma Oy, Finland, Norethisterone Acetate tablets
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Mansoura University
Endometrial Cancer, Atypical Endometrial Hyperplasia
Value of LNG-IUS as Fertility-preserving Treatment of EAH and EC
Primary end points: This clinical trial is aimed to analyze the effectiveness of Levonorgestrel-Releasing Intrauterine System (LNG-IUS, Mirena®) in the fertility-sparing treatment of atypical endometrial hyperplasia and early…
- Trial name
- NCT03463252
- Testing
- Progesterone, Mirena®, GnRH agonist
- Where
- China
- Volunteers
- 224 people
- Sponsor
- West China Second University Hospital
Endometrial Cancer, Fertility
Effect of Fertility-sparing Therapy of Early Endometrial Cancer
The purpose of this study is to investigate the effect of Fertility-sparing Therapy of Early Endometrial Cancer.
- Trial name
- ECFerSp (NCT03538704)
- Testing
- Metformin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University People's Hospital
Endometrial Adenocarcinoma, Endometrial Hyperplasia
Surgical and Obstetric Outcomes in Endometrial Adenocarcinoma and Atypical Endometrial Hyperplasia With Conservative Treatment
This observational study aims to evaluate the obstetric and oncological outcomes of patients diagnosed with endometrial adenocarcinoma (EAC) or atypical endometrial hyperplasia (AEH) who underwent conservative treatment at the…
- Conditions
- Endometrial Adenocarcinoma, Endometrial Hyperplasia, Fertility Preservation, Conservative Treatment Therapy
- Trial name
- CHOICE (NCT07077876)
- Testing
- Hysteroscopic Resection and Hormonal Therapy
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Atypical Endometrial Hyperplasia, Endometrial Carcinoma Stage I
Medroxyprogesterone Acetate Plus Atorvastatin in Young Women With Early Endometrial Carcinoma and Atypical Endometrial Hyperplasia
To explore the treatment efficacy of medroxyprogesterone acetate plus atorvastatin in patients with atypical endometrial hyperplasia (AEH) and early endometrial carcinoma (EEC) for conservative treatment.
- Trial name
- NCT05675787
- Testing
- Medroxyprogesterone acetate + Atorvastatin
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Peking University People's Hospital
Endometrioid Endometrial Adenocarcinoma
A Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients With Endometrioid Intraepithelial Neoplasia
This study will explore the use of glucagon-like peptide 1 receptor agonist (GLP-1RA) used concurrently with levonorgestrel intrauterine device in patients with poor surgical candidacy for a hysterectomy or patients who are…
- Trial name
- NCT07107334
- Testing
- Glucagon-like peptide 1 receptor agonist
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Florida