Clinical trials: Atrial Fibrillation Catheter Ablation
Persistent Atrial Fibrillation
Feasibility Study of the FARAPULSE™ Cardiac Ablation System Plus in the Treatment of Persistent Atrial Fibrillation(PersAFOne II)
The objective of this safety and feasibility study is to assess whether the endocardial creation of electrically nonconductive lesions via PEF catheter ablation applied using the FARAPULSE Cardiac Ablation System Plus is a…
- Trial name
- PersAFOne II (NCT05152966)
- Testing
- Ablation
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation
Catheter Ablation for Recently Diagnosed Paroxysmal Atrial Fibrillation
The objective is to compare the progression of Atrial Fib (AF) burden by continuous monitoring in patients with recently diagnosed paroxysmal AF treated by catheter ablation (PVI) versus anti-arrhythmic drug (AAD) therapy.
- Trial name
- CABAL (NCT01505296)
- Testing
- Antiarrhythmic drug, Catheter ablation
- Where
- 2 sites in United States, Russia
- Sponsor
- Valley Health System
Atrial Fibrillation
Radiofrequency Catheter Ablation for Chronic Atrial Fibrillation
The purpose of this study is to determine the long-term efficacy of radiofrequency catheter ablation in patients with chronic atrial fibrillation.
- Trial name
- NCT00272636
- Testing
- Radiofrequency catheter ablation, Amiodarone and cardioversion
- Where
- 2 sites in United States, Italy
- Volunteers
- 140 people
- Sponsor
- University of Michigan
Atrial Fibrillation
Does the Merged 3D Imaging Improve Contact Force and Long Term Procedure Outcome in Atrial Fibrillation?
The purpose of the study is to investigate whether or not there are the differences in acute procedure and long-term clinical outcome of radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF) using the 3D map…
- Trial name
- MICRO-AF (NCT03350581)
- Testing
- FAM 3D map group, FAM-CT 3D map group
- Where
- 2 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Korea University Guro Hospital
Atrial Fibrillation
A New Approach for Catheter Ablation of Atrial Fibrillation
This is a retrospective cohort study of radiofrequency ablation for the treatment atrial fibrillation(AF). Based on the electrophysiological phenomena found in these cases, the investigators propose a hypothesis regarding the…
- Trial name
- NCT05989321
- Testing
- PVI alone, PVI + SPs ablation
- Where
- China
- Volunteers
- 116 people
- Sponsor
- The Second Affiliated Hospital of Kunming Medical University
Atrial Fibrillation (AF)
PVI Alone vs PVI With Posterior Wall Isolation for Pulse-Field Ablation in Persistent AF
To date, no optimal treatment has been established to improve outcomes in patients with persistent atrial fibrillation. The safety and efficacy of pulsed-field ablation (PFA) have been demonstrated in several studies, and its…
- Trial name
- POBI-PFA (NCT06929897)
- Testing
- Pulmonary Vein Isolation, Additional Left Atrial Posterior Wall Ablation, Non-PV trigger test
- Where
- South Korea
- Volunteers
- 482 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University Mokdong Hospital
Atrial Fibrillation, Atrial Tachycardia
Study of Interference Between Oral Anticoagulants and Heparin During Ablation of Atrial Fibrillation (AF) or Left Atrial Tachycardia (GAD) by Catheter.
Catheter ablation of atrial fibrillation (AF) or left atrial tachycardia (GAD) is usually performed in patients treated with vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) that are increasingly used.
- Trial name
- FACADO (NCT05802576)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atrial Fibrillation (AF), Cardiac Arrhythmias
Anesthetic Safety of High-Frequency, Very-Low Tidal Volume Ventilation With Controlled Peak Pressure During Atrial Fibrillation Ablation
This prospective, observational, within-subject crossover pilot study evaluates the impact of a high-frequency, very-low tidal volume ventilation strategy with controlled peak inspiratory pressure (HFvLTV-cPP) on…
- Trial name
- HFvLTVcPPSAFE (NCT07402798)
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Centro Medico Teknon
Atrial Fibrillation
Italian Registry In the Setting of AF Ablation With Rivaroxaban (IRIS)
The aim of IRIS study is to observe the safety and efficacy of Rivaroxaban in subjects undergoing catheter ablation for atrial fibrillation (AF) in real-world clinical practice.
- Trial name
- IRIS (NCT04315974)
- Testing
- Rivaroxaban, Catheter ablation
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Dr Carlo Lavalle
Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation (AF)
Optimal PharmacoTherapy and Invasive Management of Atrial Fibrillation in Patients With Heart Failure
Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardiovascular epidemics, individually impairing quality of life and cardiac performance, as well as increasing the risk of hospitalisation and mortality.
- Trial name
- OPTIMal AF-HF (NCT07238452)
- Testing
- Pulmonary Vein Isolation, Pharmacological Rate Control
- Volunteers
- 1,050 people
- Sponsor
- University of British Columbia
Atrial Fibrillation, Post-Catheter Ablation Atrial Arrhythmia Recurrence
Ezetimibe for Arrhythmia Recurrence After AF Ablation
This single-center, prospective, single-blind randomized controlled pilot trial aims to explore whether oral ezetimibe can reduce the 6-month recurrence rate of atrial tachyarrhythmia after catheter ablation in patients with…
- Trial name
- EAFA (NCT07752758)
- Testing
- Ezetimibe, Standardized post-ablation clinical management
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Atrium; Fibrillation, Atrium; Flutter
Refralon in Patients With Recurrence Paroxysmal and Persistent Forms of Atrial Fibrillation Who Underwent Catheter Ablation
It is planned to evaluate the efficacy and safety of the class III antiarrhythmic drug refralon as a drug for pharmacological cardioversion in patients with recurrent atrial fibrillation (AF) and atrial flutter (AFL) after…
- Trial name
- NCT05456204
- Testing
- Pharmacological cardioversion with Refralon
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Atrial Fibrillation, Left Atrial Appendage
Left Atrial Appendage Electrical Isolation in Persistent Atrial Fibrillation
This project intends to enroll patients with persistent atrial fibrillation who are planning to undergo catheter ablation of atrial fibrillation.
- Conditions
- Atrial Fibrillation, Left Atrial Appendage, Left Atrial Appendage Occlusion, Catheter Ablation
- Trial name
- NCT04897204
- Testing
- Catheter ablation and left atrial appendage occlusion, Additional left atrial appendage electrical isolation combined with catheter ablation and left atrial appendage occlusion
- Volunteers
- 120 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Atrial Fibrillation, Catheter Ablation
Electroacupuncture Intervention in Catheter Ablation of Atrial Fibrillation
This is a randomized control trial to determine whether electroacupuncture(EA) intervention with Morphine can reduce the intraoperative pain and early post-operative complications in patients undergoing catheter ablation of…
- Trial name
- NCT05575544
- Testing
- Acupuncture plus morphine
- Volunteers
- 200 people
- Sponsor
- Shanghai Chest Hospital
Persistent Atrial Fibrillation
Effect of Empirical Left Atrial Appendage Isolation on Long-term Procedure Outcome in Patients With Persistent or Long-standing Persistent Atrial Fibrillation Undergoing Catheter Ablation
The purpose of this prospective randomized study is to assess whether empirical Left Atrial Appendage (LAA) isolation along with the standard approach of pulmonary vein isolation (PVI) and ablation of extra-pulmonary triggers is…
- Trial name
- BELIEF (NCT01362738)
- Testing
- RFCA of PV and extra-PV triggers, LAA isolation along with the conventional ablation strategy
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Atrial Fibrillation
Optimizing Quality of Life by Improved Patient Expectation Following Atrial Fibrillation Catheter Ablation
The aim is to investigate whether optimizing patients' expectations towards the interventional treatment of atrial fibrillation (catheter ablation) leads to a lower disease-related impairment of the patients compared to the…
- Trial name
- NCT05557526
- Testing
- Expectation optimization
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Evangelical Hospital Düsseldorf
Atrial Fibrillation (AF), Atrial Flutter
Electrophysiological Registry Duesseldorf
This registry at University Hospital Düsseldorf collects retrospective and prospective (from 2019 onward) data on patients undergoing electrophysiological studies (EPS), catheter ablation, and electrical cardioversion.
- Conditions
- Atrial Fibrillation (AF), Atrial Flutter, Supraventricular Tachycardias, Ventricular Tachycardia (VT)
- Trial name
- NCT07196176
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Atrial Fibrillation, Radiofrequency Catheter Ablation
Use of Radiofrequency Ablation to Eliminate Continuous Atrial Fibrillation in Patients Undergoing Mitral Valve Surgery
The aim of this prospective randomized clinical trial was to evaluate the early and late outcome following left atrial radiofrequency ablation during MV surgery for the treatment of continuous atrial fibrillation and to assess…
- Trial name
- NCT00238706
- Testing
- Radiofrequency ablation
- Sponsor
- University Hospitals, Leicester
Atrial Fibrillation
SMART-SF Radiofrequency Ablation Safety Study
This is a prospective safety assessment of the study device during radiofrequency (RF) ablation treatment of patients with drug refractory symptomatic atrial fibrillation (SMART-SF).
- Trial name
- NCT02359890
- Testing
- THERMOCOOL® SMARTTOUCH® (RF ablation treatment)
- Volunteers
- 165 people
- Sponsor
- Biosense Webster, Inc.