Clinical trials: Atheroscleroses
Atheroscleroses, Inflammation
Vascular Inflammation in Atherosclerosis - Whole Body Molecular PET/CT Imaging Using Folate Receptor β
This study investigates inflammation in the blood vessels of people with coronary artery disease (CAD) or a recent myocardial infarction.
- Trial name
- ATHERO-FOL (NCT07877324)
- Testing
- 18F-AlF-NOTA-Folate PET
- Where
- Finland
- Volunteers
- 90 people
- Sponsor
- Turku University Hospital
Coronary Artery Disease, Image
Concurrent OCT and FFR-guided PCI in CAD
The present study is a prospective randomized clinical trial aimed to compare the therapeutic strategy of angiography-guided versus concurrent OCT/FFR-guided intervention in patients with coronary artery disease.
- Conditions
- Coronary Artery Disease, Image, Atheroscleroses, Coronary
- Trial name
- OPTICARE-CAD (NCT06182683)
- Testing
- optical coherence tomography and fractional flow reserve, Coronary angiography
- Where
- South Korea
- Volunteers
- 700 people
- Sponsor
- Korea University Guro Hospital
Cardiovascular Diseases (CVD), Coronary Artery Disease
wCAR-Austria: A Women-Specific Score to Assess Cardiovascular Risk in Women Aged 40 to 65
The wCAR-Austria Study is a multicentre, prospective, interventional study evaluating a novel women-specific cardiovascular risk score (wCAR) in 800 women aged 40-65 years across Austria.
- Conditions
- Cardiovascular Diseases (CVD), Coronary Artery Disease, Atheroscleroses
- Trial name
- wCAR-Austria (NCT07849127)
- Testing
- Arm 1: wCAR-CARE - Precision Prevention (Arm A), Guideline-directed standard of care
- Where
- Austria
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Women's Heart Austria
Atheroscleroses, Rheumatoid Arthritis (RA
Atherosclerosis in Early Rheumatoid Arthritis Patients Using Atherogenic Index of the Plasma and Carotid Intima Media Thickness
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily affecting the peripheral joints, yet its extra-articular burden particularly on the cardiovascular (CV) system has emerged as its most consequential…
- Trial name
- NCT07772466
- Volunteers
- 70 people
- Sponsor
- Assiut University
Atheroscleroses, Geriatric
Development and Validation of a Scale of Propensity for Change in Chronic Disease Prevention
Modifiable risk factors are estimated to account for 70% of cardiovascular diseases, 40% of Alzheimer's-type dementias, and 50% of type 2 diabetes cases.
- Trial name
- ProChange (NCT07765797)
- Testing
- Scale development phase, Beta testing phase, Validation phase
- Where
- France
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
High Resolution Vessel Wall Imaging, Recurrent Stroke
Plaque Characteristics Predict Recurrent Stroke in MCA Stroke Patients
The epidemiology of TOAST classification in Asian patients seems to differ due to the higher rates of large-artery atherosclerosis.
- Conditions
- High Resolution Vessel Wall Imaging, Recurrent Stroke, Stroke, Mechanism, Atheroscleroses, Intracranial
- Trial name
- NCT06404242
- Where
- Vietnam
- Volunteers
- 75 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Moyamoya Syndrome, Moyamoya Disease
A Study of Cerebral Perfusion With tDCS in Chronic Hypoperfusion
This study is being done to examine whether transcranial direct current stimulation (tDCS) will increase cerebral blood flow which may provide a clinical benefit such as improving cognitive impairment.
- Conditions
- Moyamoya Syndrome, Moyamoya Disease, Atheroscleroses, Cerebral
- Trial name
- NCT06477107
- Testing
- Soterix® 4x1HD-TDCS, Soterix® 1x1 tDCS, Cognitive training program
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Mayo Clinic
Atherosclerosis, Atheroscleroses, Coronary
SIALIDASE INHIBITION AS ANTIATHEROSCLEROTIC THERAPY
The aim of this double-blind, randomized, placebo-controlled, multicenter study is to evaluate the pathogenetic effects of the dietary supplement "Tertinat" on a fundamental mechanism of atherosclerosis development: its ability…
- Conditions
- Atherosclerosis, Atheroscleroses, Coronary, Carotid Atherosclerosis
- Trial name
- SIAT (NCT06590012)
- Testing
- Tertinat
- Where
- 10 sites in Russia
- Volunteers
- 1,228 people
- Sponsor
- Institute for Atherosclerosis Research, Russia
Carotid Artery Stenosis Symptomatic, Ischemic Cerebral Infarction
Clinical Impact of Using IMPROVE to Select Patients for Carotid Revascularisation
Narrowing of the carotid artery due to atherosclerosis with an unstable plaque can cause a stroke. Patients with carotid artery disease who have had a TIA or minor stroke and are at high risk of another stroke are often treated…
- Conditions
- Carotid Artery Stenosis Symptomatic, Ischemic Cerebral Infarction, Stroke Ischemic, Atheroscleroses
- Trial name
- IMPROVE (NCT07556887)
- Testing
- IMPROVE Risk Model
- Where
- 10 sites in Netherlands
- Volunteers
- 613 people
- Sponsor
- Maastricht University Medical Center
Coronary Artery Disease (CAD), Computed Tomography Angiography
AI-assisted CT for Risk Stratification in Coronary Artery Disease (ACTION)
The goal of this observational study is to learn if AI-assisted cardiac CT imaging can improve cardiovascular risk stratification and prediction of future coronary events in an adult population undergoing clinically indicated…
- Conditions
- Coronary Artery Disease (CAD), Computed Tomography Angiography, Biomarkers, AI (Artificial Intelligence)
- Trial name
- ACTION (NCT07577609)
- Where
- Ireland
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Galway
CAD, Atheroscleroses, Coronary
Comprehensive Computed Tomography Guidance of Coronary Bypass Graft Surgery
Apply CT angiography, CT perfusion imaging and advanced image processing techniques to improve revascularization decision-making and surgical strategies in patients undergoing coronary artery bypass graft surgery.
- Conditions
- CAD, Atheroscleroses, Coronary, Computed Tomography, Coronary Artery Bypass
- Trial name
- NCT03894423
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Stanford University
Coronary Heart Disease, Coronary Artery Disease
A Study on Yiyang Huoluo Decoction in the Treatment of Coronary Heart Disease
The goal of this clinical trial is to learn if Yiyang Huoluo Decoction (a custom Chinese herbal medicine) works safely and effectively to treat coronary heart disease with atherosclerosis in older adults.
- Conditions
- Coronary Heart Disease, Coronary Artery Disease, Atheroscleroses
- Trial name
- NCT07493603
- Testing
- Yiyang Huoluo Decoction, conventional western medicine treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xia Liang
Erectile Dysfunction Due to Arterial Disease, Atheroscleroses
TRIal of STatin Therapy Effect on Androgen Status and Erectile functioN in Men
Aim. To study the effect of different intensities of statin therapy on androgen status and erectile function in men aged 40-65 years with high and very high cardiovascular risk.
- Conditions
- Erectile Dysfunction Due to Arterial Disease, Atheroscleroses, Erectile Disfunction, Endothelial Dysfunction
- Trial name
- NCT07460960
- Testing
- Pitavastatin 1-4 mg daily, Rosuvastatin 20-40 mg daily
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Lomonosov Moscow State University Medical Research and Educational Center
Ischemic Stroke, Atheroscleroses, Cerebral
Morphology of Advanced Symptomatic Cerebral Plaques With High Embolic Potential
The study is to attain early recognition of the unstable plaques which have an imminent embolic risk in patients with intracranial atherosclerotic disease (IAD).
- Trial name
- NCT03291652
- Testing
- DSA/3DRA
- Where
- Hong Kong
- Volunteers
- 140 people
- Sponsor
- Chinese University of Hong Kong
Ischemic Stroke, Atheroscleroses, Cerebral
Morphologic Evolution and Remodeling of Intracranial Atherosclerosis: A Longitudinal Study by 3D-rotational Angiography
This study is to elucidate the morphologic evolution and remodeling of ICAD under stringent control of cardiovascular risk factors.
- Trial name
- NCT03295773
- Testing
- 3DRA
- Where
- Hong Kong
- Volunteers
- 140 people
- Sponsor
- Chinese University of Hong Kong
Atheroscleroses, Coronary, Microbiota
Gut Microbiota Modulation With Synbiotics After Acute Coronary Syndrome
Acute coronary syndrome (ACS) remains one of the leading causes of morbidity and mortality worldwide despite major advances in acute management and secondary prevention.
- Trial name
- SYMBIO-ACS (NCT07411287)
- Testing
- Pro-B (Bionaturis),, Guideline-Directed Medical Therapy (GDMT)
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier de Bienne
Coronary Artery Disease, Atheroscleroses
Drug-Eluting Balloon Treatment vs. Guideline-Directed Medical Therapy for the Treatment of Lipid-Rich Plaques
The goal of this clinical trial is to find out whether treating vulnerable plaques in the coronary arteries with a drug-coated balloon can make them less dangerous than using standard medication alone.
- Conditions
- Coronary Artery Disease, Atheroscleroses, Cardiovascular Disease, Vulnerable Coronary Plaques
- Trial name
- DELETE-LRP (NCT07107971)
- Testing
- Paclitaxel-eluting balloon
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cardiovascular (CV) Risk, Atheroscleroses
Exploring Sustainable Alternatives to Marine Oils With Echium and Ahiflower Oils
This randomized, single-blind, crossover clinical trial aims to evaluate Echium oil and Ahiflower® oil as sustainable, plant-based alternatives to marine oils for omega-3 supplementation.
- Conditions
- Cardiovascular (CV) Risk, Atheroscleroses, Inflamation, Omega 3 Fatty Acids
- Trial name
- NCT07289919
- Testing
- Echium oil, Ahiflower oil, EPA capsules
- Where
- Brazil
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Stroke, Atheroscleroses
A Cohort Study on Cardiovascular and Cerebrovascular Outcomes
A standardized tool for grading carotid atherosclerotic plaques-dubbed Carotid Plaque-RADS (Reporting and Data System)-has recently been developed.
- Trial name
- NCT07178015
- Testing
- ultrasound scanning
- Where
- China
- Volunteers
- 855 people
- Sponsor
- Sun Yat-sen University
Cardiovascular Diseases, Obesity Prevention
Mediterranean Diet Education in Shift Nurses: Effects on Sleep, Activity, and Health Parameters
This study aimed to evaluate the effects of Mediterranean diet education on sleep quality, physical activity levels, blood parameters, and anthropometric measurements among shift-working nurses.
- Conditions
- Cardiovascular Diseases, Obesity Prevention, Atheroscleroses, Hypertension
- Trial name
- NCT07123610
- Testing
- Mediterranean Diet Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University