Clinical trials: Atelectasis, active
Shock, Preterm Birth Complication
Early Hydrocortisone Versus Regular Treatment in Shock in Extremely Preterm Neonates - an Open Randomized Controlled Trial
The goal of this clinical trial is to determine the effectiveness of early use of hydrocortisone (since the diagnosis of shock) for its resolution within the first 72 hours in premature infants under 1,500 g.
- Conditions
- Shock, Preterm Birth Complication, Preterm Intraventricular Hemorrhage, Asphyxia Perinatal
- Trial name
- NCT07248761
- Testing
- Intravascular Hydrocortisone (stress dosage): 1 mg/k/dose each 8 hours for 5 days, Vasoactive drug therapies
- Where
- Mexico
- Volunteers
- 76 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Surfactant Deficiency Syndrome Neonatal
deMISTify: The Impact of Ventilator Pressure Levels During Minimally Invasive Surfactant Therapy on Lung Aeration in Preterm Infants
Infants born preterm (before 36 weeks' gestation age) have immature lungs and struggle to breathe on their own. They are supported via respiratory machines like ventilators, as well as pharmaceutical aids like surfactant…
- Trial name
- deMISTify (NCT07522346)
- Testing
- Lung Recruitment Manoeuvre prior to Minimally Invasive Surfactant Therapy, Control (Minimally Invasive Surfactant Therapy)
- Where
- Australia
- Volunteers
- 36 people
- Sponsor
- Murdoch Childrens Research Institute
Respiratory Distress Syndrome (Neonatal), Intubation Complication
InfasurfAero™ Versus Sham Treatment in Preterm Newborns With RDS
The purpose of this clinical study is to determine the effectiveness and safety of Infasurf® administered through the InfasurfAero™, a novel oral airway delivery device specifically designed to give Infasurf in a less complicated…
- Conditions
- Respiratory Distress Syndrome (Neonatal), Intubation Complication, Death; Neonatal
- Trial name
- Aero-05 (NCT05960929)
- Testing
- Infasurf Aero™
- Where
- 10 sites in United States
- Volunteers
- 220 people
- Sponsor
- ONY
Pregnancy Complications, Atelectasis
Effect of Epidural Analgesia on Regional Lung Ventilation in Parturient Women as Assessed by Thoracic Impedance
The goal of this observational study is to learn more about the effect of obstetric epidural anesthesia on regional lung ventilation in healthy parturient women.
- Trial name
- NCT06195774
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Erasme University Hospital
Hypoxemia
Effect of Different Oxygen Concentrations Before Extubation After General Anesthesia on Hypoxemia After Extubation in Post-anesthesia Care Unit
Before extubation during the anesthesia recovery period, 100% oxygen is routinely inhaled to increase the oxygen reserves, maximizing the time window for anesthesiologists to adjust strategies when they encounter hypoxemia after…
- Trial name
- NCT07293286
- Testing
- 100% oxygen concentration inhaled, 30% oxygen concentration inhaled
- Where
- China
- Volunteers
- 590 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Respiratory Distress Syndrome, Preterm Pregnancy
Less Invasive Surfactant Administration in Late Preterm or Early Term Born Infants
The aim of this study is to see if giving less invasive surfactant administration (LISA) during high-flow nasal cannula (HFNC) oxygen treatment reduces the need for invasive ventilation in babies with breathing problems born 2-6…
- Conditions
- Respiratory Distress Syndrome, Preterm Pregnancy, Surfactant Deficiency Syndrome Neonatal
- Trial name
- NCT06421506
- Testing
- Less invasive surfactant administration during high flow nasal cannula treatment
- Where
- United Kingdom
- Volunteers
- 245 people
- Sponsor
- King's College Hospital NHS Trust
Postoperative Pulmonary Complications
Consensus Statements on Definition, Components and Grading of Postoperative Pulmonary Complications
An international team of experts is working on a project called PrECiSIOn to develop a clear, consistent definition of PPCs. The goals of this study are to: Define postoperative pulmonary complications in a way that makes sense…
- Trial name
- PrECiSIOn (NCT06916598)
- Testing
- Delphi study, Structured Interview
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Obesity, Abdominal, Anesthesia Morbidity
CPAP in Patients With Severe Obesity After Anesthesia
The goal of this study is to compare two continuous positive airway pressure (CPAP) settings on heart and lung function in patients with severe obesity after anesthesia. The main questions it aims to answer are: 1.
- Conditions
- Obesity, Abdominal, Anesthesia Morbidity, Apnea, Obstructive Sleep, Atelectases, Postoperative Pulmonary
- Trial name
- NCT06287632
- Testing
- Recruitment/ITP-CPAP (Intervention A), Standard CPAP (Intervention B), Atmospheric Pressure
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Neonates and Preterm Infants, Infant Respiratory Distress Syndrome
Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minutes Versus 5 Minutes
Respiratory distress syndrome (RDS) is common in very preterm infants due to surfactant deficiency. Surfactant replacement therapy is lifesaving, and current guidelines recommend the less invasive surfactant administration (LISA)…
- Conditions
- Neonates and Preterm Infants, Infant Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal, Surfactant
- Trial name
- SurfStab I (NCT07261787)
- Testing
- Poractant alfa (Curosurf®) - 1-minute administration, Poractant alfa (Curosurf®) - 5-minute administration
- Where
- Austria
- Volunteers
- 76 people
- Sponsor
- Medical University of Graz
Major Abdominal Surgery, Atelectasis
Optimal Interval for Periodic Alveolar Recruitment Maneuvers Achieving 90% Lung Re-expansion During Intraoperative Ventilation
This study aims to determine the optimal interval for periodic alveolar recruitment maneuvers (PARM) that can achieve effective lung re-expansion in 90% of patients undergoing intraoperative mechanical ventilation during…
- Conditions
- Major Abdominal Surgery, Atelectasis, Lung-protective Ventilation, Lung Ultrasound Score
- Trial name
- NCT07239557
- Testing
- Different interval of PARM
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB)
Comparing CPAP and BiPAP for Sleep-Disordered Breathing in People with Cervical Spinal Cord Injuries
Sleep-disordered breathing (SDB) is common in individuals with cervical spinal cord injuries, with studies suggesting prevalence rates ranging from 27% to 62%.
- Conditions
- Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB), Sleep Apnea, Cervical Spinal Cord Injruy
- Trial name
- NCT06818604
- Testing
- CPAP, BiPAP
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Mechanical Ventilation, Atelectasis
To Assess the Effectiveness of Three Distinct Mechanical Assisted Sputum Evacuation Apparatuses in the Treatment of Patients With Mechanical Ventilation-induced Atelectasis
Retention of airway secretions is a common clinical problem in patients with mechanical ventilation. Effective removal of airway secretions requires a balance between the production and removal of airway secretions through the…
- Trial name
- EOTEOMASE (NCT06631716)
- Testing
- CVT, HFCWO, MetaNeb
- Volunteers
- 84 people
- Sponsor
- Sir Run Run Shaw Hospital
RDS of Prematurity, Surfactant Deficiency Syndrome Neonatal
Surfactant Administration by Insure or Thin Catheter
This trial evaluates the efficacy and safety of surfactant administration with thin catheter technique together with analgesic premedication in comparison with the established INSURE-strategy.
- Conditions
- RDS of Prematurity, Surfactant Deficiency Syndrome Neonatal, Analgesia
- Trial name
- SAINT (NCT04445571)
- Testing
- Thin catheter technique or standard ET-tube for surfactant administration
- Where
- Sweden
- Volunteers
- 160 people
- Sponsor
- Karolinska Institutet
ARDS, AHRF
HemodynamIc eFfects of Lung Collapse and overdIstension During ARDS
The management ARDS relies on ventilatory strategies aimed at limiting ventilator-induced lung injury (VILI). The setting of PEEP is still subject of debate, as randomized clinical trials comparing standardized higher versus…
- Trial name
- HI-FIVE (NCT07423520)
- Testing
- Change in PEEP
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Lung Collapse, One-lung Ventilation
Brief Bronchial Suction for Lung Collapse During Uniportal VATS
The goal of this clinical trial is to learn whether a brief suction of the airway going to the surgical lung (bronchus) can help the lung collapse faster and more completely during uniportal video-assisted thoracoscopic surgery…
- Conditions
- Lung Collapse, One-lung Ventilation, Thoracic Anesthesia, Thoracic Surgery, Video-assisted
- Trial name
- NCT07660588
- Testing
- bronchial suction
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Postoperative Atelectasis, Lung Ultrasonography Score
Evaluation of Recruitment Effectiveness in Patients With Obstructive Sleep Apnea Syndrome Using Lung Ultrasound
Patients with obstructive sleep apnea syndrome are at higher risk for respiratory complications after surgery. Oxygen depletion and respiratory distress are common in patients with obstructive sleep apnea syndrome.
- Conditions
- Postoperative Atelectasis, Lung Ultrasonography Score, Recruitment
- Trial name
- NCT07061002
- Testing
- Lung Recruitment Maneuver, Positional Lung Recruitment Maneuver
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Istanbul University - Cerrahpasa
Neonatal Respiratory Distress
Transference of Established Simulated Skills (TEST) Trial
This study aims to determine if skills learned in the simulation lab, specifically in managing mask leak during positive pressure ventilation (PPV), translate effectively to the delivery room.
- Trial name
- TEST (NCT06572033)
- Testing
- Simulation
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Postoperative Pulmonary Complications, One Lung Ventilation
The Effect of Single Lung Ventilation Duration on Postoperative Pulmonary Complications in Thoracic Surgery
This observational study investigates the relationship between the duration of single-lung ventilation (SLV) and the incidence of postoperative pulmonary complications (PPCs) such as pneumonia, pneumothorax, hemothorax, acute…
- Conditions
- Postoperative Pulmonary Complications, One Lung Ventilation, Ards, Postoperative Pulmonary Atelectasis
- Trial name
- NCT07100860
- Testing
- One-Lung ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Atelectasis, Postoperative Pulmonary Complications (PPCs)
Automated Intraoperative Lung Recruitment Maneuvers in Major Laparoscopic Surgery
Laparoscopic colorectal surgery is associated with an increased risk of intraoperative atelectasis due to pneumoperitoneum, Trendelenburg positioning, and prolonged anesthesia duration.
- Trial name
- NCT07349784
- Testing
- Automated Intraoperative Lung Recruitment Maneuvers
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Atelectases, Postoperative Pulmonary
Prevention and Treatment of Early Postoperative Atelectasis Using The MetaNeb System in Patients Underwent Esophagectomy
The goal of this clinical trial is to evaluate whether the MetaNeb® System can effectively prevent and treat early postoperative atelectasis in adult patients admitted to ICU after esophagectomy for esophageal cancer.
- Trial name
- NCT07284056
- Testing
- MetaNeb Therapy, Standard of care
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Shanghai Zhongshan Hospital