Clinical trials: Asthma Patients
Nasal Polyps
Study of Efficacy of Fevipiprant in Patients With Nasal Polyposis and Asthma
A Phase 3b Proof-of-Concept study to evaluate the ability of fevipiprant 150 mg and 450 mg, compared with placebo, as add-on to nasal spray standard-of-care (SoC), in reducing endoscopic nasal polyp score in adult (≥ 18 years)…
- Trial name
- THUNDER (NCT03681093)
- Testing
- Fevipiprant 150 mg, Fevipiprant 450 mg
- Where
- 25 sites in United States, Argentina and 7 more
- Volunteers
- 98 people
- Sponsor
- Novartis Pharmaceuticals
Asthma Patients, Healthy Subjects
Development and Validation of a Sputum Biomarker mRNA Panel for the Diagnostic Work-up of Asthma 1.
The main objectives of the study are 1. to study the different T cell subtypes (Th1, Th2, Th17 and Treg) in the lower airways of healthy subjects and clinically different asthma patients, based on a non-invasive procedure of…
- Trial name
- BioSput-Air (NCT01224938)
- Where
- Belgium
- Volunteers
- 395 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Asthma
Efficacy and Safety of Different Doses of Indacaterol
This study compared the 14-day bronchodilator efficacy of indacaterol with that of placebo and salmeterol
- Trial name
- NCT01079130
- Testing
- Indacaterol, Salmeterol
- Where
- 71 sites in United States
- Volunteers
- 511 people
- Sponsor
- Novartis Pharmaceuticals
Asthma (Diagnosis)
The Effect of a Cold Air Eucapnic Hyperventilation Test on Lower Respiratory Airways in Healthy Volunteers and Patients With Asthma
In this study, we want to evaluate the feasibility and safety of a CAEH test in healthy volunteers and patients with asthma. We want to develop a CAEH test to differentiate patients with different types of asthma and…
- Trial name
- CLARINET (NCT07220928)
- Testing
- Cold air challenge
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Asthma
Study of Fluticasone Propionate MDPI Compared With Fluticasone/Salmeterol MDPI in Adolescent and Adult Patients With Persistent Asthma
The primary objective of this study was to evaluate the efficacy of fluticasone propionate multidose dry powder inhaler (Fp MDPI) and fluticasone propionate/salmeterol xinafoate multidose dry powder inhaler (FS MDPI) when…
- Trial name
- NCT02139644
- Testing
- FS MDPI, Fp MDPI, albuterol/salbutamol
- Where
- 140 sites in United States, Canada and 6 more
- Volunteers
- 787 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Allergic Bronchopulmonary Aspergillosis
Study in Adult Asthmatic Patients With Allergic Bronchopulmonary Aspergillosis
A Randomized, Double-Blind, Multicenter, Placebo-Controlled, Phase 2 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Itraconazole Administered as a Dry Powder for Inhalation (PUR1900) in Adult Asthmatic…
- Trial name
- NCT03960606
- Testing
- PUR1900
- Where
- 20 sites in United States, Australia and 3 more
- Volunteers
- 7 people
- Sponsor
- Pulmatrix Inc.
Asthma
Effects of Balloon-blowing Exercises in 90/90 Bridge Position With a Ball on Pulmonary Function Among Asthmatic Patients
In asthma, the airways in the respiratory system can experience inflammation and constriction, causing increased difficulty in expelling air during exhalation.
- Trial name
- NCT06660537
- Testing
- Balloon-blowing exercises in 90/90 bridge position with a ball., Buteyko breathing exercises management
- Where
- Pakistan
- Volunteers
- 41 people
- Sponsor
- Foundation University Islamabad
Pneumonia, Pulmonary Fibrosis
Pulmonary Rehabilitation in Non-chronic Obstructive Pulmonary Disease Patients.
To determine the effect of pulmonary rehabilitation on pulmonary function in non-chronic obstructive pulmonary disease patients.To determine the effect of pulmonary rehabilitation on health related quality of life in non-chronic…
- Conditions
- Pneumonia, Pulmonary Fibrosis, Tuberculosis, Bronchiectasis
- Trial name
- NCT05174741
- Testing
- Conventional Chest Physiotherapy, Aerobic training Group
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Riphah International University
Asthma
Remote Anxiety Management for ICS-resistant Asthma Study
This study, the Remote Anxiety Management for ICS-resistant Asthma Study (RAMICS), explores strategies to improve medication adherence and anxiety management in asthma patients who are resistant to using inhaled corticosteroids…
- Trial name
- RAMICS (NCT06732141)
- Testing
- Personalized Telephone-Based Psychological Support, Standard Care with Weekly Follow-Up Calls
- Where
- 11 sites in China
- Volunteers
- 216 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Asthma
An Efficacy and Safety Evaluation of Tiotropium add-on Therapy in Patients With Severe Persistent Asthma
The primary objective of this study is to examine efficacy and safety of tiotropium compared to plac ebo as add-on therapy in severe asthmatics according to GINA step 4 classification
- Trial name
- NCT00365560
- Testing
- tiotropium
- Where
- 16 sites in Denmark, Germany and 1 more
- Volunteers
- 115 people
- Sponsor
- Boehringer Ingelheim
Asthma
Efficacy and Safety Study of Fluticasone/Salmeterol Administered With Elpenhaler
The aim of this study is to establish the therapeutic equivalence between the test (Fluticasone/Salmeterol administered with Elpenhaler®db, Rolenium®) and the reference formulation (Seretide®, administered with Diskus®), both…
- Trial name
- NCT05459194
- Testing
- RP - TA
- Volunteers
- 42 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Asthma
Vivatmo proTM EU-study: FeNO Monitoring in Asthmatic Patients Responding to ICS Treatment
This is a multi-center study to evaluate fractional exhaled nitric oxide (FeNO) measured with the Vivatmo pro in adult and pediatric subjects.
- Trial name
- NCT05553379
- Testing
- FeNO measurement
- Where
- 5 sites in Czechia, Germany
- Volunteers
- 48 people
- Sponsor
- Bosch Healthcare Solutions GmbH
Asthma, Depression
Trial of Asthma Self-Management Education in Patients With Depressive Symptoms
Although depressive and anxious symptoms are common in asthma patients and are associated with worse clinical and resource utilization outcomes, there have been no studies focusing on the particular challenges of improving asthma…
- Conditions
- Asthma, Depression, Anxiety
- Trial name
- NCT01708070
- Testing
- Asthma self-management
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Hospital for Special Surgery, New York
Sarcopenia, Asthma
Impact of Sarcopenia on Dyspnea in Patients With Asthma
Dyspnea in asthma, is mainly due to airway obstruction but can be caused by several alternative diagnoses. The impact of sarcopenia on dyspnea in patients with asthma is unknown.
- Conditions
- Sarcopenia, Asthma, Dyspnea, Dyspnea; Asthmatic
- Trial name
- MUDYSA (NCT06870890)
- Testing
- muscle evaluation, Dosage, Cardiopulmonary exercise test
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Asthma
Mechanical Heat Recovery Ventilation on House Dust Mite Sensitive Asthma
Asthma has become increasingly common in the UK, demanding our consideration of the cause. Many patients with asthma are allergic to house dust mites, which thrive in modern housing.
- Trial name
- NCT00148096
- Testing
- Mechanical Heat Recovery Ventilation
- Where
- United Kingdom
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Persistent Allergic Asthma
Omalizumab in Patients With Moderate to Severe Persistent Allergic Asthma Not Adequately Controlled Despite GINA (2009) Step 4 Therapy
This study will assess the efficacy, safety and tolerability of omalizumab, compared to placebo in 18 to 75 year old Chinese patients with moderate to severe persistent allergic asthma who have inadequate asthma control despite…
- Trial name
- NCT01202903
- Testing
- Omalizumab
- Where
- 39 sites in China
- Volunteers
- 616 people
- Sponsor
- Novartis Pharmaceuticals
Medication Adherence, Medication Compliance
Connected Healthcare for Individuals Living at Home With Chronic Conditions
Managing and taking medications as prescribed can be a difficult task. This is especially true for older adults living at home with chronic conditions while managing multiple prescribed medications.
- Conditions
- Medication Adherence, Medication Compliance, Medication Nonadherence, Hypertension
- Trial name
- NCT04339296
- Testing
- Spencer
- Where
- Canada
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Alberta Health Services, Calgary
Asthma
Assess Bronchodilator Effect QVM149 Dosed Either in the Morning or Evening Compared to Placebo in Patients With Asthma
This was a randomized, placebo-controlled, double-blind, six-sequence, three-period cross-over study in asthma patients. The study consisted of a 14-day screening period, followed by a 14-day run-in period, and a treatment epoch…
- Trial name
- QVM149 (NCT03108027)
- Where
- 7 sites in Germany, Netherlands and 1 more
- Volunteers
- 38 people
- Sponsor
- Novartis Pharmaceuticals
Asthma
Next DPI LABA, Multicentre, 5-way Cross-over, Adult Asthmatic Patients
Multinational, multicentre, randomised, double blind, double dummy, placebo and active controlled, 5-way cross over
- Trial name
- NCT00868023
- Testing
- CHF 1535 Next DPI, Foster BDP/Formoterol
- Where
- United Kingdom
- Volunteers
- 69 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Asthma
Efficacy and Safety of Four Escalating Dose Regimens of TPI ASM8 in Patients With Allergic Asthma
During this proposed clinical trial, the investigators intend to evaluate the pharmacodynamic anti-inflammatory properties and safety of TPI ASM8, by investigating the effect on sputum eosinophils and the airway responses during…
- Trial name
- NCT00822861
- Testing
- TPI ASM8
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Syntara