Clinical trials: Asphyxia
Hypoxic Ischaemic Encephalopathy (HIE), Asphyxia
BiHiVE2 Study. The Investigation and Validation of Predictive Biomarkers in Hypoxic-ischaemic Encephalopathy.
Despite recent advances in the care of mothers and newborn infants, many infants (approximately 20 per 1000 live births) continue to need resuscitation at birth.
- Trial name
- BiHiVE2 (NCT02019147)
- Where
- 2 sites in Ireland, Sweden
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University College Cork
Hypoxia Ischemia, Cerebral, Hypoxia-Ischemia, Brain
Functional Imaging of Baby Brains
Infants are at risk of developing motor and cognitive neurodevelopmental disabilities as a sequelae to hypoxic-ischemic brain injury during the perinatal period.
- Conditions
- Hypoxia Ischemia, Cerebral, Hypoxia-Ischemia, Brain, Hypoxia Neonatal, Hypoxic-Ischemic Encephalopathy
- Trial name
- FIBB (NCT05514665)
- Testing
- Diffuse Optical Tomography
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Hamilton Health Sciences Corporation
Drowning, Drowning; Anoxia
The Emergency Call on Drowning
This study aims to 1) describe patient-, setting-, and dispatcher-related characteristics in drowning-related emergency calls to the Emergency Medical Dispatch Centre (1-1-2 emergency phone) and 2) factors associated with 30-day…
- Conditions
- Drowning, Drowning; Anoxia, Drowning, Near, Drowning; Asphyxia
- Trial name
- DROWN_CALL (NCT06310486)
- Testing
- Drowning-related OHCA, Drowning-related non-OHCA
- Where
- Denmark
- Volunteers
- 1,500 people
- Sponsor
- Prehospital Center, Region Zealand
Dysphagia
Nutrition-dense Smoothie Diets Reduced Dysphagia Risk in the Elderly
The investigators aimed to compare the effect of consuming high protein (23-34% energy ratio) and low carbohydrate (25-38% energy ratio) smoothie formulas vs.
- Trial name
- NCT04901182
- Testing
- the effect of consuming diets on the swallowing capacity by using Flexible Endoscopic Evaluation of Swallowing (FEES)
- Where
- Thailand
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Neonatal Hypoxic-Ischemic Encephalopathy (HIE)
CoolCap Trial, Treatment of Perinatal Hypoxic-Ischemic Encephalopathy
This is a research study of head cooling. Its goal is to determine whether cooling babies' heads can reduce or prevent brain damage that may have resulted from temporarily reduced oxygen supply to the brain.
- Trial name
- NCT00383305
- Testing
- Cool-Cap
- Where
- 27 sites in United States, Canada and 2 more
- Volunteers
- 235 people
- Sponsor
- Olympic Medical
Swallowing Disorder, Perinatal Asphyxia
Effect of Non-nutritive Sucking on Transition to Oral Feeding in Infants With Asphyxia
The transition period to full oral feeding in infants with perinatal asphyxia is important in predicting long-term outcomes. The transition to independent oral feeding is accepted as a discharge criterion by the American Academy…
- Conditions
- Swallowing Disorder, Perinatal Asphyxia, Feeding; Difficult, Newborn, Feeding Disorder of Infancy or Early Childhood
- Trial name
- NCT05687708
- Testing
- Non-Nutritive Sucking
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medipol University
Asphyxia Neonatorum
First Breath: Neonatal Resuscitation in Developing Countries
In developing countries, neonatal death from birth asphyxia is a major problem. This study will be conducted in several countries to determine if the combined Neonatal Resuscitation Program/Essential Newborn Care Program compared…
- Trial name
- NCT00136708
- Testing
- Neonatal Resuscitation
- Where
- 7 sites in Argentina, Guatemala and 4 more
- Volunteers
- 120,009 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Birth Asphyxia
Echocardiography Sub-Study of the Umbilical Cord Milking in Non-Vigorous Infants Trial (MINVI)
Non-vigorous infants enrolled in the MINVI trial will be approached for consent for ongoing data collection. As part of the data collection, an optional echocardiogram will be performed if the parent consents.
- Trial name
- NCT03798093
- Testing
- Umbilical Cord Milking, Early Cord Clamping
- Where
- United States
- Volunteers
- 227 people
- Sponsor
- Sharp HealthCare
Apnea of Newborn, Hypoxia Neonatal
A UK Interventional Trial in Premature Infants With Apnea of Prematurity Using a Simple, Non-invasive Vibratory Device to Study the Effectiveness in Supporting Breathing and General Stability
Purpose of Study: Apnoea of Prematurity (AOP) is common, affecting the majority of infants born <34 weeks gestational age (GA). Apnea is accompanied by intermittent hypoxia (IH), which contributes to multiple pathologies…
- Conditions
- Apnea of Newborn, Hypoxia Neonatal, Bradycardia Neonatal
- Trial name
- WAVE (NCT04528030)
- Testing
- WAVE device
- Volunteers
- 17 people
- Sponsor
- Inspiration Healthcare
Hypoxic-Ischemic Encephalopathy, Neonatal Encephalopathy
Nephroprotection Following Perinatal Asphyxia: Randomized Controlled Trial
The aim of this study is to determine the value of Pentoxifylline for nephroprotection in these neonates with perinatal asphyxia, using cystatin C, regional oxygenation measured near infrared spectroscopy and renal Doppler…
- Conditions
- Hypoxic-Ischemic Encephalopathy, Neonatal Encephalopathy, Pentoxifylline Adverse Reaction
- Trial name
- NCT07088328
- Testing
- Pentoxifylline
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Asphyxia
BRAIN - Home Intervention Trial
We plan to test a home-based parent-provided early developmental intervention (EI) both in infants with mild to moderate birth asphyxia and in infants without perinatal complications who will constitute a healthy comparison group…
- Trial name
- BRAIN-HIT (NCT00639184)
- Testing
- Early intervention counseling, Health education counseling
- Where
- 3 sites in India, Pakistan and 1 more
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Asphyxia, Resuscitation
Resuscitation Table Height for Face-mask Ventilation in Infants
Positive pressure ventilation (PPV) is the most important intervention in neonatal resuscitation. During PPV, it is important to hold the face-mask with care, as applying excessive pressure could cause injury to the infant, while…
- Conditions
- Asphyxia, Resuscitation, Newborn Morbidity
- Trial name
- ForTab (NCT06254651)
- Testing
- High resuscitation table, Low resuscitation table
- Where
- Italy
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital Padova
Perinatal Asphyxia
Determination of Heart Rate in Infants Needing Resuscitation at Birth
Algorithms for neonatal resuscitation adapted to low resource settings include HR evaluation by auscultation or umbilical cord palpation at about one minute of life.
- Trial name
- NCT03854435
- Testing
- Heart rate assessment (stethoscope), Heart assessment (umbilical cord palpation)
- Where
- 2 sites in Ethiopia, Italy
- Volunteers
- 60 people
- Sponsor
- University Hospital Padova
Hypoxic-Ischemic Encephalopathy, Cell Damage
Use of Melatonin for Neuroprotection in Asphyxiated Newborns
Protection of brain development is a major aim in the Neonatal Intensive Care Unit. Hypoxic-Ischemic Encephalopathy (HIE) occurs in 3-5 per 1000 births. Only 47% of neonates have normal outcomes.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Cell Damage, Asphyxia Perinatal
- Trial name
- MELPRO (NCT03806816)
- Testing
- Melatonin
- Where
- 6 sites in Holy See, Italy
- Volunteers
- 100 people
- Sponsor
- University Hospital of Ferrara
Neonatal Asphyxia
Randomized Cluster Trial on Innovative and Standard Strategies for Neonatal Resuscitation Training (RCPNEOPERU Project)
Background: About 10% of all newborns may have difficulty breathing and require support by trained personnel. In Peru, 90% of deliveries occur in health facilities; however there is not a national neonatal resuscitation and…
- Trial name
- RCPNEOPERU (NCT03210194)
- Testing
- Standard Neonatal Resuscitation Training, MP-ICT Neonatal Resuscitation Training
- Where
- Peru
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidad Peruana Cayetano Heredia
Perinatal Asphyxia
Neuroprotective Role of Erythropoietin in Perinatal Asphyxia
Whether Erythropoietin improves the neurological outcomes of neonates with perinatal asphyxia.
- Trial name
- NCT02002039
- Testing
- Erythropoietin
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Sheri Kashmir Institute of Medical Sciences
Natural Childbirth, Water Birth
Effectiveness and Safety in Maternal and Neonatal Outcomes in Water Birth.
Childbirth is a unique and non-transferable experience in the life of a woman, her partner and her family. It is a very intense process that requires accompaniment and, in the vast majority of cases, requires analgesic support in…
- Conditions
- Natural Childbirth, Water Birth, Neonatal Asphyxia, Outcome, Adverse Birth
- Trial name
- NCT06429111
- Testing
- Epidural analgesia, Immersion water
- Where
- Spain
- Volunteers
- 642 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
IVH- Intraventricular Hemorrhage, Extreme Prematurity
Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants
This study is being conducted to compare the incidence of preterm infants (up to 28+6 weeks GA) who achieve a peripheral oxygen saturation of 80 percent by 5 minutes of life (MOL) given mask CPAP/PPV with an FiO2 of 1.0 during…
- Conditions
- IVH- Intraventricular Hemorrhage, Extreme Prematurity, Hypoxia Neonatal, Hyperoxia
- Trial name
- DOXIE (NCT04413097)
- Testing
- Delayed Cord Clamping with Low Oxygen concentration, Delayed Cord Clamping with High Oxygen concentration
- Where
- 3 sites in United States
- Volunteers
- 140 people
- Sponsor
- Sharp HealthCare
Cardiopulmonary Resuscitation, Newborn Asphyxia
Comparison of Visual Instructions for Inserting a Laryngeal Mask in a Neonatal Mannequin.
This research project compares the effectiveness of two visual instructions for inserting laryngeal masks. Researchers will assess the procedure performed by undergraduate health students on neonatal mannequins.
- Trial name
- Neo-LMi (NCT06502327)
- Testing
- Instructions A, Instructions B
- Where
- Peru
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- National University of San Marcos, Peru
Shoulder Dystocia,, Brachial Plexus Injury
New Prophylactic Maneuver: the "Pushing" Maneuver, Aiming to Reduce the Risk for Shoulder Dystocia
Shoulder dystocia is a major obstetric emergency defined as a delivery requiring maneuver in addition to downward traction on the fetal head for delivery of the shoulders.
- Conditions
- Shoulder Dystocia,, Brachial Plexus Injury, Asphyxia,, Hematoma,
- Trial name
- CONTRADYS (NCT01297439)
- Testing
- suctioning of fetal nose and mouth during delivery, Pushing maneuver
- Where
- France
- Volunteers
- 1,538 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris