Clinical trials: Ascites
Gynecologic Cancer
A Study on the Safety and Preliminary Efficacy of NK042 in the Treatment of Malignant Ascites
The purpose of this study is to assess the safety and efficacy of NK042 for treatment of malignant ascites.
- Trial name
- NCT06415500
- Testing
- NK042
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Anhui Provincial Hospital
Cirrhosis, Hepatorenal Syndrome
Terlipressin + Albumin Versus Midodrine + Octreotide in the Treatment of Hepatorenal Syndrome
From 1999, several studies have showed that the use of vasoconstrictors in association with albumin are effective in the treatment of hepatorenal syndrome (HRS).
- Trial name
- NCT00742339
- Testing
- Terlipressin plus albumin, Midodrine plus octreotide plus human albumin
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- University of Padova
Liver Cirrhosis
Faecal Microbiota Transplantation for Liver Cirrhosis
The purpose is to investigate the effect of faecal microbiota transplantation (FMT) on complications, progression, and mortality of patients with liver cirrhosis.
- Trial name
- CHiFT (NCT04932577)
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- University of Aarhus
Portal Hypertension, Liver Diseases
Achieving Portal Access With Scorpion Post-Approval Study 2
Creation of the parenchymal tract between the portal vein and the hepatic vein is the most difficult and time consuming step in a TIPS procedure.
- Conditions
- Portal Hypertension, Liver Diseases, Ascites Hepatic, Hydrothorax
- Trial name
- APASS2 (NCT06856655)
- Testing
- Scorpion Portal Vein Access Kit
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Argon Medical Devices
Ascites, Blunt Abdominal Trauma
Telesonography Adaptation and Use to Improve the Standard of Patient Care Within a Dominican Community
The role of teleradiology has far reaching implications for the health of remote and underserved populations. The ability to coordinate radiographic evaluation and diagnosis from a distance has the potential to raise the standard…
- Conditions
- Ascites, Blunt Abdominal Trauma, Cholelithiasis, Cholecystitis
- Trial name
- NCT00591968
- Testing
- SonoSite Titan portable ultrasound coupled with email telediagnosis
- Where
- Dominican Republic
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Colorectal Cancer
Immune Checkpoints in Intraabdominal Ascites Fluid
Colorectal cancers are the third most common type of cancer in the world. Peritoneal carcinomatosis and intraabdominal acid development occur in advanced stages of colorectal cancers.
- Trial name
- NCT04540159
- Testing
- Flow-cytometric analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul Training and Research Hospital
Ascites, Fluid Loss
Utility of 2- Octyl Cyanoacrylate (2-OCA)
Paracentesis is a commonly performed procedure in the inpatient and outpatient settings for treatment of ascites. The most frequent complication of paracentesis is fluid leak.
- Trial name
- NCT05278013
- Testing
- Dermabond
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Methodist Health System
Ascites Hepatic, Liver Failure
Predictive Values of Presepsin Levels in ASciteS in Patients With Chronic Liver Failure
The investigators aim to study the predictive value of presepsin in ascites in newly admitted patients with chronic liver failure.
- Conditions
- Ascites Hepatic, Liver Failure, Cirrhosis, Liver
- Trial name
- PASS (NCT06224023)
- Testing
- Determination of presepsin levels in ascites
- Where
- Romania
- Volunteers
- 30 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Ascites Hepatic, Ascites, Malignant
QOL and Sarcopenia in Patients With Ascites
Clinical data regarding quality of life in patients with refractory ascites is limited and preceded the development of newer questionnaires that may be more robust.
- Trial name
- NCT05726747
- Testing
- Quality of Life surveys
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Ascites, Variceal Bleeding
VIATORR® TIPS Study Evaluating 6-10mm Diameters (VIATIPS)
This Registry will look at patients being treated with a transjugular intrahepatic portosystemic shunt (TIPS) procedure for portal hypertension.
- Conditions
- Ascites, Variceal Bleeding, Portal Hypertension Related to Cirrhosis
- Trial name
- VIATIPS (NCT07390344)
- Testing
- GORE® VIATORR® TIPS Endoprosthesis with Controlled Expansion (6-10mm)
- Where
- 3 sites in United States
- Volunteers
- 152 people
- Sponsor
- W.L.Gore & Associates
Cirrhosis, Hepatic Encephalopathy
Allopurinol Versus Atorvastatin to Prevent Complications of Liver Cirrhosis
The study aims to compare the potential benefit of allopurinol versus atorvastatin in reducing the risk of developing cirrhosis-related complications, delaying the onset of hepatocellular carcinoma, and improving survival.
- Conditions
- Cirrhosis, Hepatic Encephalopathy, Ascites, Varices
- Trial name
- NCT05511766
- Testing
- Allopurinol 300 MG, Atorvastatin 20mg
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Tanta University
Ascites Hepatic, Cirrhosis, Liver
SGLT-2 Inhibitors in the Treatment of Ascites
The goal of this observational study is to test the efficacy of glyphozines (SGLT-2 inhibitors) in the control of ascites in patients with liver cirrhosis in class A6-B9, according to the Child-Pugh classification, and type 2…
- Conditions
- Ascites Hepatic, Cirrhosis, Liver, Diabete Type 2
- Trial name
- NCT05999773
- Testing
- SGLT2 inhibitor
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- University of Palermo
Cirrhosis, Ascites
A (M)Ulti-center, Prospective, (O)Pen Label, Uncontrolled Feasibility (S)Tudy to Assess the Safety and Effectiveness of an Automatic Low Flow (A)Scites (Alfa) Pump (I)n Patients With (C)Irrhosis and Refractory or Recurrent Ascites
The study is a multi-center, prospective, open label, uncontrolled feasibility study enrolling 30 patients with refractory or recurrent ascites and cirrhosis at up to 6 sites.
- Trial name
- MOSAIC (NCT02400164)
- Testing
- alfapump system
- Where
- 6 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Sequana Medical N.V.
Cirrhosis
TIPS With Coated Stents for Refractory Ascites in Patients With Cirrhosis
The main end point of the study is to assess survival in cirrhotic patients with refractory ascites treated by TIPS (using PTFE covered stents) vs patients treated by paracentesis + albumin infusion.
- Trial name
- NCT00222014
- Testing
- TIPS, Paracenthese
- Where
- 4 sites in France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Toulouse
Malignant Ascites
Retrospective Study in the Use of the Alfapump and the Treatment of Malignant Ascites
Treatment of malignant ascites with the alfapump offers a new treatment option for this patient group. So far, there is no systematic analysis of patients with this indication available in the literature.
- Trial name
- NCT03200106
- Testing
- Alfapump
- Where
- 3 sites in Germany, Switzerland and 1 more
- Volunteers
- 17 people
- Sponsor
- Sequana Medical N.V.
Antibiotic Toxicity, Liver Cirrhosis
A Study to Determine Pharmacokinetic Changes of Ceftriaxone in Patients With Liver Cirrhosis
The investigators designed an observational multicenter explorative in vivo study to investigate the changes in ceftriaxone pharmacokinetics in blood and ascites.
- Conditions
- Antibiotic Toxicity, Liver Cirrhosis, Renal Insufficiency, Ceftriaxone Overdose
- Trial name
- TACTILE (NCT05960006)
- Testing
- No intervention (observational study)
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Ascites, Liver Cirrhosis
Satavaptan Dose-Ranging Study in Hyponatraemic Patients With Cirrhotic Ascites
The primary objective is to determine the optimal dose or range of doses of SR121463B for the treatment of ascites and the correction of hyponatraemia when used concomitantly with a standard dose regimen of spironolactone.
- Trial name
- Hypo~CAT (NCT00501722)
- Testing
- satavaptan (SR121463B)
- Where
- 13 sites in United States, Argentina and 11 more
- Volunteers
- 110 people
- Sponsor
- Sanofi
Hepatorenal Syndrome
Noradrenalin vs Terlipressin in Hepatorenal Syndrome
The purpose of this study is to determine whether noradrenalin is as effective and safe as terlipressin in the treatment of hepatorenal syndrome
- Trial name
- NCT00370253
- Testing
- Terlipressin, Noradrenalin
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Turin, Italy
Evaluate Patient Comfort Level During Paracentesis by Numbing Skin With a Needle-less Device, Instead of Using a Needle to Numb the Skin
J-Tip Use for Paracentesis in Adults With Ascites
The purpose of this clinical trial is to evaluate the level of comfort adult patients with cirrhosis of the liver and ascites presenting to Northwestern Memorial Hospital experience during a bedside abdominal paracentesis by…
- Trial name
- NCT06996379
- Testing
- Experimental J-Tip Needle-Free Injection System, Control (Standard treatment)
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Northwestern University
Hepatic Ascites
A Study of Recombinant Human Albumin Injection to Treat Hypoalbuminemia in Cirrhotic Patients With Ascites
This study was a Phase III multicenter, blinded, and positive active-controlled clinical study to evaluate the efficacy, safety, and immunogenicity of recombinant human albumin(rHA) injection for the treatment of hypoalbuminemia…
- Trial name
- NCT06911554
- Testing
- Recombinant Human Albumin Injection, Human Albumin
- Where
- China
- Volunteers
- 416 people
- Sponsor
- Tonghua Anrate Biopharmaceutical Co., Ltd.