Clinical trials: Arthrosis
Rheumatoid Arthritis
Effect of Anti-inflammatory Diet in Rheumatoid Arthritis
In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites.
- Trial name
- NCT04748809
- Testing
- Diet 1, Diet 2
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of California, San Diego
Arthralgia, Trouble Balancing
Even-Up to Minimize Secondary Site Pain For Ankle Fracture
Evaluating impact of use of Even-Up shoe wear device for patients treated in CAM boot walker for an ankle fracture. Randomized controlled trial, randomizing patients into control group with boot treatment only versus boot…
- Trial name
- NCT04164563
- Testing
- Even-Up
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Osteoarthritis, Knee, Muscle Weakness
PB125, Osteoarthritis, Pain, Mobility, and Energetics
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important regulator in the body. It controls how well cells protect themselves against stress.
- Conditions
- Osteoarthritis, Knee, Muscle Weakness, Pain, Joint
- Trial name
- NCT04638387
- Testing
- PB125
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Colorado State University
Bilateral Total Knee Arthroplasty, Gonarthrosis; Primary, Bilateral
Bilateral Simultaneous Total Knee Arthroplasty for Bilateral Gonarthrosis
The effects of two-team and single-team simultaneous bilateral total knee arthroplasty (SBA) on peri- and postoperative complications are not clear.
- Trial name
- NCT04299516
- Testing
- Two-team simultaneous bilateral total knee arthroplasty, Single-team simultaneous bilateral total knee arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 246 people
- Sponsor
- Bezmialem Vakif University
Chronic Plaque Psoriasis, Moderate to Severe Chronic Plaque Psoriasis
A Study to Evaluate the Efficacy and Safety of Bimekizumab Compared to Placebo and an Active Comparator in Adult Subjects With Moderate to Severe Chronic Plaque Psoriasis
This is a study to compare the efficacy of bimekizumab versus placebo and an active comparator in the treatment of subjects with moderate to severe chronic plaque psoriasis (PSO).
- Conditions
- Chronic Plaque Psoriasis, Moderate to Severe Chronic Plaque Psoriasis, Psoriatic Arthritis
- Trial name
- BE VIVID (NCT03370133)
- Testing
- Bimekizumab, Ustekinumab
- Where
- 105 sites in United States, Australia and 9 more
- Volunteers
- 567 people
- Sponsor
- UCB Biopharma SRL
Chronic Pain
A Study Comparing the Effectiveness and Safety of Extended Release Tramadol HCl at 100 mg, 200 mg and 300 mg Doses to Placebo for the Treatment of Moderate to Severe Pain Due to Osteoarthritis (OA)
The purpose of this study is to compare the analgesic efficacy and safety of tramadol HCl ER 100 mg, 200 mg and 300 mg once a day (QD), with placebo in patients with moderate to severe pain due to OA.
- Trial name
- NCT00348452
- Testing
- tramadol HCl ER; celecoxib
- Volunteers
- 1,000 people
- Sponsor
- Bausch Health Americas, Inc.
Knee Chondropathy, Osteoarthritis, Knee
Platelet-rich Plasma vs Viscosupplementation in the Treatment of Knee Articular Degenerative Pathology
The investigators hypothesized that intra-articular injections of Platelet-rich Plasma (PRP) to treat knee degenerative articular cartilage pathology could determine pain relief and recovery of knee function with overall clinical…
- Trial name
- PRP2009 (NCT01670578)
- Testing
- PRP, Hyaluronic acid
- Where
- Italy
- Volunteers
- 192 people
- Sponsor
- Istituto Ortopedico Rizzoli
Knee Osteoarthritis
African American Preference for Knee Replacement: A Patient-Centered Intervention
A randomized, controlled design will be utilized to examine and compare the effectiveness of the proposed educational intervention, which includes an educational decision aid with attention control on select key patient-centered…
- Trial name
- ACTION (NCT01851785)
- Testing
- Decision Aid (DA) Intervention
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- University of Pennsylvania
Osteoarthritis of the Knee
Efficacy of Celecoxib 200mg in Relieving Pain and Walking Dysfunction in Osteoarthritis of the Knee
The purpose of this study is to compare the efficacy of celecoxib versus placebo in delaying the onset of pain and improving walking function in subjects with knee Osteoarthritis
- Trial name
- NCT00597415
- Testing
- celecoxib
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University Hospitals Cleveland Medical Center
Psoriatic Arthritis
Stronger Together Psoriatic Arthritis Wellness Study
Patients diagnosed with psoriatic arthritis (PsA) confront decisions about how to treat their disease, interact with their health care providers, and modify lifestyle choices that may improve treatment outcomes.
- Trial name
- NCT05652608
- Testing
- Immune Strength
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Global Healthy Living Foundation
Rheumatic Arthritis, Lung Function
Manual Diaphragmatic Release on Ventilatory Functions in Women With Rheumatoid Arthritis
Evaluate the effect of manual diaphragmatic release on ventilatory functions in women with rheumatoid arthritis
- Trial name
- NCT06716008
- Testing
- Aerobic training, Manual Diaphragm Release
- Volunteers
- 60 people
- Sponsor
- Middle East University
Osteoarthritis of the Knee
KineSpring® System Patient Preference Study
The primary objectives of the survey are to obtain patient preference information that can be useful during the benefit-risk assessment of the KineSpring System.
- Trial name
- NCT02934672
- Testing
- Survey
- Volunteers
- 323 people
- Sponsor
- Moximed
Osteoarthritis
Health and Risk Factors in Patients With Hip and Knee Osteoarthritis
Hip and knee osteoarthritis is one of the leading causes of global disability. There is no cure for the disease, but research and guidelines recommends that patients with osteoarthritis, early after the diagnosis, receive…
- Trial name
- NCT03438630
- Where
- Sweden
- Volunteers
- 288,276 people
- Sponsor
- Vastra Gotaland Region
Arthritis, Rheumatoid
The Anti-Inflammatory And Metabolic Effects Of Rosiglitazone In Subjects With Rheumatoid Arthritis
To assess whether the anti-inflammatory effects of rosiglitazone result in improvements in Rheumatoid Arthritis symptoms in patients for whom their existing Disease Modifying Anti-Rheumatic Drug (DMARD) treatment does not give…
- Trial name
- NCT00379600
- Testing
- rosiglitazone XR
- Where
- 5 sites in Lithuania, United Kingdom
- Volunteers
- 96 people
- Sponsor
- GlaxoSmithKline
Medial Compartment Osteoarthritis, Genu Varum
TO Plate Fixation vs. External Fixator Comparison (HTO Plate vs. ExFix Study)
This study aims to compare the efficacy, accuracy, and functional outcomes of two different surgical stabilization techniques for medial opening wedge high tibial osteotomy (HTO) in patients with varus deformity and medial…
- Conditions
- Medial Compartment Osteoarthritis, Genu Varum, Varus Deformity, High Tibial Osteotomy
- Trial name
- NCT07220434
- Testing
- Medial HTO Locking Plate, Self-Adjusting HTO External Fixator
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Muhammed Cagatay Engin
Rheumatoid Arthritis (RA)
Prospective Validation of a Pharmacological Biomarker for Low-Dose Rituximab in Rheumatoid Arthritis
Evaluation of the prediction of clinical response to rituximab at a dose of 1000 mg once using a pharmacological model including several pharmacokinetic and pharmacodynamic parameters.
- Trial name
- PROLOD-RA (NCT06933134)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Osteoarthritis of Multiple Joints
Probiotic for Osteoarthritis
The gut microbiome appears to be a significant contributor to musculoskeletal health and disease. Microbiome composition and its functional implications have been associated with prevention of bone loss and/or reducing fracture…
- Trial name
- NCT03985709
- Testing
- Probiotic product
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Rheumatoid Arthritis
Study to Assess Steady-State Trough Concentrations, Safety, and Immunogenicity of Abatacept After Subcutaneous (SC) Administration to Subjects With Rheumatoid Arthritis (RA)
The purpose of this study is to study serum levels of Abatacept after subcutaneous dosing in subjects with RA.
- Trial name
- NCT00254293
- Testing
- Abatacept
- Where
- 5 sites in United States
- Volunteers
- 87 people
- Sponsor
- Bristol-Myers Squibb
Temporomandibular Disorders
Analgesic Ointment on Temporomandibular Joint and Masticatory Muscle Pain
The purpose of this study is to compare the effectiveness of using topical cream of Ping On Ointment and using Vaseline cream in the treatment of temporomandibular joint (TMJ) and masticatory muscle pain, in order to establish…
- Trial name
- NCT00812604
- Testing
- Ping On Ointment, Vaseline
- Where
- China
- Volunteers
- 55 people
- Sponsor
- The University of Hong Kong
Osteoarthritis of Knee
Genicular Radiofrequency Ablation Versus Pulsed Radiofrequency
This study investigates the effectiveness of two treatments-genicular nerve radiofrequency ablation and pulsed radiofrequency-in reducing pain and improving function in osteoarthritis patients.
- Trial name
- GRFT-PRF (NCT06894147)
- Testing
- Genicular nerve pulse radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara City Hospital Bilkent