Clinical trials: Arthroplasties, Knee Replacement
Knee Osteoarthritis
Study Comparing Traditional and Gender-specific Total Knee Replacement Designs
The purpose of this study is to compare results obtained with gender-specific and traditional knee replacement systems design among women undergoing total knee replacement surgery.
- Trial name
- NCT00937170
- Testing
- Zimmer LPS flex Gender Specific Implant (Total knee replacement), Zimmer High Flex LPS Implant (Total knee replacement), Stryker Triathlon Implant (Total knee replacement)
- Sponsor
- UConn Health
Wound of Knee, Wound of Hip
Study to Compare Negative Pressure Wound Therapy or Standard Dressings After Orthopedic Surgery
The aim of this study is to assess the prevention of incision healing complications in patients undergoing Total Knee Arthroscopy (TKA) and Total Hip Arthroscopy (THA) treated with either Single-Use Incisional NPWT (Negative…
- Trial name
- PICO (NCT02064270)
- Testing
- Single-Use Negative Pressure Wound Therapy, Standard postsurgical dressings
- Where
- United States
- Volunteers
- 526 people
- Sponsor
- University of Missouri-Columbia
Postsurgical Pain
Multiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty
Total knee arthroplasty is a surgical treatment which involves replacing the damaged articular cartilage of the knee joint with an artificial prosthetic in end-stage knee osteoarthritis.
- Trial name
- MP-TKA (NCT06202989)
- Testing
- Multiprofen-CC™ plus standard treatment
- Where
- Canada
- Volunteers
- 306 people
- Sponsor
- KAZM Pharmaceuticals Inc.
Osteoarthritis, Care Model
The Effect of Continuous Care Counseling Based on the Roy Adaptation Model on Comfort and Quality of Life in Patients Undergoing Total Knee Arthroplasty
Osteoarthritis is a common joint disease that leads to problems such as pain, restricted mobility, and decreased quality of life in the knee joint, especially among elderly individuals.
- Conditions
- Osteoarthritis, Care Model, Quality of Life, Nursing Interventions
- Trial name
- RAM-TKA (NCT07015879)
- Testing
- Continuous Care Counseling Based on the Roy Adaptation Model
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cyprus International University
Other Acute Postoperative Pain, Systemic Inflammatory Response Syndrome
Systemic Inflammation Versus Acute Pain in Total Knee Arthroplasty (TKA)
In this study we evaluate if there is a correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA).
- Trial name
- NCT01322074
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Hvidovre University Hospital
Satisfaction, Patient
The Outcomes of Subject After Total Knee Arthroplasty
Total Knee Arthroplasty (TKA) is a standard of intervention for severe knee osteoarthritis, also been proven with benefits in improving pain, mobility, and quality of life. However, the outcomes after TKA is controversial.
- Trial name
- NCT05810090
- Testing
- Total knee arthroplasty
- Where
- Taiwan
- Volunteers
- 631 people
- Sponsor
- Changhua Christian Hospital
Arthroplasty, Overweight and Obesity
Healthy Living After Knee Replacement
The purpose of this study is to examine if a weight loss program designed for adults after knee replacement improves weight loss, physical activity, pain, and function, as well as if the program is cost effective, as compared to…
- Trial name
- NCT05190666
- Testing
- PACE Weight Loss program, Chronic Disease Self-Management
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Osteoarthritis
Comparison of Femoral Nerve Catheter and Adductor Canal Block With Steroid Adjuvant in Total Knee Replacement (TKR)
We hypothesize continuous adductor canal block with steroid adjuvant would offer no inferior analgesics and rehabilitation ability than continuous femoral nerve block for postoperative patients receiving total knee arthroplasty.
- Trial name
- NCT01973530
- Testing
- adductor canal block, femoral nerve block
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Queen Elizabeth Hospital, Hong Kong
Total Knee Arthroplasty, Total Knee Replacement
Assessing Function and Pain After Total Knee Arthroplasty With Combined Femoral and Popliteal Nerve Block
The goal of this interventional study is to examine whether a pain management technique of combined femoral and popliteal nerve block is effective in total knee arthroplasty patients.
- Conditions
- Total Knee Arthroplasty, Total Knee Replacement, Total Knee Replacement Surgery, Arthritis Knee
- Trial name
- NCT06196359
- Testing
- Combined Femoral and Popliteal nerve block
- Where
- Israel
- Volunteers
- 34 people
- Sponsor
- University of Haifa
Hip Fractures
Uncemented Versus Cemented Total Hip Arthroplasty for Displaced Intracapsular Hip Fractures
Displaced subcapital hip fractures are very common and account for almost 50% of all hip fractures. The aim of the present study is to determine whether an uncemented total hip replacement is better than conventional cemented hip…
- Trial name
- NCT04372966
- Testing
- Total hip arthroplasty
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- NHS Lothian
Analgesia, Pain Management
Clinical Impact of IPACK Block Addition to Suprainguinal Fascia Iliaca Block
In our clinic, routine suprainguinal fascia iliaca block (SIFIB) has been administered for postoperative analgesia in patients undergoing knee arthroplasty.
- Conditions
- Analgesia, Pain Management, Acute Pain
- Trial name
- NCT06054945
- Testing
- SIFIB (suprainguinal fascia iliaca block), IPACK (Interspace between the popliteal artery and capsule of the posterior knee ), Patient controlled anagesia device
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Samsun University
Osteoarthritis
Study of AQUACEL™ Ag Surgical Cover Dressing Following Total Knee Replacement
The aim of the study is to determine whether the AQUACEL™ Ag SURGICAL cover dressing is successful in reducing the incidence of wound infection in high risk patients following total knee replacement.
- Trial name
- NCT02217202
- Testing
- Aquacel Ag dressing
- Sponsor
- Golden Jubilee National Hospital
Venous Thromboembolism, Bleeding
Prospective Genotyping For Total Hip or Knee Replacement Patients Receiving Warfarin (Coumadin)
Several human genes affect how medications are metabolized by the body. It is believed that knowledge of variations of these genes can help health care providers better manage an anticoagulation medicine called warfarin…
- Trial name
- NCT00634907
- Testing
- Pharmacogenetic-based warfarin dosing, Usual care warfarin dosing
- Where
- United States
- Volunteers
- 263 people
- Sponsor
- Gwen McMillin
Blood Loss, Surgical
Arista Hemostatic Powder for Total Knee Post Operative Outcomes Study
To examine in Arista hemostatic powder results in less post-total knee arthroplasty blood loss, hematoma formation, and improved range of motion when compared to patients who did not receive the product.
- Trial name
- NCT05522153
- Testing
- Arista
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Virtua Health, Inc.
Osteo Arthritis Knee
High Versus Low Adductor Canal Block
The investigators will be comparing the efficacy of two different techniques for performing an adductor canal block to the saphenous nerve as a part of the multimodal pain control regimen for total knee arthroplasty.
- Trial name
- NCT04155983
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Carilion Clinic
Total Hip Replacement
Evaluation of Conventional Antibiotic Prophylaxis During a Change of Hip or Knee Infected at a Time
Infection is a serious complications after undergoing total hip replacement. It occurs in about 1% of cases. The optimal treatment of these infections is discussed.
- Trial name
- NCT02272205
- Testing
- Retrospective analysis of records
- Volunteers
- 80 people
- Sponsor
- University Hospital, Strasbourg, France
Osteo Arthritis Knee
Tibial and Femoral Components Migration and Adaptive Bone Remodeling After Insertion of Persona® TKA
The purpose of this study: In a prospective randomized study with 2 years of follow-up we want to compare the migration of the uncemented trabecular metal (TM) versus the cemented tibial and femoral components of the new Persona®…
- Trial name
- NCT03563131
- Testing
- Persona® total knee arthroplasty
- Where
- Denmark
- Volunteers
- 66 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Total Knee Replacement
The Effect of TENS on Early Patient Outcomes After Total Knee Arthroplasty
The Effect of TENS on Early Outcomes in Incisional Wounds After Total Knee Replacement Incisional wounds heal within 3 to 4 weeks, consistent with the normal healing process.
- Trial name
- NCT07155837
- Testing
- TENS group
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Cukurova University
Total Knee Arthroplasty
Improving Rehabilitation for Veterans After Total Knee Arthroplasty Using Individualized Recovery Trajectories
This study will examine the impact of a new clinical decision support tool for rehabilitation after total knee arthroplasty (TKA).
- Trial name
- NCT05288803
- Testing
- Clinical decision support tool (CDS tool)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development
Postoperative Cognitive Abilities
Postoperative Sleep Disturbances Role in Cognitive Test Results After Fast-track Hip and Knee Arthroplasty
The purpose of this study is to evaluate sleep cycle before and after fast-track arthroplasty (3 days before and 10 days after) combined with cognitive testing preoperatively, on postoperative day 1,2,10.
- Trial name
- NCT01383369
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
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