Clinical trials: Appendicitis Acute
Appendicitis Acute, Appendicitis
Safety & Feasibility of PERIsign System in Demonstrating Involuntary Muscle Defense as a Sign of Peritonitis in Subjects With Appendicitis
This will be an explorative, proof-of-principle, open, multi-center investigation. The investigation aims to investigate the safety of the PERIsign system and the ability of physicians to differentiate between healthy individuals…
- Conditions
- Appendicitis Acute, Appendicitis, Abdominal Pain, Peritonitis
- Trial name
- PeriSaFe01 (NCT06296953)
- Testing
- PERIsign examination
- Where
- 2 sites in Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- STB INN AB
Acute Appendicitis
Appendicectomy Versus Antibiotics in the Treatment of Acute Uncomplicated Appendicitis
Appendicectomy has been the treatment of acute appendicitis for over a hundred years. Appendicectomy, however, includes operative and postoperative risks despite being a "routine" operation.
- Trial name
- APPAC (NCT01022567)
- Testing
- Appendicectomy, Ertapenem
- Where
- 6 sites in Finland
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Acute Appendicitis, Appendicitis Perforated
Bilirubin Levels to Diagnose Appendicitis and Predict Appendiceal Perforation
The goal of this study is to learn if serum bilirubin levels can aid in the diagnosis of acute appendicitis and predict appendiceal perforation
- Trial name
- NCT06956638
- Testing
- Non-interventional
- Where
- Nepal
- Volunteers
- 98 people
- Sponsor
- Nepalese Army Institute of Health Sciences
Healthy
Environmental Game After Appendicitis Surgery
This study was conducted to determine the effect of environmental play and mobilization on fear and pain levels of children aged 6-12 years who had acute appendicitis surgery.
- Trial name
- NCT05104021
- Testing
- game
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Okan University
Appendicular Mass, Acute Appendicitis
Immediate Laparoscopic Appendectomy Versus Interval Laparoscopic Appendectomy for Early Appendicular Mass
This study compares two standard treatment approaches for patients presenting with an appendicular mass, an inflammatory lump that forms when the appendix becomes severely inflamed and walled off by surrounding abdominal tissues.
- Conditions
- Appendicular Mass, Acute Appendicitis, Appendiceal Phlegmon, Appendicitis With Periappendicular Abscess
- Trial name
- NCT07837531
- Testing
- Immediate Laparoscopic Appendectomy, Interval Laparoscopic Appendectomy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Appendicitis
Patient Choice Between Antibiotics and Appendectomy in Uncomplicated Appendicitis (FRENCH 47 - ALACARTE)
The ALACARTE study evaluates a strategy in which patients with acute uncomplicated appendicitis are given the choice between appendectomy and antibiotic therapy alone.
- Trial name
- ALACARTE (NCT07857252)
- Testing
- Shared decision-making, amoxicillin-clavulanate, Appendectomy
- Where
- France
- Volunteers
- 560 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
One Hundred Patients Aged 65 and Older Who Underwent Emergency General Surgical Interventions, Clinical Utility of These Scoring Systems
A Comparative Study of CCI, EmSFI, and FTRST Scoring Systems
Frailty assessment tools and comorbidity indices play a crucial role, particularly in predicting outcomes for elderly patients undergoing emergency surgery.
- Conditions
- One Hundred Patients Aged 65 and Older Who Underwent Emergency General Surgical Interventions, Clinical Utility of These Scoring Systems, Gastrointestinal Neoplasms, Appendicitis Acute
- Trial name
- NCT06943924
- Testing
- Frailty assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Appendicitis Acute
Online Field Test of an Appendicitis Decision Support Tool
After the recent publication of the CODA Trial comparing antibiotics and surgery for acute appendicitis, the investigators developed a comprehensive decision support tool.
- Trial name
- NCT05219786
- Testing
- Appendicitis Decision Support Tool, Control Infographic
- Where
- United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University of Washington
Acute Appendicitis
Laparoscopic-Assisted TAP Block VErsus Trocar-site Infiltration After Laparoscopic Appendectomy
This randomized controlled trial compared laparoscopic-assisted transversus abdominis plane (TAP) block with trocar-site local anesthetic infiltration for postoperative pain management in adult patients undergoing laparoscopic…
- Trial name
- NCT07849751
- Testing
- laparoscopic-assisted transversus abdominis plane block, trocar-site local anesthetic infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Acute Appendicitis
Radiomic Modeling in Differentiating Uncomplicated From Complicated Acute Appendicitis
Non-operative management (NOM) with antibiotics may be a safe alternative to surgery for uncomplicated appendicitis, but preoperative differentiation between uncomplicated and complicated appendicitis is challenging.
- Trial name
- NCT05843630
- Testing
- without
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Kecheng Zhang
Acute Appendicitis, Acute Appendicitis With Rupture
Modified Enhanced Recovery Program in Emergency Surgery (MERES)
Laparoscopic appendectomy (LA) is a widespread surgical procedure. Patients may develop considerable postoperative pain and dyspepsia resulting in prolong in-hospital stay.
- Conditions
- Acute Appendicitis, Acute Appendicitis With Rupture, Acute Appendicitis With Peritonitis, Acute Appendicitis Without Peritonitis
- Trial name
- MERES (NCT03754777)
- Testing
- Laparoscopic appendectomy
- Where
- Russia
- Volunteers
- 122 people
- Sponsor
- Pirogov Russian National Research Medical University
Acute Appendicitis
Non-operative vs. Operative Management of Acute Appendicitis in Vulnerable Patient Populations
The overall project goal is to conduct a pilot randomized clinical trial of operative (laparoscopic appendectomy) vs nonoperative (antibiotic) management of uncomplicated acute appendicitis for vulnerable populations.
- Trial name
- NCT05724628
- Testing
- Laparoscopic appendectomy, Antibiotics (IV transitioned to oral)
- Sponsor
- University of Texas Southwestern Medical Center
Acute Appendicitis, Appendicitis Recurrent
Appendectomy Versus Conservative Treatment for Uncomplicated Acute Appendicitis
On September the 15th, 2015, Italian surgeons, radiologists and pathologists with a special interest and expertise in the diagnosis and management of Acute Appendicitis (AA), met up under the auspices of the Italian Society of…
- Conditions
- Acute Appendicitis, Appendicitis Recurrent, Appendectomy, Antibiotic Therapy
- Trial name
- ACTUAA (NCT03080103)
- Testing
- Laparoscopic or Open appendectomy, Antibiotic-first therapy
- Where
- 7 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Mauro Podda
Appendicitis Acute
Diagnostic Importance of the Circulating Human Leucine-rich α-2-glycoprotein in Acute Appendicitis in Pediatric Patients
Acute appendicitis is a common and potentially serious medical condition which can be difficult to diagnose, especially in pediatric patients.
- Trial name
- NCT05093660
- Testing
- Blood specimen collection, Saliva specimen collection
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- KBC Split
Acute Appendicitis
Antibiotics vs. Placebo in Acute Uncomplicated Appendicitis
Appendicectomy has been the treatment of acute appendicitis for over a hundred years. Appendicectomy, however, includes operative and postoperative risks despite being a "routine" operation.
- Trial name
- APPACIII (NCT03234296)
- Testing
- Ertapenem
- Where
- Finland
- Volunteers
- 147 people
- Sponsor
- Turku University Hospital
Acute Appendicitis
The Role of Contrast Enhanced Ultrasound in Appendicitis
This study seeks to determine the efficacy of Contrast Enhanced Ultrasound (CEUS) in improving the diagnosis of acute appendicitis in children, when compared to the standard grey-scale ultrasound.
- Trial name
- NCT03687502
- Testing
- Sulfur hexafluoride lipid-type A microspheres
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Children's Mercy Hospital Kansas City
Abscess, Intra-Abdominal, Abdominal Abscess
A Safety and Tolerability Study of Doripenem Compared With Meropenem in Children Hospitalized With Complicated Intra-abdominal Infections
The purpose of the study is to evaluate the safety and tolerability of doripenem compared with meropenem in children hospitalized with complicated intra-abdominal infections.
- Conditions
- Abscess, Intra-Abdominal, Abdominal Abscess, Abdomen, Acute, Abdominal Pain
- Trial name
- NCT01110382
- Testing
- Doripenem, Meropenem, Amoxicillin/clavulanate potassium
- Where
- 19 sites in United States, Argentina and 6 more
- Volunteers
- 41 people
- Sponsor
- Janssen Research & Development, LLC
Appendicitis, Abdominal Pain
The Value of Pancreatic Stone Protein in Predicting Acute Appendicitis
PSP (Pancreatic Stone Protein) is a compound naturally produced mainly in the pancreas and the gut. There is evidence from experimental and clinical trials that the levels of PSP in the blood rise in the presence of inflammation…
- Conditions
- Appendicitis, Abdominal Pain, Abdominal Sepsis
- Trial name
- NCT01610193
- Testing
- Appendicectomy
- Where
- 2 sites in Switzerland
- Volunteers
- 245 people
- Sponsor
- University of Zurich
Acute Appendicitis, Acute Appendicitis Without Peritonitis
The Role of Preoperative HALP Score in Differentiating Complicated Acute Appendicitis
Acute abdomen is a frequently encountered clinical condition that can be fatal if not diagnosed early. Acute appendicitis is one of the causes of acute abdomen and is the most common clinical condition leading to acute abdomen…
- Conditions
- Acute Appendicitis, Acute Appendicitis Without Peritonitis, Acute Appendicitis With Appendix Abscess, Acute Appendicitis With Rupture
- Trial name
- Appendicitis (NCT07002671)
- Testing
- Appendectomy, blood sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 411 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Abdominal Pain, Appendicitis
Right Iliac Fossa Treatment-Turkey Audit
Background: Acute appendicitis stands out as a frequently encountered surgical emergency. Despite decades of experience and research, the diagnosis remains a formidable challenge, particularly in young females experiencing acute…
- Conditions
- Abdominal Pain, Appendicitis, Appendicitis Acute
- Trial name
- RIFT-Turkey (NCT04614649)
- Where
- Turkey (Türkiye)
- Volunteers
- 3,358 people
- Sponsor
- Gazi University