Clinical trials: Aphasia, Rehabilitation
Stroke-induced Aphasia
Overcoming Learned Non-Use in Chronic Aphasia
In this study the investigators are examining the effectiveness of intensive speech therapy in chronic moderate-to-severe stroke-induced aphasia under two conditions - responses "constrained" or unconstrained to speech.
- Trial name
- NCT02012374
- Testing
- Intensive Language Action Therapy
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Aphasia, Stroke
Effect of Anomia Rehabilitation Combined With Metacognitive Training in Patients With Chronic Vascular Aphasia
The postulate of this study is that rehabilitation combining linguistic and metacognitive training will result in a significant improvement in language performance correlated with changes in functional cerebral connectivity…
- Trial name
- METALEX (NCT06930131)
- Testing
- Semantic rehabilitation
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Toulouse
Aphasia, Acquired
Effects of rTMS on Brain Activation in Aphasia
This study will investigate the use of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation method, to improve word-finding abilities in Veterans and non-Veterans with chronic language problems…
- Trial name
- NCT03292471
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- VA Office of Research and Development
Aphasia
Combining Language Therapy With rTMS in Aphasia
With the present RCT, the investigators aimed at finding an optimal protocol for the neurorehabilitation of chronic post-stroke aphasia by combining two promising methods, ILAT (Intensive language action therapy) and 1-Hz rTMS to…
- Trial name
- ILAT+rTMS (NCT03629665)
- Testing
- Intensive Language-Action Therapy (ILAT), Repetitive navigated Transcranial Magnetic Stimulation during naming training
- Volunteers
- 17 people
- Sponsor
- Paula Heikkinen
Ischemic or Hemorrhagic Stroke
Impact of Art Therapy on Brain Connectivity in Recent Post-Stroke Aphasia
A stroke located in the left parieto-temporal junction is associated, in aphasic right-handed patients, with a poor prognosis for language recovery.
- Trial name
- ART-CONNECT (NCT03820843)
- Testing
- Art therapy and standard orthophonic rehabilitation
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aphasia, Broca's Aphasia
Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation
The purpose of this study is to help us understand if adding transcranial Direct Current Stimulation (tDCS), a non-invasive brain stimulation technique, to Speech Therapy improves language recovery in people with Broca's aphasia…
- Trial name
- STARS (NCT07688551)
- Testing
- tDCS
- Where
- 3 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of South Carolina
Aphasia, Post-Ictal
DUbbing Language-therapy CINEma-based in Aphasia Post-Stroke
The DULCINEA study aims to develop and validate a new therapy that integrates essential language characteristics and functional communication by dubbing scenes from television series that represent daily situations.
- Trial name
- NCT04289493
- Testing
- Language and functional communication therapy
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Aphasia, Rehabilitation
Acupuncture + Neuromodulation for Post-Stroke Aphasia
The aim of this clinical trial is to assess the therapeutic efficacy of acupuncture combined with neuromodulation techniques for the treatment of post-stroke aphasia and to explore the brain mechanisms involved.
- Trial name
- NCT06493747
- Testing
- Combined Low- and High-Frequency rTMS Intervention, Combined High- and Low-Frequency rTMS Intervention, rTMS
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Shanghai Yueyang Integrated Medicine Hospital
Strategy Training
Strategy Training for People With Aphasia After Stroke
One-third to one-half of acute strokes result in newly acquired cognitive impairments. Approximately 30 to 40% of people in the acute phase of stroke also sustain communication impairments.
- Trial name
- NCT03593876
- Testing
- Strategy Training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Pittsburgh
Aphasia, Stroke
Adaptive Trial Scheduling in Naming Treatment for Aphasia
Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interferes with life participation and quality of life.
- Trial name
- NCT05653466
- Testing
- Adaptive Spacing Condition, High-Item Non-Adaptive Spacing Condition, Low-Item Non-Adaptive Spacing Condition
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Pittsburgh
Broca's Aphasia
Virtual Reality Based Sensorimotor Speech Therapy
The purpose of this study is to determine whether VR based language rehabilitation scenario based on the core premises of ILAT has a beneficial effect on the linguistic performance (faster retrieval of the target lexicon and…
- Trial name
- NCT02928822
- Testing
- VR-based sensorimotor aphasia therapy, Control Group (conventional aphasia rehabilitation)
- Where
- 2 sites in Spain
- Volunteers
- 18 people
- Sponsor
- Universitat Pompeu Fabra
Aphasia, Apraxia of Speech
MIRAA - Implementation of Intensive Rehabilitation of Aphasia and/or Apraxia of Speech in Swedish Healthcare
Positive outcomes have been shown following intensive treatment of speech and/or language impairment post stroke, but how to design intensive treatment programs to achieve optimal recovery and neuroplasticity changes needs to be…
- Conditions
- Aphasia, Apraxia of Speech, Stroke
- Trial name
- MIRAA (NCT04957225)
- Testing
- MIRAA (Multimodal Intensive Rehabilitation of Aphasia and Apraxia of speech)
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Karolinska Institutet
Non Fluent Aphasia in Subacute Stroke
Dual Hemisphere rTMS for Rehabilitation of Post Stroke Aphasia
To investigate the therapeutic effect of dual hemisphere repetitive transcranial magnetic stimulation (rTMS) on post-stroke non fluent aphasia.
- Trial name
- NCT01850836
- Testing
- repetitive transcranial magnetic stimulation
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Assiut University
Aphasia
NOn-invasive Repeated THerapeutic STimulation for Aphasia Recovery
The current standard of care for rehabilitation of patients with aphasia after stroke is conventional speech and language therapy (SLT).
- Trial name
- NORTHSTAR (NCT02020421)
- Testing
- rTMS, tDCS
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 63 people
- Sponsor
- Dr. Alexander Thiel
Anomia, Aphasia
Cognitive Therapy to Improve Word Finding
Adults who sustain brain damage due to stroke, traumatic injury or surgery may develop difficulty finding words. This study compares the effectiveness of two behavior-based programs to improve picture naming ability in these…
- Conditions
- Anomia, Aphasia, Traumatic Brain Injury, Cerebrovascular Accident
- Trial name
- NCT00494520
- Testing
- Errorful training condition, Errorless training condition
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Georgetown University
Aphasia
Web-Based Treatment for Aphasia
This prospective randomized clinical trial implements an innovative broadband web-based treatment program for individuals with chronic aphasia, and evaluates its efficacy.
- Trial name
- Web-ORLA (NCT04413136)
- Testing
- Web-ORLA, Control
- Volunteers
- 35 people
- Sponsor
- Shirley Ryan AbilityLab
Aphasia, Apraxia of Speech
Changes in Neuroplasticity Following Intensive Rehabilitation of Aphasia and/or Apraxia of Speech
The present study aims to investigate the short- and long-term effects of two weeks of intensive speech-language pathology intervention with additional physiotherapy, on aphasia and apraxia of speech (AOS) and their neural…
- Conditions
- Aphasia, Apraxia of Speech, Dysarthria
- Trial name
- NCT04604444
- Testing
- Multimodal Intensive Rehabilitation of Aphasia and Apraxia of Speech
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Aphasia
Efficacy of Telerehabilitation in the Patients With Aphasia
The study will invite 30 patients to join, and they will be arranged in the face to face group and telerehabilitation group randomly.
- Trial name
- NCT02694133
- Testing
- Smart Phone Based Assistive Speech Therapeutic System, Mobile phone-based tele rehabilitation program
- Volunteers
- 4 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Primary Progressive Aphasia
Semantic Rehabilitation for Patients With Primary Progressive Semantic Aphasia
This project aims to measure the effect of a semantic rehabilitation protocol for patients with primary progressive semantic aphasia and using the SCED methodology.
- Trial name
- SCED-APPvs (NCT04957537)
- Testing
- semantic therapy and semantic re-education
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Toulouse
Aphasia, Gestures
Effects of Gesture Plus Verbal Treatment (GVT) in Cantonese Speakers With Aphasia
This research aims to explore the relative efficacy of Verbal-only and GVT on naming difficulty in Cantonese-speaking people with aphasia (PWA).
- Trial name
- NCT07455162
- Testing
- Verbal treatment, Gesture plus verbal treatment
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- Hong Kong University