Clinical trials: Anxiety, open to volunteers
Anxiety, Depression
The Effect of the Safe and Sound Protocol on Depression and Anxiety Symptoms
The goal of this study is to determine if a developed protocol involving modulated auditory stimulation is better than non-modulated auditory stimulation in reducing anxiety and depression in human subjects.
- Trial name
- SSP (NCT06701578)
- Testing
- Safe and Sound Protocol, Control
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- HealthPartners Institute
Depression, Anxiety
A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety
The goal of this study is to learn how psychedelics may help symptoms of depression and anxiety. Participants with major depressive disorder experiencing symptoms of depression and anxiety will receive one dose of either a drug…
- Conditions
- Depression, Anxiety, Major Depressive Disorder
- Trial name
- NCT06820723
- Testing
- CYB003
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University
Abdominal Pain, Isolated Extremity Fracture
Morphine or Ketamine for Analgesia
Pain is common in children presenting to the emergency department but is frequently undertreated, leading to both short- and long-term consequences.
- Conditions
- Abdominal Pain, Isolated Extremity Fracture, Pain, Pediatrics
- Trial name
- MoKA (NCT06835504)
- Testing
- Ketamine hydrochloride, Morphine sulphate
- Where
- 8 sites in United States
- Volunteers
- 1,010 people
- Sponsor
- Columbia University
Depression, Anxiety
Development of a College Student-Delivered Cognitive-Behavioral Therapy (CBT) Intervention for Rural High School Students
This research is being done to find out the effectiveness, feasibility, and acceptability of a college student-delivered cognitive-behavioral therapy (CBT) intervention in high schools in rural Schuylkill County, Pennsylvania to…
- Conditions
- Depression, Anxiety, Stress
- Trial name
- NCT07240792
- Testing
- Student Delivered Cognitive Behavioral Therapy Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Milton S. Hershey Medical Center
Rumination, Worry
Readiness and Progress in Emotion Regulation Therapy
This study is an open trial designed to examine individual changes that occur before, during, and after 6 modules of Emotion Regulation Therapy (ERT) delivered via telehealth for individuals in New York State who are experiencing…
- Conditions
- Rumination, Worry, Self-Criticism, Anxiety
- Trial name
- NCT07478393
- Testing
- Emotion Regulation Therapy via Telehealth
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Teachers College, Columbia University
Stress Ball
Effect of Stress Ball Application During Coronary Angiography on Anxiety, Procedure-related Fear, Physiological Parameters, and Comfort
The aim of this study is to investigate the effect of stress ball application during coronary angiography on anxiety, procedure-related fear, physiological parameters, and comfort.
- Trial name
- NCT07723521
- Testing
- Stress ball
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Tarsus University
Chronic Pain, Chronic Pain Due to Injury
Virtual Pain Education for Spinal Cord Stimulation Patients
Chronic pain is a leading cause of disability in the United States. When standard treatments fail, many patients develop treatment resistant pain and undergo Spinal Cord Stimulation (SCS) therapy.
- Conditions
- Chronic Pain, Chronic Pain Due to Injury, Failed Back Syndrome, Persistent Spinal Pain Syndrome
- Trial name
- SCS-PNE (NCT07743905)
- Testing
- SCS-PNE intervention
- Volunteers
- 50 people
- Sponsor
- University of Arkansas
Generalized Anxiety Disorder
A Trial of the Efficacy and Safety of a Fixed Dose of SEP-363856 in Adults With Generalized Anxiety Disorder
This is a global, phase 3, randomized, double-blind, parallel-group, 2-arm, placebo controlled, multicenter trial designed to compare the efficacy, safety and tolerability of a fixed dose of SEP-363856 (75 millligrams per day…
- Trial name
- NCT07767903
- Testing
- SEP-363856
- Where
- 11 sites in United States
- Volunteers
- 384 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Acute Pain, Procedural Anxiety
VR for Steroid Joint Injections - Feasibility
The goal of the project is to implement virtual reality for pain and anxiety management for patients undergoing intra-articular glucocorticoid injections in the outpatient pediatric rheumatology clinic.
- Conditions
- Acute Pain, Procedural Anxiety, Juvenile Idiopahtic Arthritis
- Trial name
- NCT07778069
- Testing
- VR-PAT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nationwide Children's Hospital
Generalized Anxiety Disorder
A Trial of the Safety and Tolerability of SEP-363856 in Adults With Generalized Anxiety Disorder
This is a global, Phase 3, multicenter, open-label extension trial designed to evaluate the long-term safety, tolerability and efficacy of SEP-363856 administered at doses of 50 milligrams (mg) or 75 mg per day in adult…
- Trial name
- NCT07786454
- Testing
- SEP-363856
- Where
- 2 sites in United States
- Volunteers
- 1,120 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Comfort Theory, AI-Assisted Group Music Intervention
Applying Comfort Theory to an AI-Assisted Group Music Intervention: Psychosocial and Physiological Outcomes and Feasibility in Long-Term Care Residents.
The research design adopts a sequential two-phase framework. The study will be conducted in three residential LTC facilities located in Taichung City or Changhua County, with a total planned enrollment of 60 residents.
- Conditions
- Comfort Theory, AI-Assisted Group Music Intervention, Long-Term Care Residents, Loneliness
- Trial name
- NCT07882979
- Testing
- Group music intervention, AI-assisted monitoring system
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yu Chia Chang
Depressive Symptoms, Anxiety Disorders and Symptoms
Family Spirit Strengths
This project addresses the disproportionate morbidity and mortality associated with mental and behavioral health problems in American Indian and Alaska Native communities.
- Conditions
- Depressive Symptoms, Anxiety Disorders and Symptoms, Substance Use, Mental Health Issue
- Trial name
- FSS (NCT05836090)
- Testing
- Family Spirit Strengths (FSS), Family Spirit Nurture
- Where
- 3 sites in United States
- Volunteers
- 188 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Social Anxiety Disorder
Very Brief Exposure: Development of a Novel Exposure Modality for Social Anxiety Disorder in Transition-Age Youth
The goal of this clinical trial is to identify the circuit activations by very brief exposure (VBE) among youth with social anxiety disorder (SAD) in order to develop a novel intervention for those with SAD.
- Trial name
- NCT06526260
- Testing
- Very Brief Exposure to Facial Expressions
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Sleep Disturbance, Stress
GUT-FEELINGS: Using Citizen Science for Large-Scale Prebiotic Clinical Trials for Mental Wellness in Adults
The goal of this study is to evaluate the effects of different products in participants experiencing feelings of anxiety. The main question it aims to answer is: Do these products affect feelings of anxiety and related wellness…
- Conditions
- Sleep Disturbance, Stress, Feeling Anxious
- Trial name
- NCT07752823
- Testing
- Active Gut Feeling Product 1, Active Gut Feeling Product 2
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Holobiome, Inc.
Social Anxiety Disorder, Social Fear
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)Therapy for Social Anxiety Disorder
This clinical trial aims to evaluate the efficacy and safety of transcutaneous auricular vagus nerve stimulation (taVNS) in patients with social anxiety disorder (SAD).
- Trial name
- taVNS (NCT07772401)
- Testing
- taVNS
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Anxiety Symptoms, Post-traumatic Stress Symptoms
Improving Student Mental Health Through a Universal Trauma-Informed Intervention
The goal of this trial is to identify the most effective ways for schools to deliver RAP Club, a universal school-based mental health intervention.
- Conditions
- Anxiety Symptoms, Post-traumatic Stress Symptoms, Depressive Symptoms, Behavioral Problems
- Trial name
- PPP (NCT07842432)
- Testing
- RAP Club Delivered by a School Clinician, RAP Club Delivered by a Teacher, Standard Supervision
- Where
- 3 sites in United States
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Anxiety, Depression
Weighted Blankets for Dental Anxiety
The objective of this project is to determine the effectiveness of weighted blankets as an anxiety-reducing intervention for neurotypical adult patients with dental anxiety undergoing routine dental procedures at the University…
- Trial name
- NCT07879846
- Testing
- Blanket at visit 1., No blanket at visit 1, Blanket at visit 2.
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Autism Spectrum Disorder (ASD), Anxiety
Adapted Group Therapy Compared With Usual Care for Anxiety and Depression in Adults With an Autism Diagnosis
The goal of this clinical trial is to learn whether an adapted group therapy works to treat anxiety and depression in adults with an autism diagnosis. The therapy is a form of cognitive behavioral therapy (CBT).
- Conditions
- Autism Spectrum Disorder (ASD), Anxiety, Depression
- Trial name
- CoMind (NCT07880028)
- Testing
- Autism-adapted group cognitive behavioral therapy
- Volunteers
- 154 people
- Sponsor
- Lovisenberg Diakonale Hospital
Perinatal Anxiety, Perinatal Depression
Improving Perinatal Mental Health Through a Collaborative, Community Health Worker and Social Worker Intervention
The goal of this clinical trial is to learn if an intervention can improve mental health outcomes among pregnant and postpartum Latinas.
- Trial name
- NCT07880457
- Testing
- Patient Navigation (PN), Problem Solving Therapy (PST)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- American University
Pain, Anxiety
The Effect of ShotBlocker on Symptoms of Pain, Anxiety, and Cortisol Hormone Levels
The aim of this study is to evaluate the effect of Shotblocker, administered during lumbar puncture, on patients' pain levels, anxiety levels, and cortisol levels (a physiological stress indicator).
- Trial name
- NCT07880496
- Testing
- Intervention Group, Control
- Volunteers
- 68 people
- Sponsor
- Ataturk University