Clinical trials: Antihypertensive Agents
Hypertension, Type 2 Diabetes Mellitus
Amiloride for Resistant Hypertension
To evaluate the antihypertensive effect of amiloride added to triple antihypertensive therapy in patients with resistant hypertension (RH) and type 2 diabetes mellitus (T2DM)
- Conditions
- Hypertension, Type 2 Diabetes Mellitus, Microalbuminuria
- Trial name
- NCT02122731
- Testing
- Amiloride
- Where
- 4 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- Ib Abildgaard Jacobsen
Hypertension, Grade 1, Hypertension Treatment
Hypertensive Ambulatory Trial to Compare the Efficacy of HCTZ and Lisinopril
The purpose of this trial is to evaluate if an objective clinical decision of anti-hypertensive therapy can be made using an N-of-1 (single patient) trial design.
- Conditions
- Hypertension, Grade 1, Hypertension Treatment, N of 1 Study Design, Hypertension
- Trial name
- 1HAT (NCT01258764)
- Testing
- Lisinopril, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Scripps Translational Science Institute
Resistant Arterial Hypertension
Clinical One-stage Controlled Study of reSistant Arterial Hypertension for the desiGning of a personAlized Approach to Therapy
This study was planned to assess the concentration of antihypertensive drugs in the blood plasma in patients with controlled and uncontrolled arterial hypertension.
- Trial name
- SAGA (NCT05899920)
- Testing
- Blood samples will be taken for pharmacokinetics and pharmacogenetics
- Where
- Russia
- Volunteers
- 190 people
- Sponsor
- Ryazan State Medical University
Hypertension
Losartan and HCTZ and Amlodipine vs Atenolol and Amlodipine (0954A-309)(COMPLETED)
A study to evaluate the effects of combination losartan versus combination atenolol in patients with ambulatory systolic hypertension.
- Trial name
- NCT00140959
- Testing
- MK0954, losartan potassium/Duration of Treatment: 18 weeks, Comparator: losartan, HCTZ, amlodipine, atenolol/Duration of Treatment: 18 weeks
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Hypertension
ACEI/CCB Versus ACEI/DIU Combination Antihypertensive Therapy in Chinese Hypertensive Patients (ACvAD)
1. Study name: ACEI/CCB versus ACEI/DIU combination antihypertensive therapy in Chinese hypertensive patients (ACvAD) 2. Rationale:Most current hypertension guidelines recommend the combination therapy of an…
- Trial name
- NCT03682692
- Testing
- ACEI/CCB, ACEI/DIU
- Where
- China
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Hypertension
The Evaluation of Clevidipine in Patients Requiring ICP Monitoring and IV Antihypertensive Therapy
This is a single-arm, open label safety and dose titration study evaluating the use of Clevidipine to rapidly control elevated blood pressure in patients who have an Intracranial Pressure Monitoring device.
- Trial name
- NCT01910532
- Testing
- Clevidipine
- Where
- United States
- Sponsor
- Mario Ammirati
Primary Aldosteronism
Finerenone for Patients With Primary Aldosteronism (FAIRY)
Using spironolactone as the control, to assess the efficacy and safety of finerenone in patients with primary aldosteronism(PA).
- Trial name
- NCT06457074
- Testing
- Finerenone Oral Tablet, Spironolactone Oral Tablet
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Chongqing Medical University
Postpartum Complication, Maternal Hypertension
Safest Choice of Antihypertensive Regimen for Postpartum Hypertension
The purpose of this investigator-initiated randomized control trial is to determine whether oral Nifedipine versus oral Labetalol is superior in controlling high blood pressures in the postpartum period.
- Conditions
- Postpartum Complication, Maternal Hypertension, High Blood Pressure
- Trial name
- SCARPH (NCT05551104)
- Testing
- Oral Nifedipine, Oral Labetalol
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Loma Linda University
Hypertension
A Study To Evaluate The Efficacy Of Eplerenone Compared With Losartan For The Treatment Of Patients With Mild To Moderate Hypertension
The purpose this study is to compare the efficacy of eplereonone and losartan in patients with mild to moderate hypertension.
- Trial name
- NCT00649311
- Testing
- eplerenone, Losartan
- Where
- 2 sites in Taiwan
- Volunteers
- 248 people
- Sponsor
- Pfizer
Cerebral Small Vessel Diseases, Stroke
Folic Acid and Intensive Antihypertensive Therapy for Hypertension With CSVD
The primary objectives of this trial are: 1. Efficacy evaluation of amlodipine folic acid tablets: To assess the effects of amlodipine folic acid tablets 5.8 mg (5 mg amlodipine + 0.8 mg folic acid)versus amlodipine tablets 5 mg…
- Trial name
- FAITH (NCT05169021)
- Testing
- Amlodipine folic acid 5.8mg+intensive antihypertensive therapy, Amlodipine folic acid 5.8mg+standard antihypertensive therapy, Amlodipine+intensive antihypertensive therapy
- Where
- China
- Volunteers
- 15,000 people
- Sponsor
- Beijing Tiantan Hospital
Hypertension, Hypertrophy, Left Ventricular
The SILVER Study: Systolic Hypertension Interaction With Left Ventricular Remodeling
The purpose of this study is to evaluate the safety and efficacy of ALT-711 in the treatment of isolated systolic hypertension in a formal study in patients with left ventricular hypertrophy.
- Trial name
- NCT00045994
- Testing
- ALT-711
- Volunteers
- 180 people
- Sponsor
- Synvista Therapeutics, Inc
Arterial Hypertension, Diabetes Mellitus Type 2 IRC or NIR
Effect of the Known Antihypertensive Drug Telmisartan on Red Blood Cells and Circulation in the Smallest Blood Vessels
The hypothesis of the presented study is: Telmisartan induces an increase of eNOS activity in RBC resulting in an enhanced intravascular NO bioavailability, an ameliorated RBC deformability and a reduction of RBC and platelet…
- Trial name
- ITEM (NCT00559286)
- Testing
- Telmisartan
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- RWTH Aachen University
Ischemic Stroke
The Effect of Losartan Versus Amlodipine-based Therapy in Ischemic Stroke (0954-338)(COMPLETED)
To compare the effect of losartan vs amlodipine-based antihypertensive therapy on atherosclerotic inflammatory markers and cerebrovascular regulation in Ischemic stroke patients.
- Trial name
- NCT00754429
- Testing
- losartan, amlodipine
- Volunteers
- 40 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Cardiovascular Diseases, Coronary Disease
Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
To determine if the combined incidence of nonfatal myocardial infarction and coronary heart disease death differs between diuretic-based and each of three alternative antihypertensive pharmacological treatments.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Diabetes Mellitus, Heart Diseases
- Trial name
- NCT00000542
- Testing
- Inhibitors, ACE, amlodipine, lisinopril
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertension
Aliskiren and Valsartan vs Valsartan Alone in Patients With Stage II Systolic Hypertension and Type II Diabetes Mellitus
The purpose of the study was to evaluate the blood pressure (BP)-lowering efficacy of the combination of aliskiren and valsartan, as initial therapy, compared to valsartan monotherapy in Type II Diabetic patients with Stage II…
- Trial name
- ViVID (NCT00927394)
- Testing
- Aliskiren, Valsartan
- Where
- 4 sites in United States
- Volunteers
- 1,143 people
- Sponsor
- Novartis
Cardiovascular Diseases
Effectiveness of "Medisinstart"
"Medisinstart" is a new service developed for use in Norwegian pharmacies. It is intended for patients that are about to start a new medicine for a chronic or long-term condition.
- Trial name
- NCT02261402
- Testing
- Medisinstart
- Where
- 67 sites in Norway
- Volunteers
- 1,480 people
- Sponsor
- Apokus AS
Stage II Hypertension
Candesartan Effect in Second Stage Arterial Hypertension
To compare the changes in mean sitting DBP from baseline after 4 weeks of therapy with either candesartan cilexetil/HCT combination therapy or candesartan cilexetil monotherapy regimen
- Trial name
- CAESAR (NCT00621153)
- Testing
- Candesartan Cilexetil, Hydrochlorothiazide
- Where
- South Korea
- Volunteers
- 214 people
- Sponsor
- AstraZeneca
Diabetes Mellitus Type 2, Hypertension
MATCHED (MC-1 and ACE Therapeutic Combination for Hypertensive Diabetics)
The purpose of this study is to determine whether MC-1 alone and in combination with an ACE inhibitor is effective in reducing blood pressure and metabolic dysfunctions associated with diabetes
- Conditions
- Diabetes Mellitus Type 2, Hypertension, Metabolic Syndrome
- Trial name
- NCT00157729
- Testing
- pyridoxal-5'-phosphate with and without ACE inhibitor
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- Medicure
Hypertension
Effectiveness of Valsartan/Amlodipine (EXforge®) and Nifedipine treAtment coMparison in Treating Chinese Hypertensive Patients
The purpose of this study was to compare the efficacy and safety of Valsartan/Amlodipine (EXforge®) with nifedipine, as well as vascular function index.
- Trial name
- EXAM (NCT01167153)
- Testing
- Valsartan/Amlodipine, Nifedipine
- Where
- China
- Volunteers
- 564 people
- Sponsor
- Novartis
Hypotensive Anesthesia
Comparison Between Two Drugs (Propofol and Nitroglycerin as a Hypotensive Agents During Endoscopic Sinus Surgery
Background and Objectives: FESS is a common minimally invasive surgery that requires a clear field to be performed well. Hypotensive anesthesia is one of the most common maneuvers performed to help in keeping the field clear.
- Trial name
- prop (NCT04220281)
- Testing
- Propofol, Nitroglycerin
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University