Clinical trials: Antibiotic Prescriptions
Lower Resp Tract Infection
An Algorithm to Decide on Antibiotic Prescription in Lower Respiratory Tract Infection in Primary Care
The study is randomized clustered pragmatic trial whose objective is to decrease unnecessary antibiotic prescription in adult patients with lower respiratory tract infection managed at primary care level in Switzerland, using a…
- Trial name
- UltraPro (NCT03191071)
- Testing
- UltraPro, Procalcitonin, Blood sampling
- Where
- Switzerland
- Volunteers
- 469 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Acute Respiratory Tract Infection, Urinary Tract Infections
Routine Antibiotic Prescription Monitoring in Primary Care Physicians: A Nationwide Trial
Antibiotic resistance is an increasingly serious problem in Switzerland which is associated with the exposure and overall uptake of antibiotics in a population.
- Trial name
- NCT03379194
- Testing
- Antibiotic stewardship program
- Where
- Switzerland
- Volunteers
- 3,426 people
- Sponsor
- University Hospital, Basel, Switzerland
Patients at High Risk of Antibacterial Treatment Upon Admission
Impact of Prescription Quality, Infection Control and Antimicrobial Stewardship on Gut Microbiota Domination by Healthcare-Associated Pathogens
Extended-spectrum beta-lactamase producing Enterobacteriaceae (EPE), vancomycin-resistant enterococci (VRE) and Clostridium difficile have become a major threat to hospitalised patients worldwide.
- Trial name
- PILGRIM (NCT03765528)
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- University Hospital of Cologne
Modality of Discharge Instructions
Effect of Modality on Discharge Instruction in Patients Receiving Outpatient Antibiotic Prescriptions From the Emergency Department
Outpatient antibiotics are frequently prescribed from the emergency department, and limited health literacy may impact compliance with recommended treatments.
- Trial name
- NCT01775969
- Testing
- Text Message, Voicemail
- Where
- United States
- Volunteers
- 2,874 people
- Sponsor
- Hennepin Healthcare Research Institute
Respiratory Tract Infections
Patient Centered Communication Training to Reduce Antibiotic Use in Acute Respiratory Tract Infections
The purpose of this study is to evaluate the effectiveness of a short training program for general practitioners in patient-centered communication to reduce antibiotic prescription for acute respiratory tract infections (ARTI).
- Trial name
- NCT00105248
- Testing
- patient-centered communication training
- Where
- Switzerland
- Volunteers
- 900 people
- Sponsor
- University Hospital, Basel, Switzerland
Fever Without Source
Impact of the Lab-score on Antibiotic Prescription Rate in Children With Fever Without Source
Detecting serious bacterial infections (SBI) in children presenting to the Pediatric Emergency Department (PED) with fever without source (FWS) is a frequent diagnostic challenge.
- Trial name
- NCT02179398
- Testing
- Allocation to the Lab-score group, Allocation to the control group
- Where
- Switzerland
- Volunteers
- 278 people
- Sponsor
- University Hospital, Geneva
Acute Otitis Media (AOM), Upper Respiratory Infection
Artificial Intelligence Diagnostic Decision Support to Reduce Antimicrobial Prescriptions in Young Children With Colds
Ear infections are common in young children with cold symptoms, but they can be difficult to diagnose due to small ear canals, child movement, and limited viewing time.
- Trial name
- IMAGE (NCT06876259)
- Testing
- Standard Clinical Ear Exam, AI app ear exam and diagnosis
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Timothy Shope
Antimicrobial Resistance
Optimizing Antibiotics Prescription
Interventions that are low-cost, do not add substantially to the physician workload, are consistent with good physician practices and WHO guidelines, and serve as a reminder on the risks of overprescribing antibiotics are…
- Trial name
- NCT06436690
- Testing
- Diagnosis Mandate, Individualized Feedback
- Where
- 2 sites in United States, Nepal
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Penn State University
Infectious Diseases
Prescription Support System for Antimicrobial Use in Belgian Primary Care
Inappropriate antibiotic prescribing in primary care remains an important contributor to antimicrobial resistance. Despite the availability of evidence-based clinical guidelines, antibiotics are still frequently prescribed for…
- Trial name
- PaSSo (NCT07347015)
- Testing
- Prescription Support System (PSS)
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- KU Leuven
Respiratory Tract Infections, Urinary Tract Infections
Intervention Study to Improve Antibiotic Prescription in Outpatient Care
Antimicrobial resistance has become a world-wide problem and antibiotic consumption is a major driving force for the development of resistance.
- Trial name
- SAPI (NCT01358916)
- Testing
- Mailing of antibiotic therapy guidelines to the sentinel physicians
- Where
- Switzerland
- Volunteers
- 140 people
- Sponsor
- University of Bern
SARS-CoV Infection, Antimicrobial Stewardship
Analysis of the Quality and Quantity of Antibiotic Prescriptions for Bacterial Respiratory Tract Superinfection in Patients Hospitalized in COVID-19 Wards
In this prospective observational study, a quantitative and qualitative analysis of antibiotic prescriptions for presumed respiratory tract (super)infection in patients hospitalized on COVID-19 wards will be made.
- Conditions
- SARS-CoV Infection, Antimicrobial Stewardship, Respiratory Tract Infections, Antibiotic Resistance
- Trial name
- NCT04544072
- Where
- Belgium
- Volunteers
- 400 people
- Sponsor
- Universitair Ziekenhuis Brussel
Infection
Do Fair Comparisons or Harms Data Increase Responsiveness to Feedback About Antibiotic Prescribing: 2x2 Factorial Trial
Antibiotic overuse is common and antibiotic prescribing contributes to rising rates of antimicrobial resistance. Primary care physicians prescribe the majority of all antibiotics and there is large inter-physician variability in…
- Trial name
- NCT04594200
- Testing
- Audit and Feedback (A&F)
- Where
- Canada
- Volunteers
- 5,107 people
- Sponsor
- Women's College Hospital
Antibiotic Prescribing for Acute Respiratory-tract Infections
Effect of CRP and SAA Point-of-care Testing on Antibiotic Prescribing for Acute Respiratory-tract Infections
The study was a practical, cluster-randomized controlled trial to evaluate the impact of CRP and SAA point-of-care testing (CRP\&SAA POCT) on antibiotic prescribing in patients with acute respiratory-tract infections (ARI) at…
- Trial name
- NCT06568432
- Testing
- CRP+SAA POCT
- Where
- China
- Volunteers
- 35,108 people
- Sponsor
- Huazhong University of Science and Technology
Antibiotic Prescription
Impact of a Communication Toolkit on Antibiotic Prescribed by General Practitioners: a Randomised Trial
This study is a pragmatic, randomised, controlled, before-after interventional study conducted in one region in France in primary care.
- Trial name
- NCT04562571
- Testing
- Charter & patient information leaflets
- Where
- France
- Volunteers
- 349 people
- Sponsor
- Central Hospital, Nancy, France
Community Acquired Pneumonia in Children, Antibiotic Stewardship
Antibiotic Prescription in Children Hospitalized for Community-acquired Pneumonia
A study to observe how often antibiotics are prescribed in children hospitalized for pneumonia and how doctors decide if a child needs antibiotics or not. Parent satisfaction will also be recorded.
- Trial name
- NCT04681339
- Testing
- Antibiotic treatment, No antibiotic treatment
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
Acute Respiratory Tract Infections
Optimisation of Antibiotic Prescription in Acute Noncomplicated Respiratory Tract Infections in Children (OptimAP Study)
Background: High-volume antibiotic prescribing in primary care is a major driver of antibiotic resistance. Education of physicians and patients can lower prescribing levels, but it frequently relies on highly trained staff.
- Trial name
- OptimAP (NCT05166369)
- Testing
- Communication skills training, Mobile phone application on RTI
- Where
- 4 sites in Spain
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Antibiotic Susceptibility Reporting
Discontinuation of Antibiotic Susceptibility Testing on Enterococcus Faecalis Positive Urine Cultures in Hospitalized Patients: an Impact on Antibiotic Prescriptions? (FaecaCible)
The objective of the study is to evaluate the impact of not reporting antibiotic susceptibility tests on antibiotic consumption for Enterococcus faecalis positive urine cultures in adult hospitalized patients.
- Trial name
- FaecaCible (NCT05743192)
- Testing
- Stop performing an antibiotic susceptibility test
- Where
- France
- Volunteers
- 217 people
- Sponsor
- Central Hospital, Nancy, France
Drug Use
E-PAUse: Encouraging Proper Antibiotic Use in Outpatient Setting
Specific Aim 1: To determine the knowledge, attitude, and practice (KAP) of PHCC physicians regarding appropriate prescription of antibiotics in the outpatient setting.
- Trial name
- E-PAUse (NCT06135376)
- Testing
- comprehensive multi-component interventions
- Where
- Qatar
- Volunteers
- 100,000 people
- Sponsor
- Hamad Medical Corporation
Antibiotic Side Effect
Antibiotic Prescription for Children With Acute Upper Respiratory Tract Infections in Assiut District
Antibiotics are one of the most commonly prescribed drugs in pediatric care all over the world. Over prescription of antibiotics is a major public health problem and the most important factor in the emergence of antibiotic…
- Trial name
- NCT04127682
- Testing
- Antibiotic KAP questionnaire
- Where
- Egypt
- Volunteers
- 186 people
- Sponsor
- Assiut University
Antibiotic Prescription
Prescription Pattern and Awareness About Antibiotic Prophylaxis and Resistance
To assess the knowledge of Pediatric dentists regarding the prescription of antibiotics, antibiotic prophylaxis and antibiotic resistance
- Trial name
- NCT04031443
- Where
- Egypt
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Cairo University