Clinical trials: Antibiotic Allergy
Staphylococcus Aureus Bacteremia, Anti-Bacterial Agents
Phase IIa Clinical Study of N-Rephasin® SAL200
This study is performed to evaluate safety and to explore the efficacy of a single intravenous dose of N-Rephasin® SAL200 (3 mg/kg) in addition to the conventional standard treatment, for persistent Staphylococcus aureus…
- Trial name
- NCT03089697
- Testing
- N-Rephasin® SAL200
- Where
- 2 sites in South Korea
- Volunteers
- 25 people
- Sponsor
- Intron Biotechnology, Inc.
Atopic Dermatitis
Role of Antimicrobial Peptides in Host Defense Against Vaccinia Virus
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by recurrent viral skin infections. Recent studies have demonstrated that the skin of people with AD my have decreased antimicrobial peptide (AMP)…
- Trial name
- NCT00407069
- Where
- United States
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Penicillin Allergy
Geisinger Antibiotic Allergy Pilot Program: Assess and Address
This is a prospective non-inferiority study to evaluate penicillin allergy history in patients with reported penicillin allergy, who require penicillin or penicillin-derivative antibiotic during inpatient admission using a…
- Trial name
- GAAP (NCT05464615)
- Testing
- Amoxicillin
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- Geisinger Clinic
Atopic Dermatitis (AD)
Targeted Microbiome Transplant in Atopic Dermatitis
The purpose of this study is to examine the safety and effectiveness of a new therapy, commensal lotion containing infection fighting bacteria, on decreasing or eliminating the infection causing bacteria found on the skin of…
- Trial name
- NCT03151148
- Testing
- TMT Lotion
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
LRTI
Procalcitonin for Stewardship in Respiratory Infections A Stewardship Project
Antibiotics are overused in hospitals nationwide, leading to unnecessary drug costs and adverse events. Antibiotic stewardship is now a national and international priority and regulatory authorities are mandating antibiotic…
- Trial name
- NCT03109106
- Testing
- PCT Arm
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- Johns Hopkins University
COPD, Respiratory Tract Infections
Targeted AntiBiotics for Chronic Pulmonary Diseases
This is a prospective, randomized multi-center trial investigating the impact of lower airway infection with P. aeruginosa in COPD patients. The aim of the study is to evaluate if targeted antibiotic therapy against P.
- Conditions
- COPD, Respiratory Tract Infections, Pseudomonas Aeruginosa, Bronchiectasis
- Trial name
- Target-ABC (NCT03262142)
- Testing
- Piperacillin/tazobactam, Ciprofloxacin
- Where
- Denmark
- Volunteers
- 51 people
- Sponsor
- Chronic Obstructive Pulmonary Disease Trial Network, Denmark
Severe Atopic Dermatitis
Efficacy of Combining Topical Antibiotic/Steroid/Moisturizer Therapy Compared to Active Comparator in Atopic Dermatitis.
Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease that occurs most commonly during early infancy and childhood.
- Trial name
- NCT03052348
- Testing
- Polyethylene glycol hexadecyl ether & Betamethasone valerate cream 0.1%, Fusidic acid, polyethylene glycol hexadecyl ether & Betamethasone valerate cream 0.1%
- Where
- 3 sites in South Africa
- Volunteers
- 78 people
- Sponsor
- Red Cross War Memorial Childrens Hospital
Penicillin Allergy
Perioperative Antibiotic Choices for Surgical Prophylaxis in Penicillin-allergic Pediatric Patients
The proposed research project will retrospectively review the anesthetic records over the past 5 years and identify patients who present with a history of penicillin allergy or allergy to an antibiotic in the penicillin family.
- Trial name
- NCT02036840
- Testing
- Antibiotic
- Where
- United States
- Volunteers
- 513 people
- Sponsor
- Joseph D. Tobias
Beta Lactam Allergy, Hematologic Malignancy
Allergy Delabeling in Antibiotic Stewardship - Intervention
The overall goal of the RENEW-IN intervention is to assess the impact of a BL allergy delabeling intervention on antibiotic use and clinical outcomes in patients with a hematologic malignancy.
- Trial name
- RENEW-IN (NCT07133074)
- Testing
- RENEW-IN Algorithm for assessment of a beta-lactam intervention, EMR Review
- Where
- United States
- Volunteers
- 3,800 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Drug Allergy, Antibiotic Allergy
Improved Basophil Activation Test (BAT) in the Diagnostics of Drug Allergy
Current study evaluates the use of the improved Basophil Activation Test (BAT) in the diagnostics of IgE-mediated allergy to antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs).
- Conditions
- Drug Allergy, Antibiotic Allergy, NSAID-Induced Anaphylactoid Reaction
- Trial name
- NCT03164044
- Where
- Belarus
- Volunteers
- 45 people
- Sponsor
- The Republican Research and Practical Center for Epidemiology and Microbiology
Drug Hypersensitivity, Penicillin Allergy
Drug Challenges Without Prior Skin Testing
The investigators are conducting a prospective study to determine the safety and outcomes of placebo-controlled graded drug challenges without prior skin testing in patients with a low-risk history of antibiotic hypersensitivity…
- Conditions
- Drug Hypersensitivity, Penicillin Allergy, Antibiotic Allergy
- Trial name
- NCT03158831
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Penicillin Allergy
Feasibility Assessment of Risk Stratification and Oral Challenge in Hospitalized Children at Low Risk for Antibiotic Allergy
Children are often reported to have antibiotics allergies, with approximately 10% of the US population labeled as allergic to an antibiotic.
- Trial name
- NCT04441021
- Testing
- Penicillin Allergy Risk Stratification and Evaluation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Acute Exacerbation COPD
Pattern of Microbial Infection in AECOPD Patients and Its Sensitivity to Antibiotics
Measurement of bacterial species causing AECOPD and their Sensitivity pattern to antibiotics.
- Trial name
- NCT06123780
- Volunteers
- 140 people
- Sponsor
- Assiut University
Helicobacter Pylori Infection
Tailored Therapy for Helicobacter Pylori Treatment in Patients With Penicillin Allergy
Increasing drug resistance presents a significant challenge to the efficacies of common empiric eradication regimens for Helicobacter pylori treatment in the mainland of China.
- Trial name
- NCT03708848
- Testing
- Esomeprazole, Bismuth Potassium Citrate, Clarithromycin
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Atopic Dermatitis
Effects of Pimecrolimus on Skin Biopsy Ex-plants From Patients With Atopic Dermatitis
THe study seeks to determine if pimecrolimus has a positive effect on increasing antimicrobial peptide expression and reducing vaccinia virus growth in the skin explants from patients with atopic dermatitis.
- Trial name
- NCT00379678
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Jewish Health
Nosocomial Infection in Neonatal Intensive Care Unit
Bacteriological Profile and Antibiotic Sensitivity in Neonatal Intensive Care Unit at Assuit University Children Hospital
The study aims to assess the bacteriological profile and antibiotic sensitivity in NICU of pediatric hospital of assuit university.
- Trial name
- NCT06891768
- Testing
- Blood culture
- Volunteers
- 134 people
- Sponsor
- Assiut University
Urinary Tract Infections, Antiobiotic Stewardship
Post-Emergency Optimization of Antibiotic Therapy for Urinary Tract Infection (UTI)
Prospective, multicenter, non-interventional study conducted over 6 months, including patients presenting to the emergency department with suspected urinary tract infection managed as outpatients and discharged with or without…
- Conditions
- Urinary Tract Infections, Antiobiotic Stewardship, Emerging Infectious Disease
- Trial name
- REVIU48 (NCT07559318)
- Testing
- Adaptation of antibiotics therapy for outpatient urinary infection following emergency care
- Where
- 3 sites in France
- Volunteers
- 330 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Pharmacokinetics, Beta Lactam Adverse Reaction
Beta-lactam Pharmacokinetics in Secondary Care
Currently in the UK, TDM is routinely performed for aminoglycosides and glycopeptide antimicrobial agents, given fears over the narrow therapeutic window of these agents and the serious adverse events associated with toxicity.
- Conditions
- Pharmacokinetics, Beta Lactam Adverse Reaction, Penicillin Allergy
- Trial name
- NCT03033394
- Testing
- Beta-lactam antibiotic
- Where
- United Kingdom
- Volunteers
- 65 people
- Sponsor
- Imperial College London
Stevens-Johnson Syndrome
Stevens-Johnson Syndrome Antimicrobial
Steven-Johnson's syndrome, or great multiform erythema, appears as a systemic disturbance, with skin involvement and mucous membranes, related to several factors, such as, viral or bacterial infections and mainly the…
- Trial name
- NCT00844038
- Where
- Brazil
- Volunteers
- 1 people
- Sponsor
- University of Pernambuco
Chronic Periodontitis
STUDY ON THE EFFECTS OF PERIODONTAL TREATMENT ALONG WITH THE USE OF ANTIBIOTICS OVER HIGH SENSITIVE C-REACTIVE PROTEIN. RANDOMIZED CONTROLLED CLINICAL TRIAL.
Human periodontitis is a group of highly prevalent oral inflammatory diseases and infections with relatively easy treatment and preventive features.
- Trial name
- NCT01906450
- Testing
- Scaling and root planing plus Azithromycin
- Where
- Colombia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidad del Valle, Colombia