Clinical trials: Anovulation
Ovulatory Dysfunction, Anovulation
Traditional Clomiphene Citrate Administration vs. Stair-step Approach
The purpose of this study is to compare the length of time to achieve ovulation and pregnancy with a traditional protocol administration of clomiphene citrate versus a stair step administration.
- Conditions
- Ovulatory Dysfunction, Anovulation, Ovulation Induction
- Trial name
- Clomid (NCT01008319)
- Testing
- clomiphene citrate
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Oklahoma
Infertility, Female, Unexplained Infertility
Serum Kisspeptin Levels in Infertile Women
The study population is comprise of 90 women those age varies between 18-38 year-old. The first group will comprise of 30 women with polycystic ovaries or anovulatory cycles, the second group will comprise of 30 women with…
- Conditions
- Infertility, Female, Unexplained Infertility, Anovulation
- Trial name
- NCT03018314
- Testing
- Blood sample
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Anovulatory
The Effect of Sildenafil Citrate on the Success Rate of Ovulation Induction Using Clomiphene
The aim of the study is to evaluate the effect of sildenafil citrate on the pregnancy rate in women undergoing induction of ovulation using clomiphene citrate.
- Trial name
- NCT02663830
- Testing
- Sildenafil & clomiphene citrate, clomiphene only
- Volunteers
- 210 people
- Sponsor
- Ain Shams University
Polycystic Ovary Syndrome
PCOS Twin Study - Environmental Factors in the Development of Polycystic Ovary Syndrome, Phase 2
Polycystic Ovary Syndrome, or PCOS, is the most common endocrine disorder in women. Depending on the strictness of the diagnostic criteria used, it is thought to occur in about 6-10% of all women, many of whom do not know they…
- Trial name
- NCT00444288
- Where
- United States
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Anovulation, Polycystic Ovary Syndrome
Circulating Androgen Levels Are Not Affected by the Administration of Vaginal Micronized Progesterone for Withdrawal Bleeding in Patients With Polycystic Ovarian Syndrome
Hormonal evaluation of women who are suspected of having Polycystic ovary syndrome (PCOS) involves the measurement of basal levels of androgens and 17-hydroxyprogesterone (17-OHP), which are generally used to establish the…
- Conditions
- Anovulation, Polycystic Ovary Syndrome, Hyperandrogenism
- Trial name
- NCT03088046
- Testing
- Micronized Progesterone
- Volunteers
- 15 people
- Sponsor
- Fundacion Dexeus
Infertility, Anovulation
Concomitant CC and E2 Versus CC Alone in Ovulation Induction
The purpose of this study is to evaluate the effect of concomitant administration of estradiol during use of clomiphene citrate (CC) for induction of ovulation in infertile women.
- Trial name
- NCT02186782
- Testing
- Clomiphene citrate and Estradiol
- Where
- 3 sites in Egypt
- Volunteers
- 600 people
- Sponsor
- Maher elesawi kamel elesawi
Infertility, Polycystic Ovarian Syndrome
Letrozole Versus Clomifene Citrate for Ovulation Induction
The primary aim of the study is to assess the efficacy of letrozole as an ovulation induction agent and to test the hypothesis that letrozole will generate better pregnancy rates with fewer multiple pregnancies and higher live…
- Trial name
- NCT00478504
- Testing
- Letrozole, Clomifene citrate
- Where
- United Kingdom
- Volunteers
- 159 people
- Sponsor
- University of Nottingham
Female Infertility Associated With Anovulation
Amlodipine on Blood Flow of Preovulatory Follicle in Polycystic Ovarian Patients
On the basis of the current study, amlodipine seems to be a promising drug on improving uterine, ovarian blood flow, size of pre-ovulatory follicle, midluteal progesterone level and pregnancy outcome in patients with pco.
- Trial name
- NCT02544776
- Testing
- Clomifene citrate ( clomid 50 mg ), Amlodipine
- Volunteers
- 60 people
- Sponsor
- Ahmed Fathy Ali Mohamed Ghanem
Anovulation, Oligo-ovulation
Trial to Assess the Clinical Efficacy and Safety of MSJ-0011 in Inducing Ovulation in Anovulatory or Oligo-ovulatory Japanese Women
This is an open-label, parallel-group, randomized, multicenter Phase III trial to compare the efficacy and safety of a single 250 microgram (mcg) subcutaneous dose of MSJ-0011 to a single 5,000 international units (IU)…
- Conditions
- Anovulation, Oligo-ovulation, Hypothalamic-pituitary Dysfunction, Polycystic Ovarian Syndrome
- Trial name
- NCT01653743
- Testing
- MSJ-0011, urinary hCG (u-hCG), Follitropin alpha
- Where
- 6 sites in Japan
- Volunteers
- 81 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Subfertility, Anovulatory
The Effects of an Intensive Lifestyle Intervention on Reproductive Outcomes
This is a study to determine whether a low calorie diet using meal replacement shakes compared to current counseling about diet, followed by 3 cycles of clomiphene citrate (if needed) will result in: 1) improvements in ability to…
- Conditions
- Subfertility, Anovulatory, Obese
- Trial name
- NCT01894074
- Testing
- Intensive Dietary Intervention
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Amy E Rothberg
Polycystic Ovary Syndrome
Metformin in Infertile PCOS Patients
Metformin, an oral biguanide administrated for treating type-2 diabetes mellitus, is a safe and effective drug recently experimented also in patients with polycystic ovary syndrome (PCOS).
- Trial name
- NCT00501904
- Testing
- Metformin
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University Magna Graecia
Anovulation, Polycystic Ovary Syndrome
Letrozole Versus Clomiphene Citrate for Ovulation Induction in Women With Poly Cystic Ovary Syndrome ( PCOS )
110 infertile women diagnosed as polycystic ovary syndrome (PCOS) at the age group of 20-35 distributed randomly : 55 women will receive letrozole 2.5mg twice daily orally from the 2nd day to the 6thday of the cycle for three…
- Trial name
- LVCCFOROI (NCT02551367)
- Testing
- Letrozole, Clomiphene citrate, hcg hormone
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- mostafa gomaa hamid halawa
Infertility
Study to Assess the Efficacy and Safety of Three Dosage Strengths of Pulsatile GnRH Delivered From a Iontophoretic Patch Compared to Oral Treatment With Clomiphene or Placebo in Infertile Females
The primary objective of this study is to determine the safety and efficacy of pulsatile GnRH delivered from a iontophoretic patch (Lutrepatch) for induction of ovulation in women with anovulatory/ oligoovulatory infertility…
- Trial name
- NCT00796289
- Testing
- GnRH iontophoretic transdermal Lutrepatch, clomiphene citrate
- Where
- 35 sites in United States
- Volunteers
- 350 people
- Sponsor
- Ferring Pharmaceuticals
Anovulation
Evaluation of Efficacy and Safety of Highly Purified Urofollitropin for Ovulation Induction in Chinese Females
Evaluate the Efficacy and Safety of Highly Purified Urofollitropin for Injection Compared to Recombinant Human Follitropin Alfa for Injection for Ovulation Induction in Chinese females
- Trial name
- Compass (NCT01923194)
- Testing
- Highly Purified Urofollitropin, Recombinant Human Follitropin Alfa
- Where
- 12 sites in China
- Volunteers
- 215 people
- Sponsor
- Ferring Pharmaceuticals
Anovulation, Disorder Due Cytochrome P450 CYP2D6 Variant
Influence of Pharmacogenetic Factors, Paroxetine and Clarithromycin on Pharmacokinetics of Clomiphene
Aim of the study is the clinical validation of the metabolism and the pharmakokinetic of Clomifen in correlation to CYP2D6 and inhibition of CYP3A4.
- Conditions
- Anovulation, Disorder Due Cytochrome P450 CYP2D6 Variant, Cytochrome P450 CYP3A Enzyme Deficiency
- Trial name
- NCT01289756
- Testing
- Clomiphene, clomiphene and paroxetine, clomiphene and clarithromycin
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF)
Anovulation
Phase III Clinical Study of Domestic Recombinant Human Follitropin for Injection to Treat WHO Class II Anovulation
The purpose of this study is to evaluate the efficacy and safety of Domestic Recombinant Human Follitropin (Gonal-F) for Injection for treatment of WHO Ⅱ anovulation (including polycystic ovarian syndrome [PCOS] subjects).
- Trial name
- NCT02335879
- Testing
- Gonal-F
- Volunteers
- 534 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Anovulation
Predictors of Ovarian Response During Clomiphene Citrate Ovulation Induction in Patients With Polycystic Ovary Syndrome
The purpose of this study is to determine whether Visceral fat area and other criteria assessed during initial screening could predict the response to ovulation induction with clomiphene citrate (CC) in patients with polycystic…
- Trial name
- NCT02269306
- Testing
- clomiphen citrate
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Menoufia Obstetrics and Gynecology Group
Anovulation, FHA
FHA: Characterization of Metabolic Status, Brain Circuitry, and Stress-Reactivity
Functional Hypothalamic Amenorrhea (FHA), the spontaneous cessation of the menstrual cycle for at least 6 months after menstrual cyclicity has been established, is a common and reversible form of anovulation not due to…
- Conditions
- Anovulation, FHA, Eumenorrhea, Polycystic Ovary Syndrome
- Trial name
- NCT00453219
- Testing
- Screening evaluation, Meal Response, Blood Collection
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Anovulation, Infertility
Gonadotrophin Dosage Using a Threshold Nomogram for Ovulation Induction in WHO Group II Anovulatory Infertility
Ovulation disorders are a common cause of infertility in women. Most of these women can be classified as World Health Organization (WHO) Group II anovulatory patients as they have irregular or absent menstrual cycles but normal…
- Trial name
- NCT01250821
- Testing
- Menopur
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Anovulatory Infertility Related to Polycystic Ovary Syndrome
Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS
Anovulatory infertility is a common feature of the polycystic ovary syndrome (PCOS). Even if several first-step treatments have been proposed for anovulatory infertile PCOS patients, very few data are available in literature…
- Trial name
- NCT00461643
- Testing
- Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
- Where
- 3 sites in Italy
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia