Clinical trials: Anovulation
Anovulation, Polycystic Ovary Syndrome
Ovarian Laser Treatment in Women With Polycystic Ovarian Syndrome: A Randomized Study on the Laser Dose
BACKGROUND: A new effective way, transvaginal ultrasound-guided ovarian interstitial laser-coagulation treatment, in management of anovulation in patients with polycystic ovary syndrome (PCOS), has been presented in the data…
- Conditions
- Anovulation, Polycystic Ovary Syndrome, Infertility
- Trial name
- NCT00643708
- Testing
- ovarian interstitial laser treatment
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Shen-Zhen City Maternity and Child Healthcare Hospital
Infertility, Ovulation Induction
SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile Women
Efficacy and safety studies in the past have suggested that a starting dose of 75 International Unit (IU) of SJ-0021, and an increase in the dose by 37.5 IU every 7 days, are safe for treatment of subjects with ovulatory…
- Trial name
- NCT01185782
- Testing
- Gonalef® (Follitropin alfa), Purified pituitary gonadotropin (Fertinorm-P®)
- Where
- Japan
- Volunteers
- 300 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Polycystic Ovary Syndrome
PCOSMIC Trial - PolyCystic Ovary Syndrome, Metformin for Infertility With Clomiphene
1. Metformin increases the pregnancy rate when added to the standard treatment of anovulatory polycystic ovary syndrome (PCOS). 2.
- Trial name
- PCOSMIC (NCT00795808)
- Testing
- Metformin, Metformin + Clomiphene, Clomiphene
- Where
- New Zealand
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Hypothalamic Amenorrhea, Functional, Hypothalamic Amenorrhea
The REgistry of Very Early Estrogen and AnovuLation
The purpose of this study is to to build a registry of women with early estrogen loss due to Functional Hypothalamic Amenorrhea (FHA) to understand the prevalence, racial and ethnic diversity of this condition.
- Conditions
- Hypothalamic Amenorrhea, Functional, Hypothalamic Amenorrhea, Functional Hypogonadotropic Hypogonadism
- Trial name
- REVEAL (NCT06583408)
- Testing
- Automated Self-Administered 24-hour Dietary Assessment Tool (ASA24), REVEAL Questionnaire
- Where
- 2 sites in United States
- Volunteers
- 100,000 people
- Sponsor
- Mayo Clinic
Polycystic Ovary Syndrome
PCOS Twin Study - Environmental Factors in the Development of Polycystic Ovary Syndrome, Phase 2
Polycystic Ovary Syndrome, or PCOS, is the most common endocrine disorder in women. Depending on the strictness of the diagnostic criteria used, it is thought to occur in about 6-10% of all women, many of whom do not know they…
- Trial name
- NCT00444288
- Where
- United States
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Anovulation, Amenorrhea
Effects of Gynecological Age on LH Sensitivity to Energy Availability
The purpose of this experiment is to investigate whether the dependence of luteinizing hormone pulsatility on energy availability declines during adolescence.
- Conditions
- Anovulation, Amenorrhea, Infertility, Starvation
- Trial name
- NCT00260286
- Testing
- Energy availability
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ohio University
Infertility, Polycystic Ovary Syndrome
Treatment of Anovulatory Infertility in PCOS Patients
Clomiphene citrate (CC) and metformin are two effective drugs used to induce ovulation in patients with polycystic ovary syndrome (PCOS), even if it is still unclear which compound between them should be initially administered.
- Conditions
- Infertility, Polycystic Ovary Syndrome, Anovulation
- Trial name
- NCT00471523
- Testing
- Clomiphene citrate, Metformin
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University Magna Graecia
Ovulation Induction
AS900672-Enriched in Ovulation Induction
This is a Phase 2, interventional, multi-center, randomized, assessor-blind, active-comparator, dose-finding study to evaluate a new investigational long-acting follicle stimulating hormone (FSH) in oligo-anovulatory women…
- Trial name
- NCT00553514
- Testing
- AS900672-Enriched 10 microgram (mcg), AS900672-Enriched 20 mcg, AS900672-Enriched 30 mcg
- Where
- Switzerland
- Volunteers
- 71 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Polycystic Ovary Syndrome
Metformin Administration in Infertile Anovulatory PCOS Patients
In a recent prospective study evaluating the efficacy of 1700 mg/day metformin as first-line approach for infertile anovulatory patients with PCOS, we identified predictors for metformin efficacy.
- Trial name
- NCT00501787
- Testing
- Metformin
- Where
- Italy
- Sponsor
- University Magna Graecia
PCOS, Infertility, Female
Effect of Acupuncture Plus Governor Vessel Moxibustion Combined With Letrozole on Live Birth in Anovulatory Infertile Women With Spleen-kidney Yang Deficiency PCOS
Investigators expected to verify this hypothesis through this study:acupuncture and moxibustion combined with LE induced ovulation in Chinese anovulatory PCOS women has a higher rate of live birth than LE induced ovulation alone.
- Trial name
- PCOS (NCT04987632)
- Testing
- Letrozole, acupuncture, Governor vessel moxibustion
- Volunteers
- 90 people
- Sponsor
- Qiu-ping Lin
Polycystic Ovary Syndrome
A Trial of the May Health Device in Transvaginal Ablation of Ovarian Tissue Under ULTRAsound Visualization in Women With PCOS Infertility
The objective of this study is to provide preliminary evidence for the safety and effectiveness of the May Health Kit in transvaginal ablation of ovarian tissue under ultrasound visualization in women with infertility due to…
- Trial name
- NCT03760926
- Testing
- May Health Kit
- Where
- 6 sites in Belgium, France and 1 more
- Volunteers
- 28 people
- Sponsor
- May Health
Infertility
Study to Investigate the Optimal Dose of Org 36286 to Induce Monofollicular Ovulation in Women With WHO Group II Anovulatory Infertility (P07016)
The objectives of this trial were to investigate the feasibility and the optimal dose of a single administration of Org 36286 to induce monofollicular ovulation in women with WHO Group II anovulatory infertility and to assess the…
- Trial name
- NCT00702585
- Testing
- Org 36286
- Volunteers
- 55 people
- Sponsor
- Organon and Co
Anovulation
Sildenafil Vaginal Gel Co-treatment With Clomiphene Citrate in Infertile Women With Thin Endometrium
This is a prospective self controlled clinical trial. Women with clomiphene Citrate failure, and thin endometrium were recruited (N = 42).
- Trial name
- NCT02710981
- Testing
- clomiphene citrate, Sildenafil vaginal gel
- Volunteers
- 42 people
- Sponsor
- Assiut University
Polycystic Ovary Syndrome
Improved Effects of MI Plus Alpha-LA in PCOS
PCOS patients are initially treated with 2 g myo-inositol and 0.2 mg folic acid, two times per day by oral route, for three months.
- Trial name
- NCT03422289
- Testing
- myo-inositol plus folic acid, myo-inositol plus folic acid plus alpha-lactalbumin
- Where
- Italy
- Volunteers
- 37 people
- Sponsor
- Lo.Li.Pharma s.r.l
Infertility, Female, Unexplained Infertility
Serum Kisspeptin Levels in Infertile Women
The study population is comprise of 90 women those age varies between 18-38 year-old. The first group will comprise of 30 women with polycystic ovaries or anovulatory cycles, the second group will comprise of 30 women with…
- Conditions
- Infertility, Female, Unexplained Infertility, Anovulation
- Trial name
- NCT03018314
- Testing
- Blood sample
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Polycystic Ovary Syndrome, Anovulation
LOD vs Gn in Anovulatory PCOs Resistant to First Line Agents
PCOS is a complex disease that is diagnosed by the presence of two of the following three: oligo/anovulation, clinical and/or biochemical hyperandrogenism, or polycystic ovaries by ultrasound .
- Trial name
- NCT04325295
- Testing
- Laparoscopic ovarian drilling, Recombinant FSH (rFSH)
- Volunteers
- 200 people
- Sponsor
- Assiut University
Sleep Apnea, Obstructive, Anovulation
Using CPAP to Improve Menstruation in Women With Polycystic Ovarian Syndrome and Obstructive Sleep Apnea
The purpose of this study is to determine if treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure in women with both OSA and polycystic ovarian syndrome will improve the regularity of the women's…
- Conditions
- Sleep Apnea, Obstructive, Anovulation, Polycystic Ovarian Syndrome
- Trial name
- NCT03155828
- Testing
- CPAP
- Where
- United States
- Sponsor
- University of Louisville
InFertility
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Three Dosage Strengths of Pulsatile GnRH
This study will be performed in approximately 132 women with anovulatory/oligoovulatory infertility.
- Trial name
- NCT00296465
- Testing
- Pulsatile gonadotropin-releasing hormone (GnRH), Clomiphene Citrate
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Infertility, Female, Anovulatory Infertility
Autologous PRP Intra Ovarian Infusion to Restore Ovarian Function in Menopausal Women
Autologous PRP intra ovarian infusion may restore ovarian function, may promote folliculogenesis and may improve hormonal profile of women in menopause.
- Conditions
- Infertility, Female, Anovulatory Infertility, Menopause, Amenorrhea
- Trial name
- PRP (NCT03916978)
- Testing
- Autologous PRP intra ovarian infusion, Autologous PFP intra ovarian infusion
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genesis Athens Clinic
Polycystic Ovary Syndrome, Hypothalamic-Pituitary-Ovarian Axis Dysfunction (Disorder)
Subclinical Hypothyroidism and Normogonadotropic Anovulation
Thyroid hormones (TH) can modify the functioning of the hypothalamic-pituitary-ovarian axis, affecting the functions of granulosa cells and the development and apoptosis of preantral follicles.
- Trial name
- NCT05782725
- Testing
- Comparison of laboratory test results in women in the 4 study arms
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- Jagiellonian University