Clinical trials: Anorectal Disorder
Bleeding Hemorrhoids, Rectal Evacuation Disorders
Rectal Evacuation Disorders and Straining-associated Symptoms in Bleeding Hemorrhoids
This study aims to understand the mechanisms of straining on anorectal testing, to better help people receive more effective treatment advice.
- Trial name
- NCT07161765
- Testing
- Anorectal manometry
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Fecal Incontinence
Effect of Anorectal Biofeedback on Encopresis in School Aged Girls After Sexual Assault
Females who have been sexually abused anally, have a disturbed anorectal motility. They have an increased resting pressure at the lower part of the anal canal.
- Trial name
- NCT04652024
- Testing
- Anorectal manometry
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Badr University
Anorectal Disorder, Fecal Incontinence
Normal Values in Ano-rectal 3D High Resolution Manometry
Ano-rectal manometry is indicative in patients with either fecal incontinence or constipation. Recently anorectal 3D- high resolution manometry has been developed.
- Conditions
- Anorectal Disorder, Fecal Incontinence, Constipation
- Trial name
- NOMAD (NCT01710579)
- Testing
- Anorectal 3D-high resolution manometry, Anorectal radial endosonography (rotative 360° probe), Dynamic anorectal endosonography (sagittal and radial)
- Where
- France
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Anorectal Disorder
The Guarding Reflex Anal, Study of the Modulation Function of Rectal Distension
The term Guarding Reflex refers to a progressive, involuntary increase in the external urethral sphincter activity during bladder filling.This is a mechanism of continence, preventing from unwanted urine leakage in situation of…
- Trial name
- NCT04409054
- Testing
- Cough and Valsalva effort
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Gérard Amarenco
Gastroschisis, Anorectal Malformation
Children's Surgery in Sub-Saharan Africa
Background: Five billion people worldwide do not have access to safe, affordable surgical care. A significant proportion live in sub-Saharan Africa (SSA), where up to 50% of the population are children.
- Conditions
- Gastroschisis, Anorectal Malformation, Appendicitis, Intussusception
- Trial name
- PaedSurgAfrica (NCT03185637)
- Testing
- Various interventions for each of the conditions.
- Where
- United Kingdom
- Volunteers
- 1,407 people
- Sponsor
- King's College London
Fecal Incontinence
Bulking Agent Versus Electrostimulation Therapy in Anal Incontinence
Randomized trial with a estimated number of 60 patients with mild or moderate anal incontinence at the clinic Physiology of the Hospital das Clínicas of the Medical School of the University of São Paulo (HC-FMUSP).
- Trial name
- Bulking (NCT03052946)
- Testing
- Bulking agent, Endoanal electrostimulation
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Anal Fistula, LIFT-plug
LIFT-plug vs LIFT, a RCT Trial
To validate the effect of Ligation of Intersphincteric Fistula Tract (LIFT) Versus LIFT-plug procedure for Anal Fistula Repair in 7 medical centers
- Conditions
- Anal Fistula, LIFT-plug, Healing Rate, Anal Function
- Trial name
- LIFT 02 (NCT04310800)
- Testing
- LIFT-plug technique
- Where
- 7 sites in China
- Volunteers
- 384 people
- Sponsor
- Zhen Jun Wang
Constipation
Mechano-physiological Approach to Anorectal Function
We hypothesize that defecatory disorders can be described in mechanical terms which would allow a mechanistic description of disorders which would in turn allow better directed biofeedback mechanisms to treat disorders of…
- Trial name
- NCT00219518
- Testing
- defecography
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Pelvic Radiotherapy, Vaginal Stenosis
Vaginal Dilator Therapy After Pelvic Radiation
This study is testing a new program to help women who have had pelvic radiation therapy to use vaginal dilators more regularly. Vaginal dilators are important tools that can help prevent or treat vaginal narrowing (called vaginal…
- Conditions
- Pelvic Radiotherapy, Vaginal Stenosis, Pelvic Cancer, Gynecologic Cancers
- Trial name
- NCT07216456
- Testing
- Improving Engagement with Vaginal Dilator Therapy after Pelvic Radiation
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Duke University
Anorectal Fistula
Retrospective Review of the Cook Biodesign® Fistula Plug to Treat Anorectal Fistulas
The study is a retrospective review of the use of the Biodesign® Fistula Plug (C-FPS-[X]). A total of 73 patients will be enrolled who have had a fistula plug placed to treat anorectal fistulas and will therefore be eligible for…
- Trial name
- NCT03321266
- Testing
- Cook Biodesign® Fistula Plug
- Where
- 4 sites in United States, Germany
- Volunteers
- 79 people
- Sponsor
- Cook Group Incorporated
Ulcerative Colitis
Anal Manometry Examination in Patients With Ulcerative Colitis
Inflammatory bowel diseases (IBD), which include Crohn's disease (CD) and ulcerative colitis (UC), are chronic immune-related diseases.
- Trial name
- NCT05488041
- Testing
- Performing anorectal manometry
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Assaf-Harofeh Medical Center
Hemorrhoids, Anal Fissure
Topical vs Oral Metronidazole After Benign Anorectal Surgery
While some investigators found oral metronidazole to be effective in reducing pain after hemorrhoidectomy, other researchers did not find a significant analgesic effect of systemic metronidazole.
- Conditions
- Hemorrhoids, Anal Fissure, Anal Fistula
- Trial name
- NCT05038605
- Testing
- Topical metronidazole, oral metronidazole
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Mansoura University
Anal Cancer, Rectal Cancer
A Phase 2 Study of Axalimogene Filolisbac (ADXS11-001) in Participants With Carcinoma of the Anorectal Canal
This is a single arm Phase 2 study. Stage 1 and 2 of the study are monotherapy evaluations of ADXS11-001 in 31 and 24 participants, respectively with persistent/recurrent, loco-regional or metastatic squamous cell carcinoma…
- Trial name
- NCT02399813
- Testing
- Axalimogene filolisbac
- Where
- 10 sites in United States
- Volunteers
- 36 people
- Sponsor
- Advaxis, Inc.
Fecal Incontinence
Sacral Neuromodulation as Treatment for Fecal Incontinence
The objective of this study is to investigate if low level laser therapy will do more good than harm for patients with severe refractory fecal incontinence. It is a proof of concept study without a placebo arm.
- Trial name
- LLLT-FI (NCT03825575)
- Testing
- Low level laser therapy (LLLT)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Anorectal Malformations
Frequency of Vertebrospinal Anomalies in Patients Presenting With Anorectal Malformations
To determine the frequency of different vertebrospinal anomalies in patients with ARM
- Trial name
- NCT06234020
- Testing
- To see the frequency of vertebrospinal anomalies in patients presenting with Anorectal Malformation
- Where
- Pakistan
- Volunteers
- 106 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Pain, Prostate Cancer
Anorectal Application of 5% Lidocaine Cream Reduces Pain Prior to Periprostatic Nerve Block During Transrectal Ultrasound Guided Biopsy
Transrectal ultrasound guided prostate biopsy is performed with a periprostatic nerve block to the neurovascular bundle bilaterally. This does not reduce the pain due to probe insertion and manipulation prior to nerve blockage.
- Conditions
- Pain, Prostate Cancer, Rectal/Anal
- Trial name
- NCT04064047
- Testing
- Trans rectal ultrasound guided prostate biopsy, Trans rectal ultrasound, Prostate biopsy
- Volunteers
- 284 people
- Sponsor
- Assaf-Harofeh Medical Center
Hirschsprungs Disease
Electrophysiological Activity of the Anorectum in Children Suspected of Hirschsprung Disease
Children with chronic constipation, suspected of having hirschsprungs disease, who are admitted for rectal biopsy will be included in the study.
- Trial name
- NCT02342457
- Testing
- Child suspected of Hirschsprung disease
- Volunteers
- 20 people
- Sponsor
- Rabin Medical Center
Anterior Resection Syndrome, Bowel Dysfunction
Studies in Patients With Low Anterior Resection Syndrome (LARS)
Colorectal Cancer is the commonest cancer diagnosed for both genders combined in Hong Kong. In 2015 16.6% of all new cancer cases registered on the Hong Kong registry were cancer of colon and rectum.
- Trial name
- NCT03885999
- Testing
- Fecobionics
- Where
- Hong Kong
- Volunteers
- 12 people
- Sponsor
- Giome
Constipation, Children
Influence of Body Position on the Defecation Model During Anorectal Manometry.
Anorectal 3D manometry (3D HRAM) is the most advanced version of manometric equipment that measures pressures along the anal canal in a very detailed manner.
- Conditions
- Constipation, Children, Anorectal Disorder
- Trial name
- HRAMposition (NCT06924957)
- Testing
- 3D HRAM
- Where
- Poland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Anorectal Malformations
Longterm Outcomes of Individuals With Anorectal Malformations
This is a cross-sectional observational study with the aim to assess longterm outcomes in a large cohort of individuals with anorectal malformations.
- Trial name
- NCT04901819
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Karolinska Institutet