Clinical trials: Angina (Stable)
Coronary Heart Disease, Stable Angina
Percutaneous Coronary Intervention Versus Medical Treatment for Stable Angina Pectoris
Patients with ischemic heart disease and symptoms due to lack of oxygen to the heart on exertion (stable angina pectoris) are usually treated by either percutaneous coronary intervention (PCI) or optimal medical therapy (OMT)…
- Conditions
- Coronary Heart Disease, Stable Angina, Ischemic Heart Disease
- Trial name
- DANANGINA (NCT04496648)
- Testing
- Percutaneous Coronary Intervention
- Where
- Denmark
- Volunteers
- 450 people
- Sponsor
- Herlev and Gentofte Hospital
Coronary Artery Disease, Chronic Stable Angina
LEADERS FREE IV (RCT): BioFreedom™ Ultra vs BioFreedom™ in HBR Patients
This study aims to demonstrate that the BioFreedom™ Ultra Drug Coated Stent (DCS) is non-inferior to the BioFreedom™ DCS, with respect to in-stent late lumen loss, and that it has safety characteristics similar to the BioFreedom™…
- Conditions
- Coronary Artery Disease, Chronic Stable Angina, Unstable Angina, Silent Ischemia
- Trial name
- NCT06657326
- Testing
- BioFreedom™ Ultra cobalt-chromium Biolimus A9™-coated stent, BioFreedom™ stainless steel Biolimus A9™-coated stent
- Where
- 6 sites in Malaysia
- Volunteers
- 444 people
- Sponsor
- Biosensors Europe SA
Angina, Stable
Cost-effectiveness and Safety of the CADScorSystem in Patients With Symptoms Suggestive of Stable Coronary Artery Disease.
This study evaluates the addition of the CADScorSystem to a standard Diamond-Forrester score guided rule-out strategy in ambulatory patients referred with symptoms suggestive of stable coronary artery disease.
- Trial name
- FILTER-SCAD (NCT04121949)
- Testing
- CADScor®System
- Where
- 6 sites in Denmark, Sweden
- Volunteers
- 2,016 people
- Sponsor
- Bispebjerg Hospital
Stable Angina, Unstable Angina
Impact of Low Frame Rate Fluoroscopy and Cine-angiography on Reducing Operator and Patient Dose
The investigators sought to investigate the efficacy of low frame rate (fluoroscopy at 7.5 frames per second (FPS) and Cine at 10 pulse per second (PPS) vs.
- Conditions
- Stable Angina, Unstable Angina, Acute Coronary Syndrome
- Trial name
- NCT02574949
- Testing
- Radiation: 15 FPS Cine 15 PPS, Radiation: 7.5 low Frame rate, Low Cine
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- University Health Network, Toronto
Ischemic Heart Disease
GS-6615 in Adults With Chronic Stable Angina and Coronary Artery Disease
This study will evaluate the effect of GS-6615 in adults with chronic stable angina and coronary artery disease (CAD) receiving a stable daily dose of up to 2 antianginal medications.
- Trial name
- NCT02377336
- Testing
- GS-6615
- Sponsor
- Gilead Sciences
Angina (Stable), CAD - Coronary Artery Disease
Advanced NanoTherapies Dual-API DCB to Treat De-Novo and ISR Lesions in Patients With Symptomatic Coronary Artery Disease
The study objectives are: 1. To evaluate the safety and performance of the SirPlux Duo PTCA to treat coronary ISR lesions 2.00-4.00 mm (inclusive) in diameter in patients with symptomatic coronary artery disease. 2.
- Conditions
- Angina (Stable), CAD - Coronary Artery Disease, Unstable Angina, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- ADVANCE-DUO (NCT07368933)
- Testing
- SirPlux Duo™ Dual API-Coated PTCA Balloon Catheter
- Where
- 3 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Advanced NanoTherapies
Angina Pectoris
Effect of Increased Oxygenation in the Air During Endurance Training in Stable Angina Pectoris Patients
The study investigates whether endurance training breathing 100% oxygen gives a additional improvement of maximal oxygen uptake in stable Angina Pectoris patients, compared to training without extra oxygen supplementation.
- Trial name
- NCT00184444
- Testing
- Hypoxic interval training, Normoxic interval training
- Where
- Norway
- Volunteers
- 25 people
- Sponsor
- Norwegian University of Science and Technology
Coronary Arterial Disease (CAD), Angina (Stable)
The Effect of Sublingual Nitroglycerin on Absolute Coronary Blood Flow
The goal of this clinical trial is to investigate the effect of sublingual nitroglycerin on absolute coronary blood flow in adult patients undergoing coronary angiography.
- Trial name
- FLOW-NITRO (NCT06823843)
- Testing
- Glycerin trinitrate (GTN)
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- VZW Cardiovascular Research Center Aalst
Chronic Stable Angina
Multi-slice CT Coronary Angiography in Patients With Stable Angina
early identification of vulnerable plaques by remodeling index prior to rupture and development of acute event is of considerable importance especially by a reliable non-invasive method as CT coronary angiography.
- Trial name
- NCT03963609
- Testing
- multisclice CT
- Volunteers
- 150 people
- Sponsor
- Benha University
Stable Angina
Objective Randomised Blinded Investigation With Optimal Medical Therapy of Angioplasty in Stable Angina
In this study the investigators will use careful scientific blinding of patient and their subsequent healthcare staff so that the investigators can determine exactly how much difference coronary angioplasty makes to symptoms and…
- Trial name
- ORBITA (NCT02062593)
- Testing
- Coronary angioplasty
- Where
- 5 sites in United Kingdom
- Volunteers
- 230 people
- Sponsor
- Imperial College London
Angina, Stable, Coronary Artery Disease
Clinical Outcomes of CT-FFR Versus QFR-guided Strategy for Decision-Making in Patients With Stable Chest Pain
This study is a multicenter, prospective, blinded (blinding of clinical evaluators), randomized controlled, event-driven non-inferiority clinical trial.
- Trial name
- CONFIDENT (NCT05857904)
- Testing
- CT-FFR, QFR
- Where
- China
- Volunteers
- 4,648 people
- Sponsor
- Shanghai Zhongshan Hospital
Chronic Stable Angina Pectoris
A Study on the Metabolic Characteristics of Meridian Phenomenon for the Heart and Lung Meridians Based on Patients With Stable Angina Pectoris
Although some important progresses were made in the field of the meridian research, no breakthroughs have been achieved. Besides,there are some problems in meridian researches.
- Trial name
- NCT04041245
- Testing
- Near infrared spectroscopy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhejiang Chinese Medical University
Triple Vessel Disease, Unstable Angina
Comparison of Saphenous Vein Graft Harvested From Upper Versus Lower Leg in Coronary Artery Bypass Grafting
In coronary artery bypass grafting, saphenous veins are widely used as a composite grafts that are Y-anastomosed to in-situ left internal thoracic artery.
- Conditions
- Triple Vessel Disease, Unstable Angina, Stable Angina, Myocardial Infarction
- Trial name
- COSAVEGUL-1 (NCT01974492)
- Testing
- Upper leg vein harvesting, Lower leg vein harvesting
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Seoul National University Hospital
Acute Myocardial Infarction, Stable Angina
Development and Efficacy Evaluation of Integrated Chronic Care and Health Promotion Model for Patients With Coronary Artery Disease in Taiwan
The hypothesis of this project is to examine whether the integrated health care program as the intervention group can reduce the recurrence and mortality of coronary artery-related diseases than the traditional one as the…
- Trial name
- NCT01357096
- Testing
- Integrated health care team, Traditional group
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Coronary Heart Disease, Angina Pectoris
Aspirin Non-responsiveness and Clopidogrel Endpoint Trial.
In the ASCET study, 1000 patients with documented coronary heart disease will be randomized to either continued treatment with aspirin 160 mg/d or change to clopidogrel 75mg/d.
- Conditions
- Coronary Heart Disease, Angina Pectoris, Atherosclerosis
- Trial name
- ASCET (NCT00222261)
- Testing
- aspirin, clopidogrel
- Where
- Norway
- Volunteers
- 1,001 people
- Sponsor
- Ullevaal University Hospital
Stable Angina
Aspirin Resistance and Percutaneous Coronary Intervention (PCI)
The objective of this study is to evaluate if aggressive antiplatelet therapy would reduce ischemic events in aspirin (ASA) resistant patients after percutaneous coronary intervention (PCI).
- Trial name
- RESIST (NCT01103440)
- Testing
- Intravenous Glycoprotein inhibitor + ASA, Clopidogrel, Antiplatelet Therapy (ASA, Clopidogrel)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Icahn School of Medicine at Mount Sinai