Clinical trials: Angina, Microvascular
Dysmetabolic Iron Overload Syndrome, Genetic Hemochromatosis
Effects of Polyphenols on Iron Absorption in Iron Overload Disorders.
Dysmetabolic iron overload syndrome and genetic hemochromatosis are frequent causes of iron overload. Polyphenols are efficient iron-chelators.
- Conditions
- Dysmetabolic Iron Overload Syndrome, Genetic Hemochromatosis, Iron Absorption, Polyphenols
- Trial name
- POLYFER (NCT03453918)
- Testing
- polyphenols
- Where
- France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Clermont-Ferrand
First Episode Psychosis (FEP), Metabolic Syndrome X
Nursing Intervention in Weight and Metabolic Syndrome Management in First-episode Psychosis (MetaKOP)
The goal of this clinical trial is to evaluate if a nursing intervention based on the carbohydrate-insulin model can effectively reduce weight and manage the risk of metabolic syndrome (MetS) in individuals with first-episode…
- Trial name
- MetaKOP (NCT06650943)
- Testing
- Nursing Consultation in Weight Management and Metabolic syndrome
- Where
- Spain
- Volunteers
- 88 people
- Sponsor
- Hospital de Basurto
Microvascular Angina, Angina, Stable
iCorMicA - Stratified Medicine in Angina
The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry.
- Conditions
- Microvascular Angina, Angina, Stable, Ischemia With No Obstructive Coronary Arteries (INOCA), Coronary Microvascular Dysfunction (CMD)
- Trial name
- iCorMicA (NCT04674449)
- Testing
- Disclosure of IDP results, IDP performed but results not disclosed
- Where
- 39 sites in Ireland, Netherlands and 2 more
- Volunteers
- 1,500 people
- Sponsor
- NHS Greater Glasgow and Clyde
Metabolic Syndrome X
Effect of Exercise Training on the Function of the High Density Lipoprotein (HDL)-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Metabolic Syndrome(HERMET-Study)
The purpose of the present study is to characterize the quality of HDL-Cholesterol in patients with metabolic syndrome and reduced blood HDL-Cholesterol levels and to examine the effect of exercise training on the…
- Trial name
- HERMET (NCT00515476)
- Testing
- physical exercise
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Healthy, Metabolic Syndrome X
Investigation of Genetic Risk of Metabolic Syndrome in Company Employee (NGK Study)
The metabolic syndrome is a highly prevalent disorder, which causes atherosclerotic cardiovascular disease and is closely associated with insulin resistance.
- Conditions
- Healthy, Metabolic Syndrome X, Hyperlipidemia, Hypertension
- Trial name
- NCT00408824
- Where
- Japan
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Nagoya University
Metabolic Syndrome X
Comparison of Two Different Diets on Health Outcomes
The purpose of this study is to compare the effects of a low-carbohydrate diet and a high-carbohydrate, high-fiber diet, on insulin sensitivity and blood chemicals considered risk markers for heart disease, in persons with the…
- Trial name
- NCT00269646
- Testing
- Low-carbohydrate and high-carbohydrate diets
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 2, Metabolic Syndrome X
Functional MRI Biomarkers of Cognitive Decrements in Diabetes
The exact neuronal mechanism underlying the cognitive decline associated with diabetes mellitus type 2 (DM2) still remains to be elucidated.
- Conditions
- Diabetes Mellitus, Type 2, Metabolic Syndrome X, Mild Cognitive Impairment
- Trial name
- NCT01705210
- Where
- Netherlands
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Stable Angina, Coronary Artery Disease
Impact of Rotational Atherectomy on Coronary Microcirculation
The purpose of this observational study is to compare the impact of rotational atherectomy to conventional stenting and to investigate how it may affect coronary microcirculation in patients with calcified coronary artery lesions…
- Trial name
- MICRO-ROTA (NCT05771961)
- Testing
- coronary pressure/temperature sensor-tipped guidewire, Angiography-derived index of microcirculatory resistance (IMRangio)
- Where
- Lithuania
- Volunteers
- 300 people
- Sponsor
- Lithuanian University of Health Sciences
Hyperlipidemias, Metabolic Syndrome X
Effect of Vegetable Oils for Use by the Snack Food Industry on Plasma Lipid Levels and Inflammatory Markers
The current study is designed to assess the effect of a conventional cooking oil (hydrogenated oil) and a reformulated fat low in trans fatty acids on cardiovascular disease risk factors.
- Conditions
- Hyperlipidemias, Metabolic Syndrome X, Cardiovascular Diseases
- Trial name
- NCT00175071
- Testing
- Comparison of cooking oils
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tufts University
Angina Pectoris, Metabolic Syndrome X
Rosiglitazone Versus Placebo in Chronic Stable Angina
We wish to see if the drug rosiglitazone, currently used in the treatment of type 2 diabetes, could be used as a new treatment for angina when compared with placebo in overweight subjects who do not have overt diabetes.
- Trial name
- NCT00225355
- Testing
- Rosiglitazone
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Glasgow
Microvascular Coronary Dysfunction
Development of a Novel Stress Testing Protocol to Define the Relationship Between Coronary Microvascular Dysfunction and Diastology in Women With Angina But No Evidence of Obstructive Coronary Artery Disease
Microvascular coronary dysfunction (MCD) (abnormities in small blood vessels/arteries in heart) with symptoms of persistent chest pain, primarily impacts women.
- Trial name
- NCT02301663
- Testing
- Handgrip, Altitude simulation, Leg exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Metabolic Syndrome X
Soy Nut Study on Markers of Health
The investigators hope to learn about the effects of soy nuts on markers of health. When some people eat soy foods, their gut bacteria make equol. Equol is a soy metabolite (small molecule made during metabolism).
- Trial name
- NCT01173380
- Testing
- Soy nuts, Matched food
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of California, Davis
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Insulin Resistance Syndrome X, Pancreatic Beta Cell Function
Mechanism of Fatty Acid-Induced Impairment of Glucose-Stimulated Insulin Secretion
A prolonged elevation of plasma free fatty acids (FFA) impairs glucose stimulated insulin secretion. The concept of fatty acid impairment of glucose stimulated insulin secretion (lipotoxicity) has now been well accepted.
- Trial name
- NCT00188773
- Testing
- N-acetylcysteine, intralipid, heparin
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Microvascular Angina
Non-invasive Diagnosis of Coronary Microvascular Disease: Pilot Study
40% of patients presenting with stable chest pain (angina) have no significant blockage of the main heart arteries. Identifying why these patients have symptoms will mean better treatment options can be developed.
- Trial name
- NCT06070662
- Testing
- Coronary microvascular disease testing during coronary angiography, Cardiac magnetic resonance scan including exercise, Additional analysis of already acquired CT scan
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Leicester
Insulin Resistance, Metabolic Syndrome X
Description of an Immune Activation Profile Linked to Insulin Resistance in Subjects Aged 55-69
The aim of the study is to describe an immune activation profile of people at risk of insulin resistance based on a wide range of markers which will allow easy identification of patients at risk.
- Trial name
- METACTIV (NCT03309761)
- Testing
- Blood test
- Where
- 2 sites in France
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Hypogonadism, Metabolic Syndrome X
Effects of Interleukin-1 Beta on Low Testosterone Levels in Men With Obesity and Metabolic Syndrome
Obesity and the metabolic syndrome in men are associated with a high prevalence of hypogonadism of up to 50%. Increased fat mass leads to augmented release of adipocytokines and pro-inflammatory cytokines such as IL-1-beta, IL-6…
- Conditions
- Hypogonadism, Metabolic Syndrome X, Obesity
- Trial name
- TestIL (NCT02672592)
- Testing
- Anakinra, Sodium Chloride 0.9%
- Where
- 2 sites in Switzerland
- Volunteers
- 70 people
- Sponsor
- University Hospital, Basel, Switzerland
Schizophrenia, Schizoaffective Disorder
The Effects of Aripiprazole on Patients With Metabolic Syndrome
The primary goal of this study is to assess the effect of aripiprazole on patients who developed metabolic syndrome while taking other second generation antipsychotic medications.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Metabolic Syndrome X
- Trial name
- NCT00224822
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- New Mexico VA Healthcare System
Coronary Microvascular Dysfunction, Coronary Microvascular Disease
A Placebo-Controlled Trial of CLBS16 in Subjects With Coronary Microvascular Dysfunction
This clinical trial will explore the efficacy and safety of GCSF-mobilized autologous CD34+ cells for the treatment of CMD in adults currently experiencing angina and with no obstructive coronary artery disease.
- Conditions
- Coronary Microvascular Dysfunction, Coronary Microvascular Disease, Microvascular Coronary Artery Disease
- Trial name
- FREEDOM (NCT04614467)
- Testing
- CLBS16
- Where
- 7 sites in United States
- Volunteers
- 34 people
- Sponsor
- Lisata Therapeutics, Inc.
Coronary Microvascular Dysfunction (CMD), Angina Patients With Non-obstructive Coronary Artery Disease
Inorganic Nitrate as a Treatment for ANOCA: NO-ANOCA
The purpose of this study is to see if inorganic nitrate in the form of beetroot juice helps blood flow and physical fitness in women with ANOCA and CMD.
- Trial name
- NO-ANOCA (NCT06948201)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Virginia