Clinical trials: Aneurysm, Ruptured
Intracranial Aneurysms, Unruptured Intracranial Aneurysm
ANEURYSM@RISK: Automatic Intracranial Aneurysm Quantification and Feature Learning Modelling to Optimize Intracranial Aneurysm Rupture Prediction
ANEURYSM@RISK is an observational study aiming to develop and validate an artificial intelligence (AI)-based prediction model for the growth and rupture of intracranial aneurysms (IAs).
- Conditions
- Intracranial Aneurysms, Unruptured Intracranial Aneurysm, Subarachnoid Hemorrhage (SAH) From Ruptured Aneurysm
- Trial name
- NCT07111975
- Where
- Netherlands
- Volunteers
- 3,800 people
- Sponsor
- UMC Utrecht
Abdominal Aortic Aneurysms
Physician Modified Endovascular Grafts
The primary objectives of this study are to determine whether physician modified endovascular grafts (PMEG) and specified company manufactured investigational devices are a safe and effective method of treating patients with…
- Trial name
- PMEG (NCT01538056)
- Testing
- Fenestrated Endovascular Graft or Company Manufactured Terumo Aortic Fenestrated TREO Endovascular Graft
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Washington
Intracranial Hemorrhage Ruptured Aneurysm
International Subarachnoid Aneurysm Trial II
The purpose of this study is to compare the clinical outcome of surgical clipping and endovascular coiling for ruptured intracranial aneurysms not included in the original ISAT Study.
- Trial name
- ISATII (NCT01668563)
- Testing
- surgical management, Endovascular management
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 1,724 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Aneurysm Abdominal, Cerebral Aneurysm Ruptured
Occurrence of Abdominal Aortic Aneurysms in Patients With Aneurysmal Subarachnoid Hemorrhage
Rationale: Aneurysms of different types are known to be associated. In literature, concurrence of intracranial- and aortic aneurysms is described.
- Trial name
- TRACE-aSAH (NCT07312565)
- Where
- Netherlands
- Volunteers
- 233 people
- Sponsor
- Leiden University Medical Center
Aneurysm, Ruptured, Aneurysmal Subarachnoid Hemorrhage
Brain Imaging After Non-traumatic Intracranial Hemorrhage (SAVEBRAINPWI)
The study is an observational prospective evaluation of an approved and unchanged clinical management, evaluating different diagnosis methods to assess brain perfusion in patients with an aneurysmal or AVM-related intracranial…
- Conditions
- Aneurysm, Ruptured, Aneurysmal Subarachnoid Hemorrhage, Arteriovenous Malformations, Intracranial Aneurysm
- Trial name
- SAVEBRAINPWI (NCT05276934)
- Testing
- Brain computed tomography
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Erasme University Hospital
Brain Aneurysm, Aneurysm, Ruptured
Superior Cervical Ganglion Block, Transcranial Doppler
The aim of this study is to assess blood flow velocity in middle cerebral artery measured by transcranial doppler to determine the efficacy of SCG block in decreasing incidence or severity of vasospasm after MCA aneurysm surgery.
- Trial name
- NCT04439760
- Testing
- Superior Cervical Ganglion Block
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Fatma Ibrahim El Sayed Salman
Abdominal Aortic Aneurysm, Abdominal Aortic Aneurysm, Ruptured
Predicting Aneurysm Growth and Rupture With Longitudinal Biomarkers
First aim: PARIS study The main aim of the current study is to determine the association between abdominal aortic aneurysm (AAA) progression and the evolution of proteases and cytokines levels.To achieve this aim, we will…
- Trial name
- PARIS (NCT03320408)
- Where
- 2 sites in Netherlands
- Volunteers
- 790 people
- Sponsor
- Ron Balm
Ruptured and Unruptured Intracranial Aneurysms
Mid-term Data Collection of the Treatment of Intracranial Aneurysms With the WEB™ Aneurysm Embolization System
Flow disruption is a new endovascular approach for treatment of both ruptured and unruptured intracranial aneurysms, which involves placement of an endosaccular device (WEB) which modifies the blood flow at the level of the neck…
- Trial name
- NCT03312725
- Testing
- WEB aneurysm embolization system
- Where
- Belgium
- Volunteers
- 1 people
- Sponsor
- Medical Therapy Solutions
Abdominal Aortic Aneurysm
Immediate Management of the Patient With Rupture : Open Versus Endovascular Repair
The purpose of this trial is to assess whether a strategy of endovascular repair (if aortic morphology is suitable, open repair if not) versus open repair reduces early mortality for patients with suspected ruptured abdominal…
- Trial name
- IMPROVE (NCT00746122)
- Testing
- Open repair, EVAR
- Where
- 30 sites in Canada, United Kingdom
- Volunteers
- 613 people
- Sponsor
- Imperial College London
Aneurysmal Subarachnoid Hemorrhage, Endovascular Procedures
Study on Prognosis of Acutely Ruptured Intracranial Aneurysms
The SPARTA study is a prospective multicenter observational trial in the Netherlands with the aim of identifying the best clinical care in patients with aneurysmal subarachnoidal haemorrhage.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Endovascular Procedures, Craniotomy, Patient Outcome Assessment
- Trial name
- SPARTA (NCT05851989)
- Where
- 6 sites in Netherlands
- Volunteers
- 880 people
- Sponsor
- Haaglanden Medical Centre
Aneurysmal Subarachnoid Hemorrhage
Early Versus Ultra Early Surgical Treatment of Ruptured Intracranial Aneurysms
The goal of this clinical trial is to determine the most effective timing for clipping in adults with ruptured intracranial aneurysms.
- Trial name
- NCT06457347
- Testing
- Ultra early (<24 hours) ruptured aneurysm clipping, Early (24-72 hours) ruptured aneurysm clipping
- Volunteers
- 100 people
- Sponsor
- Revaz Dzhindzhikhadze
Aneurysmal Subarachnoid Hemorrhage
Cerebral Hemodynamic Optimization by Milrinone to Prevent Delayed Cerebral Ischemia
The present study is a randomized, multi-center, double-blind, prospective study that tests the efficacy of intravenous milrinone to optimize cerebral hemodynamic and prevent delayed cerebral ischemia (DCI) during the high-risk…
- Trial name
- OPTIMIL (NCT04282629)
- Testing
- Milrinone Injection
- Where
- 5 sites in France
- Volunteers
- 234 people
- Sponsor
- University Hospital, Toulouse
Self Efficacy, Medical Device Complication
Chinese Registry of Assisted Embolization for Ruptured Wide Necked Intracranial Aneurysm Using LVIS Stent
This study aims to investigating the efficacy and safety of low profile visualized intraluminal support (LVIS) stents for the treatment of ruptured intracranial saccular aneurysms. The follow-up duration is 1 year.
- Trial name
- CRANIAL-2 (NCT02830386)
- Testing
- LVIS stent
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Changhai Hospital
Aneurysm, Ruptured, Intracranial Aneurysm
Bare Platinum Coils Versus Second-generation Hydrocoils
Comparison of clinical and radiological outcomes between bare platinum coil group and second-generation hydrogel coils for treatment of ruptured intracranial aneurysms.
- Trial name
- NCT04988503
- Testing
- Coil embolization
- Where
- 3 sites in South Korea
- Volunteers
- 68 people
- Sponsor
- Seoul National University Hospital
Juxtarenal Abdominal Aortic Aneurysm
University of Utah PS-IDE: Physician Modified Endovascular Grafts for the Treatment of Elective, Symptomatic or Ruptured Juxtarenal Aortic Aneurysms
The purpose of this study is to assess the effects of a physician-modified endovascular graft (PMEG) for juxtarenal aortic aneurysms by collecting data on its performance.
- Trial name
- NCT07065760
- Testing
- Endovascular Aneurysm Repair with Physician Modified Endograft
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Cali Johnson
Subarachnoid Aneurysm Hemorrhage, Microsurgery
Structural and Clinical Predictors of Cognitive Impairment After Surgical Treatment for Ruptured Cerebral Aneurysms
This study investigates the clinical and structural predictors of long-term cognitive impairment in patients who underwent microsurgical clipping for aneurysmal subarachnoid hemorrhage.
- Conditions
- Subarachnoid Aneurysm Hemorrhage, Microsurgery, Cognitive Impairment
- Trial name
- SCOPE-aSAH (NCT07723131)
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- University of Campinas, Brazil
Abdominal Aortic Aneurysm
Reduction of Myocardial Infarction by Preconditioning in Patients With Ruptured Abdominal Aortic Aneurysm
Preconditioning in patients treated for elective abdominal aneurysm showed that the rate of perioperative myocardial infarction could be reduced by 80 %(ARR from 27% to 5%).
- Trial name
- PreconRAAA (NCT00883363)
- Testing
- Precondition
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Nikolaj Eldrup
MMPs and NGAL in Ruptured and Non-ruptured Aneurysms
Matrix Metalloproteinases (MMPs),Neutrophil Gelatinase-associated Lipocalin (NGAL) Tissue and Plasma Levels and Aneurysms
An association between arterial aneurysms and matrix metalloproteinases (MMPs) has been described previously. MMPs regulate extracellular structural proteins and tissue remodeling.
- Trial name
- NCT02145533
- Where
- Italy
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Bleeding, Aortic Rupture
Life-saving Treatment With Dry-plasma for Massive Bleeding in an Pre-hospital Setting
The overall goal of this clinical trial is to study how prehospital transfused dry plasma affect outcomes in terms of mortality as well as complications and coagulation status of patients in or about to develop bleeding shock.
- Conditions
- Bleeding, Aortic Rupture, Gastrointestinal Hemorrhage, Obstetric Bleeding
- Trial name
- NCT07012863
- Testing
- Dry plasma
- Volunteers
- 650 people
- Sponsor
- Vastra Gotaland Region
Subarachnoid Hemorrhage, Aneurysmal
Safety/Pharmacokinetic Study Comparing Intracisternal EG-1962 to Standard of Care Enteral Nimodipine in Adults With aSAH
Safety and Pharmacokinetic study comparing intracisternal EG-1962 to enternal nimopidine in the treatment of aneurysmal subarachnoid hemorrhage.
- Trial name
- NCT02893826
- Testing
- EG-1962 (nimodipine microparticles), Enteral Nimodipine
- Where
- 4 sites in United States, Canada
- Volunteers
- 6 people
- Sponsor
- Edge Therapeutics Inc