Clinical trials: Anesthesia; Adverse Effect
Injection Site Irritation, Injection Site Bruising
Comparison of Subcutaneous Injection of Normal Saline and Bacteriostatic Saline
This is a randomized, double-blind, single-center clinical trial comparing normal saline and bacteriostatic saline subcutaneous injection within a single subject.
- Conditions
- Injection Site Irritation, Injection Site Bruising, Injection Site Discomfort, Benzoic Acid Adverse Reaction
- Trial name
- NCT05109000
- Testing
- Sodium Chloride 0.9% Inj, Bacteriostatic Sodium Chloride 0.9 % INJECTION VIAL (ML)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Jeffrey Alan Klein, MD
Adverse Effect
Phenylephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia
The purpose of this study is to investigate the suitable infusion dose of phenylephrine for prophylaxis against postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean section.
- Trial name
- NCT04576663
- Testing
- Normal saline, Phenylephrine
- Volunteers
- 95 people
- Sponsor
- General Hospital of Ningxia Medical University
Anaesthesia, Adverse Effects
Laryngeal Mask or Endotracheal Tube for Back Surgery in the Prone Position
The aim of the study is to compare anaesthesia (for back surgery) using endotracheal intubation (patients anaesthized in the supine position)with anaesthesia using a laryngeal mask (anaesthesia induced and the laryngeal mask…
- Trial name
- NCT01041352
- Testing
- laryngeal mask, endotracheal tube
- Where
- Denmark
- Volunteers
- 136 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Complications; Cesarean Section, Anesthesia; Adverse Effect, Spinal and Epidural
Non-invasive Cardiac Output Monitoring in Obstetric Patients
The investigators hypothesize that continuously measuring stroke volume (SV) and cardiac output (CO) will 1) reveal hemodynamic instability in a timely manner and alert the physician promptly, 2) provide information for the…
- Trial name
- NCT01516697
- Testing
- experimental, Control
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Tonsillectomy With or Without Adenoidectomy
Effects of Remimazolam and Ciprofol TIVA on PRAE in Pediatric Tonsillectomy and Adenoidectomy
To observe the effects of remimazolam versus ciprofol TIVA on PRAE in pediatric tonsillectomy and adenoidectomy.
- Trial name
- NCT07118579
- Testing
- Remimazolam, Propofol, Ciprofol
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Tongji Hospital
Acute Kidney Injury, Hypotension
A Pilot Analysis of the Association Between Anesthesia Induction Dosing and AKI in the Elderly Population
This study proposes to perform a pilot observational study looking at the doses of propofol used for the induction of general anesthesia and its association with the development of hypotension and AKI among elderly patients at…
- Conditions
- Acute Kidney Injury, Hypotension, Anesthesia; Adverse Effect
- Trial name
- NCT03699696
- Testing
- Propofol
- Where
- United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Yale University
Propofol Adverse Reaction, Anesthesia
Impact of Propofol Reduction in Anesthesia Induction
Objective: Determine if, by reducing the dose of propofol and increasing the time elapsed between fentanyl and propofol administration, hemodynamic response is improved.
- Trial name
- NCT04194151
- Testing
- Propofol Injection
- Where
- Spain
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Hospital Central de la Defensa Gómez Ulla
Anesthesia, Local, Anesthesia
Dual Guidance in Regional Anesthesia
Regional anaesthesia is a frequently used procedure. Currently, blockades are increasingly carried out without nerve stimulation. The risk of nerve lesion is about 3 %.
- Conditions
- Anesthesia, Local, Anesthesia, Anesthesia; Adverse Effect
- Trial name
- NCT03383770
- Testing
- Regional Anesthesia Touhy, Regional Anesthesia Facet
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Tonsillitis, Post-operative Nausea and Vomiting (PONV)
Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery
This is a prospective, randomized, controlled, non-inferiority study of patients undergoing tonsil surgeries at Boston Children's Hospital Waltham.
- Conditions
- Tonsillitis, Post-operative Nausea and Vomiting (PONV), Emergence Delirium, Opioid Analgesic Adverse Reaction
- Trial name
- NCT06326983
- Testing
- Dexmedetomidine, Acetaminophen, Ketorolac
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Boston Children's Hospital
Epinephrine Causing Adverse Effects in Therapeutic Use
Cardiovascular Effects of Racemic Epinephrine Pellets
The primary aim of this study was to determine if topical racemic epinephrine pellets affect heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) or mean arterial pressure (MAP) in children receiving…
- Trial name
- NCT04688346
- Testing
- HemeRX epinephrine pellets
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Washington
Preeclampsia, Intracranial Pressure Increase
Assessment of Optic Nerve Sheath Diameter in Preeclamptic Pregnant Women Using Ultrasonography and Anesthetic Management
Preeclampsia is a serious condition associated with complications such as pulmonary edema, placental abruption, hemolysis, thrombocytopenia, and cardiac, renal, and neurological complications, occurring at a rate of 2.7-8% in…
- Conditions
- Preeclampsia, Intracranial Pressure Increase, Pregnancy; Anesthesia, Adverse Effect, Central Nervous System
- Trial name
- NCT06522295
- Testing
- ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Adverse Effect
Intensive Versus Standard Treatment for Spinal Anesthesia-induced Hypotension in Preeclamptic Patients
The objective of this study is to investigate the impact of varying maternal blood pressure maintenance targets on neonatal outcomes in preeclamptic patients following cesarean section.
- Trial name
- NCT06151431
- Testing
- Alpha-Agonist, α-adrenergic receptor agonist
- Where
- China
- Volunteers
- 390 people
- Sponsor
- General Hospital of Ningxia Medical University
Hypotension, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Use of Perfusion Index Change as a Predictor of Hypotension During Propofol Sedation in Adult Patients Undergoing Hip Surgery Under Spinal Anesthesia: A Prospective Observational Study
This observational study is to evaluate Perfusion Index Change as a Predictor of Hypotension During Propofol Sedation in Adult Patients Undergoing Hip Surgery Under Spinal Anesthesia.
- Trial name
- NCT03556969
- Testing
- Observation
- Where
- South Korea
- Volunteers
- 39 people
- Sponsor
- Samsung Medical Center
Anesthesia; Adverse Effect
Perfusion Index Changes in Cardiovascular Autonom Neuropathia Type-2 Dm Whit Spinal Anesthesia
Cardiovascular autonomic neuropathy in diabetic patients, hypertension, sympathovagal imbalance, orthostatic hypotension, painless myocardial infarction, ischemia, left ventricular dysfunction, cardiac sympathetic and…
- Trial name
- PI (NCT03869775)
- Testing
- perfusion index monitor, ewing test
- Where
- Turkey (Türkiye)
- Volunteers
- 240 people
- Sponsor
- Erzincan University
Delirium in Old Age, Anesthesia; Adverse Effect
Postoperative Dexmedetomidine in Prevention of Postoperative Delirium
The goal of this clinical trial is to learn how postoperative infusion of dexmedetomidine would influence postoperative delirium in elderly patients undergoing lung surgery. The main questions it aims to answer are : 1.
- Trial name
- NCT06382961
- Testing
- Dexmedetomidine injection, Sufentanil injection
- Where
- China
- Volunteers
- 287 people
- Sponsor
- Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd.
Methods of Nasal Anesthesia Before Transnasal Endoscopy, Side Effects of Transnasal Endoscopy
Endoscopic-guided Versus Cotton-tipped Applicator Gauze Pledgetting for Nasal Anesthesia Before Transnasal Endoscopy
Unsedated transnasal esophago-gastro-duodenoscopy (UT-EGD) has gained wide popularity and is one of the most frequently performed diagnostic procedures in Japan and Europe.
- Conditions
- Methods of Nasal Anesthesia Before Transnasal Endoscopy, Side Effects of Transnasal Endoscopy, Patient's Tolerance to Transnasal Endoscopy
- Trial name
- NCT01785173
- Testing
- Endoscopic-guided gauze pledgetting, Cotton-tipped applicator gauze pledgetting
- Where
- Taiwan
- Volunteers
- 242 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Postoperative Pain, Adverse Effects
Continuous Interscalene Block Results in Superior Recovery Throughout the First Postoperative Week
The investigators undertook this prospective, randomized trial to compare the recovery profile throughout the first postoperative week in patients receiving continuous (CISB) interscalene brachial plexus block, single injection…
- Trial name
- NCT01881776
- Testing
- ISB
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Comparison of Buffered Versus Non Buffered Local Anesthetic In Inflamed Tissues
"Comparison of Buffered Versus Non-Buffered Local Anesthetic in Patients With Inflamed Tissues for Pain Perception, Onset, Duration and Adverse Effects"
This study aims to determine whether buffered or non-buffered local anesthetic (LA) is more effective and safer for managing pain in patients with inflamed tissues undergoing surgical procedures.
- Trial name
- NCT07592143
- Testing
- Buffered Local Anesthesia
- Volunteers
- 68 people
- Sponsor
- King Edward Medical University
Morbid Obesity, Opioid Use
Inflammatory Response to Opioid Versus Opioid Free Anesthesia
Anesthetic agents, including opioids can modulate the altered immune function in patients with obesity through mechanisms that involve the expression and release of cytokines.
- Conditions
- Morbid Obesity, Opioid Use, Fentanyl Adverse Reaction, Cytokine Storm
- Trial name
- NCT04854252
- Testing
- Fentanyl
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- University of Guadalajara
Hemodynamic Monitoring, Anesthesia; Adverse Effect
Hemodynamic Impact of Epidural Anesthesia in Relation to Age in Pediatric Patients.
Epidural analgesia is established as the gold standard in the management of post-surgical pain in multiple modalities, including the pediatric patient.
- Conditions
- Hemodynamic Monitoring, Anesthesia; Adverse Effect, Pediatric Major Surgery, Epidural Analgesia
- Trial name
- REHAEPP-2022 (NCT05543824)
- Testing
- Levobupivacaine
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Fe