Clinical trials: Anesthesia,General
Cholecystectomy, Laparoscopic, Anesthesia, General
Comparison of Pupillometry-guided Anesthesia With Surgical Pleth Index Guided Anesthesia
In this study, the investigators measure a pupil size every 5 minutes during the operation in patients undergoing laparoscopic cholecystectomy under general anesthesia.
- Conditions
- Cholecystectomy, Laparoscopic, Anesthesia, General, Reflex, Pupillary
- Trial name
- PUPIL (NCT03586791)
- Testing
- Pupillometry guided anesthesia, SPI guided anesthesia, Standard management
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Daegu Catholic University Medical Center
Epinephrine Causing Adverse Effects in Therapeutic Use
Cardiovascular Effects of Racemic Epinephrine Pellets
The primary aim of this study was to determine if topical racemic epinephrine pellets affect heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) or mean arterial pressure (MAP) in children receiving…
- Trial name
- NCT04688346
- Testing
- HemeRX epinephrine pellets
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Washington
Anesthesia, General
Sugammadex After Continuous Infusion of Rocuronium During Sevoflurane and Propofol Anesthesia (P05949; MK-8616-028)
The objective of the trial was to show equivalence in recovery from neuromuscular block after a single dose of 4.0 mg/kg sugammadex, administered at first twitch (T1) 3-10% after continuous infusion of rocuronium, between…
- Trial name
- NCT00559468
- Testing
- Sugammadex, Rocuronium, Sevoflurane
- Volunteers
- 52 people
- Sponsor
- Merck Sharp & Dohme LLC
Nephrolithiasis, Postoperative Pain
Effect of a Low-Dose Ketamine-Dexmedetomidine-Based Opioid-Sparing Anesthesia Protocol on Postoperative Quality of Recovery After Percutaneous Nephrolithotomy
Percutaneous nephrolithotomy (PCNL) is a minimally invasive surgical procedure used to remove large or complex kidney stones. Although effective, dilation of the surgical tract and the placement of a nephrostomy tube cause…
- Conditions
- Nephrolithiasis, Postoperative Pain, Quality of Recovery
- Trial name
- NCT07855068
- Testing
- Ketamine and Dexmedetomidine, Fentanyl
- Volunteers
- 100 people
- Sponsor
- Assiut University
Remimazolam, Anesthesia, General
Bispectral Index and Patient State Index During General Anesthesia With Remimazolam
The aim of this study is to compare the bispectral index (BIS) and patient state index (PSI) during general anesthesia using remimazolam.
- Conditions
- Remimazolam, Anesthesia, General, Hypnotics and Sedatives, Thyroid Disease
- Trial name
- NCT05432050
- Testing
- Bispectral index and Patient state index monitoring
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Hemodynamic Instability, General Anesthesia
End-eXpiratory Occlusion Test to Predict fluId REsponsiveness in the Operating Room (EXPIRE)
The purpose of the study is to evaluate the influence of different durations of the end-expiratory occlusion test to predict fluid responsiveness in mechanically ventilated patients in the operating room.
- Conditions
- Hemodynamic Instability, General Anesthesia, Surgery, Protective Mechanical Ventilation
- Trial name
- EXPIRE (NCT04399278)
- Testing
- Diagnostic Test: end-expiratory occlusion (EEO) test
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Anesthesia, General, Neuromuscular Transmission Disorders
Influence of Sevoflurane and Propofol on Maximum Muscular Strength, Speed of Contraction and Relaxation
Many drugs have an influence on neuromuscular transmission. In clinical practice, neuromuscular blocking agents are commonly used, but even in the absence of neuromuscular blocking agents, anesthetic drugs can influence…
- Trial name
- NCT05615025
- Testing
- Sevoflurane, Propofol
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Brugmann University Hospital
General Anesthesia
Safety and Feasibility of a New Neuromuscular Monitoring Device
The aim of the study is to compare, during general anesthesia using neuromuscular blocking agent, the feasibility of a new mechanographic device (ITF handle and Visual ITF software) with a standard acceleromyographic device (TOF…
- Trial name
- MONITOF (NCT03847740)
- Testing
- Isometric Trumb Force handle
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Poitiers University Hospital
Prostate Cancer Surgery
Spinal Anesthesia for Robotic Assisted Laparoscopic Prostatectomy
The investigators hypothesised that spinal anesthesia as an adjunct to general anesthesia would facilitate faster recovery and less pain in patients undergoing laparoscopic robotic prostatectomy.
- Trial name
- NCT06860893
- Testing
- Spinal Anesthesia with Bupivacaine
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- University Hospital of North Norway
Gastrointestinal Neoplasms, Anesthesia, General
The Effect of Blood Pressure on Cerebral Blood Flow During Propofol Anesthesia
General anesthesia often reduces blood pressure whereby blood flow to the brain and other vital organs may become insufficient. Thus, medicine is often administered to maintain blood pressure but it is unclear at what level blood…
- Trial name
- CA (NCT03309917)
- Testing
- MAP set at 80-85 mmHg for 5 min, MAP set at 70-75 mmHg for 5 min, MAP set at 60-65 mmHg for 5 min
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Healthy Participants Study, General Anesthesia
Safety, Pharmacokinetics, and Pharmacodynamics of Continuous KL0011034 Infusion in Healthy Chinese Adults
This Phase 1 study will evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of continuous intravenous infusion of KL0011034 Injection in healthy Chinese adults.
- Trial name
- NCT07841626
- Testing
- KL0011034 Injection, Propofol Injectable Emulsion
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Preoxygenation, Anesthesia
High-Flow Nasal Cannula (HFNC) Preoxygenation in Obese Patients Undergoing General Anesthesia
This study aims to evaluate the effectiveness of the High Flow Nasal Cannula (HFNC) for the preoxygenation of obese patients undergoing a general anesthesia.
- Conditions
- Preoxygenation, Anesthesia, Obesity
- Trial name
- NCT03615417
- Testing
- High Flow Nasal Cannula (HFNC), Standard anesthesia FaceMask (FM)
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Erasme University Hospital
Postoperative Pain
The Analgesic Efficacy of Wound Infiltration With Tramadol
This double-blind, randomized trial examined whether tramadol wound infiltration decreased postoperative pain following cesarean delivery under general anesthesia or reduced the need for analgesics in the immediate postoperative…
- Trial name
- NCT02518438
- Testing
- Tramadol
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yeditepe University Hospital
Regional Anesthesia, Diaphragm Issues
Ultrasound Assessment of Diaphragmatic Dysfunction in Regional Anesthesia
Awake thoracic surgery is a feasible and safe alternative to general anesthesia for pulmonary biopsy in interstitial lung disease patients, but there is still no evidence as to its superiority in terms of outcome.
- Conditions
- Regional Anesthesia, Diaphragm Issues, Thoracic Surgery, Ultrasounds
- Trial name
- NCT04700943
- Testing
- Regional awake anesthesia
- Where
- Italy
- Volunteers
- 41 people
- Sponsor
- University of Turin, Italy
Insomnia, Anesthesia
Orexin-A Levels in Insomnia Patients
In the pathophysiology of insomnia, the increase of the orexin-A (OXA) peptide released from orexin neurons in the lateral hypothalamus plays an important role. Orexins takes part at the emergence of anesthesia.
- Trial name
- NCT05664295
- Testing
- Jenkins Sleep Disorders scale and Epworth Sleepiness scale
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Early Feeding
Length of Stay Between Early Versus Delayed Oral Postoperative Feeding
Length of stay between early versus delayed oral postoperative feeding after gynecologic surgery under General Anesthesia: Randomized Controlled Trial, single center The goal of this Randomized Controlled Trial is to compare…
- Trial name
- LOS (NCT05955495)
- Testing
- Food
- Where
- Thailand
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Prosthesis Failure, Dental
Clinical Success of Anterior and Posterior Crowns in a Group of Children Treated Under General Anesthesia
This incidence study aims to evaluate the clinical success of anterior and posterior full-coverage restorations among a group of Egyptian children treated under general anesthesia.
- Trial name
- NCT06201481
- Testing
- anterior and posterior full coverage crowns
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Colonic Neoplasms, Rectal Neoplasms
Endoscopically Assisted Colostomy With Colopexy for Critically Ill Patients Without General Anesthesia or Laparotomy
Indications for colostomy are rectal or anal cancer, diverticular disease, radiation enteritis, complex perirectal fistulas, anorectal trauma, severe incontinence, motility and functional disorders.
- Conditions
- Colonic Neoplasms, Rectal Neoplasms, Fecal Incontinence
- Trial name
- EACC (NCT02308631)
- Testing
- ENDOSCOPICALLY ASSISTED COLOSTOMY WITH COLOPEXY
- Where
- Brazil
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cholelithiasis
Comparing Epidural Versus General Anesthesia for LESS Cholecystectomies
This study is a prospective, comparative, controlled, blinded study that will enroll a total of 70 adults that will undergo elective laparoendoscopic single-site incision gallbladder removal.
- Trial name
- NCT03247257
- Testing
- General Anesthesia, Epidural Anesthesia
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Florida Hospital Tampa Bay Division
Altered State of Consciousness, General Anesthetics
Correlating EEG Dynamics With Consciousness Alteration Under Anesthesia
This prospective observational study is designed to investigate and compare the dynamic features of whole-brain electroencephalogram (EEG) during the induction of unconsciousness using various anesthetic agents with distinct…
- Trial name
- NCT07410702
- Testing
- Anesthetic Agents
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Huazhong University of Science and Technology