Clinical trials: Anesthesia, General
General Anesthesia
The Association Between Telomere Length and Propofol Dose in Anesthesia-induction
Telomeres are protein-bound DNA repeat structures at the end of eukaryotic chromosomes that are made up of a simple repetitive sequence (in humans, TTAGGG) and regulate cellular replicative capacity and cellular proliferation…
- Trial name
- NCT03429309
- Testing
- Propofol
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
General Anesthesia
Safety and Efficacy of Maintenance of Etomidate in General Anesthesia
This study was designed to use etomidate combined with sevoflurane intravenously to maintain anesthesia process under the monitoring of BIS. Propofol was used as the controls.
- Trial name
- NCT05223907
- Testing
- Etomidate, Propofol
- Where
- China
- Volunteers
- 1,080 people
- Sponsor
- Henan Provincial People's Hospital
Ventricular Tachycardia
Inducibility and Stability of Ventricular Tachycardia Inpatients Undergoing VT Ablation Under General Anesthesia
This research study is being done to see whether general anesthesia (GA) affects our ability to start ventricular tachycardia (VT) during an VT ablation procedure.
- Trial name
- NCT02419547
- Testing
- Versed, Fentanyl, Propofol
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Brigham and Women's Hospital
Hemodynamic Instability, General Anesthesia
End-eXpiratory Occlusion Test to Predict fluId REsponsiveness in the Operating Room (EXPIRE)
The purpose of the study is to evaluate the influence of different durations of the end-expiratory occlusion test to predict fluid responsiveness in mechanically ventilated patients in the operating room.
- Conditions
- Hemodynamic Instability, General Anesthesia, Surgery, Protective Mechanical Ventilation
- Trial name
- EXPIRE (NCT04399278)
- Testing
- Diagnostic Test: end-expiratory occlusion (EEO) test
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Surgery, Anaesthesia
Local Assessment of Ventilatory Management During General Anesthesia for Surgery
Objectives 1. To characterize mechanical ventilation practices during general anesthesia for surgery 2. To assess the dependence of intra-operative and post-operative pulmonary complications on intra-operative Mechanical…
- Conditions
- Surgery, Anaesthesia, Ventilator-Induced Lung Injury, Lung Injury
- Trial name
- LAS VEGAS (NCT01601223)
- Where
- 19 sites in United States, Estonia and 6 more
- Volunteers
- 10,690 people
- Sponsor
- European Society of Anaesthesiology
Remimazolam, Body Composition
Body Composition Analysis and Time to Emergence From Remimazolam
Remimazolam is a novel general anesthetic drug. The time to emergence from remimazolam-based general anesthesia is variable among patients, but little is known about the risk factors for delayed emergence.
- Trial name
- NCT05512559
- Testing
- body composition analysis
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Samsung Medical Center
Hypovolemia
Fluid Responsiveness Using Forehead Sensor in Children
Forehead sensor can predict the more accurate fluid responsiveness than finger sensor in children
- Trial name
- forehead (NCT03132480)
- Testing
- fluid resuscitation
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Spinal Injuries
Comparison by Neuromonitoring of Two Techniques of Tracheal Intubation in Patients With Unstable Cervical Spine
Patients who present with an unstable cervical spine following an accident need a general anesthesia for the necessary surgery. Commonly, the management of the tracheal intubation is performed by a fiberoptic technique.
- Trial name
- NCT02382887
- Testing
- tracheal intubation, Airtraq, fiberscope
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Lausanne Hospitals
Pregnancy, Cesarean Delivery
Pharmacogenetics of Remifentanil in Patients With Hypertension Undergoing Cesarean Delivery Under General Anesthesia
Caesarean delivery under general anaesthesia (GA) carries nowadays still 25% risk of insufficient depth of anaesthesia in a time before the fetus delivery. The reason is the lack of opioid administration.
- Conditions
- Pregnancy, Cesarean Delivery, General Anesthesia
- Trial name
- NCT01550640
- Testing
- Remifentanil
- Where
- Czechia
- Volunteers
- 149 people
- Sponsor
- Charles University, Czech Republic
Surgery With General Anesthesia
Validation of the Effect of Propofol and Opiates Closed-loop Administration Device During Anesthesia and Sedation
Sleeping medication and analgesia are standard administered during anesthesia. Sleeping medication, Propofol (Diprivan, AstraZeneca), and analgesia, Remifentanil (GlaxoSmithKline), are most frequently used In the University…
- Trial name
- NCT00764855
- Testing
- Automatic administration of propofol and opiates during routine clinical practice
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- University Hospital, Ghent
Neurodevelopmental Disorders, Child Behavior Disorders
Impact of General Anesthesia in Childhood on Cognitive Processes
This study aims to evaluate the potential long-term cognitive effects of general anesthesia administered before the age of 4. Specifically, it investigates executive functions-including inhibition, working memory, and cognitive…
- Trial name
- NCT07141797
- Testing
- Executive functions assessment
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
General Anesthesia
Comparison of Deep Neuromuscular Block and Moderate Neuromuscular Block on Quality of Recovery in Patients Undergoing Robotic Gastrectomy
The purpose of this study is to investigate and compare the postoperative quality of recovery between the deep neuromuscular blockade and moderate neuromuscular blockade during robotic gastrectomy.
- Trial name
- NCT02762890
- Testing
- Deep neuromuscular blockade, Moderate neuromuscular blockade
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Yonsei University
Postoperative Recovery, General Anaesthesia
Intercultural Adaptation and Validation of the Ukrainian Quality of Recovery-15 Questionnaire
The Quality of Recovery 15-questionnaire (QoR-15) is used to assess postoperative quality of recovery after surgery and anesthesia from the patient's perspective.
- Conditions
- Postoperative Recovery, General Anaesthesia, Validation, Questionnaire
- Trial name
- NCT07510360
- Testing
- Quality of Recovery-15 questionnaire, Ukrainian version
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rostyslav Voloshchuk
General Anesthesia
Comparative Analysis of Phase Lag Entropy (PLE) and Bispectral Index (BIS) as an Anesthetic Depth Indicator
The aim of this comparative analysis is to evaluate the reliability of PLE value as an anesthetic depth indicator
- Trial name
- NCT03424720
- Testing
- PLE and BIS
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Hallym University Medical Center
Atelectasis
Continuous Positive Airway Pressure Decreased Lung Collapse During General Anesthesia Induction in Pediatric Patients
Anesthesia-induced atelectasis is a well-known entity observed in approximately 68-100% of pediatric patients undergoing general anesthesia.
- Trial name
- NCT03461770
- Testing
- CPAP
- Where
- Argentina
- Volunteers
- 42 people
- Sponsor
- Hospital Privado de Comunidad de Mar del Plata
Secretion Removal Above ETT Cuff
Evaluation of Above the Cuff Suctioning During General Anesthesia
The aim of this prospective, randomized, pilot study is compare ease of tracheal intubation, amount of microaspiration and efficacy of secretion removal using three FDA (Food and Drug Administration)-cleared endotracheal tubes…
- Trial name
- NCT01386879
- Testing
- methylene blue
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Anesthesia
Efficacy and Safety of HSK3486 Compared to Propofol in Induction of General Anesthesia in Adults Having Elective Surgery
This is a multicenter, randomized, double-blinded, propofol-controlled, Phase 3 clinical study to evaluate the efficacy and safety of HSK3486 for induction of general anesthesia in adults undergoing elective surgery.
- Trial name
- NCT04711837
- Testing
- HSK3486, Propofol
- Where
- 13 sites in United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Endotracheal Intubation, General Anesthesia
Ultrasound-guided Identification of Cricoid Cartilage in Cricoid Pressure
This study is aimed to provide the evidence that ultrasound-guided identification of the cricoid cartilage can improve effectiveness of cricoid pressure.
- Trial name
- NCT03990337
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Airway Management, Supraglottic Airway
I-gel Plus Supraglottic Airway Device for Elective Laparoscopic Surgery
i-gel Plus is a novel supraglottic airway device (SGA). Feasibility of second-generation SGAs in patients undergoing elective laparoscopic surgery has been demonstrated in various studies.
- Conditions
- Airway Management, Supraglottic Airway, General Anesthesia, Laparoscopic Surgery
- Trial name
- NCT06602830
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Anesthesia Awareness
Heart Rate Variability to Quantify General Anesthesia Depth
The shortage of anesthetic agents can lead to intraoperative awareness while overdosing can trigger severe intra and postoperative problems.
- Trial name
- NCT04788732
- Testing
- ECG and EEG monitoring
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo