Clinical trials: Anaphylaxis
Health Literacy, Anaphylaxis
Health Literacy Among Caregivers of Children With IgE-mediated Allergy With Risk of Anaphylaxis
Research on health literacy among caregivers of children with IgE-mediated allergy at risk of anaphylaxis (life-threatening allergic reaction).
- Trial name
- NCT04475003
- Testing
- Teaching
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Aspirin Sensitivity, Aspirin-exacerbated Respiratory Disease
Characteristics of Patients Diagnosed With NSAID Sensitivity in Thailand
Study clinical characteristics and phenotypes of patients diagnosed with NSAID sensitivity in Thailand
- Conditions
- Aspirin Sensitivity, Aspirin-exacerbated Respiratory Disease, Aspirin-Induced Angioedema-Urticaria, Aspirin Allergy
- Trial name
- NCT03849625
- Testing
- aspirin, NSAIDs, paracetamol
- Where
- Thailand
- Volunteers
- 158 people
- Sponsor
- Chulalongkorn University
Wheat Allergy, Anaphylaxis Food
Major Allergen in Wheat Anaphylaxis in Thai Population
To study Major allergen in Wheat anaphylaxis in Thai population To study and compare demographic data between group of wheat anaphylaxis
- Conditions
- Wheat Allergy, Anaphylaxis Food, Anaphylaxis Exercise
- Trial name
- NCT03487315
- Testing
- immunoblot
- Where
- Thailand
- Volunteers
- 36 people
- Sponsor
- Mahidol University
Food Allergy, Anaphylaxis Food
Inhibition of Anaphylaxis by Ibrutinib
This is a phase II open label study on the use of Ibrutinib on the inhibition of food-induced anaphylaxis in adults with food allergy.
- Trial name
- NCT03149315
- Testing
- Ibrutinib
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Eczema, Egg Allergy
Promoting Tolerance to Peanut in High-Risk Children
This study will evaluate whether early exposure to peanuts promotes tolerance and provides protection from developing peanut allergy in children who are allergic to eggs or who have severe eczema.
- Conditions
- Eczema, Egg Allergy, Food Allergy
- Trial name
- LEAP (NCT00329784)
- Testing
- Peanut Consumption Group
- Where
- United Kingdom
- Volunteers
- 640 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Idiopathic Anaphylaxis, Drug Anaphylaxis
Cause of Unexplained Anaphylaxis
This study will explore the possible cause of unexplained, or idiopathic, anaphylaxis. Anaphylaxis is a rapid, life-threatening, severe reaction that occurs suddenly after contact with an allergy-causing substance, usually a…
- Conditions
- Idiopathic Anaphylaxis, Drug Anaphylaxis, Venom Anaphylaxis, Food Anaphylaxis
- Trial name
- NCT00719719
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Anaphylaxis
Intravenous Heparin as an Adjunct for the Treatment of Anaphylactic Reactions in an Emergency Department
To determine if intravenous unfractionated heparin (with standard therapy) for treatment of anaphylaxis results in faster time to recovery.
- Trial name
- NCT00657228
- Testing
- Intravenous heparin, Saline
- Where
- 2 sites in United States
- Sponsor
- University of Missouri, Kansas City
Hypersensitivity Reactions
Post-market Safety Study of LUMISIGHT
This study is a prospective, multi-center, observational post-market safety study evaluating the incidence of anaphylaxis and hypersensitivity reactions associated with LUMISIGHT (pegulicianine) administration in adults with…
- Trial name
- NCT07572162
- Where
- 2 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Lumicell, Inc.
Anaphylactic Reaction, Vaccine Reaction
Allergy and COVID-19 Vaccines
Prospective and retrospective multicenter study to estimate the proportion of patients who tolerated continuation of COVID-19 vaccination (absence of anaphylactic manifestations).
- Trial name
- COVALL (NCT05028257)
- Testing
- COVID-19 Vaccines
- Where
- France
- Volunteers
- 117 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mastocytosis, Anaphylaxis
Blood Factors in Mastocytosis and Unexplained Anaphylaxis and Flushing
This study will 1) identify characteristics of bone marrow mast cells in patients with unexplained anaphylaxis and flushing or with mastocytosis and 2) determine whether mastocytosis might be the underlying cause of unexplained…
- Trial name
- NCT00047918
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hypersensitivity, Anaphylaxis
Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing, Immunotherapy or Oral Challenges
The goal of this exploratory study is to evaluate the effects of inhaled epinephrine in subjects, who may not be eligible for the GHL-101 trial, and who are experiencing systemic allergic reaction (SAR) that occur following…
- Trial name
- NCT07038746
- Testing
- Inhaled Epinephrine
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Dr. George Luciuk
Fish Allergy, Food Hypersensitivity
FASC: Fish Allergy in Spanish Children - A Study of New Cases of Fish Allergy in Children and Adolescents
Fish allergy is one of the leading causes of food-induced allergic reactions in children, but the clinical presentation and patterns of sensitization vary considerably among patients and geographical regions.
- Conditions
- Fish Allergy, Food Hypersensitivity, IgE-Mediated Food Allergy
- Trial name
- FASC (NCT07727148)
- Volunteers
- 120 people
- Sponsor
- Carmelo Escudero
Allergic Asthma
Pharmacosurveillance Data Repository of Patients With and Without History of Anaphylactic Reactions Subsequent to Xolair Dosing
This study will establish a clinical data and serum repository of anaphylaxis cases associated with Xolair administration and control patients who have received Xolair without associated anaphylaxis.
- Trial name
- X-PAND (NCT00813748)
- Testing
- Xolair
- Where
- 7 sites in United States
- Volunteers
- 118 people
- Sponsor
- Genentech, Inc.
Anaphylactic Reaction
Study of Inhaled DMC-IH1 and Intramuscular (EpiPen®) Epinephrine in Healthy Male and Female Participants.
This is a phase 1, randomised, double blind placebo controlled 2-part study to assess the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of inhaled DMC-IH1 (epinephrine) and relative bioavailability and carryover effects…
- Trial name
- NCT06013150
- Testing
- Epinephrine
- Where
- Australia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- De Motu Cordis
Asthma in Children, Allergy
Advanced Multimodal Wireless Vital Signs Monitoring for Patients With Asthma and Anaphylaxis
The primary objective of this study is to assess the function and reliability of a non-invasive, skin-like electronic sensor. We hypothesize that this skin sensor will address an unmet need to wirelessly, noninvasively, and…
- Trial name
- NCT04360213
- Testing
- Advanced multimodal wireless vital signs monitor
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Northwestern University
Food Hypersensitivity, Anaphylaxis
A Registry for the Food Allergy Community
The FARE Patient Registry will serve as a prospective, observational food allergy reporting system that stores detailed health and other basic information about patients' real-world experiences with food allergies, to encourage…
- Conditions
- Food Hypersensitivity, Anaphylaxis, Eosinophilic Esophagitis, Food Sensitivity
- Trial name
- FPR (NCT04653324)
- Where
- United States
- Volunteers
- 23,000 people
- Sponsor
- Food Allergy Research & Education
Hypersensitivity, Anaphylaxis
Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing Immunotherapy or Oral Challenges
The purpose of this exploratory study is to evaluate the effects of inhaled epinephrine in patients with known or suspected metabisulfite sensitivity who experience a systemic allergic reaction (SAR) while undergoing allergy…
- Trial name
- NCT06445374
- Testing
- Inhaled Epinephrine
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Dr. George Luciuk
Food Allergy
One-year Survey of Anaphylaxis in Outpatient Children Allergic to Peanuts, Walnuts/Hazelnuts, Shellfish
In Italy, few data about anaphylaxis due to peanuts in pediatric age are available, conversely data about walnuts/hazelnuts, shellfish/mollusks anaphylaxis have not yet been collected.
- Trial name
- NCT02640560
- Testing
- Food allergy questionnaire, Control Questionnaire
- Volunteers
- 200 people
- Sponsor
- Stefania La Grutta, MD
Bee Sting
Tolerance in Beekeepers
Beekeepers experience multiple bee stings each year. Many of these beekeepers (25-60%) become sensitized to bee venom through the production of specific antibodies that target the bee venom.
- Trial name
- NCT06156046
- Testing
- skin prick test, Blood tests
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital Plymouth NHS Trust
Pharmacokinetics, Epinephrine
Study of Drug Exposure in Systemic Circulation of Primatene Mist by Oral Inhalation, Versus Epinephrine Injection by Intramuscular Injection and ProAir by Oral Inhalation in Healthy Individuals
To assess the drug exposure profile in systemic circulation of Primatene Mist by inhalation, versus Epinephrine by intramuscular injection, and ProAir HFA by inhalation in healthy adults.
- Conditions
- Pharmacokinetics, Epinephrine, Albuterol, Asthma
- Trial name
- NCT04207840
- Testing
- Epinephrine (0.125 mg/inhalation), Epinephrine Injection Auto-Injector (0.3mg/0.3mL), Albuterol Sulfate (0.09 mg/inhalation)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Amphastar Pharmaceuticals, Inc.