Clinical trials: Analgesics, Opioid
Mild to Heavy Alcohol Consumption
Cognitive, Behavioral and Aging Effects of Pain Medication in Alcohol Users
The purpose of this study is to examine the relationship between heavy alcohol use, pain, and response to pain medication in older adults.
- Trial name
- CAAP (NCT02945293)
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Washington
Bone Metastasis, Cancer Pain
Phase 3 Study on the Efficacy and Safety of Tanezumab in Patients With Cancer Pain Due to Bone Metastasis Who Are Taking Background Opioid Therapy
The purpose of this study is to determine whether tanezumab is effective in the treatment of cancer pain due to bone metastasis in patients already taking background opioid therapy.
- Trial name
- NCT02609828
- Testing
- Tanezumab
- Where
- 89 sites in Argentina, Australia and 14 more
- Volunteers
- 156 people
- Sponsor
- Pfizer
Osteoarthritis
Prevalence of Potential Cytochrome P450 Pharmacokinetic Incident Drug-Drug Interactions(DDI) Among Osteoarthritis Patients
Using a retrospective database analysis, OA patients taking at least one CYP450-metabolized opioid (codeine, fentanyl, hydrocodone, methadone, oxycodone, or tramadol) and at least one other prescription drug metabolized via the…
- Trial name
- NCT01177267
- Volunteers
- 10,000 people
- Sponsor
- NEMA Research, Inc.
Pain, Postoperative, Surgery--Complications
Celecoxib vs. Acetaminophen/Codeine/Caffeine for Post-operative Analgesia in Rhinoplasty.
The primary aim of this study is to evaluate whether celecoxib (CELEBREX) is equivalent to acetaminophen-codeine-caffeine (TYLENOL# 3) for the management of pain after primary elective open septorhinoplasty with osteotomies.
- Conditions
- Pain, Postoperative, Surgery--Complications, Opioid Analgesic Adverse Reaction, Opioid Use
- Trial name
- NCT04259333
- Testing
- Celecoxib 200mg, Acetaminophen, Codeine Drug Combination
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Blake Raggio
Pain, Postoperative, Anesthesia, Local
Improving Pain Relief Following Laparoscopic Ventral Hernia Repair
Aim The general aim of this study is to improve post-operative pain and reduce morphine consumption following laparoscopic ventral hernia repair (LVHR).
- Conditions
- Pain, Postoperative, Anesthesia, Local, Hernia, Ventral, Laparoscopy
- Trial name
- NCT02785276
- Testing
- AutoFuser Pain Pump, Ropivacaine, Normal Saline (0.9%)
- Where
- New Zealand
- Sponsor
- University of Auckland, New Zealand
Thyroid Surgeries, Intraoperative Analgesic Use
qCON/qNOX-Guided Anesthesia in Patients Undergoing Thyroidectomy Surgery
The aim of this study is to evaluate the effect of using the non-invasive Conox monitor on intraoperative opioid consumption. Additionally, the study aims to assess the impact of Conox monitoring on recovery time, postoperative…
- Conditions
- Thyroid Surgeries, Intraoperative Analgesic Use, Anesthesia Depth Monitoring
- Trial name
- NCT07445659
- Testing
- Connox EEG Monitoring, standard anesthesia management
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Single-level Lumbar Arthrodesis
Intravenous Lidocaine Versus Erector Spinae Plane Block After Lumbar Arthrodesis (LIBERA)
The hypothesis of this study is that intraoperative intravenous lidocaine infusion provides postoperative analgesia and opioid-sparing effects that are at least equivalent to those achieved with a bilateral erector spinae plane…
- Trial name
- LIBERA (NCT07895368)
- Testing
- Single-level posterior lumbar arthrodesis
- Where
- France
- Volunteers
- 90 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Anesthesia Recovery Period, Pain, Postoperative
Controlled-Release Oxycodone For Postoperative Analgesia After Video-Assisted Thoracic Surgery
The main hypothesis of this study is that preoperative administration of controlled-release (CR) oxycodone may reduce acute postoperative pain and improve time to discharge from the post-anesthesia care unit in patients…
- Trial name
- NCT00681174
- Testing
- Morphine, oxycodone, Paravertebral block
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- University of Parma
Opioid Use, Postoperative Pain
Comparing Intrathecal Morphine With Modified Thoracoabdominal Nerve Block Through Perichondral Approach in Major Abdominal Surgery
Abdominal surgery causes severe postoperative pain due to retraction of the abdominal wall and direct manipulation of visceral organs. It leads to delayed postoperative recovery, increased postoperative morbidity and mortality.
- Trial name
- NCT06346860
- Testing
- Regional Block Comparison
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Marmara University
Postoperative Pain Management, Analgesia, Postoperative
Superficial vs Deep Serratus Anterior Plane Block for Analgesia After Mammoplasty
The serratus anterior plane block (SAPB) is an ultrasound-guided fascial plane block used for perioperative analgesia in thoracic and breast surgeries.
- Conditions
- Postoperative Pain Management, Analgesia, Postoperative, Breast Surgery, Mammoplasty Patient
- Trial name
- DSAPvsSSAP (NCT07502846)
- Testing
- Superficial Serratus Anterior Plane Block, Deep Serratus Anterior Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Pain Due to Certain Specified Procedures
Pilot Study of Sucrose to Reduce Pain in Sick Babies
Small amounts of sweet tasting sugar water reduces pain in babies during painful blood tests and injections. The investigators do not know if sugar also reduces pain in babies already receiving a continuous infusion of opioid…
- Trial name
- NCT01438008
- Testing
- 24% sucrose po solution
- Where
- Canada
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
Laparoscopic Cholecystectomy, Analgesics，Opioid
ED50 of Sufentanil for Intraoperative Analgesia
1. Sufentanil as an strong analgesic is used widespreadly during laparoscopic cholecystectomy. 2. Lower dosages of sufentanil facilitated with dexmedetomidine can offer enough analgesia effect. 3.
- Trial name
- ED50 (NCT06662656)
- Where
- China
- Volunteers
- 26 people
- Sponsor
- China International Neuroscience Institution
Prescription Drug Abuse
Using m-Health Tools to Reduce the Misuse of Opioid Pain Relievers
The aim of this study is to pilot test a web-based, patient-centered educational program that encourages the patient to have an informed discussion about pain medication options with their emergency department (ED) provider.
- Trial name
- NCT03012087
- Testing
- MyHealthyChoices, Health Risk Assessment
- Where
- 2 sites in United States
- Volunteers
- 123 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cancer Pain
Unique Treatment of Oncology Pain in Advanced Cancer
This will be a proof-of-concept, single arm study with a maximum of 20 patients to evaluate preliminary analgesic efficacy and safety of Trichomylin® in patients with advanced cancer (male and female) who suffer from moderate to…
- Trial name
- UTOPIA-1 (NCT06533657)
- Testing
- Trichomylin® capsule (5 mg delta-9-tetrahydrocannabinol: 5 mg cannabidiol: 5 mg cannabichromene)
- Where
- 3 sites in Canada
- Volunteers
- 11 people
- Sponsor
- ZYUS Life Sciences Inc.
Chronic Cholecystitis
Anesthesia With Propofol, Dexmedetomidine and Lidocaine Infusions for Laparoscopic Cholecystectomy
Opioids may attenuate postoperative hyperalgesia and postoperative nausea and vomiting. Our hypothesis is: opioid-free total intravenous anesthesia with propofol, dexmedetomidine and lidocaine infusions for laparoscopic…
- Trial name
- NCT01833819
- Testing
- Dexmedetomidine and lidocaine, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bezmialem Vakif University
Acute Pain
Acute Pain Episodes in Patients Under Opioid Maintenance Therapy : Clinical Management and Long Term Effects
To define a rational pharmacological management of pain for the subjects under opioid maintenance therapy (methadone or buprenorphine), it is first of all necessary to estimate the efficiency of the current practices on pain…
- Trial name
- NCT00738036
- Where
- France
- Volunteers
- 151 people
- Sponsor
- University Hospital, Toulouse
Postoperative Pain
An Open-label Study of Hydromorphone Oral Solution in Subjects Aged 28 Days to 16 Years for Postoperative Pain
The primary objective of this study is to characterize the pharmacokinetics and pharmacodynamics of hydromorphone oral solution in pediatric subjects aged 28 days to 16 years inclusive.
- Trial name
- Palladone (NCT00465647)
- Testing
- Hydromorphone
- Where
- 14 sites in United States
- Volunteers
- 116 people
- Sponsor
- Purdue Pharma LP
Opioid Consumption, Postoperative, Pain, Postoperative
Comparison of Pain Relief Methods for Hip Surgery: A Study on Two Different Nerve Block Techniques
This prospective randomized comparative study aims to compare the analgesic efficacy of pericapsular nerve group block (PENG) and lumbar erector spinae plane block (L-ESP) groups to relieve postoperative pain in participants over…
- Conditions
- Opioid Consumption, Postoperative, Pain, Postoperative, Nerve Block, PENG Block
- Trial name
- NCT06821516
- Testing
- Evaluation of the postoperative analgesic effectiveness of PENG block in participants undergoing total hip arthroplasty under spinal anesthesia, Evaluation of the postoperative analgesic effectiveness of lumbar erector spinae block in participants undergoing total hip arthroplasty under spinal anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Advanced Cancers
Self Reported Deviations From Opioid Analgesic Prescription
Primary Objective: 1. To determine the frequency of self-reported over and under use of opioid analgesics in patients with advanced cancer.
- Trial name
- NCT00907192
- Testing
- Personal Interview, Questionnaire
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- M.D. Anderson Cancer Center
Pain, Unspecified Adult Solid Tumor, Protocol Specific
Valdecoxib in Treating Chronic Pain in Cancer Patients
RATIONALE: Valdecoxib may be effective in relieving chronic pain in cancer patients. It is not yet known if valdecoxib is effective in treating chronic pain.
- Trial name
- NCT00021996
- Testing
- valdecoxib
- Where
- 2 sites in United States
- Sponsor
- Dana-Farber Cancer Institute