Clinical trials: Analgesics
Analgesic Efficacy, Dexmedetomidine
Analgesic Efficacy of Adding Dexmedetomidine to Erector Spinae Plane Block Versus Subcostal Transverse Abdominis Plane Block in Laparoscopic Cholecystectomy
Our scientific work aimed to evaluate the analgesic efficacy of dexmedetomidine as an adjuvant to erector spinae plane block versus subcostal transverse abdominis plane block in patients undergoing laparoscopic cholecystectomy.
- Conditions
- Analgesic Efficacy, Dexmedetomidine, Erector Spinae Plane Block, Subcostal Transverse Abdominis Plane Block
- Trial name
- NCT07075913
- Testing
- Subcostal transverse abdominis plane block, Erector spinae plane block
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Kafrelsheikh University
Mastectomy, Mastectomy Plus Axillary Lymph Node Dissection
Effect of Serratus and Pectoralis II Plane Block Versus Pectoralis II Alone on Acute Postoperative Pain After Mastectomy
The goal of this randomized controlled clinical trial is to determine whether adding a serratus anterior plane block (SAPB) to a pectoralis II (PECS II) block improves pain relief and reduces the need for opioids in adult women…
- Conditions
- Mastectomy, Mastectomy Plus Axillary Lymph Node Dissection, Nerve Block; Pain Medication, Pectoralis Nerve Block
- Trial name
- PECS (NCT07881237)
- Testing
- Serratus Anterior Plane Block (SAPB) group, Pectoral nerve block (PECS)
- Where
- Lebanon
- Volunteers
- 80 people
- Sponsor
- Lebanese American University
Analgesics, Opioid, Anesthesia, General
Asleep Fiberoptic vs Direct Laryngoscopy Effect on Hemodynamic Stability Using Opioid Free Anesthesia Induction
The goal of this clinical trial is to compare heart rate between the fiberoptic and direct oral intubation using opioid free anesthesia induction.
- Conditions
- Analgesics, Opioid, Anesthesia, General, Heart Rate, Blood Pressure
- Trial name
- NCT06487988
- Testing
- direct conventional laryngoscopy, fiberoptic guided intubation
- Where
- Lebanon
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Opioid Abuse (Disorder), Opioid Analgesia
Reducing Opioid Use After Upper Extremity Surgery: Testing Lower Prescriptions and Pill Quantity
The goal of this clinical trial is to evaluate strategies for optimizing postoperative multimodal pain regimens and reducing opioid dependency in patients undergoing upper extremity surgery.
- Conditions
- Opioid Abuse (Disorder), Opioid Analgesia, Opioid Analgesic Adverse Reaction, Opioid Consumption
- Trial name
- NCT07750639
- Testing
- Naproxen, Acetaminophen, oxycodone
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Mobile-based Mindfulness Intervention to Reduce Preoperative Anxiety, Pre-operative Anxiety
Effects of Mobile-based Mindfulness Intervention to Reduce Preoperative Anxiety for Patients Undergoing Elective Surgery
This study is a pilot randomized controlled trial (RCT) conducted at Tin Shui Wai Hospital to evaluate the effectiveness of a mobile-based mindfulness intervention in reducing preoperative anxiety among patients scheduled for…
- Conditions
- Mobile-based Mindfulness Intervention to Reduce Preoperative Anxiety, Pre-operative Anxiety, Postoperative Pain, Postoperative Use of Analgesics
- Trial name
- NCT07005973
- Testing
- mobile-based mindfulness intervention
- Where
- Hong Kong
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Hospital Authority, Hong Kong
Behavioral Symptoms, Suicide
Natural History of Depression, Bipolar Disorder and Suicide Risk
Mood disorders, such as depression and bipolar disorder, are difficult to treat. One reason is that there are no objective ways to measure how these disorders affect the body and respond to different treatments.
- Conditions
- Behavioral Symptoms, Suicide, Self-Injurious Behavior, Sensory System Agents
- Trial name
- NCT06462196
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Mental Health (NIMH)
Postoperative Pain, Analgesics, Opioid
The Effects of TFPB on Opioid Consumption in Patients Undergoing HLDN
This study aims to evaluate whether a regional anesthesia technique called the transversalis fascia plane block (TFPB) can improve pain control after hand-assisted laparoscopic donor nephrectomy (HALDN), a minimally invasive…
- Conditions
- Postoperative Pain, Analgesics, Opioid, Pain Management, Anesthesia Regional
- Trial name
- NCT07396753
- Testing
- Ultrasound-guided transversalis fascia plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Koç University
Surgery, Analgesics, Opioids
Methods for Effective Disposal of Surplus Analgesics to Facilitate Elimination
The primary objective is to evaluate the difference in outcomes for mail-in vs. in-home disposal methods for leftover prescription opioids after discharge from surgery.
- Trial name
- MEDSAFE (NCT05991687)
- Testing
- In-home drug disposal pouch, Mail-in prepaid envelope
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Michigan
Analgesics, Opioid, Acute Pain
Alternatives to Dental Opioid Prescribing After Tooth Extraction
The goal of this clinical trial is to test a three-item intervention in oral surgeons who remove teeth. The main questions it aims to answer are: Can the intervention reduce opioid prescriptions to adolescents and young adults…
- Conditions
- Analgesics, Opioid, Acute Pain, Tooth Extraction, Adolescent
- Trial name
- ADOPT (NCT06275191)
- Testing
- Multicomponent intervention, Usual care
- Where
- United States
- Volunteers
- 38,159 people
- Sponsor
- Douglas Oyler
Pancreatic Cancer Pain, Intrathecal Analgesic
Evaluating the Effectiveness of AIT in the Treatment of Pain Related to Pancreatic Cancer
The aim of this clinical trial is to assess the effectiveness of intratracheal analgesia on pain intensity in cancer patients, from the start of treatment up to 3 months. It will also investigate the safety of this technique.
- Conditions
- Pancreatic Cancer Pain, Intrathecal Analgesic, Intrathecal Administration of the Drug, Pancreatic Carcinoma
- Trial name
- PIT (NCT07733427)
- Testing
- Intrathecal catheter connected to an implantable pump, Administration of medication, including analgesics, via an intrathecal catheter connected to an implantable pump or via periodic injections
- Where
- 3 sites in France
- Volunteers
- 40 people
- Sponsor
- Clinique Bizet
Postoperative Recovery, Anesthesia, General
Quality of Recovery-15 After Opioid-free Versus Opioid-based General Anesthesia in Major Urological Surgery
This randomized controlled trial evaluates postoperative quality of recovery assessed with the Quality of Recovery-15 questionnaire in adult patients undergoing elective major urological surgery under opioid-free versus…
- Conditions
- Postoperative Recovery, Anesthesia, General, Analgesics, Opioid, Urologic Surgical Procedure
- Trial name
- QoR-OFA-URO (NCT07665463)
- Testing
- Remifentanil-based general anesthesia, Opioid-free general anesthesia
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Jagiellonian University
Postoperative Pain, Postoperative Analgesia
A Predictive Model for Postoperative Analgesic Requirements After Abdominal Surgery
Postoperative pain remains a common challenge after abdominal surgery despite the use of standard multimodal pain management strategies.
- Conditions
- Postoperative Pain, Postoperative Analgesia, Opioid Analgesic Requirement, Pain Management After Abdominal Surgery
- Trial name
- NCT07803575
- Testing
- Intravenous Morphine Patient-Controlled Analgesia
- Where
- Malaysia
- Volunteers
- 65 people
- Sponsor
- Chaw Sook Hui
Analgesics, Opioid, Anesthesia, Endotracheal
Opioid-free Anesthesia as an Alternative to General Anesthesia in Abdominal Surgery
Opioid-free anesthesia (OFA) is a multimodal technique that eliminates intraoperative opioids by combining dexmedetomidine, ketamine, lidocaine, NSAIDs, and regional analgesia.
- Conditions
- Analgesics, Opioid, Anesthesia, Endotracheal, Anesthesia, General
- Trial name
- NCT06380244
- Testing
- anesthesia without opioids
- Where
- Poland
- Volunteers
- 600 people
- Sponsor
- Jagiellonian University
Modified Thoracoabdominal Nerve Block (M-TAPA), Analgesic Technique
Bilateral Modified Thoracoabdominal Nerve Block as an Analgesic Technique in Comparison With Bilateral Thoracic Erector Spinae Plane Block in Abdominoplasty Operations
This study aimed to compare the analgesic effect of bilateral ultrasound-guided modified thoracoabdominal nerve block with bilateral ultrasound-guided erector spinae plane block in abdominoplasty surgery.
- Conditions
- Modified Thoracoabdominal Nerve Block (M-TAPA), Analgesic Technique, Thoracic Erector Spinae Plane Block, Abdominoplasty
- Trial name
- NCT07738900
- Testing
- General Anaesthesia using intravenous propofol, fentanyl intravenous, and atracurium besylate, Modified thoracoabdominal nerve block using 25 mL of bupivacaine 0.25%, Erector spinae plane block using 25 mL of bupivacaine 0.25%
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Mansoura University
Mechanical Ventilation, Pediatric Acute Respiratory Failure
Optimizing Pain Treatment in Children On Mechanical Ventilation
In this clinical trial, investigators want to learn more about using non-opioid pain medications for children with acute respiratory failure.
- Conditions
- Mechanical Ventilation, Pediatric Acute Respiratory Failure, Analgesics, Opioid, Sedation and Analgesia
- Trial name
- OPTICOM (NCT06994442)
- Testing
- Acetaminophen, Ketorolac
- Where
- 16 sites in United States
- Volunteers
- 644 people
- Sponsor
- Weill Medical College of Cornell University
Analgesic Efficacy
Suzetrigine Frame Trial Comparing Suzetrigine and Acetaminophen
Local anesthetic infiltration is a primary source of acute pain during stereotactic procedures.
- Trial name
- NCT07525219
- Testing
- Suzetrigine, acetaminophen
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Wake Forest University Health Sciences
The Lumbar Spine Surgical Intervention, Arthrodesis
Evaluation of the Effect of Reiki on Pain After Lumbar Surgery
The goal of this clinical trial (prospective, comparative, and randomized double-blind study) is to learn if Reiki (a non-pharmacological intervention), when used alongside standard care, can treat and reduce postoperative pain…
- Conditions
- The Lumbar Spine Surgical Intervention, Arthrodesis, Severe Herniated Disc, Scoliosis
- Trial name
- REDAL (NCT07722117)
- Testing
- Reiki treatment and chirurgy
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Clinique Bizet
Coronavirus, Coronavirus Infection
Natural Killer Cell (CYNK-001) Infusions in Adults With COVID-19
This study is a Phase 1 / 2 trial to determine the safety and efficacy of CYNK-001, an immunotherapy containing Natural Killer (NK) cells derived from human placental CD34+ cells and culture-expanded, in patients with moderate…
- Conditions
- Coronavirus, Coronavirus Infection, Severe Acute Respiratory Syndrome Coronavirus 2, Pneumonia
- Trial name
- CYNKCOVID (NCT04365101)
- Testing
- CYNK-001
- Where
- 4 sites in United States
- Volunteers
- 7 people
- Sponsor
- Celularity Incorporated
Analgesic Efficacy, Quadro-Iliac Plane Block
Analgesic Efficacy of Quadro-Iliac Plane Block Versus Erector Spinae Plane in Total Hip Arthroplasty
This study aims to compare the Quadro-Iliac Plane Block versus Erector Spinae Plane Block after total hip arthroplasty.
- Conditions
- Analgesic Efficacy, Quadro-Iliac Plane Block, Erector Spinae Plane Block, Total Hip Arthroplasty
- Trial name
- NCT07537036
- Testing
- Quadro-iliac plane block, Erector spinae plane block
- Where
- Egypt
- Volunteers
- 76 people
- Sponsor
- Tanta University
Lumbar Microdiscectomy Surgery, Lumbar Erector Spinae Plane Block
Comparison of the Analgesic Efficacy of Erector Spinae Plane Block in Lumbar Microdiscectomy Surgeries
Comparison of the Analgesic Efficacy of Lumbar Erector Spinae Plane Block and Sacral Erector Spinae Plane Block in Lumbar Microdiscectomy Surgeries
- Conditions
- Lumbar Microdiscectomy Surgery, Lumbar Erector Spinae Plane Block, Sacral Erector Spinae Plane Block, Postoperative Pain
- Trial name
- NCT07652177
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital