Clinical trials: Analgesia Tolerance
Hyperalgesia, Pain Insensitivity, Congenital
The Relationship Between Saliva β-endorphins Levels, Cold Pressor Test and Perception of Pain in Oral Surgery Procedures
The purpose of this study is to evaluate the correlation between β-endorphin levels in blood plasma and saliva in healthy participants with different pain sensitivity and in those with acute pain in oral and maxillofacial region.
- Trial name
- NCT03164161
- Testing
- Cold pressor test, β-endorphins evaluation in saliva, β-endorphins evaluation in blood plasma
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Exercise Induced Hypoalgesia, Circadian Rhythm
Pain Perception and Exercise-Induced Hypoalgesia Across Circadian Rhythms
The goal of this randomized crossover clinical trial is to investigate whether exercise-induced hypoalgesia (EIH) is influenced by circadian rhythm in healthy adults aged 18-40 years.
- Conditions
- Exercise Induced Hypoalgesia, Circadian Rhythm, Pain Perception, Healthy Participants
- Trial name
- NCT07290465
- Testing
- High-Intensity Functional Training (HIFT), Supervised Deep Breathing
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Medipol University
Pain, Acute
Duration of Music Interventions and Pain Tolerance (DOMINANT)
This study will investigate the effect of different durations of music interventions (1, 5 and 20 minutes of music) on pain tolerance.
- Trial name
- DOMINANT (NCT06286137)
- Testing
- Listening to music for 1 minute, Listening to music for 5 minutes, Listening to music for 20 minutes
- Where
- Netherlands
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Pain, Pain, Postoperative
Cryoablation of Intercostal Nerves for Post-Operative Pain Management in Opioid-Tolerant Patients
The main objective study is to compare the use of the cryoSPHERE probe to the standard-of-care method for pain management of patients receiving robotic-assisted thoracoscopic surgery, including reductions in opioid pain…
- Trial name
- NCT05276258
- Testing
- cryoSPHERE Ablation, Bupivacaine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The Methodist Hospital Research Institute
Cancer, Pain
Oral Ketamine as an Adjuvant to Opioids for Pain Treatment in Cancer Patients
In the current research the investigators would like to examine the effect of a well acquainted drug, Ketamine, which is used by anesthesiologists to induce sleep in operations.
- Conditions
- Cancer, Pain, Tolerance
- Trial name
- NCT01207206
- Testing
- oral ketamine
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Pain, Acute
Tolerance Assesment of the Usage of an Analgesic Dose of Esketamine for Treatment of Moderate to Intense Pain in an Emergency Departement
KETAMINE has been used for several years in emergency departments for analgesic purposes. Its ease of use and its analgesic effect have been demonstrated in several studies.
- Trial name
- ESKETAMINE (NCT05666869)
- Testing
- Esketamine perfusion
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Association pour la Formation l'Enseignement et la Recherche du Service de l'Accueil des Urgences
Scoliosis
Effect of Early Morphine Administration on the Development of Acute Opioid Tolerance During Pediatric Scoliosis Surgery
The purpose of this study is to examine if morphine administered by bolus before initiating Remifentanil by infusion decreases the incidence of acute post-operative opioid tolerance as demonstrated by decreased post - operative…
- Trial name
- NCT00737997
- Testing
- Morphine, Saline
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- The Hospital for Sick Children
Pain, Opioid Tolerance
Effect of N-methyl D-aspartate (NMDA) Receptor Antagonist Dextromethorphan on Opiods Analgesia and Tolerance in Pediatric Intensive Care Unit Patients
Effect of N-methyl D-aspartate (NMDA) receptor antagonist Dextromethorphan on Opiods analgesia and tolerance in Pediatric Intensive Care Unit Patients
- Conditions
- Pain, Opioid Tolerance, Analgesia Tolerance
- Trial name
- NCT01553435
- Testing
- Dextromethorphan
- Where
- Saudi Arabia
- Volunteers
- 36 people
- Sponsor
- King Abdullah International Medical Research Center
Acupressure, Urinary Calculi
Acupressure as Complementary Analgesia in Shock Wave Lithotripsy
This study aims to evaluate the efficacy of acupressure applied to the LI4 (Hegu) and Qiu points before Extracorporeal Shock Wave Lithotripsy (ESWL) in patients with kidney or proximal ureteral stones.
- Conditions
- Acupressure, Urinary Calculi, Urolithiasis, ESWL
- Trial name
- NCT07885696
- Testing
- Acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Medipol University
Intractable Pain, Intensive Care
Ketamine and Refractory Painful Care in a Palliative Unit
Pain is one of the major symptoms in palliative care units and often is very difficult to treat, being considered as a refractory pain.
- Conditions
- Intractable Pain, Intensive Care, Pressure Ulcer, Pain Management
- Trial name
- KETAREF (NCT02587130)
- Testing
- Ketamine
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Lille Catholic University
Opioid-Related Disorders, Substance-Related Disorders
Differential Acute Tolerance Development to Effects of Nitrous Oxide - 7
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used…
- Trial name
- NCT00000255
- Testing
- Nitrous oxide
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Adhesive Capsulitis, Adhesive Capsulitis of Unspecified Shoulder
Suprascapular Nerve Block to Improve Tolerance and Outcomes of Shoulder Hydrodistension in Adhesive Capsulitis
Adhesive capsulitis ("frozen shoulder") causes significant pain and loss of shoulder mobility. Shoulder hydrodistension is an established treatment that can improve movement and reduce symptoms, but the procedure itself may be…
- Conditions
- Adhesive Capsulitis, Adhesive Capsulitis of Unspecified Shoulder, Adhesive Capsulitis, Shoulder, Frozen Shoulder
- Trial name
- SHINE (NCT07380087)
- Testing
- Shoulder Hydrodistention, suprascapular nerve block
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Universidade do Porto
Idiopathic Scoliosis, Spondylolisthesis
Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia
The purpose of this study is to: 1. Establish whether ketamine can decrease opioid consumption and modulate the onset of opioid tolerance and prevent opioid-induced hyperalgesia in pediatric subjects, ages 10 years to 18 years…
- Trial name
- KPSF (NCT01325493)
- Testing
- Ketamine, Normal Saline
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Julia Finkel
Opioid-Related Disorders, Substance-Related Disorders
Lack of Acute Tolerance Development to Effects of Nitrous Oxide - 4
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used…
- Trial name
- NCT00000252
- Testing
- 0% N2O, 10% N2O, 20% N2O
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Pain, Analgesia
The Influence of Music Choice on Pain Tolerance in the Context of Social Background
This study will investigate the effect of different music on the pain tolerance during an increasing electric stimulus in healthy individuals, taking social background into account.
- Trial name
- MOSART (NCT06008951)
- Testing
- Listening to music, Listening to a podcast
- Where
- Netherlands
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Markus Klimek
Pain
Pre- Versus Post-Incisional Epidural Morphine: Higher Postoperative Pain Perception and Extra Morphine Consumption
Background and Objectives: Neuraxial administration of morphine is an effective way of controlling postoperative pain and reducing analgesic consumption.
- Trial name
- NCT01095575
- Testing
- normal saline 3 ml, morphine 3mg
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Chronic Pain
Effect of Guanfacine on Opioid-induced Hyperalgesia (OIH) and Tolerance
Dual medication (guanfacine and morphine) as a standard treatment for chronic pain.
- Trial name
- NCT01681264
- Testing
- Morphine, Guanfacine 1mg, Guanfacine 2mg
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Massachusetts General Hospital
Pain, Post-operative
Memantine for Post-Operative Pain Control
Pain is a common element of surgery. Opiates (morphine, oxycodone, hydrocodone, methadone, fentanyl) are very helpful in decreasing pain after surgery.
- Trial name
- NCT01041313
- Testing
- Memantine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Washington
Sedation and Analgesia Management in Patients Undergoing Flexible Bronchoscopy
Midazolam Alone Versus Midazolam With Ketorolac for Sedation During Flexible Bronchoscopy.
Flexible bronchoscopy has evolved into a vital diagnostic and therapeutic intervention in respiratory medicine due to its frequent and diverse applications.
- Trial name
- NCT07352059
- Testing
- Midazolam Alone, Midazolam + ketorolac
- Volunteers
- 50 people
- Sponsor
- SYED HAIDER ALI