Clinical trials: Analgesia, open to volunteers
Analgesia, Donor Nephrectomy
PQLB vs TFPB in HALDN
This prospective randomized non-inferiority trial is designed to compare postoperative analgesic effect of transversalis fascia plane block and posterior quadratus lumborum block in hand assisted laparoscopic donor nephrectomy.
- Conditions
- Analgesia, Donor Nephrectomy, Postoperative Pain, Fascial Plane Block
- Trial name
- NCT07852663
- Testing
- Quadratus Lumborum Block type 2, Transversalis Fascia Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Koc University Hospital
Pain, Acute Post-Operative, Dexmedetomidine
Esmolol Versus Dexmedetomidine for Opioid-sparing in Laparoscopic Gynecological Surgery
The aim of this study is to investigate and compare the effects of a continuous infusion of low-dose esmolol and dexmedetomidine versus placebo on intraoperative and postoperative opioid consumption and analgesic efficacy in…
- Conditions
- Pain, Acute Post-Operative, Dexmedetomidine, Analgesia, Esmolol
- Trial name
- NCT07846722
- Testing
- Esmolol hydrochloride, Dexmedetomidine, Normal (0.9%) saline
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- Vasiliki Samartzi
Local Analgesia Via Infiltration
A Study of Bupivacaine Liposome Injection in Local Analgesia of Pediatric Patients
The study is being conducted to evaluate the safety and efficacy of bupivacaine liposome injection for local infiltration analgesia in pediatric orthopedic surgery in the real world.
- Trial name
- NCT06344091
- Testing
- Bupivacaine Liposome Injection
- Where
- China
- Volunteers
- 232 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Opioid Use, Substance Use Disorders
Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use
The purpose of this study is to understand how kratom affects people. In this study, kratom will be compared with another substance and a placebo (an inactive substance).
- Conditions
- Opioid Use, Substance Use Disorders, Opioid Analgesia
- Trial name
- NCT07218549
- Testing
- Oxycodone HCl, Kratom 8g, Kratom 12g
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Christopher D. Verrico
Labor Analgesia
The Impact of Needle Manipulation and Accuracy Between Hand Held Automatic and Traditional Ultrasound Device
In this double blinded randomized controlled trial, the investigators would like to compare the effects on needle manipulation when relatively inexperienced sonographist (< 1 year of ultrasound experience) perform ultrasound…
- Trial name
- NCT05909085
- Testing
- Traditional ultrasound, Automated ultrasound
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yale University
Hip Fractures, Arthroplasty, Replacement, Hip
PENG Block + LIA For Endoprosthesis Surgery
The goal of this clinical trial is to learn if a new local anesthesia technique can control pain as well as the standard spinal anesthesia for adults having hip endoprosthesis surgery.
- Conditions
- Hip Fractures, Arthroplasty, Replacement, Hip, Pain, Postoperative, Anesthesia and Analgesia
- Trial name
- PENG 360° (NCT07239817)
- Testing
- Pericapsular Nerve Group Blocks with Local Infiltration Analgesia, spinal anesthesia
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- ASST Gaetano Pini-CTO
Gastrectomy, Postoperative Analgesia
Efficacy and Safety of Anrikefon Injection for the Treatment of Postoperative Pain in Patients Undergoing Totally Laparoscopic Radical Distal Gastrectomy
Anruikefen is a peripherally highly selective kappa receptor agonist that does not easily cross the blood-brain barrier, resulting in a low incidence of central adverse reactions such as respiratory depression, sedation, and…
- Trial name
- NCT07330063
- Testing
- Anruikefen (Intravenous Bolus), Anruikefen (Intravenous Infusion)
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Hindfoot Surgery, Analgesia
Postoperative Analgesia Using a Perineural Catheter Versus a Single Nerve Block in Rearfoot Surgery
Postoperative pain following hindfoot surgery is often severe and can persist for several days. It frequently leads to the use of systemic analgesics, particularly opioids, whose adverse effects are well known.
- Conditions
- Hindfoot Surgery, Analgesia, Perineural Catheter
- Trial name
- CATHORNOT (NCT07638514)
- Testing
- Phone contact, perineural catheter, Regional Anesthesia
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Angers
Analgesia
Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine for Intermediate Cervical Plexus Block
Background: Many thyroidectomy patients suffer from postoperative pain that could delay early hospital discharge and place a significant burden on both the patient and the healthcare team.
- Trial name
- NCT05793060
- Testing
- Dexmedetomidine Hydrochloride, Dexamethasone Phosphate
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour Teaching Hospital
Post Operative, Post Operative Analgesia
Postoperative Tizanidine Use in Pelvic Reconstructive Surgery: A Pilot Study
The goal of this clinical trial is to evaluate whether adding tizanidine to the standard postoperative pain regimen improves recovery after pelvic reconstructive surgery in adult women.
- Conditions
- Post Operative, Post Operative Analgesia, Urogynecologic Surgery
- Trial name
- TIPS (NCT07766837)
- Testing
- Tizanidine, Standard-of-Care Therapy
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Hartford Hospital
Pain, Postoperative, Inguinal Hernia Unilateral
Intrathecal Morphine and Transversalis Fascia Plane Block for Analgesia After Open Inguinal Hernia Repair
Inguinal hernia is a common surgical condition, and open inguinal hernia repair may be associated with significant postoperative pain.
- Conditions
- Pain, Postoperative, Inguinal Hernia Unilateral, Intrathecal Morphine, Transversalis Fascia Plane Block
- Trial name
- NCT07826741
- Testing
- Intrathecal Morphine Group, Transversalis Fascia Plane Block Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Labor Epidural Analgesia, Perfusion Index
Perfusion Index Variability During Epidural Labor Analgesia
This prospective, single-centre observational study evaluates changes in the peripheral Perfusion Index (PI) - a non-invasive parameter derived from the pulse-oximetry photoplethysmographic waveform - in women receiving epidural…
- Conditions
- Labor Epidural Analgesia, Perfusion Index, Pain
- Trial name
- NCT07831967
- Testing
- Epidural (or opioid-only combined spinal-epidural) labor analgesia
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Gdansk
Failed Epidural Analgesia, Post-partum Recovery
Failing Epidural Analgesia During Labor
This prospective multicenter observational study is being conducted at the Gregorio Marañón University General Hospital and the La Paz University Hospital in Madrid, Spain.
- Trial name
- FEA25 (NCT07473609)
- Testing
- No Intervention: Observational Cohort
- Where
- 2 sites in Spain
- Volunteers
- 500 people
- Sponsor
- Nicolas Brogly
Procedural Sedation and Analgesia
PRedictors Of Maladaptive Behaviors in Children Undergoing Procedural SEDation
Procedural sedation for children outside of the operating room is a common practice in emergency departments, outpatient clinics, radiology suites, and dental offices for painful and anxiety-provoking procedures.
- Trial name
- PRoSEED (NCT07495826)
- Where
- 2 sites in Canada
- Volunteers
- 2,145 people
- Sponsor
- London Health Sciences Centre Research Institute
Opioid Consumption, Postoperative, Multimodal Analgesia
Assessing Suzetrigine for Pain Reduction Following Ureteroscopic Surgery
Urologic surgery has advanced with new technologies to allow less invasive management of common afflictions such as kidney stones, these procedures are notoriously painful as the ureter must be dilated to accommodate any…
- Conditions
- Opioid Consumption, Postoperative, Multimodal Analgesia, Ureteroscopy, Ureteral Stents
- Trial name
- NCT07654296
- Testing
- multimodal analgesia regimen without suzetrigine, Suzetrigine
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Brigham and Women's Hospital
Pain, Postoperative, Breast Surgery
One-level and Bi-level ESPB Application in Patients Undergoing Breast Surgery
Acute pain after breast surgery can significantly reduce the quality of life for patients. If acute pain is not adequately treated, it can develop into chronic pain.
- Conditions
- Pain, Postoperative, Breast Surgery, Erector Spinae Plane Block, Multimodal Analgesia
- Trial name
- NCT07747623
- Testing
- One-level Erector Spinae Plane Block, Bi-level Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Quadroiliac Plane Block, Transmuscular Quadratus Lumborum Block
Quadroiliac Plane Block Versus Transmuscular Quadratus Lumborum Block for Postoperative Analgesia After Total Hip Arthroplasty
This study aims to evaluate and compare the postoperative analgesic efficacy, opioid consumption, motor function preservation, and quality of recovery of ultrasound-guided Quadroiliac Plane Block (QIPB) versus transmuscular…
- Conditions
- Quadroiliac Plane Block, Transmuscular Quadratus Lumborum Block, Postoperative Analgesia, Total Hip Arthroplasty
- Trial name
- NCT07815145
- Testing
- Quadroiliac Plane Block, Transmuscular quadratus lumborum block
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Esophageal Cancer, Esophagectomy
PAravertebral CaTheter Versus Epidural Analgesia in Totally Minimally Invasive Esophagectomies
Esophageal cancer ranks as the seventh leading cause of cancer globally, with 604,100 new cases, and the sixth leading cause of cancer-related deaths worldwide.
- Conditions
- Esophageal Cancer, Esophagectomy, Multimodal Analgesia, Minimally Invasive Surgery
- Trial name
- PACEMIE (NCT07434739)
- Testing
- paravertebral catheter analgesia, Epidural group
- Where
- France
- Volunteers
- 506 people
- Sponsor
- University Hospital, Lille
Analgesia, Cardiac Surgery
Precision Analgesia for Cardiac Surgery
The proposed research is an important extension of an ongoing perioperative personalized analgesia and intravenous opioid pharmacogenetic research.
- Trial name
- NCT05612399
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Kathirvel Subramaniam
Postoperative Analgesia After Cesarean Delivery
Ultrasound-Guided Posterior Quadratus Lumborum Block With Bupivacaine and Dexmedetomidine Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Delivery
Cesarean delivery (CD) is one of the most commonly performed surgical procedures worldwide, with millions of women undergoing the procedure annually (1).
- Trial name
- NCT07807592
- Testing
- Intrathecal Morphine, Ultrasound-Guided Posterior Quadratus Lumborum Block
- Volunteers
- 80 people
- Sponsor
- Assiut University