Clinical trials: Analgesia
Labor Pain
Intrathecal Clonidine Addiction for Combined Spinal Epidural Analgesia During Labor
The study aims to evaluate the impact of the addition of 20 mcg of intrathecal clonidine in combined spinalepidural for labor analgesia on the local anesthetic consumption, on labor performance and on maternal fetal well-being.
- Trial name
- ICA (NCT03018171)
- Testing
- Clonidine, Sufentanil
- Where
- Italy
- Volunteers
- 268 people
- Sponsor
- San Giovanni Calibita Fatebenefratelli Hospital
Caudal Block, Pediatric Urologic Surgeries
Comparison of Caudal Block Combined With General Anesthesia and Penile Block and Intravenous Fentanyl in Pediatric Surgeries
Urogenital surgery is one of the most frequently performed surgical procedures in the pediatric patient population. There is no consensus on which analgesic method is most effective for pain control in these patients.
- Conditions
- Caudal Block, Pediatric Urologic Surgeries, Fentanyl, Pediatric Delirium
- Trial name
- NCT06862271
- Testing
- Group 1 ( Caudal block group ), Group 2 (Penile block and IV Fentanyl group)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Miray Gözde Özdemir
Pain Management
The Effect of the Flipped Classroom Model on Pediatric Pain Management Knowledge and Learning Motivation of Nursing Students
The aim of this randomized controlled trial was to evaluate the effect of the flipped classroom model on pediatric pain management knowledge and learning motivation among nursing students.
- Trial name
- FLIPNURSE (NCT07129044)
- Testing
- Flipped Classroom Training on Pediatric Pain Management, Self-Directed Learning on Pediatric Pain Management
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Mustafa Belli
Gynecologic Surgical Procedures
Rectus Sheath Block for Analgesia After Gynecological Laparotomy
Thirty subjects undergoing laparotomy for Gynecologic oncology surgery will be prospectively enrolled and will receive a bilateral rectus sheath block (RSB) under ultrasound guidance using 133 mg liposomal bupivacaine and 20 ml…
- Trial name
- NCT06575699
- Testing
- Rectus sheath block, Thoracic Epidural Analgesia, Liposomal bupivacaine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Duke University
Restlessness, Pain
Effects of Dexmedetomidine on Stress Response and Postoperative Analgesia
Dexmedetomidine is a highly selective α2 adrenoreceptor agonist approved by the US FDA for short-term postoperative sedation and analgesia.It can also reduce the stress response without respiratory depression.
- Trial name
- NCT01517932
- Testing
- dexmedetomidine
- Volunteers
- 60 people
- Sponsor
- Fang Luo
Breast Cancer, Postoperative Pain
The Effect of Rhomboid Intercostal Block and Serratus Anterior Plane Block on Postoperative Respiratory Functions
Rhomboid intercostal block is used to block lateral cutaneous branches of intercostal nerves between T3 and T9 dermatomes. Serratus anterior plane block is used to block lateral cutaneous branches of intercostal nerves between T2…
- Conditions
- Breast Cancer, Postoperative Pain, Respiratory Function Impaired
- Trial name
- RIBSAB (NCT05547932)
- Testing
- RIB+SAP blocks
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Muğla Sıtkı Koçman University
Laparoscopic Abdominal Surgeries, Erector Spinae Plane Block
Erector Spinae Plane Block Versus Modified Thoracoabdominal Nerve Block for Analgesia in Pediatric Laparoscopic Abdominal Surgeries
Laparoscopic abdominal surgeries are frequently performed in pediatric patients and are often associated with significant postoperative pain, which, if inadequately managed, may delay recovery and increase the risk of chronic…
- Conditions
- Laparoscopic Abdominal Surgeries, Erector Spinae Plane Block, Modified Thoracoabdominal Nerve Block (M-TAPA)
- Trial name
- NCT07240064
- Testing
- Erector Spinae Plane Block, Modified thoracoabdominal plane block
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Acute Low-back Pain, Chronic Low-back Pain
Impact of DuoTherm Compared to TENS on Pain and Disability With Acute and Chronic Low Back Pain
Evaluate pain and disability change in Low Back Pain with DuoTherm Compared to Active Control
- Conditions
- Acute Low-back Pain, Chronic Low-back Pain, Pain, Intractable
- Trial name
- NCT04494698
- Testing
- Duotherm VibraCool Back Device, TENS 8-channel unit
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- MMJ Labs LLC
Analgesia; Postoperative
Effect of Single Dose Intravenous Magnesium Sulfate on Postoperative Analgesic Consumption in Patients Undergoing Laparoscopic Cholecystectomy
This study describes a randomized controlled trial designed to evaluate the impact of a single intravenous dose of magnesium sulfate on postoperative analgesic consumption in patients undergoing laparoscopic cholecystectomy.
- Trial name
- NCT07328893
- Testing
- Magnesium Sulfate 30 mg/kg intravenous diluted in 100 ml Normal Saline.
- Where
- 2 sites in India
- Volunteers
- 106 people
- Sponsor
- Tata Main Hospital
Burn
VRH Pain Reduction During Burn Wound Care and Physical Therapy
Using Virtual Reality Hypnosis to relief pain and anxiety for burn patients.
- Trial name
- VRH (NCT00260221)
- Testing
- using VR hypnosis/distraction and audio hypnosis
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Opioid Dependence, Pain
The Effects of Minocycline in Opioid-maintained Patients
Opioids are the most commonly utilized pharmacological treatment for moderate to severe pain. However, their clinical value is hindered by the development of opioid-induced hyperalgesia (OIH).
- Trial name
- NCT02359006
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Yale University
Pain, Postoperative, Surgery--Complications
Celecoxib vs. Acetaminophen/Codeine/Caffeine for Post-operative Analgesia in Rhinoplasty.
The primary aim of this study is to evaluate whether celecoxib (CELEBREX) is equivalent to acetaminophen-codeine-caffeine (TYLENOL# 3) for the management of pain after primary elective open septorhinoplasty with osteotomies.
- Conditions
- Pain, Postoperative, Surgery--Complications, Opioid Analgesic Adverse Reaction, Opioid Use
- Trial name
- NCT04259333
- Testing
- Celecoxib 200mg, Acetaminophen, Codeine Drug Combination
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Blake Raggio
Internal Derangement of Knee
Infrapatellar Nerve Block for Post-operative Knee Arthroscopy Pain Control
The purpose of this study is to determine whether infrapatellar branch of the saphenous nerve blocks are effective in decreasing analgesic use, promoting earlier mobility, and improving long term outcome scores after knee…
- Trial name
- NCT01279447
- Testing
- 0.25% Bupivacaine, Normal Saline
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Surgery, Breast Cancer
Chronic Pain and Minor Breast Cancer Surgery
Breast cancer is the most frequent in women. Early diagnosis and recent treatments have improved overall mortality. However, chronic pain (pain lasting more than 3 months after surgery) remains a public health problem with impact…
- Conditions
- Surgery, Breast Cancer, Pain, Postoperative, Pain, Chronic
- Trial name
- DCPO Sein (NCT03912948)
- Where
- France
- Volunteers
- 205 people
- Sponsor
- Institut Claudius Regaud
Chest Tube Removal, Children
The Effects of EMLA Cream and Cold Application on Pain, Fear and Vital Signs Before Chest Tube Removal in Children
This study is being conducted to determine the effect of EMLA cream and cold application on pain, fear and vital signs before chest tube removal in children aged 7-18 years.
- Conditions
- Chest Tube Removal, Children, Pain Management
- Trial name
- NCT06913855
- Testing
- EMLA Cream, Cold application
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Istanbul Medeniyet University
Percutaneous Nephrolithotomy (PCNL), Perioperative Analgesia
Anterior QLB for PCNL
Aim: In this study, we primarily aimed to determine the effect of anterior Quadratus Lumborum Block (QLB) on intraoperative and postoperative opioid consumption in patients undergoing percutaneous nephrolithotomy (PCNL) surgery…
- Conditions
- Percutaneous Nephrolithotomy (PCNL), Perioperative Analgesia, Quadratus Lumborum Block, Opioid Consumption
- Trial name
- NCT07487415
- Testing
- ANTERİOR QUADRATUS LUMBORUM BLOCK ( anterior QLB)
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Zonguldak Bulent Ecevit University
Edema, Pain
Comparison of Hyaluronidase and Dexametasone in Reduction of Postoperative Edema
The present study is designed to reveal effectiveness of hyaluronidase and dexamethasone on reduction of postoperative edema, pain, trismus, and infection.
- Conditions
- Edema, Pain, Trismus, Infection, Surgical Site
- Trial name
- NCT05466604
- Testing
- Hyaluronidase Injection mesomedica, Dexamethasone dekort
- Where
- 2 sites in Cyprus, Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Labour Analgesia and Neonate Activity
Labour Analgesia and Movement in Babies
This study aims to measure movements in babies after they are born using an actigraph, a wristwatch-sized device worn on the ankle, which works similarly to the device used by runners to count the number of steps they have taken.
- Trial name
- LAMB (NCT01280084)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cesarean Section; Dehiscence
Preemptive Analgesia With Intravenous Paracetamol for Post-cesarean Section Pain Control
The investigators designed a prospective randomized study to investigate the efficacy of intravenous (IV) preemptive paracetamol on postoperative pain scores, patient satisfaction, total morfin consumption and the incidence of…
- Trial name
- NCT02369133
- Testing
- paracetamol
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Baskent University
Carpal Tunnel Surgery, Trigger Finger Disorder
NAC-REPAIR for Post-surgical Pain
This pilot asks whether peri-operative N-acetylcysteine (NAC) improves recovery after common outpatient hand/foot-ankle surgery-specifically, does NAC reduce pain and opioid use and enhance function by modulating…
- Conditions
- Carpal Tunnel Surgery, Trigger Finger Disorder, De Quervain Syndrome, Guyon's Canal
- Trial name
- NCT07227649
- Testing
- NAC
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Arizona