Percutaneous Nephrolithotomy (PCNL)NCT07487415
Anterior QLB for PCNL
A study testing ANTERİOR QUADRATUS LUMBORUM BLOCK ( anterior QLB) in people with Percutaneous Nephrolithotomy (PCNL) and Perioperative Analgesia, run by Zonguldak Bulent Ecevit University at 1 site in Turkey (Türkiye).
Trial summary
Aim: In this study, we primarily aimed to determine the effect of anterior Quadratus Lumborum Block (QLB) on intraoperative and postoperative opioid consumption in patients undergoing percutaneous nephrolithotomy (PCNL) surgery under general anesthesia. Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- Percutaneous Nephrolithotomy (PCNL), Perioperative Analgesia, Quadratus Lumborum Block
- What is being tested?
- ANTERİOR QUADRATUS LUMBORUM BLOCK ( anterior QLB)
- Type of treatment
- Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 54 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 May 2024to 1 Oct 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age between 18 and 75 years.
- American Society of Anesthesiologists (ASA) physical status I-III.
- Patients undergoing percutaneous nephrolithotomy (PCNL) under general anesthesia
Who cannot join
- Known allergy to local anesthetics.
- Coagulopathy or bleeding disorders.
- Infection at the site of intervention.
- Neurological or neuromuscular diseases.
- Psychiatric disorders.
- Chronic pain syndromes.
Show all 12Show fewer
- Chronic analgesic or opioid use.
- History of opioid abuse.
- Contraindications to regional anesthesia.
- Cardiac dysrhythmia that could interfere with Analgesia Nociception Index (ANI) monitoring.
- Patients requiring vasoactive or chronotropic drugs (e.g., atropine, ephedrine, nitroglycerin, or noradrenaline) to maintain hemodynamic stability during surgery.
- Refusal to participate in the study.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Zonguldak Bülent Ecevit University Hospital
Zonguldak, Zonguldak Province
About this study
Official title: Perioperative Analgesia Management in Patients Undergoing Percutaneous Nephrolithotomy Following Anterior Quadratus Lumborum Block
Aim: In this study, we primarily aimed to determine the effect of anterior Quadratus Lumborum Block (QLB) on intraoperative and postoperative opioid consumption in patients undergoing percutaneous nephrolithotomy (PCNL) surgery under general anesthesia. Secondarily, we aimed to evaluate opioid-related complications and investigate the impact of anterior QLB on the quality of postoperative recovery using the QoR-15 (Quality of Recovery-15) questionnaire.
Materials and Methods: The study included 60 patients aged 18-75, with ASA physical status I-III, who were scheduled for elective PCNL. Patients were randomly assigned to either the Control Group (n=30) or the Anterior QLB Group (n=30). Following dropouts during follow-up, a total of 54 patients (27 in each group) were analyzed. Preoperative block was performed in the Anterior QLB group. In both groups, following anesthesia induction, anesthesia maintenance was provided with sevoflurane to maintain a BIS value of 40-60, and the remifentanil dosage was adjusted to keep the ANI between 50-70. Operation time, surgical duration, extubation time, intraoperative hemodynamic data, ANI values, and the amount of intraoperative remifentanil consumed were recorded. Postoperative recovery unit pain scores, incidence of nausea and vomiting, and additional analgesic requirements were documented. Pain scores at the 1st, 2nd, 6th, 12th, and 24th postoperative hours, postoperative complications (nausea, vomiting, etc.), opioid consumption, and the results of the QoR-15 questionnaire at the 24th hour were recorded.
Read more
Results: Intraoperative remifentanil consumption, both in terms of total dose and weight-adjusted infusion rate, was significantly lower in the Anterior QLB group (p<0.001). Pain scores were significantly lower in the Anterior QLB group both in the recovery unit and at all postoperative time points (p<0.05). Postoperative cumulative tramadol consumption was also lower in the Anterior QLB group across all time intervals (p<0.05). No significant difference was found between the two groups regarding the incidence of postoperative nausea and vomiting. Furthermore, no significant difference was observed in the QoR-15 questionnaire scores evaluated at the 24th postoperative hour.
Conclusion: Anterior QLB is an effective analgesic method in percutaneous nephrolithotomy surgery, reducing perioperative opioid consumption and postoperative pain scores. It is concluded that anterior QLB is effective as a significant component of the multimodal analgesia strategy by preventing potential side effects associated with opioid consumption.
- Conditions
- Percutaneous Nephrolithotomy (PCNL), Perioperative Analgesia, Quadratus Lumborum Block, Opioid Consumption
- Being tested
- ANTERİOR QUADRATUS LUMBORUM BLOCK ( anterior QLB)
- Keywords
- anterior quadratus lumborum block, opioid consumption, percutaneous nephrolithotomy, Quality of Recovery-15
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ANTERİOR QUADRATUS LUMBORUM BLOCK ( anterior QLB)Procedure or surgery
injection local anesthetic between quadratus lumborum and psaos major
| Study group | Role | What they receive |
|---|---|---|
| group control | No intervention | patients receive standart general anesthesia |
| group anterior QLB | Active comparator | Patients receiving and ultrasound guided anterior quadratus lumborum block in addition to general anesthesia before surgery Receives: Procedure: ANTERİOR QUADRATUS LUMBORUM BLOCK ( anterior QLB) |
What is being measured
The primary outcome is the main question the study is designed to answer.
intraoperative and total postoperative opioid consumption in the first 24 hours
primary aimed to determine the effect of anterior Quadratus Lumborum Block (QLB) on intraoperative and postoperative opioid consumption in patients undergoing percutaneous nephrolithotomy (PCNL) surgery under general anesthesia.
Measured: first 24 hours after surgery
Secondary outcomes (2)
Quallty of recovery by using QoR-15 questionnaire
Measured: postoperative 24th hour
evaluate opioid-related complications
Measured: postoperative 0, 1, 2, 6, 12, 24 th hour
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Mar 2026
- Study start1 May 2024
- Primary completion1 Oct 2025
- Study completion1 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Percutaneous Nephrolithotomy (PCNL)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 54 participants (actual)
Sponsor and investigators
- Lead sponsor
- Zonguldak Bulent Ecevit University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Gülbeyaz Yalçın, Zonguldak Bulent Ecevit University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07487415
- Sponsor's protocol ID
- 2024/08-3
- Status last verified
- Feb 2026
- First submitted
- 17 Mar 2026
- Last updated
- 23 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 23 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Perioperative Analgesia Management in Patients Undergoing Percutaneous Nephrolithotomy Following Anterior Quadratus Lumborum Block
- ClinicalTrials.gov ID
- NCT07487415
- Acronym / sponsor ID
- 2024/08-3
- Conditions
- Percutaneous Nephrolithotomy (PCNL), Perioperative Analgesia, Quadratus Lumborum Block, Opioid Consumption
- Keywords
- anterior quadratus lumborum block, opioid consumption, percutaneous nephrolithotomy, Quality of Recovery-15
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 54 participants (actual)
- Lead sponsor
- Zonguldak Bulent Ecevit UniversityUniversity, hospital or other
- Study start
- 1 May 2024 (actual)
- Primary completion
- 1 Oct 2025 (actual)
- Study completion
- 1 Oct 2025 (actual)
- First posted
- 23 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Aim: In this study, we primarily aimed to determine the effect of anterior Quadratus Lumborum Block (QLB) on intraoperative and postoperative opioid consumption in patients undergoing percutaneous nephrolithotomy (PCNL) surgery under general anesthesia. Secondarily, we aimed to evaluate opioid-related complications and investigate the impact of anterior QLB on the quality of postoperative recovery using the QoR-15 (Quality of Recovery-15) questionnaire.
Materials and Methods: The study included 60 patients aged 18-75, with ASA physical status I-III, who were scheduled for elective PCNL. Patients were randomly assigned to either the Control Group (n=30) or the Anterior QLB Group (n=30). Following dropouts during follow-up, a total of 54 patients (27 in each group) were analyzed. Preoperative block was performed in the Anterior QLB group. In both groups, following anesthesia induction, anesthesia maintenance was provided with sevoflurane to maintain a BIS value of 40-60, and the remifentanil dosage was adjusted to keep the ANI between 50-70. Operation time, surgical duration, extubation time, intraoperative hemodynamic data, ANI values, and the amount of intraoperative remifentanil consumed were recorded. Postoperative recovery unit pain scores, incidence of nausea and vomiting, and additional analgesic requirements were documented. Pain scores at the 1st, 2nd, 6th, 12th, and 24th postoperative hours, postoperative complications (nausea, vomiting, etc.), opioid consumption, and the results of the QoR-15 questionnaire at the 24th hour were recorded.
Results: Intraoperative remifentanil consumption, both in terms of total dose and weight-adjusted infusion rate, was significantly lower in the Anterior QLB group (p<0.001). Pain scores were significantly lower in the Anterior QLB group both in the recovery unit and at all postoperative time points (p<0.05). Postoperative cumulative tramadol consumption was also lower in the Anterior QLB group across all time intervals (p<0.05). No significant difference was found between the two groups regarding the incidence of postoperative nausea and vomiting. Furthermore, no significant difference was observed in the QoR-15 questionnaire scores evaluated at the 24th postoperative hour.
Conclusion: Anterior QLB is an effective analgesic method in percutaneous nephrolithotomy surgery, reducing perioperative opioid consumption and postoperative pain scores. It is concluded that anterior QLB is effective as a significant component of the multimodal analgesia strategy by preventing potential side effects associated with opioid consumption.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| group control | No intervention | –patients receive standart general anesthesia |
| group anterior QLB | Active comparator | Procedure: ANTERİOR QUADRATUS LUMBORUM BLOCK ( anterior QLB)Patients receiving and ultrasound guided anterior quadratus lumborum block in addition to general anesthesia before surgery |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Age between 18 and 75 years.
- American Society of Anesthesiologists (ASA) physical status I-III.
- Patients undergoing percutaneous nephrolithotomy (PCNL) under general anesthesia
Key exclusion criteria (12 listed)
- Known allergy to local anesthetics.
- Coagulopathy or bleeding disorders.
- Infection at the site of intervention.
- Neurological or neuromuscular diseases.
- Psychiatric disorders.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ANTERİOR QUADRATUS LUMBORUM BLOCK ( anterior QLB)injection local anesthetic between quadratus lumborum and psaos major | Procedure or surgery | group anterior QLB |
Primary outcome
intraoperative and total postoperative opioid consumption in the first 24 hours
Time frame: first 24 hours after surgery
primary aimed to determine the effect of anterior Quadratus Lumborum Block (QLB) on intraoperative and postoperative opioid consumption in patients undergoing percutaneous nephrolithotomy (PCNL) surgery under general anesthesia.
2 secondary outcomes
Quallty of recovery by using QoR-15 questionnaire
Time frame: postoperative 24th hour
evaluate opioid-related complications
Time frame: postoperative 0, 1, 2, 6, 12, 24 th hour
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Mar 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing ANTERİOR QUADRATUS LUMBORUM BLOCK ( anterior QLB) in people with Percutaneous Nephrolithotomy (PCNL) and Perioperative Analgesia, run by Zonguldak Bulent Ecevit University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 23 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
intraoperative and total postoperative opioid consumption in the first 24 hours (time frame: first 24 hours after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Mar 2026.