Clinical trials: Anal Fissure Chronic
Chronic Anal Fissure
Percutaneous Tibial Nerve Stimulation - an Alternative Treatment Option for Chronic Therapy Resistant Anal Fissure
At a tertiary referral centre, 10 patients (4 male and 6 female; mean age 49.8 years) were given neuromodulation via the posterior tibial nerve to the sacral nerve for 30 min on 10 consecutive days.
- Trial name
- NCT03554421
- Testing
- Percutaneous tibial nerve stimulation
- Volunteers
- 10 people
- Sponsor
- Region Skane
Chronic Anal Fissure
AI-Assisted Written Information in Chronic Anal Fissure
This single-center, prospective, 1:1 randomized, parallel-group controlled superiority trial compares standard verbal counseling with AI-assisted written patient information in adults with primary chronic anal fissure receiving…
- Trial name
- AF-AI (NCT07701811)
- Testing
- AI-assisted written patient information, Standardized verbal counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people
- Sponsor
- Sanliurfa Education and Research Hospital
Chronic Anal Fissure
Treatment Of Chronic Anal Fissure
The purpose of this study is to investigate the effect of Levorag Emulgel compared with diltiazem gel on the healing of chronic anal fissures.
- Trial name
- TOCA (NCT02158013)
- Testing
- Levorag Emulgel, Diltiazem
- Where
- 2 sites in Denmark
- Volunteers
- 55 people
- Sponsor
- Bispebjerg Hospital
Anal Fissure Chronic
Short-Term Outcome of Medical Vs. Surgical Management Of Chronic Anal Fissure
Several topical agents have been proposed for Chronic anal fissure (CAF) treatment with the common goal of increasing anodermal blood flow to promote healing but approaching the use of medical treatment in CAFs is not…
- Trial name
- NCT06617026
- Testing
- Sucralfate, Azadirachtin, fissurectomy and lateral sphincterectomy
- Where
- Egypt
- Volunteers
- 99 people
- Sponsor
- Suez Canal University
Anal Fissure
Sungurtekin Technique vs. Closed Lateral Internal Sphincterotomy Technique
BACKGROUND: Currently, the lateral internal sphincterotomy is the treatment of choice for a chronic anal fissure. However, the length of the internal sphincter incision varies, due to lack of standardization.
- Trial name
- NCT04428697
- Testing
- Sungurtekin Technique
- Volunteers
- 200 people
- Sponsor
- Pamukkale University
Chronic Anal Fissure
An Open Label Study to Examine the Effect of Coated Nifedipine Suppository on Anal Fissure Pain and Healing in Human Subjects
This is an open label study. The study will consist of 1 treatment group: coated Nifedipine suppository containing 12 mg of Nifedipine, administered BID to subjects with chronic anal fissure.
- Trial name
- NCT00972907
- Testing
- Nifedipine coated suppositories
- Where
- 2 sites in Israel
- Volunteers
- 20 people
- Sponsor
- RDD Pharma Ltd
Anal Fistula, Anal Fissure Chronic
Effect of Enhanced Recovery After Surgery for Benign Anorectal Conditions
This study aims to assess the role of Enhanced recovery after surgery(ERAS) protocol in reducing postoperative urine retention (POUR) after surgery for benign anorectal conditions.
- Conditions
- Anal Fistula, Anal Fissure Chronic, Haemorrhoid, Enhanced Recovery After Surgery (ERAS) Protocol
- Trial name
- NCT06803550
- Testing
- Enhanced recovery after surgery protocol, Routine pathway
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Fissure in Ano
Complex Treatment of a Chronic Anal Fissure
This study is aimed at studying the efficacy and safety of treating chronic anal fissure with botulinum toxin versus lateral subcutaneous sphincterotomy.
- Trial name
- NCT03855046
- Testing
- IncobotulinumtoxinA 50 U Intramuscular Powder for Solution, Lateral subcutaneous sphincterotomy.
- Where
- 7 sites in Russia
- Volunteers
- 340 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Chronic Anal Fissure
Closed Versus Open Lateral Internal Sphincterotomy for Chronic Anal Fissure
This randomized controlled trial will compare closed versus open lateral internal sphincterotomy (LIS) under spinal anesthesia in patients with chronic anal fissure.
- Trial name
- LIS-CLOSED Tri (NCT07496216)
- Testing
- Closed Lateral Internal Sphincterotomy, Open Lateral Internal Sphincterotomy
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- Services Hospital, Lahore
Chronic Anal Fissures
Efficacy and Safety Study With Diltiazem Hydrochloride Cream to Treat Anal Fissures
The purpose of this study is to determine if the study drug, VEN307 (diltiazem hydrochloride cream) is safe and to see if it will help with treatment of pain associated with anal fissures.
- Trial name
- NCT01690221
- Testing
- VEN 307
- Where
- 103 sites in United States
- Volunteers
- 434 people
- Sponsor
- Ventrus Biosciences, Inc
Chronic Anal Fissure
Perianal Versus Endoanal Application of Glyceryl Trinitrate 0.4% Ointment for Chronic Anal Fissure
Perianal topical nitroglycerin has been widely used as a means for avoiding surgery in patients with anal fissure. However, nitroglycerin has not been universally accepted for this application because of inconsistency of efficacy…
- Trial name
- NCT01132391
- Testing
- Rectogesic® (glyceryl trinitrate 0.4% ointment)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital General Universitario Elche
Fissure in Ano
The Use of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure
use of platelet rich plasma had good effect in treating chronic wounds. healing of perianal fissure could be prolonged and associated with pain.
- Trial name
- NCT05837403
- Testing
- Platelet rich plasma injection, Nitroglycerin ointment
- Where
- Iraq
- Volunteers
- 460 people
- Sponsor
- Al-Kindy College of Medicine
Chronic Anal Fissure
Surgical Treatment of a Chronic Anal Fissure
This study is aimed at studying the effectiveness and safety of surgical treatment of chronic anal fissure.
- Trial name
- STCAF (NCT05117697)
- Testing
- lateral subcutaneous sphincterotomy
- Where
- 2 sites in Russia
- Volunteers
- 120 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Chronic Anal Fissure
Botulinum Toxin Type A in the Treatment of Chronic Anal Fissure
This study is aimed at studying the effectiveness and safety of surgical treatment of chronic anal fissure.
- Trial name
- BTATCAF (NCT05598164)
- Testing
- Botulinum toxin type A
- Where
- Russia
- Volunteers
- 140 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Anal Fissures Treatment and Oligoantigenic Diet
Oligo-antigenic Diet in the Treatment of Chronic Anal Fissures.
Patients with chronic constipation due to food hypersensitivity (FH) had an elevated anal sphincter resting pressure. No studies have investigated a possible role of FH in anal fissures (AF).
- Trial name
- NCT01637857
- Testing
- oligoantigenic diet
- Where
- Italy
- Volunteers
- 161 people
- Sponsor
- University of Palermo
Pain
Application of Vitamin E on Anal Fissure
Patients were randomized into 2 groups: Vitamin E: Vitamin E ointment will be applied during 8 weeks Nitroglycerin: Nitroglycerin ointment will be applied during 8 weeks Healing rate of chronic anal fissure in patients receiving…
- Trial name
- NCT03787030
- Testing
- Vitamin E Acetate ointment, Glyceryl trinitrate ointment
- Where
- Spain
- Volunteers
- 160 people
- Sponsor
- Hospital General Universitario Elche
Chronic Anal Fissure
The Effect of Intra-anal Nifedipine, Used As Add-on to Conservative Therapy, on Pain in Patients With Anal Fissure
The objective of the study is to examine the effect of Nifedipine, applied intra-anally through our drug delivery device, on rectal pain severity in anal fissure patients that are being managed with conservative treatment.
- Trial name
- NCT02527109
- Testing
- Nifedipine
- Where
- 24 sites in Bulgaria, Moldova and 2 more
- Volunteers
- 339 people
- Sponsor
- RDD Pharma Ltd
Fissure in Ano
Comparison of Injections of Botulinum Toxin and Topical Nitroglycerin Ointment for the Treatment of Chronic Anal Fissure
Patients will be randomized to receive treatment with either a total of 20 U of botulinum toxin(diluted in saline to a concentration of 50 U per milliliter.
- Trial name
- NCT05590520
- Testing
- Botulinum injection, GTN OINTMENT
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Pak Emirates Military Hospital
Fissure in Ano, Rectal Diseases
Diltiazem Ointment With Lidocaine vs. Nifedipine Ointment With Lidocaine Ointment for Treatment of Chronic Anal Fissure
Anal fissure is a common anorectal diseases characterized by tear of the anoderm from the dentate line to the anal verge leading to pain and bleeding during and post defecation.
- Conditions
- Fissure in Ano, Rectal Diseases, Rectal Bleed
- Trial name
- NCT04887818
- Testing
- 2% Diltiazem ointment with 1.5% lidocaine, 0.3% Nifedipine ointment with 1.5% lidocaine
- Where
- Canada
- Volunteers
- 430 people
- Sponsor
- University of Calgary
Anal Fissure, Microbial Colonization
Microbiota in Chronic Anal Fissure and Its Association With Prognosis
In this study, we will try to answer the following questions: 1. What are the salient features of the microbiota in chronic anal fissure? 2. Are these features associated with prognosis and response to therapy? 3.
- Trial name
- NCT05405634
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lasse Krogsbøll