Clinical trials: Altered Level of Consciousness
Consciousness, Level Altered
Investigating Near-Threshold Perception During Ultrasonic Deep Brain Stimulation
This research is studying changes in awareness and metabolism in the brain that may take place in various brain regions stimulated with ultrasound (low-intensity focused ultrasound pulsation or LIFUP) while undergoing magnetic…
- Trial name
- NCT07840521
- Testing
- Low-intensity focused ultrasound pulsation (LIFUP), Functional Magnetic Resonance Imaging (fMRI), Magnetic Resonance Spectroscopy
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Consciousness Disorders, Brain Injury
Paired Vagus Nerve Stimulation in Mobilization of Patients With Prolonged Disorders of Consciousness
Prolonged disorders of consciousness (pDOC) are defined as DOC lasting >1 year post injury for patients with Traumatic Brain Injury (TBI) and >3 months post injury for patients with non-TBI and at present there are limited…
- Conditions
- Consciousness Disorders, Brain Injury, Altered Level of Consciousness
- Trial name
- NCT06930716
- Testing
- Transcutaneous vagus nerve stimulation (taVNS), Physical therapy using Hocoma, Standard of Care
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Anesthesia, Healthy
REcovery From DEXmedetomidine-induced Unconsciousness
This pilot study in healthy volunteers aims to determine if biological sex has an impact on recovery from dexmedetomidine-induced unconsciousness, and if transcranial magnetic stimulation combined with electroencephalography…
- Conditions
- Anesthesia, Healthy, Consciousness, Level Altered
- Trial name
- REDEX (NCT06003127)
- Testing
- Transcranial Magnetic Stimulation-Electroencephalography
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Brain Injury Traumatic Severe (Diagnosis), Coma
Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of Consciousness
Phase 1 of the STIMPACT trial is an open label,dose-escalation,safety study of intravenous (IV) methylphenidate (MPH) therapy in patients with disorders of consciousness (DoC) caused by severe brain injuries.
- Conditions
- Brain Injury Traumatic Severe (Diagnosis), Coma, Consciousness, Level Altered, Anoxic Brain Injury
- Trial name
- STIMPACT (NCT03814356)
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Mechanical Ventilator Weaning, Acute Brain Injury
Brain-injured Patients Extubation Readiness Study
The BIPER study is a stepped wedge cluster randomised clinical trial aiming to decrease extubation failure in critically-ill brain-injured patients with residual impaired consciousness using a simple clinical score.
- Conditions
- Mechanical Ventilator Weaning, Acute Brain Injury, Altered Level of Consciousness, Mechanical Ventilation
- Trial name
- Biper (NCT04080440)
- Testing
- Extubation readiness clinical score, Usual Care
- Where
- 21 sites in France
- Volunteers
- 660 people
- Sponsor
- University Hospital, Clermont-Ferrand
Consciousness, Level Altered
The Electroencephalographic Mechanisms of Anesthesia and Human Consciousness
In the field of general anesthesia research, the neural mechanism underlying the loss of consciousness has long been a highly core issue. It remains unclear what consciousness is and how it emerges from brain activity.
- Trial name
- NCT07145697
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Hypotension, Consciousness, Level Altered
The Effect of phoSPHocreatine on mEdical Emergency Team (Met) tREated Patients
Unexpected deaths and unplanned intensive care unit (ICU) admissions are common during hospital stay and are often preceded by warning abnormalities in patients' vital signs.
- Conditions
- Hypotension, Consciousness, Level Altered, Airway Disease, Respiratory Failure
- Trial name
- SPHERE (NCT06503016)
- Testing
- Phosphocreatine
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Università Vita-Salute San Raffaele
Mental Health Wellness 1, Happiness
Effects of an 8-day Advanced Meditation, Samyama on Physical, Psychological and Spiritual Wellbeing ,and Associated Neural Mechanisms
The purpose of this study is to investigate the effects of Samyama program on blood levels of selected neurotransmitters before and after the program, and associate with corresponding effects on mind/psyche before and after the…
- Conditions
- Mental Health Wellness 1, Happiness, Depression, Consciousness, Level Altered
- Trial name
- NCT04366544
- Testing
- Part A1: Survey, Part A2: Sample collection, Part B:
- Where
- United States
- Volunteers
- 759 people, healthy volunteers welcome
- Sponsor
- Indiana University
Nursing Caries, Consciousness, Level Altered
Mindfulness Training in Nurses and Its Effect on Work Stress
The aim of the study, which was planned in the experimental design type, was to determine the effect of the mindfulness-based stress reduction training on nurses' job stress.
- Trial name
- NCT06029205
- Testing
- Conscious Awareness-Based Educatıon, Stress coping training
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Poisoning, Consciousness, Level Altered
Non-invasive Airway Management of Comatose Poisoned Emergency Patients
A decreased level of consciousness is a common reason for presentation to the emergency department (ED) and is often the result of intoxication (up to 1% of all ED visits and 3% of ICU admission).
- Conditions
- Poisoning, Consciousness, Level Altered, Comatose
- Trial name
- NICO (NCT04653597)
- Testing
- Close monitoring, Endotracheal intubation
- Where
- France
- Volunteers
- 237 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Status Epilepticus, Altered Level of Consciousness
eegCap Application in Paediatrics wiTh redUced GCS in REsus
Children frequently present with altered or reduced consciousness levels to emergency departments. By using EEG monitoring, subclinical seizure activity may be detected, leading to earlier pharmacological intervention and…
- Conditions
- Status Epilepticus, Altered Level of Consciousness, Non-epileptic Seizures, Epilepsy
- Trial name
- CAPTURE (NCT05259891)
- Where
- Ireland
- Volunteers
- 20 people
- Sponsor
- University College Cork
Acquired Brain Injury, Consciousness, Level Altered
Physical Activity on Heart Rate Variability in Patients With Severe Acquired Brain Injury
This study aims to explore autonomic cardiovascular regulation, through measures of heart rate variability (HRV), during different passive and active activities in patients with severe acquired brain injury and a low conscious…
- Trial name
- NCT03328221
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Monitoring, Physiologic, Vital Signs
Bodytrak® Feasibility Study
Bodytrak® is a wireless earpiece which can monitor the user's vital signs such as tympanic (ear) temperature and heart rate. The earpiece is non-invasive and should fit comfortably within the right ear, similar to an earphone…
- Conditions
- Monitoring, Physiologic, Vital Signs, Sepsis, Altered Level of Consciousness
- Trial name
- NCT03139955
- Testing
- Bodytrak
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Inova Design Solutions Ltd
Altered Level of Consciousness
Documentation of Altered Mental Status
Altered mental status (AMS) is common in older patients. However there is a lack of standardization in the definition and documentation of this compliant.
- Trial name
- NCT03040843
- Where
- Turkey (Türkiye)
- Volunteers
- 1,200 people
- Sponsor
- Nevsehir Public Hospital
Consciousness, Level Altered
The Neural Mechanisms of Anesthesia and Human Consciousness
The explanation of consciousness poses one of the greatest challenges to science and philosophy in the 21st century. It remains unclear what consciousness is and how it emerges from brain activity.
- Trial name
- LOC-2013 (NCT01889004)
- Testing
- Dexmedetomidine, Propofol
- Where
- Finland
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Turku