Clinical trials: Alteration in Cognition
Cognitive Change, Atrophy Brain
Physiologic Volume and Atrophy of Brain and Spinal Cord Measured by Magnetic Resonance Imaging
Spinal cord (SC) involvement is prevalent in multiple sclerosis (MS) and contributes importantly to disease progression. To be able reliably evaluate spinal cord volume and its changes in MS patients we need to understand…
- Conditions
- Cognitive Change, Atrophy Brain, Atrophy; Spinal Cord, Multiple Sclerosis
- Trial name
- NCT03706118
- Testing
- Magnetic resonance imaging
- Where
- Czechia
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Dana Horakova
Schizophrenia and Related Disorders, Sleep Disturbance
SPARK Healthy Sleep
SPARK-Healthy Sleep is a digital mental health intervention designed to help college students who may be at risk for psychosis and experience sleep problems.
- Trial name
- SPARK (NCT07119268)
- Testing
- SPARK Healthy Sleep
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Indiana University
Cognitive Change
Neural Mechanisms of Mindfulness
This project focuses on understanding the cognitive and neural mechanisms by which mindfulness training (MT) results in positive behavioral change and enhanced psychological well-being.
- Trial name
- NCT03466164
- Testing
- Mindfulness Based Stress Reduction Program
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Chewing Problem, Cognitive Decline
Cognitive Changes and Neural Correlates After Rehabilitation of Masticatory Function in Elderly -an Intervention Study
Today in elderly tooth loss and loss of oral function is widespread, but it is an underexplored modifiable risk factor potentially contributing to the development of dementia.
- Conditions
- Chewing Problem, Cognitive Decline, Magnetic Resonance Imaging, Degenerative; Dementia
- Trial name
- NCT04458207
- Testing
- Oral prosthetic rehabilitation
- Where
- 2 sites in Sweden
- Volunteers
- 80 people
- Sponsor
- Folktandvården Stockholms län AB
Cognitive Change
Brain Exercises for Synaptic Plasticity
The BEST study will investigate the feasibility of cognitive interventions in a randomized, placebo-controlled, clinical trial. The investigators will recruit 45 cognitively normal subjects and engage them in one of three cohorts…
- Trial name
- BEST (NCT03058055)
- Testing
- Origami, Reading
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Subthreshold Depression, Exercise
The Effect of Exercise on Cognition and Preventing Depression in Young People
It is estimated that approximately 30% of child and adolescents manifest subthreshold depression (including other specified depressive disorder and unspecified depressive disorder), which can further develop into major depression…
- Conditions
- Subthreshold Depression, Exercise, Clinically-well, Cognitive Change
- Trial name
- NCT04816617
- Testing
- Aerobic exercise intervention, Psycho-education
- Where
- China
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- Guangzhou Psychiatric Hospital
Aging Well, Aging Problems
Aquatic Exercise for Cognition and Mobility in Older Adults
The purpose of this study is to assess the effects of an aquatic exercise program on cognition and physical function of older adults.
- Conditions
- Aging Well, Aging Problems, Cognitive Change, Gait, Unsteady
- Trial name
- NCT05501249
- Testing
- Aquatic Integrated Cognitive Motor Training
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Emily Dunlap
Postoperative Cognitive Dysfunction, Mild Cognitive Impairment
Cognitive Changes After Major Joint Replacement
Patients assume that cognitive performance rapidly returns to baseline after anesthesia and surgery. Several studies have shown that one week after major non-cardiac surgery about 27% of patients have postoperative cognitive…
- Conditions
- Postoperative Cognitive Dysfunction, Mild Cognitive Impairment, Delirium, Cognitive Deficit
- Trial name
- Cognigram (NCT02964221)
- Testing
- Cognitive Testing
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dr. Stephen Choi
Alteration of Cognitive Function
The Effect of Breakfast Size Prior to Morning Exercise on Cognition, Mood and Appetite in Habitually Active Women
Both regular exercise and breakfast consumption have well known health benefits. Consuming breakfast prior to morning exercise may influence appetite, mood and cognitive function later in the day.
- Trial name
- NCT01711008
- Testing
- Cereal, No breakfast
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Stress, Mood
Effects of Indena's Virtiva® Plus Ginkgo Biloba Extract on Stress, and Cognitive Performance
This is a randomized, double-blind, 5-week intervention clinical study that aims to investigate the dose-dependent effects of Virtiva® Plus on stress, and cognitive performance in participants experiencing heightened stress.
- Conditions
- Stress, Mood, Cognitive Change
- Trial name
- NCT06583941
- Testing
- Low Dose Virtiva Plus, High Dose Virtiva Plus
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Memory Deficits, Cognitive Change
An Exploratory Investigation of a Supplement to Promote Brain Health
Providing a combination of synergistic dietary supplements, such as vitamins B6, B12, and folate, as well as curcumin, lemon balm, and American ginseng is hypothesized to promote brain health and aid with brain fog, mental…
- Conditions
- Memory Deficits, Cognitive Change, Stress
- Trial name
- NCT05520424
- Testing
- The Daily Supplement
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Parable
Stress, Cognitive Change
Surviving Daily Life
The primary goal of this project is to evaluate the feasibility of a 14-day mobile daily diary study among racially diverse breast cancer survivors.
- Conditions
- Stress, Cognitive Change, Breast Cancer, Breast Carcinoma
- Trial name
- GOCE (NCT07054723)
- Testing
- Mobile Daily Diary
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Thomas Jefferson University
Cognitive Change
Yoga Training and Retinal Vasculature
This study will compare the impact of a novel high-speed, cued yoga program to a standard yoga program on retinal microvasculature, cognition and neuromuscular function.
- Trial name
- NCT06099405
- Testing
- High-speed, Cognitive Challenge Yoga, Traditional yoga
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Miami
Sleep, Sleep Deprivation
Resilience to Sleep Deprivation and Changes in Sleep Architecture in Shoonya Meditators
This study aims to investigate the effect of a 15-minute meditation practice on sleep architecture and high-frequency Heart Rate Variability (HF-HRV), as well as cognitive performance after both a well-rested and sleep-deprived…
- Conditions
- Sleep, Sleep Deprivation, Cognitive Change
- Trial name
- REST (NCT05026541)
- Testing
- Nap Practitioners, Shoonya Meditation
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Diabetes Mellitus, Type II, Hypoglycemia
Effects of Mild Hypoglycaemia on Cognitive Function in Type 2 Diabetes
Hypoglycaemia in subjects suffering from type 2 diabetes may have substantial consequences including a significant negative impact on quality of life.
- Conditions
- Diabetes Mellitus, Type II, Hypoglycemia, Cognitive Change
- Trial name
- NCT03014011
- Testing
- Hypoglycaemic clamp, Euglycaemic clamp
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Bispebjerg Hospital
Cognitive Change, Effects of Ginseng on Cognitive Function
Investigating the Acute and Chronic Effects of an American Ginseng Root Extract on Cognition and Mood
Ginseng refers to the extract of any slow growing perennial plant with a fleshy root, deriving from the Panax genus of the Araliaceae family.
- Trial name
- NCT03579095
- Testing
- Cereboost
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Reading
Cognitive Change, Inflammation
NAD+ Oral Supplement Pilot Intervention in Adult Females
The goal of this clinical trial is to learn whether Nicotinamide adenine dinucleotide (NAD+) can influence cognition and biomarkers in healthy, cognitively intact women aged 40-80.
- Conditions
- Cognitive Change, Inflammation, Neurodegenerative Diseases
- Trial name
- NCT06579209
- Testing
- Treatment
- Where
- 2 sites in United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Avitaminosis, Delirium, Dementia, Amnestic, Cognitive Disorders
Interaction of Cobalamin Status With Nitrous Oxide in Relation to Postoperative Cognitive Changes in the Elderly
Low cobalamin (vitamin B12) levels are frequent in the elderly. Most often they reflect a mild metabolic abnormality without clinical symptoms (subclinical cobalamin deficiency).
- Trial name
- NCT00212147
- Testing
- General anesthesia with nitrous oxide, General anesthesia without nitrous oxide
- Where
- 2 sites in United States
- Volunteers
- 444 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cognitive Change
Mindfulness Training for Senior Leaders
The overarching goal of the project is to investigate if a mindfulness-based attention training (MBAT) program contextualized for Military Senior Leaders (SLs) might benefit SLs in three key domains: (1) cognitive abilities, (2)…
- Trial name
- NCT04576832
- Testing
- Mindfulness-Based Attention Training (MBAT) web-course
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Miami
Cognitive Change
CMI-168 on Cognitive Function in Healthy Middle-aged Men and Women
The investigators propose to conduct the present study in order to primarily assess the effects of CMI-168 in neurocognition enhancement.
- Trial name
- NCT03612752
- Testing
- CMI-168
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cerebos Pacific Limited