Clinical trials: Alteplase
Acute Distal Vessel Occlusion Stroke
Early Recanalization After Intravenous Thrombolysis With Tenecteplase Versus Alteplase in Distal Vessel Occlusion Strokes
The purpose of this monocentric retrospective study is to compare, in patients with acute distal vessel occlusion stroke, the early rates of successful recanalization in patients treated with Alteplase (ALT) versus Tenecteplase…
- Trial name
- DISTAL-IVT (NCT05635786)
- Testing
- Alteplase (0.9mg/kg), Tenecteplase (0.25mg/kg)
- Where
- France
- Volunteers
- 319 people
- Sponsor
- Centre Hospitalier Sud Francilien
Ischemic Stroke
Combination Anti-Platelet and Anti-Coagulation Treatment After Lysis of Ischemic Stroke Trial (CATALIST)
Ischemic stroke is caused by a blood clot that blocks the flow of blood to the brain and damages brain cells. The clot, or thrombus, is made up of platelets and fibrin.
- Trial name
- CATALIST (NCT00061373)
- Testing
- Aspirin, tinzaparin sodium, eptifibatide
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Acute Stroke
A Study of Intravenous Thrombolysis With Alteplase in MRI-Selected Patients
This study was jointly developed and is jointly led by investigators at Massachusetts General Hospital and the intramural division of NINDS.
- Trial name
- MR WITNESS (NCT01282242)
- Testing
- IV rt-PA
- Where
- 14 sites in United States
- Volunteers
- 88 people
- Sponsor
- Lee Schwamm
Stroke, Acute
The Intravascular Cooling in the Treatment of Stroke 2/3 Trial
The purpose of this trial is to determine whether the combination of thrombolysis and hypothermia is superior to thrombolysis alone for the treatment of acute ischemic stroke.
- Trial name
- ICTuS2/3 (NCT01123161)
- Testing
- hypothermia and anti-shivering treatment, Group1: IV t-PA and normothermia
- Where
- 31 sites in United States, Austria and 1 more
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Pleural Infection, Empyema
Fibrinolysis Compared to Thoracoscopy for Pleural Infection
The purpose of this prospective randomized clinical trial is to compare two currently accepted standard-of-care treatment strategies: Medical thoracoscopy as compared to instillation of intrapleural tissue Plasminogen Activator…
- Conditions
- Pleural Infection, Empyema, Pleural Diseases, Parapneumonic Effusion
- Trial name
- NCT03468933
- Testing
- tissue plasminogen activator (tPA) and human recombinant deoxyribonuclease (DNase), Medical Thoracoscopy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Tulane University
Myocardial Infarction
Female Sex is an Independent Predictor of Death and Bleeding Among Fibrinolytic Treated Patients With AMI
This study evaluated differences between men and women in the presentation, management and outcome of heart attacks within the GUSTO V study.
- Trial name
- NCT00245648
- Testing
- fibrinolytic therapy or combination reduced fibrinolytic therapy
- Where
- United States
- Sponsor
- NYU Langone Health
Intracranial Embolism, Thrombosis
Ultrasound Enhanced Thrombolytic Therapy of Middle Cerebral Artery Occlusion
The purpose of the present, randomized, controlled multicenter phase III trial is to investigate the safety and efficacy of continuous 1-hour insonation of occluded middle cerebral artery with 2 MHz TCCS in stroke patients…
- Trial name
- NCT00336596
- Testing
- transcranial ultrasound in patients treated with iv t-PA
- Where
- 6 sites in Switzerland
- Volunteers
- 400 people
- Sponsor
- University of Zurich
Acute Ischemic Stroke
Thrombolysis Treated With TNK-tPA in Acute Ischemic Stroke Patients （3T Stroke-II）
The trial is prospective, block randomized, open-label, blinded endpoint (PROBE) design. Patients with acute ischemic stroke, who are eligible for standard intravenous thrombolysis within 4.5 hours of stroke onset will be…
- Trial name
- NCT05281549
- Testing
- Alteplase, Tenecteplase
- Where
- 28 sites in China
- Volunteers
- 225 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Ischemic Stroke
Feasibility Study of IV Recombinant Tissue Plasminogen Activator (rtPA) vs. Primary Endovascular Therapy for Acute Ischemic Stroke
This pilot trial will be the first step toward direct comparison of delivery of endovascular reperfusion therapy to intravenous recombinant tissue plasminogen activator (rt-PA) in a time-to-treatment framework shown as most…
- Trial name
- EARLY (NCT01869478)
- Testing
- Intravenous Thrombolysis, Endovascular Arterial Reperfusion
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Stroke
Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis- (ATTEST)
A pilot evaluation of tenecteplase compared to alteplase in acute ischaemic stroke patients currently eligible for intravenous alteplase treatment in a prospective, randomised, blinded outcome evaluation clinical trial using…
- Trial name
- ATTEST (NCT01472926)
- Testing
- Tenecteplase, alteplase
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- NHS Greater Glasgow and Clyde
Ischemic Stroke
Efficacy and Safety of SP-8203 (Otaplimastat) in Patients With Acute Ischemic Stroke Receiving Thrombolytic Standard of Care
This clinical study is designed to evaluate the efficacy and safety of the combination therapy of SP-8203 (otaplimastat) and thrombolytic standard of care in acute ischemic stroke patient.
- Trial name
- SP-8203-3001 (NCT06660719)
- Testing
- SP-8203
- Where
- 2 sites in South Korea
- Volunteers
- 852 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Ischemic Stroke
Early Mobilization of Ischemic Stroke Patients Within 24-hours After Intravenous-Tissue Plasminogen Activator (IV-tPA)
The purpose of this study is to study the safety and feasibility of mobilization of acute ischemic stroke patients treated with IV-tPA between 12-24 hours of treatment.
- Trial name
- EMISTPA (NCT01331200)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Stroke
Thrombolytic Care During Inter-hospital Transfer
Evaluation of ischemic stroke patients receiving tissue plasminogen activator (rtPA) during air ambulance transfer
- Trial name
- NCT02752256
- Testing
- Tissue Plasminogen Activator
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Ischemic Stroke
Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants
DO-IT is an international, prospective observational registry evaluating whether the administration of intravenous thrombolysis (IVT) is safe and improves functional outcome in ischemic stroke patients with recent direct oral…
- Trial name
- DO-IT Cohort (NCT06556446)
- Testing
- Tenecteplase and Alteplase
- Where
- 33 sites in Austria, Belgium and 13 more
- Volunteers
- 2,800 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Stroke
A Multicenter, Retrospective, Observational Cohort Study on Intravenous Thrombolysis Beyond the Time Window for Acute Ischemic Stroke
A multicenter, retrospective, observational cohort study on intravenous thrombolysis beyond the time window for acute ischemic stroke
- Trial name
- TRAILBLAZER (NCT07419997)
- Where
- China
- Volunteers
- 2,600 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke
Endovascular Stroke Treatment Only (ESTO) Trial
The specific aims of this study are to: 1. Determine whether the endovascular treatment (mechanical thrombectomy) alone without using intravenous (IV) recombinant tissue plasminogen activator (rt-PA) in acute ischemic stroke…
- Trial name
- NCT04240470
- Testing
- Thrombectomy
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Missouri-Columbia