Clinical trials: Allogeneic Transplantation
Degenerative Disc Disease
Study to Assess the Performance of MagnEtOs Flex Matrix Compared to Cellular Allograft
The purpose of this study is to demonstrate the performance of MagnetOs Flex Matrix in patients with leg pain and/or back pain.
- Trial name
- NCT06415123
- Testing
- MagnetOs Flex Matrix
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Research Source
Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Chronic Lymphocytic Leukemia
Allogeneic Stem Cell Transplant for CLL
This phase I/II trial studies the best dose and side effects of gemcitabine and how well it works with clofarabine and busulfan and donor stem cell transplant in treating participants with chronic lymphocytic leukemia.
- Conditions
- Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia, Richter Syndrome
- Trial name
- NCT01629511
- Testing
- Allogeneic Hematopoietic Stem Cell Transplantation, Anti-Thymocyte Globulin, Busulfan
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Hematological Malignancies
Allogeneic HCT With HLA-matched Donors : a Phase II Randomized Study Comparing 2 Nonmyeloablative Conditionings
The present project aims at comparing two nonmyeloablative regimens currently used in 2 major HCT centers in the US for patients with HLA-matched related or unrelated donor: the one from the Seattle group consisting of 2 Gy TBI…
- Trial name
- NCT00603954
- Testing
- Conditioning regimen: TBI + Fludarabine, Conditioning regimen:TLI (8 Gy) + ATG
- Where
- 11 sites in Belgium, Netherlands
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Liege
Chronic Periodontitis
Evaluation of Amnion Chorion Membrane and Demineralized Bone Matrix Putty Allograft in Periodontal Intrabony Defects
A clinical and radiographic evaluation of 2 regenerative techniques, bioresorbable membrane and bone allograft for management of periodontal intrabony defects.
- Trial name
- NCT02679209
- Testing
- Demineralized bone matrix in putty form, Amnion chorion membrane
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Diseases
Periodontal Regeneration With Recombinant Human Platelet Derived Growth Factor (rH-PDGF-BB) and Allograft
Growth factors are defined as small proteins that trigger a cellular response after binding to cell receptors; Tissue engineering is now clinically applicable in a commercially available system involving the use of recombinant…
- Trial name
- NCT06162832
- Testing
- Allograft and rHPDGF-BB, Allograft and Saline solution
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Nuevo Leon
Bone Graft, Tooth Extraction
Ridge Preservation With FDBA (Freeze Dried Bone Allograft) Using Dexamethasone vs. Saline
Following the removal of a tooth, a bone graft is often placed in the socket to try to maintain the volume of bone that was there when the tooth was present so that the bone does not "shrink".
- Trial name
- NCT06556095
- Testing
- Dexamethasone 4mg/ml solution
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Graft-versus-host Disease (GVHD)
The Application of Novel Identified CD8 Regulatory Precursors in Inducing Immune Tolerance After Allo-HSCT
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the most effective treatment for acute leukaemia. The reconstitution of the recipient's immune system with donor-derived HSCT cells and the development of immune…
- Trial name
- NCT06864598
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Leukemia, Hematopoetic Stem Cell Transplantation
Exercise as an Immune Adjuvant for Allogeneic Cell Therapies
This study aims to improve the treatment of blood cancer by using exercise to collect healthier immune cells from donors. Allogeneic adoptive cell therapy is a treatment where immune cells from a healthy donor are given to a…
- Conditions
- Leukemia, Hematopoetic Stem Cell Transplantation, Donor Lymphocyte Infusion, CAR T-Cell Therapy
- Trial name
- Allo-X (NCT06643221)
- Testing
- Exercise, Isoproterenol, Bisoprolol Fumarate Tablet 10 mg
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Apicomarginal Defects
TO DETERMINE THE EFFECT OF ALLOGRAFT AND iPRF WITH OR WITHOUT COLLAGEN MEMBRANE ON HEALING OF APICOMARGINAL DEFECTS
To determine the effect of allograft and iPRF with or without collagen membrane on healing of apicomarginal defects : A Randomized Controlled Trial
- Trial name
- NCT07048171
- Testing
- Endodontic Micro-Surgery
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Graft Failure, Sickle Cell Disease
Allo HSCT for High Risk Hemoglobinopathies
A single center, open label, interventional, phase II trial for donor transplant for high risk hemoglobinopathies and other red cell transfusion dependent disorders utilizing allogeneic hematopoietic stem cell transplantation…
- Conditions
- Graft Failure, Sickle Cell Disease, Hemoglobinopathies
- Trial name
- NCT06872333
- Testing
- Alemtuzumab, Total Body Irradiation, Cell Infusion
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Immediate Implant Placement, Gap Filling With e-PRF
Extended Platelet Rich Fibrin Versus Allograft as Space Filling Material
Twenty-eight patients seeking prosthetic replacement of non-restorable single rooted maxillary teeth by dental implant will be selected from the outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of…
- Conditions
- Immediate Implant Placement, Gap Filling With e-PRF, Gap Filling With Allograft
- Trial name
- NCT07445776
- Testing
- Allograft, e-PRF
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Transplant
Technology Enabled And Molecular Monitoring of the Allograft and Transplant rEcipient
The primary objective of the study is to assess the impact of AlloCare mHealth remote monitoring on the early post-transplant period in solid organ transplantation.The outcome measure for primary objective is overall reduction in…
- Trial name
- TEAMMATE (NCT05033548)
- Where
- 10 sites in United States
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- CareDx
Tooth Extraction
Histological Comparison of Ridge Preservation Using Mineralized FDBA Alone Versus a Combined Mineralized-Demineralized Freeze Dried Bone Allograft
This entire protocol involves procedures that are standard care. The purpose of the research is to evaluate whether there are any differences in new bone formation following tooth extraction and grafting of the extraction socket…
- Trial name
- NCT01924390
- Testing
- Mineralized freeze-dried bone allograft alone, Combination of Mineralized and demineralized freeze-dried bone allograft alone
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Leukemia, Lymphoid, Leukemia, Myeloid
Myeloid-Derived Suppressor Cells and Checkpoint Immune Regulators' Expression in Allogeneic SCT Using FluBuATG
This study is examining a chemotherapy regimen and immune suppressive medications in the setting of an allogeneic stem cell transplant.
- Conditions
- Leukemia, Lymphoid, Leukemia, Myeloid, Myelodysplastic Syndromes, Myelofibrosis
- Trial name
- FluBuATG (NCT02916979)
- Testing
- Fludarabine, Busulfan, Rabbit ATG
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Osteoarthritis Hand
Use of Allograft Adipose Matrix for Small Joint Arthritis of the Hand
The purpose the research is to evaluate the safety and efficacy of injection of adipose allograft matrix (AAM) to the small joints of the hand for treatment of early stage osteoarthritis.
- Trial name
- NCT05747469
- Testing
- local anaesthetic injection, Human Adipose Allograft
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Periodontal Diseases
Amnion-Chorion Allograft Barrier Used for Root Surface and Guided Tissue Regeneration
The purpose of this pilot project is to evaluate the efficacy of application of Amnion-Chorion allograft membrane on the root surface of periodontally diseased teeth in conjunction with bone substitute covered by Amnion-Chorion…
- Trial name
- NCT03095976
- Testing
- Amnion-Chorion allograft membrane on the root surface of periodontally diseased site.
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Indiana University
Pelvic Organ Prolapse
Anterior Prolapse Repair With and Without Graft Augmentation
This is a randomized control trial comparing anterior colporrhaphy with augmentation with dermal allograft (ARCUS) to anterior colporrhaphy with a suture-based repair (native tissue).
- Trial name
- ARCUS (NCT04085952)
- Testing
- dermal graft (ARCUS repliform) for anterior colporrhaphy, suture based anterior colporrhaphy
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Sinus; Dental, Implant Complication
Evaluation of the Efficacy of Allograft Versus Tenting Technique in Open Sinus Lifting With Immediate Implant Placement
Implant placement in deficient posterior maxilla is a challenging clinical situation that necessitates appropriate treatment options to restore this area.
- Conditions
- Sinus; Dental, Implant Complication, Surgery-Complications
- Trial name
- NCT06254378
- Testing
- Sinus lifting with allograft, Sinus lifting without graft
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Acute Myelogenous Leukemia
Randomized Study of Haploidentical Hct and Subsequent Donor nk Cell Infusion in High-risk AML and MDS
This is a single center, open label, random comparison phase 2b study. The primary objective of this study is, by random comparison, to assess the anti-leukemia effect of allogeneic, donor-derived natural killer (NK) cells…
- Trial name
- DNKI-4 (NCT02477787)
- Testing
- allogeneic, donor-derived NK cells
- Where
- South Korea
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Severe Combined Immunodeficiency
Study Through Imaging of Visceral Lymphoid Organs in Patients With SCID Who Have Recieved Bone Marrow Allograft
To investigate the presence of seconday of lymphoid organs in patients who underwent allogenic hematopoietic stem cell transplantation 15 to 45 years ago.
- Trial name
- LymphImaging (NCT04246840)
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Association Pour l'Aide a la Recherche en Immunologie Pediatrique