Immediate Implant PlacementNCT07445776
Extended Platelet Rich Fibrin Versus Allograft as Space Filling Material
A study testing Allograft and e-PRF in people with Immediate Implant Placement and Gap Filling With e-PRF, run by Mansoura University at 1 site in Egypt.
Trial summary
Twenty-eight patients seeking prosthetic replacement of non-restorable single rooted maxillary teeth by dental implant will be selected from the outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University Read more about this study
- Who is it for?
- Ages 18 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Immediate Implant Placement, Gap Filling With e-PRF, Gap Filling With Allograft
- What is being tested?
- Allograft and e-PRF
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 28 participants
- Where
- 1 siteEgypt
- Study dates
- 1 May 2024to 1 Sep 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Patients with badly destructed teeth due to trauma or caries.
- Patients willing to complete the study follow up intervals.
- Patients with good oral hygiene.
- Adequate inter-arch space that can accommodate implant abutment and future restoration.
- No gender preference in selection of the patients.
Who cannot join
- Patients with systemic diseases that absolutely contraindicate dental implant placement.
- Patients with parafunctional habits (bruxism and clenching).
- Heavy smokers (i.e. More than 20 cigarettes/day)34 and alcoholism.
- Presence of local infection or lesions at the proposed area for dental implant.
- Pregnancy.
- Patient taking drugs that could affect bone healing process as immunosuppressive drugs and bisphosphonates.
- Patients with bad oral hygiene and untreated periodontal disease
- Uncooperative patients
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Extended Platelet Rich Fibrin Versus Allograft as Space Filling Material in Immediate Dental Implant Placement
Twenty-eight patients seeking prosthetic replacement of non-restorable single rooted maxillary teeth by dental implant will be selected from the outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University
- Being tested
- Allograft, e-PRF
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AllograftOther
after immediate implant placement the gap will be filled with allograft
e-PRFOther
after immediate implant placement the gap will be filled with e-PRF
| Study group | Role | What they receive |
|---|---|---|
| Group 1 | Experimental | 14 immediate implants placed in the maxillary esthetic zone then placement of allograft in the gap distance around the implant. Receives: Other: Allograft |
| Group 2 | Experimental | 14 immediate implants placed in the maxillary esthetic zone then placement of e-PRF in the gap distance around the implant. Receives: Other: e-PRF |
What is being measured
The primary outcome is the main question the study is designed to answer.
Implant stability
Resonance frequency analysis (RFA) values expressed as implant stability quotient (ISQ) will be recorded by (Osstell Mentor Device)
Measured: immediately ,6months follow up & one year
Secondary outcomes (1)
Marginal bone loss
CBCT was done to assess the buccal marginal bone loss
Measured: immeditely,6months follow up & one year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Mar 2026
- Study start1 May 2024
- Primary completion1 Sep 2024
- Study completion1 Sep 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Immediate Implant PlacementStudies of the same condition, open and under way.
- More trials run by Mansoura UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 28 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mansoura University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hala Elnaggar, Mansoura University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07445776
- Sponsor's protocol ID
- A0303024OS
- Status last verified
- Feb 2026
- First submitted
- 25 Feb 2026
- Last updated
- 3 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Elnaggar HMMA, El-Gohary N, Yaseen AAM, Tawfik MA. Extended platelet rich fibrin versus allograft as a space filling material in immediate dental implant placement. BMC Oral Health. 2026 Jun 29;26(1):1130. doi: 10.1186/s12903-026-08891-6.
PubMed 42374383
Study at a glance
From the registry record, last updated by the sponsor on 3 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Extended Platelet Rich Fibrin Versus Allograft as Space Filling Material in Immediate Dental Implant Placement
- ClinicalTrials.gov ID
- NCT07445776
- Acronym / sponsor ID
- A0303024OS
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 28 participants (actual)
- Lead sponsor
- Mansoura UniversityUniversity, hospital or other
- Study start
- 1 May 2024 (actual)
- Primary completion
- 1 Sep 2024 (actual)
- Study completion
- 1 Sep 2025 (actual)
- First posted
- 3 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Twenty-eight patients seeking prosthetic replacement of non-restorable single rooted maxillary teeth by dental implant will be selected from the outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group 1 | Experimental | Other: Allograft14 immediate implants placed in the maxillary esthetic zone then placement of allograft in the gap distance around the implant. |
| Group 2 | Experimental | Other: e-PRF14 immediate implants placed in the maxillary esthetic zone then placement of e-PRF in the gap distance around the implant. |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Patients with badly destructed teeth due to trauma or caries.
- Patients willing to complete the study follow up intervals.
- Patients with good oral hygiene.
- Adequate inter-arch space that can accommodate implant abutment and future restoration.
- No gender preference in selection of the patients.
Key exclusion criteria (8 listed)
- Patients with systemic diseases that absolutely contraindicate dental implant placement.
- Patients with parafunctional habits (bruxism and clenching).
- Heavy smokers (i.e. More than 20 cigarettes/day)34 and alcoholism.
- Presence of local infection or lesions at the proposed area for dental implant.
- Pregnancy.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Allograftafter immediate implant placement the gap will be filled with allograft | Other | Group 1 |
| e-PRFafter immediate implant placement the gap will be filled with e-PRF | Other | Group 2 |
Primary outcome
Implant stability
Time frame: immediately ,6months follow up & one year
Resonance frequency analysis (RFA) values expressed as implant stability quotient (ISQ) will be recorded by (Osstell Mentor Device)
1 secondary outcome
Marginal bone loss
Time frame: immeditely,6months follow up & one year
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Mar 2026.
- Derived from this study: PubMed 42374383Elnaggar HMMA, El-Gohary N, Yaseen AAM, Tawfik MA. Extended platelet rich fibrin versus allograft as a space filling material in immediate dental implant placement. BMC Oral Health. 2026 Jun 29;26(1):1130. doi: 10.1186/s12903-026-08891-6.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Allograft and e-PRF in people with Immediate Implant Placement and Gap Filling With e-PRF, run by Mansoura University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Implant stability (time frame: immediately ,6months follow up & one year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07445776, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Mar 2026.