Clinical trials: Allergy Pollen
Pollen Allergy
Identification of Allergen-reactive Antibodies in the Blood of Pollen Allergic Patients
The project examines the hypothesis that monoclonal allergen-neutralizing antibodies can be recombinantly produced from B lymphocytes isolated from pollen allergic patients.
- Trial name
- NCT03727399
- Testing
- blood withdrawal
- Where
- Switzerland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mabylon AG
Pollen Allergy, Venom Allergy
Identification of B Regulatory Cells by Flow Cytometry
The goal of this laboratory and observational study is to develop a test to quantify B-regulatory cells in blood. This will be used to detect changes in B-regulatory cell populations in pollen and insect venom allergic patients…
- Trial name
- NCT06876506
- Testing
- Venepuncture, Allergen Specific Immunotherapy
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Birch Pollen Allergy
Study of DM-101PX in Adults With Birch Pollen Allergy
Randomized, double-blind placebo-controlled phase 2 trial with the aim to investigate safety and efficacy of DM-101-PX in reducing allergic symptoms provoked by nasal allergen challenge in birch pollen allergic adults.
- Trial name
- BASIT (NCT07254871)
- Testing
- DM-101PX
- Where
- Canada
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Desentum Oy
Allergic Rhinitis, Seasonal Allergic Rhinitis
Threshold Concentrations for Ragweed and Birch Pollen in Seasonal Allergic Rhinitis
The ragweed Ambrosia artemisiifolia is spreading in northern Europe due to climate change. The pollen are considered highly allergenic and might trigger allergy symptoms at much lower concentrations than e.g.
- Conditions
- Allergic Rhinitis, Seasonal Allergic Rhinitis, Ragweed Allergy, Birch Pollen Allergy
- Trial name
- UBAMBI (NCT05346718)
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Severe Asthma, Allergy and Asthma
Multi-omics in Severe Asthma From Olive Pollen Allergy
Patients with severe olive pollen allergy exhibit characteristic sensitization profiles, marked by strong recognition of minor allergens like Ole e 7, and, more importantly, show poor clinical responses to pharmacological…
- Conditions
- Severe Asthma, Allergy and Asthma, Pollen; Allergy, Asthma
- Trial name
- DUPITEOLE (NCT07721376)
- Where
- Spain
- Volunteers
- 18 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Allergic Asthma, Thunderstorm Asthma
Creating A Risk Assessment Tool for Thunderstorm Asthma: the CARISTA Study
Thunderstorm asthma is a recurring public health emergency in South-Eastern Australia which occurs in springtime. The major identified risk factors for thunderstorm asthma is hay fever and allergy to ryegrass pollen.
- Conditions
- Allergic Asthma, Thunderstorm Asthma, Seasonal Allergic Rhinitis, Grass Pollen Allergy
- Trial name
- CARISTA (NCT07055542)
- Testing
- Observational
- Where
- 6 sites in Australia
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Allergic Rhinoconjunctivitis, Grass Pollen Allergy
Grass Pollen Immunotherapy Plus Dupilumab for Tolerance Induction
The primary objective of this study is to assess whether the combination of grass allergen sublingual immunotherapy (SLIT) and dupilumab for 2 years is more effective than double placebo in suppressing the nasal allergen…
- Trial name
- GRADUATE (NCT04502966)
- Testing
- Dupixent®, Grazax®
- Where
- United Kingdom
- Volunteers
- 199 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Grass Pollen Allergy
GRASS (Grass MATA MPL Real-world Assessment Study)
Objective of this non-interventional study (NIS) is to collect data on the use of Grassmuno® in routine clinical practice.
- Trial name
- GRASS (NCT07412990)
- Testing
- Grassmuno®
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Allergy Therapeutics
Allergic Rhinoconjunctivitis, Birch Pollen Allergy
Safety and Efficacy of STALORAL® Birch 300 IR in a Paediatric Population With Birch Pollen-induced ARC w/o Asthma
Allergic rhinoconjunctivitis due to birch pollen is a seasonal problem which manifests as a combination of nasal symptoms (such as congestion, runny nose, sneezing, itching of the nose) and ocular symptoms (such as red, itchy and…
- Trial name
- YOBI (NCT05668390)
- Testing
- STALORAL® Birch 300 IR
- Where
- 62 sites in Austria, Bulgaria and 10 more
- Volunteers
- 553 people
- Sponsor
- Stallergenes Greer
Allergy Pollen, Allergic Reaction
Phleum Pratense and Dactylis Glomerata Allergen Extracts Standardization
The primary objective is to assess the concentration of each allergen extract (Phleum pratense and Dactylis glomerata) that induces a wheal size equivalent to that produced by a 10 mg/mL histamine dihydrochloride solution.
- Conditions
- Allergy Pollen, Allergic Reaction, Allergic Skin Reaction
- Trial name
- NCT06957496
- Testing
- Allergenic extracts
- Where
- Spain
- Volunteers
- 31 people
- Sponsor
- Inmunotek S.L.
Grass Pollen Allergy, Rhinoconjunctivitis
A Motivation-enhancing App to Retain Patients With Hay Fever in a Trial After Treatment
The motivation-enhancing intervention is designed for participants in the ILIT.NU trial. The participants are patients with hay fever who are treated with a vaccination in an inguinal lymph node.
- Trial name
- NCT05560698
- Testing
- Motivation-enhancing intervention, Standard intervention
- Where
- Denmark
- Volunteers
- 224 people
- Sponsor
- University of Aarhus
Allergic Reaction, Allergic Skin Reaction
Quercus Ilex and Quercus Robur Allergen Extracts Standardisation
The objective of this study is to determine the biological activity of Quercus illex and Quercus robur allergen extracts in histamine equivalent prick (HEP) units, in order to be used as in-house reference preparation (IHRP).
- Conditions
- Allergic Reaction, Allergic Skin Reaction, Allergy Pollen
- Trial name
- NCT05532566
- Testing
- Allergenic extract
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Inmunotek S.L.
House Dust Mite Allergy, Birch Pollen Allergy
Evaluation of an Adjusted Cutoff Value for S.P.A.T (Skin Prick Automated Test) Device in Allergic Subjects
Skin prick test (SPT) is a first line diagnostic test to detect type I hypersensitivity in patients suspected of an inhalant allergy. A novel S.P.A.T.
- Trial name
- SPATprovocatio (NCT06803953)
- Testing
- Skin Prick Automated Test, Skin Prick Manual Test, Nasal Allergen Challenge
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Hippocreates
Hayfever, Allergy Pollen
Breathe-Easy: Hayfever Care for Patients With Seasonal Allergic Rhinitis
This waitlist-controlled trial aims to evaluate the therapeutic effectiveness of Hayfever Care by assessing disease-specific symptoms over a 4-week period.
- Conditions
- Hayfever, Allergy Pollen, Allergic Rhinitis
- Trial name
- NCT06765239
- Testing
- Hayfever Care, Wait-list Control
- Where
- India
- Volunteers
- 63 people
- Sponsor
- Innowage Limited
Pollen Allergy
Impacts of Nitrogen Deposition in the Natural Environment on Pollen Allergy in Belgium
The investigators want to study the effect of environmental nitrogen enrichment on the allergy burden in pollen-sensitized subjects.
- Trial name
- NITROPOL-BE (NCT06714149)
- Testing
- Immunoreactivity testing, Immunoreactivity testing (negative control)
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- prof. dr. Rik Schrijvers
Allergy Pollen, Allergic Reaction
Juniperus Oxycedrus and Cupressus Arizonica Allergen Extracts Standardisation.
The objective of this study is to determine the biological activity of Juniperus oxycedrus and Cupressus arizonica. allergen extracts in histamine equivalent prick (HEP) units, in order to be used as in-house reference…
- Conditions
- Allergy Pollen, Allergic Reaction, Allergic Skin Reaction
- Trial name
- NCT05533385
- Testing
- Allergenic extract
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Inmunotek S.L.
Birch Pollen Allergy
Study to Evaluate Safety, Tolerability and Explorative Efficacy of DM-101PX in Birch Pollen Allergic Participants
Randomized, double-blind placebo-controlled phase I trial with the primary aim to investigate safety and tolerability of three ascending dosing schemes of DM-101-PX in birch pollen allergic adults.
- Trial name
- NCT06037148
- Testing
- DM-101PX
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Desentum Oy
Rhinitis, Allergic, Seasonal, Hay Fever
Methylprednisolone Injections Treating Birch Pollen Induced Allergic Rhinitis.
This study evaluates the effect of intramuscular injected methylprednisolone treating birch pollen induced rhinitis compared to placebo.
- Conditions
- Rhinitis, Allergic, Seasonal, Hay Fever, Pollen Allergy, Allergic Rhinitis
- Trial name
- NCT04622917
- Testing
- MethylPREDNISolone 40 Mg/mL Injectable Suspension, NaCl 9 MG/ML Injectable Solution
- Where
- Sweden
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Allergy to House Dust, Allergy Pollen
Validation and Reproducibility of S.P.A.T. With Allergens
To improve accuracy and take out human error opportunities, Hippo Dx developed S.P.A.T., an automated skin prick test. This study will provide a comparison between manual and automated skin prick test in allergic and non-allergic…
- Trial name
- NCT05824637
- Testing
- Skin Prick Automated Test, Skin Prick Manual Test
- Where
- Belgium
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Hippocreates
Allergic Rhinoconjunctivitis, Perennial Allergic Rhinitis
Efficacy and Safety Evaluation for the Treatment of Asthma and Allergic Rhinitis/Rhinoconjunctivitis
Prospective, randomized, placebo-controlled, multicenter of 3 active treatment groups, compared to 1 placebo group, for the determination of the efficacy and safety of subcutaneous immunotherapy in patients with mild to moderate…
- Conditions
- Allergic Rhinoconjunctivitis, Perennial Allergic Rhinitis, House Dust Mite Allergy, Pollen Allergy
- Trial name
- NCT04874714
- Testing
- MM09-MG01(30.000-30.000), MG01(30.000), MM09(30.000)
- Where
- 13 sites in Spain
- Volunteers
- 18 people
- Sponsor
- Inmunotek S.L.