Clinical trials: All-Cause Mortality
Ischemic Heart Failure, Lipids
Serum Lipids and Glucose Levels in Relation to CVD Outcomes in Patients With Ischemic Heart Failure
Current prospective cohort study is to evaluate the association between fasting lipid profiles (including total cholesterol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol, triglycerides, apolipoprotein…
- Conditions
- Ischemic Heart Failure, Lipids, Fasting Plasma Glucose, Cardiovascular Outcomes
- Trial name
- NCT03206593
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Guangdong Provincial People's Hospital
Cardiovascular Diseases, Cancer
Relationship Between Dietary Protein Intake and Fatal and Non-fatal Health Outcomes
The aim of the current study was to clarify the relationship between protein intake and health by using a very large, general population cohort study, UK Biobank, to study the associations between reported protein intake…
- Conditions
- Cardiovascular Diseases, Cancer, All-cause Mortality
- Trial name
- NCT03243578
- Testing
- None as this is an observational study
- Volunteers
- 502,628 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
ISCHEMIC CARDIOMYOPATHY
Efficacy of EVP 1001-1 (SeeMore) in the Assessment of Myocardial Viability in Patients With Cardiovascular Disease
The investigator hopes to introduce a novel MRI contrast agent with SeeMore ™ that directly defines viable myocardium. Identifying viable myocardium non-invasively using cardiac MRI is still a moving target and a question we plan…
- Trial name
- NCT01989195
- Testing
- 'SEEMORE' - MANGANESE-ENHANCED MRI CONTRAST REAGENT
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Stanford University
Hyperuricemia
Lowering Serum Uric Acid to Prevent Acute Kidney Injury
Acute kidney injury is associated with a rise in serum uric acid during cardiovascular surgery and can cause poor blood flow to the kidneys making them vulnerable to kidney injury.
- Trial name
- RasbAKI (NCT00756964)
- Testing
- Rasburicase
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Florida
All-cause Mortality, Hospitalization
HiLo: Pragmatic Trial of Higher vs Lower Serum Phosphate Targets in Patients Undergoing Hemodialysis
HiLo will be a pragmatic, open-label, multicenter, clinical trial with individual level randomization of ~4400 patients with ESRD undergoing in-center maintenance hemodialysis at 120-150 units maintained by two dialysis…
- Trial name
- NCT04095039
- Testing
- Hemodialysis
- Where
- 84 sites in United States
- Volunteers
- 793 people
- Sponsor
- Duke University
Atrial Fibrillation (AF), Heart Failure
AV Nodal Ablation With Conduction System Pacing Versus Cardiac Resynchronization for Symptomatic Heart Failure Patients With Atrial Fibrillation
The goal of this clinical trial is to learn if conduction system pacing works as well as cardiac resynchronization therapy (CRT) post atrioventricular (AV) node ablation in adult patients with symptomatic heart failure and atrial…
- Conditions
- Atrial Fibrillation (AF), Heart Failure, Cardiac Pacing
- Trial name
- APAF-CSP (NCT07604727)
- Testing
- Conduction System Pacing, Cardiac resynchronization therapy
- Where
- 23 sites in France, Germany and 2 more
- Volunteers
- 292 people
- Sponsor
- University Medical Center Groningen
DCM - Dilated Cardiomyopathy
Observational Study for Patients With Dilated Cardiomyopathy
Observational study on patients with dilated cardiomyopathy aims to investigate the correlation between cardiac fibrosis, as indicated by cardiac magnetic resonance, and the prognosis of patients with dilated cardiomyopathy, and…
- Trial name
- NCT04837612
- Testing
- No intervention nor exposure
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Guangdong Provincial People's Hospital
Transthyretin Amyloid Cardiomyopathy
Study of ALXN2220 Versus Placebo in Adults With ATTR-CM
The primary objective of this study is to access the efficacy of ALXN2220 in the treatment of adult participants with ATTR-CM by evaluating the difference between the ALXN2220 and placebo groups as assessed by the total…
- Trial name
- DepleTTR-CM (NCT06183931)
- Testing
- ALXN2220
- Where
- 213 sites in United States, Argentina and 25 more
- Volunteers
- 1,182 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Renal Impairment, All Cause Mortality
Low-dose Albumin Solution in SBP: a Randomized Double-blind Pilot Study
Spontaneous bacterial peritonitis (SBP) is a common and severe complication of cirrhosis. The most serious complication of SBP is the hepatorenal syndrome (HRS), which occurs in up to 30 percent of patients, with high mortality.
- Trial name
- ALTERNATE (NCT00852800)
- Testing
- Albumin
- Where
- Brazil
- Volunteers
- 43 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
End-stage Renal Disease, Cardiovascular Disease
Effect of Increased Convective Clearance by On-Line Hemodiafiltration on All Cause Mortality in Chronic Hemodialysis Patients
The purpose of this study is to compare the effect of low flux hemodialysis with online hemodiafiltration on all cause mortality and a combination of cardiovascular morbidity and mortality in chronic hemodialysis patients.
- Trial name
- CONTRAST (NCT00205556)
- Testing
- on-line hemodiafiltration, low flux hemodialysis
- Where
- 29 sites in Canada, Netherlands and 1 more
- Volunteers
- 715 people
- Sponsor
- Amsterdam UMC, location VUmc
Wounds and Injuries, Mortality
Evaluation of Three Trauma Mortality Scores in Adults Admitted to Intensive Care in Tunisia
The goal of this retrospective observational study is to learn how well three simple trauma scores predict death during the hospital stay in adults admitted to intensive care after an injury in Tunisia.
- Conditions
- Wounds and Injuries, Mortality, Critical Illness
- Trial name
- TICU-SCORES (NCT07848776)
- Testing
- Trauma mortality prediction scores: GAP, MGAP, and T-NTS
- Volunteers
- 1,000 people
- Sponsor
- University Tunis El Manar
Healthy Diet, Mortality
Spermidine Intake and All-cause Mortality
This study seeks to test the potential association between spermidine content in diet and mortality in humans.
- Trial name
- NCT03378843
- Testing
- Spermidine content of natural diet
- Volunteers
- 829 people
- Sponsor
- Medical University Innsbruck
Cardiovascular Mortality, Cardiac Function
Intervention With Selenium and Q10 on Cardiovascular Mortality and Cardiac Function in the Elderly Population in Sweden
The dietary supplements selenium and Q10 has been evaluated in a double blind placebo-controlled study in an elderly Swedish population.
- Trial name
- KiSel-10 (NCT01443780)
- Testing
- Selenium and ubiquinon (Q10) combined
- Where
- Sweden
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Acute Lung Injury, Adult Respiratory Distress Syndrome
Airway Pressure Release Ventilation (APRV) Compared to ARDSnet Ventilation
Traditional modes of ventilation have failed to improve patient survival. Subsequent observations that elevated airway pressures observed in traditional forms of ventilation resulted in barotrauma and extension of ALI lead to the…
- Conditions
- Acute Lung Injury, Adult Respiratory Distress Syndrome, Kidney Injury
- Trial name
- PRESSURE (NCT00793013)
- Testing
- Volume-Cycled Assist-Control (AC) mode, Airway Pressure Release Ventilation (APRV) mode
- Where
- United States
- Sponsor
- University of Tennessee, Chattanooga
Atrial Fibrillation, Ischemic Stroke
Direct Oral Anticoagulants in Patients With Atrial Fibrillation (DOACs vs Warfarin)
The purpose of this study is to assess safety and effectiveness of direct oral anticoagulants (DOACs) and warfarin for stroke prevention in patients with non-valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation, Ischemic Stroke, Systemic Embolization, Major Bleed
- Trial name
- NCT03596502
- Testing
- Direct oral anticoagulants (DOACs), Warfarin
- Where
- Canada
- Volunteers
- 402,764 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Hypomagnesemia
Dynamic Magnesium Replacement Strategies and 28-Day Mortality in Non-Cardiac Critically Ill Patients With Hypomagnesemia: A Target Trial Emulation
This study looks at how different ways of giving magnesium (a nutrient) affect the risk of death within 28 days for adults with low magnesium levels who are in the intensive care unit (ICU) for non-heart-related reasons.
- Trial name
- NCT07380542
- Where
- China
- Volunteers
- 12,887 people
- Sponsor
- Fujian Provincial Hospital
Malaria, All-cause Mortality
Effects of Insecticide Treated Bednets on Child Morbidity and Mortality
Insecticide-impregnated bed nets and curtains (ITN) have been shown to be effective against malaria. However, given that most ITN studies were of limited length, researchers have postulated the hypothesis that in areas of intense…
- Trial name
- NCT00225368
- Testing
- Insecticide treated bednets
- Where
- Burkina Faso
- Sponsor
- Heidelberg University
Cardio-pulmonary Bypass, Coronary Artery Bypass Graft
Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardio-Pulmonary Bypass
During a heart bypass procedure, a substance called "complement" is released by the body. This complement causes inflammation, which can lead to side effects such as chest pain, heart attacks, heart failure, or impairment of…
- Trial name
- NCT00048308
- Testing
- pexelizumab
- Where
- 186 sites in United States, Canada
- Volunteers
- 3,000 people
- Sponsor
- Alexion Pharmaceuticals, Inc.