Clinical trials: Alcohol Use Disorder, pill or tablet or capsule or oral, open to volunteers
- Condition Alcohol Use Disorder
- Drug or intervention pill OR tablet OR capsule OR oral
- Status Open to volunteers
Alcohol Use Disorder (AUD), Nicotine Use Disorder
Pharmaceutically-Enhanced Reinforcement for Reduced Alcohol and Smoking
Using a randomized controlled trial (RCT), the goal of this study is to evaluate the ability of evidence based behavioral treatment (contingency management: CM) to significantly decrease alcohol use and cigarette smoking among…
- Trial name
- PERRAS (NCT05181891)
- Testing
- Contingency Management, Non-contingent control
- Where
- United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Washington State University
Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD)
Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder
This study will evaluate whether pregnenolone is an effective treatment for adults with Alcohol Use Disorder (AUD) and Major Depressive Disorder (MDD).
- Trial name
- PREG-AUD-RO1 (NCT07734701)
- Testing
- Pregnenolone
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Sherwood Brown, MD, PhD
Alcohol Use Disorder
Orexin Receptor Antagonism for the Treatment of Alcohol Use Disorder and Stress-Related Drinking
The goal of this clinical trial is to learn if, how, and for whom suvorexant (SUV) works to treat alcohol use disorder (AUD). The main questions it aims to answer are: Is SUV effective for AUD? Does SUV dampen stress reactivity?…
- Trial name
- NCT07214207
- Testing
- Suvorexant 10 mg
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Ohio State University
Healthy Volunteers, Alcohol Use Disorder (AUD)
Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms
Background: Alcohol use disorder (AUD) is a leading cause of disease and death worldwide. New treatments for AUD are needed. Dopamine, a chemical that carries signals between brain cells, is thought to play a role in alcohol…
- Trial name
- NCT06484075
- Testing
- Siemens 3T PRISMA MR Scanner, PET/CT Scanner, Suvorexant
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder
A First in Human Study of CMND-100 in Healthy and Alcohol Use Disorder (AUD) Subjects
The primary objective of this study is to find the tolerable dose and characterize the safety and pharmacokinetics/ pharmacodynamics (PK/PD) of single and repeated dose of CMND-100 in Healthy Volunteers (HV) and Subjects with…
- Trial name
- NCT05913752
- Testing
- CMND-100
- Where
- 4 sites in United States, Israel
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Clearmind Medicine Inc.
Alcohol Use Disorder
Methylphenidate and Response to Alcohol Cues
The purpose of this study is to determine whether changes in attention levels related to taking a single dose of a medication called methylphenidate, also known as Ritalin, affects responses to alcohol cues.
- Trial name
- NCT07306078
- Testing
- Methylphenidate Pill
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Florida
Alcohol Use Disorder
Pilot Study: Effects of Nimodipine on Alcohol Drinking
This is an open label trial aiming to recruit 5 non-treatment seeking adults with Alcohol Use Disorder. All will participate in an alcohol drinking paradigm (ADP) lab session at the Hospital Research Unit (HRU) at Yale-New Haven…
- Trial name
- NCT06900998
- Testing
- Nimodipine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Alcohol Use Disorder
Guanfacine for Alcohol Use Disorder (AUD)
The investigators assess whether guanfacine extended release (GXR; 3mg/d) compared with placebo (PBO) will attenuate drinking and drinking-related factors in N=200 men and women with Alcohol Use Disorder (AUD) across 12-weeks.
- Trial name
- NCT06629259
- Testing
- Guanfacine Extended Release (XR)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Indiana University
Alcohol Use Disorder, Insomnia
Daridorexant for People With Insomnia and Alcohol Use Disorder Study
The goal of this clinical trial is to see if a sleep medication, daridorexant (DTX), can help decrease drinking in people who have alcohol use disorder (AUD) and insomnia.
- Trial name
- DIAS (NCT07701928)
- Testing
- Daridorexant, Brief Counseling, MEMS and Medication Accounting
- Where
- United States
- Volunteers
- 205 people
- Sponsor
- Sterling McPherson
Alcohol Consumption, Heavy Drinker
Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers
The purpose of this research study is to find out about the effects of a drug called mavoglurant on alcohol consumption.
- Conditions
- Alcohol Consumption, Heavy Drinker, Alcohol Use Disorder (AUD)
- Trial name
- NCT06136195
- Testing
- Mavoglurant
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Yale University
Alcohol Use Disorder, Alcohol-associated Liver Disease
Pomegranate Dietary Supplements in AUD and ALD
The goal of this project is to determine an individual's ability to generate active gut microbial metabolites called urolithins upon consumption of pomegranate dietary supplements.
- Conditions
- Alcohol Use Disorder, Alcohol-associated Liver Disease, Alcoholic Cirrhosis, Healthy
- Trial name
- NCT07678567
- Testing
- Pomegranate Dietary Ssupplement
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Alcohol Use Disorder
Neurobehavioral Mechanisms of Psilocybin-assisted Treatment for AUD
This is a double-blind, randomized, placebo-controlled Phase 2 mechanistic clinical trial designed to evaluate the therapeutic neural mechanisms of psilocybin in patients with alcohol use disorder (AUD), and to determine whether…
- Trial name
- NCT06349083
- Testing
- Psilocybin, Supportive therapy sessions
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Alcohol, Alcohol Use Disorders
A Phase I Study of the Interaction of Alcohol With Oral AFA-281 in Healthy Volunteers
The goal of this clinical trial is to evaluate if alcohol interacts with the drug candidate AFA-281 in adults (healthy volunteers). This trial will evaluate blood concentration levels of AFA-281 and ethanol.
- Trial name
- NCT06719908
- Testing
- AFA-281 is a small molecule, orally available, Alcohol (Ethanol)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Afasci Inc
Alcohol Use Disorder (AUD)
A Randomised Controlled Trial of N-acetylcysteine for the Management of Alcohol Use Disorder
To explore the effectiveness of n-acetylcysteine in improving treatment outcomes for alcohol use disorder in a double-blind randomised placebo-controlled trial.
- Trial name
- NAC-AUD (NCT05408247)
- Testing
- N-acetyl cysteine
- Where
- 3 sites in Australia
- Volunteers
- 280 people
- Sponsor
- University of Sydney
Alcohol Use Disorder, Alcohol Withdrawal
Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder
The goal of this clinical trial is to learn the effects of ketone supplement compared to placebo on alcohol withdrawal symptoms during a 4 day alcohol withdrawal management treatment in adults with moderate to severe alcohol use…
- Conditions
- Alcohol Use Disorder, Alcohol Withdrawal, Ketosis
- Trial name
- KSAW (NCT06559995)
- Testing
- ketone supplement "D-beta-hydroxybutryric acid and R-1,3 butanediol" 12g of ketones,, magnetic resonance imaging session
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Alcohol Use Disorder, Alcohol Dependence
The Impact of Heavy Alcohol Use on Saliva and Oral Health
Background: People with alcohol use disorder (AUD) have a higher rate of dental and gum disease. Poor oral health can increase the risk of other diseases, such as diabetes and stroke.
- Trial name
- NCT06684483
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Alcohol Use Disorder, Alcoholism
Psilocybin-Assisted Psychotherapy for Alcohol Use Disorder
The aim of this study is to determine if a single dose of psilocybin administered with motivational enhancement therapy (MET) can reduce heavy drinking in patients with an alcohol use disorder (AUD).
- Trial name
- PAP-AUD (NCT05995769)
- Testing
- Psilocybin
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- University of Calgary
Alcohol Abuse, Alcohol Abuse/addiction
A Study of the Safety and Exploratory Efficacy of Oral AFA-281 in Patients with Alcohol Use Disorder
This study will evaluate the safety and exploratory efficacy of AFA-281 in patients with Alcohol use disorder on cravings, subjective response to alcohol, pain thresholds, anxiety, depression, and sleep.
- Conditions
- Alcohol Abuse, Alcohol Abuse/addiction, Anxiety, Pain Threshold
- Trial name
- NCT06710431
- Testing
- AFA-281
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Afasci Inc
Alcohol Use Disorder
Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder
The goal of this clinical trial is to identify sex-specific biomarkers that confer greater susceptibility for Alcohol Use Disorder (AUD) and differentiate how treatment response varies by sex in people with Alcohol Use Disorder.
- Trial name
- ABSTAIN (NCT06426303)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Milky Kohno
Alcohol Use Disorder
Suvorexant and Alcohol
This research will translate findings from preclinical research and provide the initial clinical evidence that orexin antagonism reduces motivation for alcohol, as well as other alcohol-associated maladaptive behaviors in people…
- Trial name
- NCT06326684
- Testing
- Alcohol, Suvorexant
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- William Stoops