Clinical trials: Alcohol Dependence
Alcohol Dependence
Feasibility of Integrating Olfactory Stimuli Into Virtual Reality Cue Exposure for Patients With Alcohol Dependence
Alcohol dependence (AD) is a prevalent and burdensome clinical condition with high relapse rates. A central risk factor for relapse is craving for alcohol, which can be evoked by both real-world and virtual cues in immersive…
- Trial name
- NCT07388693
- Testing
- VR Cue-Exposure Including Olfactory Stimuli
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
Fear, Stress
Epi-Genetic Modulators of Fear Extinction in Alcohol Dependence
Background: Researchers want to learn if people with alcohol dependence have more difficulty learning to feel calm, or learn to fear things more easily.
- Conditions
- Fear, Stress, Alcohol Dependence
- Trial name
- NCT02438969
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder, Alcohol Dependence
Transcranial Magnetic Stimulation (TMS) Effects Using Magnetoencephalography (MEG) Study
Alcohol use disorder (AUD) is a complex chronic brain disease characterized by compulsive alcohol use, loss of control over drinking, and negative emotional states.
- Conditions
- Alcohol Use Disorder, Alcohol Dependence, Alcohol Consumption
- Trial name
- TMS (NCT06770556)
- Testing
- Active iTBS, 10 Hz TMS, 1 Hz TMS
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Alcohol Dependence, Alcohol Drinking
Characterization Imaging Instruments in Alcoholics and Non-Alcoholics
Background: People with alcoholism have differences in their brains compared with healthy people. People who are dependent on alcohol also perform differently on behavioral tasks.
- Conditions
- Alcohol Dependence, Alcohol Drinking, Alcohol-Related Disorders, Alcoholism
- Trial name
- NCT02108080
- Where
- United States
- Volunteers
- 389 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Dependence, Alcohol Drinking
Behavioral and Functional Task Development, Implementation, and Testing
Background: Scientists know that alcohol use disorders affect brain structure. They want to know more about the effects of alcohol use disorders on a person s behavior.
- Conditions
- Alcohol Dependence, Alcohol Drinking, Alcoholism, Alcohol Use Disorder
- Trial name
- NCT02108054
- Testing
- 7T MRI
- Where
- United States
- Volunteers
- 173 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Substance Use Disorders, Substance Use
Harnessing Telemedicine to Improve Alcohol Use Disorder Outcomes in Primary Care Patients
The purpose of this trial is to test new programs to see if they might help people manage their health and health behaviors related to alcohol use and well-being.
- Conditions
- Substance Use Disorders, Substance Use, Substance Dependence
- Trial name
- NCT05410561
- Testing
- Enhanced Usual Care (EUC), TeleTx intervention
- Where
- 2 sites in United States
- Volunteers
- 277 people
- Sponsor
- University of Michigan
Asperger's Disorder, Asperger Disorder
QAIAx (AIhealth4U) - AI Smart Health Cities: Microcity Enclave Program (Quantum AI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum AI/AGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Alcohol Use Disorder, Alcoholism
Safety and Effectiveness of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for Treatment and Reduction of Heavy Drinking in Individuals With of Alcohol Use Disorder (AUD)
The study will compare alcohol use in two groups of subjects. One group will be assigned to the Deep TMS treatment and the other group will be assigned to the sham treatment.
- Conditions
- Alcohol Use Disorder, Alcoholism, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT07216872
- Testing
- Deep TMS (DTMS)
- Where
- 10 sites in United States, Israel and 1 more
- Volunteers
- 186 people
- Sponsor
- Brainsway
Alcohol Use Disorder, Alcohol Dependence
The Impact of Heavy Alcohol Use on Saliva and Oral Health
Background: People with alcohol use disorder (AUD) have a higher rate of dental and gum disease. Poor oral health can increase the risk of other diseases, such as diabetes and stroke.
- Trial name
- NCT06684483
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Alcohol Dependence, Alcohol Withdrawal Syndrome
Assessment of Valproate on Ethanol Withdrawal
Alcohol use disorder, or heavy drinking, is commonly seen in patients who present to trauma centers. These patients are at risk for Alcohol Withdrawal Syndrome (AWS), which is collection of symptoms that can range from anxiety…
- Conditions
- Alcohol Dependence, Alcohol Withdrawal Syndrome, Trauma, Heavy Drinking
- Trial name
- PAVE (NCT03235531)
- Testing
- Valproate, Lorazepam
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- CAMC Health System
SCHIZOPHRENIA 1 (Disorder), Alcohol Use Disorder
Snoezelen Therapy in Adults With Alcohol Dependence and Adults With Schizophrenia
The purpose of the study: obtaining knowledge about the impact of Snoezelen® therapy on the health of adults suffering from schizophrenia and requiring permanent institutional care, adults suffering from schizophrenia and adults…
- Conditions
- SCHIZOPHRENIA 1 (Disorder), Alcohol Use Disorder, Alcohol Dependence (Primary Condition)
- Trial name
- NCT07748078
- Testing
- Snoezelen® therapy for 6 weeks, Snoezelen® therapy for 12 weeks
- Where
- 2 sites in Poland
- Volunteers
- 140 people
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Alcohol Use Disorder, Alcohol Dependence
Telehealth Treatment for Alcohol Use Disorder
Participants with alcohol use disorder will be randomly assigned to either the Ria Treatment Platform or a waitlist control. The Ria Treatment Platform is a telehealth approach that incorporates medical assessment, medications…
- Conditions
- Alcohol Use Disorder, Alcohol Dependence, Alcoholism
- Trial name
- NCT05747703
- Testing
- Ria Treatment Platform
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Ria Health
Alcohol Dependence, Dependence
Screening for Alcohol-related Cognitive Impairments in Cirrhotic Patients
80% of patients with alcohol use disorders (AUD) present cognitive impairments, such as memory and executive functions. These disorders may have repercussions in addiction treatment by altering the patient's adherence to care.
- Conditions
- Alcohol Dependence, Dependence, Cognitive Impairments, Cirrhosis
- Trial name
- CirCo (NCT04490330)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Alcohol Dependence, Sleep Disorder
Validation of a Short Questionnaire (SSI) for Sleep Disorders in Patients With Alcohol
Sleep disorders are very common in alcohol patients (40-90% according to studies) These sleep disorders may persist after withdrawal and represent a major factor in relapse.
- Trial name
- NCT04007042
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Alcohol Use Disorder, Alcohol Abuse
Theta Burst Stimulation as a Tool to Decrease Drinking in Treatment-seeking Alcohol Users
There is growing interest in the utilization of transcranial magnetic stimulation (TMS) as a novel, non-pharmacologic approach to decreasing alcohol use among treatment-seeking individuals with Alcohol Use Disorder (AUD).
- Conditions
- Alcohol Use Disorder, Alcohol Abuse, Alcohol Dependence, Craving
- Trial name
- NCT04154111
- Testing
- Real TBS to the vmPFC, Real TBS to the dlPFC
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Wake Forest University Health Sciences
Alcohol Dependence, Alcohol Abuse
A Smartphone Based Intervention for the Prevention of Relapse in Alcohol Dependence
The rate of relapse following an inpatient alcohol rehabilitation program has been around 50% for a number of years. Offered treatments mainly focus on conscious and controllable aspects of behaviour, but research has found that…
- Conditions
- Alcohol Dependence, Alcohol Abuse, Alcohol Use Disorder
- Trial name
- SPIRA (NCT03952429)
- Testing
- Anti Alcohol App with Active Cognitive Bias, Inactive Cognitive Bias Modification
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Salus Klinik Lindow
Alcohol Dependence
Study of Acamprosate in Driving Under the Influence (DUI) Court Participants
Acamprosate will be given to approximately 30 DUI Court participants for 3 months and outcomes will be monitored. The hypothesis is that acamprosate will be safe and well-tolerated and that subjects' craving and other symptoms…
- Trial name
- NCT00425711
- Testing
- Acamprosate
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Oklahoma
Alcohol Use Disorder, Alcohol Withdrawal
Effects of Ketone Supplementation on Acute Alcohol Withdrawal
The goal of this study is to study the effects of the ketone supplement Kenetik compared to placebo (an inactive beverage) on alcohol withdrawal symptoms during the 5 days of clinical alcohol withdrawal management treatment at…
- Conditions
- Alcohol Use Disorder, Alcohol Withdrawal, Alcohol Dependence, Ketosis
- Trial name
- NCT06173973
- Testing
- Kenetik; Ketone Concentrate
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Alcohol Dependence
Neuromodulation and Mindfulness Patients With AUD
Our primary objective is to integrate tVNS and mindfulness meditation within a structured mindfulness-based relapse prevention (MBRP) program for detoxified alcohol-dependent patients (AD).
- Trial name
- NCT06308484
- Testing
- Transcutaneous vagus nerve stimulation, Closed-loop AM-tACS
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Charite University, Berlin, Germany
Alcohol Use Disorder, Alcohol Abuse/Dependence
Effects of Tirzepatide on Alcohol Intake in Patients Diagnosed With Schizophrenia and Alcohol Use Disorder
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), approved for the treatment of type 2 diabetes and obesity, have shown promise as a novel treatment for alcohol use disorder (AUD).
- Conditions
- Alcohol Use Disorder, Alcohol Abuse/Dependence, Alcohol Dependence, Alcoholism
- Trial name
- DUALPSYCHIATRY (NCT06939088)
- Testing
- Tirzepatide
- Where
- 2 sites in Denmark
- Volunteers
- 108 people
- Sponsor
- Anders Fink-Jensen, MD, DMSci