Clinical trials: Alcohol Biomarkers
Alcohol Consumption, Insulin Resistance
Identification of Biomarkers for Acute Intake of Beer and Alcohol and Acute Effects on Plasma and Insulin Response
The objective of the study is to identify biomarkers for acute intake of beer and alcohol in individuals with a high or low habitual intake.
- Trial name
- METABEER (NCT02449577)
- Testing
- Beverage sequence ABCD, Beverage sequence CADB, Beverage sequence DACB
- Where
- Denmark
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Emotional Regulation, Alcohol Drinking in College
Momentary Coping Prompts and Hair Steroids in College Students
This study looks at the moments when college students feel a strong emotional swing, and how those moments relate to reacting online when upset, drinking alcohol, and eating in response to emotions.
- Conditions
- Emotional Regulation, Alcohol Drinking in College, Emotional Eating, Aggression
- Trial name
- REACT-Bio (NCT07782398)
- Testing
- Momentary coping prompt, Active control message
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Florida
Alcohol Drinking, Pregnancy
Alcohol Self-reporting During Pregnancy. AUTOQUEST Study.
The effects of alcohol consumption during pregnancy have been known for decades. However, alcohol consumption in pregnant women remains today a public health problem and its identification is primordial.
- Trial name
- AUTOQUEST (NCT04786587)
- Testing
- blood test, self-administered questionnaire
- Where
- France
- Volunteers
- 2,425 people
- Sponsor
- University Hospital, Lille
Chronic Liver Disease, Alcohol Use Disorder
Nottingham Community Liver Biomarkers Cohort
Deaths due to advanced liver scarring (liver cirrhosis) continue to increase, and liver disease is now the 3rd leading cause of premature death in the United Kingdom.
- Conditions
- Chronic Liver Disease, Alcohol Use Disorder, Type 2 Diabetes, Persistently Elevated ALT
- Trial name
- NCT02037867
- Testing
- Fibrosis Biomarkers
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- University of Nottingham
Cannabis Use, Alcohol Use Disorder
VRT as a Biomarker of Cerebellar Dysfunction in Chronic Cannabis Use
Chronic cannabis consumption has been associated with poor psychosocial functioning that could be associated to cerebellar dysfunction.
- Conditions
- Cannabis Use, Alcohol Use Disorder, Healthy
- Trial name
- NCT03662737
- Testing
- Visuomotor adaptation task
- Where
- Spain
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Non-communicable Diseases (NCD), Addiction to Opioids
Systematic Examination of Health Inequalities: Documentation, Patterns, and Determinants
The existence of social inequalities is a major global issue and a salient challenge for the European Union. During COVID-19 pandemic, health disparities became more evident.
- Conditions
- Non-communicable Diseases (NCD), Addiction to Opioids, Incarceration, Opioid-use Disorders
- Trial name
- CHANCE (NCT07558187)
- Where
- 5 sites in Greece
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Alcohol Use Disorder, Alcohol Drinking
Virtual Incentive Treatment for Alcohol
The overall objective of this program of research is to utilize phosphatidylethanol (PEth), a blood-based biomarker that can detect alcohol use for up to 28 days to deliver a feasible telehealth-based 26-week CM intervention.
- Conditions
- Alcohol Use Disorder, Alcohol Drinking, Alcohol Abuse, Alcohol Dependence
- Trial name
- VITA (NCT06265506)
- Testing
- Contingency Management, Computer Based Training for Cognitive Behavioral Therapy for AUD (CBT4CBT)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Washington State University
Transplant; Failure, Liver, Addiction, Alcohol
Addiction Intervention in Liver Transplantation Candidates
Addiction care is "a la carte treatment", adapted to the motivation and time constrains of users. Thus, various types of psychotherapeutic follow-up can be considered, different addictolytic medications or opioid maintenance…
- Trial name
- Addictolive (NCT05322226)
- Testing
- Addiction follow-up before and after liver transplantation
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Montpellier
Severe Alcoholic Hepatitis
LiverTREM-1: Hepatic TREM-1 Expression and Prognosis in Severe Alcoholic Hepatitis
Background \& Rationale Severe alcohol-related hepatitis (SAH) is a serious condition with a 3-month mortality rate of ~30%. Diagnosis and prognosis are complex due to non-specific and insensitive clinical, biological, and…
- Trial name
- Liver TREM-1 (NCT07176741)
- Testing
- TREM-1 expression (via immunohistochemistry) between SAH patients and controls
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Healthy
Effects of Fish Oil and Red Wine on Oxidative Stress Biomarkers
The American Heart Association and the American College of Cardiology (AHA/ACC) recently encouraged "increased consumption of omega-3 fatty acids in the form of fish or capsule form (1 g/day) for risk reduction" and stated that…
- Trial name
- NCT00682318
- Testing
- Fish Oil, Safflower Oil, Ethanol
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Carsten Skarke, MD
Hepatobiliary Diseases
Sulfation of Bile Acids as a Biomarker for Hepatobiliary Diseases
The investigators hypothesize that the extent of sulfation of toxic BAs and their urinary elimination can be used as a biomarker to predict the severity and prognosis of hepatobiliary diseases.
- Trial name
- NCT01200082
- Where
- United States
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
E-cigarette, Alcohol
Flavored Ready-to-Drink Alcohol Restriction in Young Adults: Behavioral and Biomarker Outcomes
This pilot randomized behavioral study evaluates the feasibility, adherence, and acceptability of an intervention to restrict flavored ready-to-drink (RTD) alcoholic beverages among young adults who regularly use both alcohol and…
- Trial name
- NCT07840625
- Testing
- Flavored Ready-to-Drink alcoholic beverage use restriction
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Alcohol Abuse, IPV
Wearable Technology and Alcohol-Facilitated Intimate Partner Violence
This project seeks to develop interactive treatment options to successfully reduce AUD and IPV concurrently. The purpose of the study is to examine the usability, feasibility, and acceptability of wearable activity trackers (like…
- Conditions
- Alcohol Abuse, IPV, Couples
- Trial name
- START (NCT05374798)
- Testing
- Heart Rate Variability-Biofeedback (HRV-B) via Smartwatch Device Intervention
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Medical University of South Carolina
Alcohol Dependence
Biomarkers to Measure Treatment Response for Alcohol Dependence
The purpose of the research study of the K23 award is to develop a blood test that can check how much alcohol a person has consumed in the past few days.
- Trial name
- NCT02315885
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Alcohol-related Liver Disease
Alcohol Biomarkers in Post-Liver Transplant Patients
The aim of this study is to compare the predictive validity and reliability of PEth testing at detecting alcohol use in post liver transplant patients. A prospective cohort study will be used to test the primary hypothesis.
- Trial name
- NCT01812226
- Where
- 2 sites in United States
- Volunteers
- 214 people
- Sponsor
- Northwestern University
Depression - Major Depressive Disorder, Schizophenia Disorder
A Novel Blood Test as a Biomarker in Mental Health
This longitudinal, observational study aims to assess whether the characteristics of a novel blood peripheral biomarker can serve as indicators for depression and schizophrenia in patients at the Royal Columbian Hospital…
- Conditions
- Depression - Major Depressive Disorder, Schizophenia Disorder, Psychosis, Mania (Neurotic)
- Trial name
- LEADING-MH (NCT06856161)
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Fraser Health
Alcohol
Piloting a Biomarker-augmented Alcohol Screening, Brief Intervention, and Referral to Treatment (SBIRT) Program Among HIV-affected Adolescents and Young Adults in Zambia
This will be a pilot study of an alcohol screening, brief intervention, and referral to treatment (SBIRT) program conducted within existing HIV prevention and treatment services for adolescents and young adults (AYA) in Lusaka…
- Trial name
- NCT06903143
- Testing
- Screening, brief intervention, and referral to treatment (SBIRT)
- Where
- Zambia
- Volunteers
- 60 people
- Sponsor
- Centre for Infectious Disease Research in Zambia
Alcohol Dependence, Alcohol Drinking
Characterization Imaging Instruments in Alcoholics and Non-Alcoholics
Background: People with alcoholism have differences in their brains compared with healthy people. People who are dependent on alcohol also perform differently on behavioral tasks.
- Conditions
- Alcohol Dependence, Alcohol Drinking, Alcohol-Related Disorders, Alcoholism
- Trial name
- NCT02108080
- Where
- United States
- Volunteers
- 389 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Fetal Alcohol Spectrum Disorders
Development of an Epigenetic Biomarker for Prediction of Fetal Alcohol Spectrum Disorder
The objective of the study is to validate epigenetic changes as biomarkers in a prospective sampling of newborn blood samples collected at birth (umbilical cord blood) and during routine screening (heel stick blood) in newborns…
- Trial name
- NCT03494738
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- CAMC Health System
Alcohol Use Disorder, Alcohol Dependence
The Impact of Heavy Alcohol Use on Saliva and Oral Health
Background: People with alcohol use disorder (AUD) have a higher rate of dental and gum disease. Poor oral health can increase the risk of other diseases, such as diabetes and stroke.
- Trial name
- NCT06684483
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)