Clinical trials: Alcohol
Alcohol-Related Disorders
Melatonin Use for Sleep Problems in Alcohol Dependent Patients
A double blind Randomized Controlled Trial with two arms will be used. Subjects with Alcohol use disorder and sleep problems will be recruited and assigned randomly to the active treatment Melatonin or Placebo arms.
- Trial name
- NCT03043443
- Testing
- Melatonin
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Centre for Addiction and Mental Health
Diabetes, Chronic Kidney Diseases
Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)
This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop…
- Conditions
- Diabetes, Chronic Kidney Diseases, Cancer, Bowel Disease
- Trial name
- BRANCH-P (NCT05473325)
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Willows Health
Acute Alcoholic Hepatitis
Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis
This study will compare two different treatments of acute alcoholic hepatitis. The current standard of care is treatment with corticosteroids (methylprednisolone).
- Trial name
- NCT01809132
- Testing
- Anakinra, Pentoxifylline, Zinc Sulfate
- Where
- 4 sites in United States
- Volunteers
- 104 people
- Sponsor
- Mack Mitchell
Dual Diagnosis, Risk Youth
Virtual Reality (VR-GINSO) as an Complement to Intervention for Alcohol and Cannabis Use in Youth in Residential Care
The goal of this RCT is to evaluate the effects of a virtual reality intervention on self-efficacy regarding alcohol and cannabis use among at-risk youth in various residential mental health treatment centers who have…
- Conditions
- Dual Diagnosis, Risk Youth, Antisocial Behavior
- Trial name
- VR-GINSO (NCT07834606)
- Testing
- Virtual Reality, Treatment as Usual (TAU)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Universidad Francisco de Vitoria
Alcohol Abuse, Craving
Using Neurofeedback to Understand the Relationship Between Stress and Alcohol Consumption
In this research project, the aim is to discover the role specific brain networks play in the relationship between stress reactions and the desire for alcohol and alcohol consumption.
- Conditions
- Alcohol Abuse, Craving, Psychosocial Stressor, Neural Stress Response
- Trial name
- NeuStress (NCT06247306)
- Testing
- ScanSTRESS fMRI-paradigm (Streit et al., 2014), real-time fMRI neurofeedback
- Where
- Germany
- Volunteers
- 102 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Alcohol Approach/Avoidance Task, Sham Approach/Avoidance Task
Marijuana Approach Bias Retraining and Neural Response in Youth
This study aims to determine if a marijuana (MJ) Approach Avoidance Task (AAT) intervention reduces cannabis use compared to a control condition containing no active components of AAT.
- Trial name
- MJ-AAT (NCT02723149)
- Testing
- Marijuana Approach Avoidance Training
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Chronic Hepatitis, Chronic Hepatitis C
The Effect of High Dose Vitamin C on the Liver Function in Chronic Hepatitis Patients
The investigators will evaluate the efficacy of high dose vitamin C in chronic hepatitis patients whose serum liver enzymes are elevated more than upper limit.
- Conditions
- Chronic Hepatitis, Chronic Hepatitis C, Chronic Alcoholic Hepatitis
- Trial name
- NCT01413360
- Testing
- High dose vitamin C
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital
Alcohol Sensitivity
Prevention of Alcohol Intolerance
This study is designed to determine whether Asians who are especially sensitive to alcohol exposure can be protected by boosting their activities of an alcohol disposing enzyme.
- Trial name
- NCT01845220
- Testing
- Broccoli Sprout Extract
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sexual Behavior, Alcohol Drinking
Adolescent Safer Sex Social Network Intervention
Social networks are thought to hold the potential for shaping behavior on the grounds that social and situational factors more strongly influence behavior than do personality variables.
- Conditions
- Sexual Behavior, Alcohol Drinking, Marijuana Smoking
- Trial name
- NCT00107562
- Testing
- Adolescent Safer Sex Social Network Intervention
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
SARS-CoV-2 Infection, COVID-19
Effect of COVID-19 Lockdown on Alcohol and Tobacco Use in Two Chilean Universities
This is a longitudinal study of participants from two university communities in Chile. The primary objective is to examine the effect of a regional lockdown on alcohol and tobacco use, using a difference-in-difference analysis to…
- Trial name
- NCT05069090
- Testing
- Lockdown and other social distancing measures
- Where
- 2 sites in Chile
- Volunteers
- 1,038 people, healthy volunteers welcome
- Sponsor
- Universidad de La Frontera
Cannabis, Alcohol Effect
Ethanol and Cannabinoid Effects on Simulated Driving and Related Cognition: Sub-Study II
The overarching goal of this study is to characterize the effects of ethanol and cannabinoids on simulated driving and related cognition.
- Conditions
- Cannabis, Alcohol Effect, Driving Under the Influence of Alcohol and Other Drugs
- Trial name
- THC-ETOH-II (NCT02710097)
- Testing
- Active inhaled cannabis, Active Oral Ethanol
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcoholism, Child Abuse, Sexual
Group Therapies for Reducing HIV-risk Behavior in Women Who Have Survived Childhood Sexual Abuse
This study will evaluate the effectiveness of trauma-focused group therapy for reducing HIV-risk behavior and revictimization among adult women survivors of childhood sexual abuse (CSA).
- Conditions
- Alcoholism, Child Abuse, Sexual, Sexual Abuse, Sexual Behavior
- Trial name
- NCT00220597
- Testing
- Trauma-focused group therapy
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Stanford University
Accidents, Traffic
Influence of Alcohol and Peer Passengers on Risky Driving Behavior in Young Adults
Among the many risk factors that contribute to young drivers' crash involvement, two are critical: peer passenger presence, which is unique to young drivers, and the influence of alcohol, a universal risk for drivers but one…
- Trial name
- NCT01595659
- Testing
- Passenger
- Where
- Canada
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Alcoholism
Combined Pharmacotherapies for Alcoholism (Naltrexone/Ondansetron)
This study will compare the effectiveness of ondansetron (Zofran) and naltrexone (ReVia) both alone and in combination in treating Early Onset Alcoholics versus Late Onset Alcoholics.
- Trial name
- NCT00027079
- Testing
- ondansetron (Zofran), naltrexone (ReVia), Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Suvorexant for Treatment of AUD and PTSD
This study is to determine if suvorexant (SUV) will reduce insomnia in 76 men and women veteran and non-veterans between the ages 21-65 with posttraumatic stress disorder (PTSD) symptoms and alcohol use disorder (AUD).
- Conditions
- Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD), Insomnia
- Trial name
- SUV (NCT06679062)
- Testing
- Suvorexant
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Liver Transplantation (LT)
Mental Health Outcomes and Psychological Evaluation After Liver Transplantation
Receiving a liver transplant is a major life event that can be physically and emotionally challenging. During the first five years after transplantation, more than one in two liver transplant recipients experience a mental health…
- Trial name
- mHOPE (NCT07734142)
- Testing
- questionnaires, Individual semi-structured interview
- Volunteers
- 250 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Complication of Hemodialysis
The Efficacy of Alcohol After Betadine and Combination of Alcohol and Betadine on Inflammation Vascular Access
The purpose of this study was to compare the efficacy of combination of alcohol and povidone iodine 10% and Alcohol 70% after povidone iodine 10% on inflammation and infection related to vascular access area in hemodialysis…
- Trial name
- NCT02263196
- Testing
- Alcohol and povidone iodine, combination of alcohol and betadin
- Where
- Iran
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Alcohol Drinking
Pragmatic Clinical Trial of Two Recommendations Regarding Alcohol Consumption: a Pilot Study NAMETI_ALCOHOL
NAMETI-Alcohol, from the acronym for Navarra Medical Trialist Initiative, is a pilot study in which two patterns of alcohol consumption, abstention and Mediterranean alcohol-drinking pattern, and their effects on health in the…
- Trial name
- NAMETI_ALCOHOL (NCT06214416)
- Testing
- Abstention, Mediterranean alcohol-drinking pattern
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Alcohol Dependence
ALK33-005: A Study of ALKS33 (RDC-0313) in Adults With Alcohol Dependence
This study will evaluate the safety and efficacy of ALKS33 (RDC-0313) compared with placebo in adults with alcohol dependence. There will be 11 study visits conducted over a period of about 4 months.
- Trial name
- NCT00981617
- Testing
- ALKS33 (RDC-0313) (1 mg), ALKS33 (RDC-0313) (2.5 mg), ALKS33 (RDC-0313) (10 mg)
- Where
- 27 sites in United States
- Volunteers
- 406 people
- Sponsor
- Alkermes, Inc.
Alcohol Use Disorder (AUD)
LSD Treatment for Persons With Alcohol Use Disorder
Lysergic acid diethylamide (LSD) was investigated in numerous clinical trials during the 1950s and 1960s. Specifically, the use of LSD in the treatment of AUD was investigated extensively.
- Trial name
- LYTA (NCT05474989)
- Testing
- LSD
- Where
- 2 sites in Switzerland
- Volunteers
- 128 people
- Sponsor
- Felix Mueller