Clinical trials: Airway Inflammation
Severe, Refractory Asthma, Airway Inflammation
A Randomized, Placebo-Controlled, Double-Blind Pilot Study of Pioglitazone Hydrochloride in Severe, Refractory Asthma
Background: Individuals who have severe asthma that is not easily controlled by current treatments are in need of new treatments to prevent potentially life-threatening asthma attacks.
- Conditions
- Severe, Refractory Asthma, Airway Inflammation, Airflow Obstruction
- Trial name
- NCT00994175
- Testing
- Pioglitazone
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Obstructive Pulmonary Disease
Biomarkers in Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide and is characterized by fixed airflow obstruction.
- Trial name
- NCT01145300
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Leiden University Medical Center
Allergic Rhinitis
Nasal Budesonide Efficacy on Nasal FeNO in Children With Allergic Rhinitis
In clinical trials for treatment of allergic rhinitis a significant reduction of the total symptom score compared to baseline has been demonstrated by using nasal budesonide.Previous results in adults show that the assessment and…
- Trial name
- NCT02409563
- Testing
- Budesonide nasal spray (100 mcg bid), Budesonide nasal spray (50 mcg bid
- Where
- Italy
- Volunteers
- 39 people
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Tetraplegia, Asthma
Exhaled Breath Condensate Biomarkers of Inflammation in Individuals With Chronic Cervical Spinal Cord Injury
The purpose of this study is to obtain markers of airway inflammation from the exhaled breath condensate (the moisture in exhaled air) for comparison to blood based markers.
- Trial name
- NCT02235714
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Healthy Subjects
Novel Noninvasive Techniques to Study Neutrophil Airway Inflammation in an Ozone Challenge Model
The primary objective of this pilot study is to establish a model of neutrophil airway inflammation for future testing of anti-inflammatory substances in an early stage of clinical development.
- Trial name
- NCT00743704
- Testing
- ozoneexposure
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Chronic Rhinitis, Chronic Pharyngitis
Efficacy and Safety of High-Concentration 35 kDa Hyaluronan Gel for Chronic Nasopharyngitis
This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of nasopharyngeal administration of 13.6% high-concentration 35 kDa hyaluronan (HA35) care gel in subjects with chronic…
- Conditions
- Chronic Rhinitis, Chronic Pharyngitis, Nasopharyngitis, Posterior Pharyngeal Inflammation
- Trial name
- HA35 (NCT07568548)
- Testing
- 13.6% High-Concentration 35 kDa Hyaluronan (HA35) Nasopharyngeal Care Gel
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nakhia Impex LLC
Asthma, COPD
The Mixed Phenotype of Asthma and COPD: the Overlap Syndrome
RATIONALE: In asthmatic subjects, smoking can lead to several changes in disease characterictics. in smokers of more than 20 pack-years, chronic obstructive pulmonary disease (COPD) can be associated with asthma, also called…
- Trial name
- NCT03817333
- Where
- Canada
- Volunteers
- 115 people
- Sponsor
- Laval University
COPD
A Safety, Tolerability and Efficacy Study in Chronic Obstructive Pulmonary Disease (COPD) Patients With QBM076.
This was a 2 Part study. Part 1 was a safety and tolerability study in GOLD I-III COPD patients. Part 2 was an efficacy study in GOLD I-III COPD patients.
- Trial name
- NCT01972776
- Testing
- QBM076
- Where
- 7 sites in United States, Germany and 2 more
- Volunteers
- 48 people
- Sponsor
- Novartis Pharmaceuticals
Cystic Fibrosis,
Evaluation of Bronchial Inflammation in Allergic Bronchopulmonary Aspergillosis (ABPA)
Chronic bronchial inflammation is an important clinical feature in cystic fibrosis. Approximately 10% of patients with cystic fibrosis suffer from Allergic Bronchopulmonary Aspergillosis.
- Trial name
- ABPA (NCT00906568)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Cystic Fibrosis
Non-Invasive Biomarkers in Cystic Fibrosis
Background Chronic airway inflammation is present in cystic fibrosis. Non-invasive inflammometry may be useful in disease management.
- Trial name
- NCT00413140
- Where
- 4 sites in Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Cystic Fibrosis
Modulation by Sex Hormones of Inflammation and Susceptibility to Pseudomonas Aeruginosa in Cystic Fibrosis Airways
The general objective is to elucidate the mechanisms whereby sex hormones may modulate the severity of respiratory disease. An important component of this proposal is a systematic and intensive approach to characterize how the…
- Trial name
- NCT00700050
- Testing
- Hypertonic saline
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery
The goal of this clinical trial is to understand the mechanisms leading to olfactory dysfunction (OD) in chronic rhinosinusitis (CRS).
- Trial name
- IMMUNODOR (NCT06776042)
- Testing
- Nasal brushing of the olfactory cleft, Smell testing
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Asthma
The Effect of Asthma on Systemic Inflammation, Oxidative Stress and Cardiovascular Morbidity
Asthma is a chronic airway inflammation which involves the interplay of different types of inflammatory cells and cytokines in the airway.
- Trial name
- NCT00957281
- Where
- 4 sites in Hong Kong
- Volunteers
- 748 people
- Sponsor
- The University of Hong Kong
Asthma, COPD
Airway Inflammation and Remodeling in Asthma and COPD.
Asthma and chronic obstructive pulmonary disease (COPD) are inflammatory airway diseases. Although the clinical features of asthma and COPD may be similar, the pathogenesis of these diseases differs in many aspects.
- Trial name
- NCT02069054
- Where
- Poland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Asthma
Inflammatory Processes in the Airway of Asthmatics With Persistent Bronchial Hyperreactivity
The purpose of this study is to examine inflammatory processes in the airway of moderate to severe persistent asthmatics who have persistent bronchial hyperreactivity despite chronic administration of inhaled glucocorticoids.
- Trial name
- NCT00217854
- Testing
- Bronchoscopic
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Washington University School of Medicine
Airway Control, Anesthesia
Ketamine Versus Etomidate for Rapid Sequence Intubation
The purpose of this study is to compare the effectiveness and safety of ketamine and etomidate during rapid sequence intubation (RSI).
- Conditions
- Airway Control, Anesthesia, Intubation, Complication
- Trial name
- NCT01823328
- Testing
- Ketamine, Etomidate
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- Hennepin Healthcare Research Institute
Mechanical Ventilation Pressure High, Ventilator-Associated Pneumonia (VAP)
Dynamic Airway Resistance & ML: Guide Sputum Suction in Ventilated Patients
Research has shown that timely suctioning not only improves survival rates but also enhances the quality of life in ventilator-dependent patients.
- Conditions
- Mechanical Ventilation Pressure High, Ventilator-Associated Pneumonia (VAP), Respiratory Depression Neonatal
- Trial name
- NCT07375667
- Testing
- The dynamics of airway resistance, conventional suctioning
- Where
- 3 sites in China
- Volunteers
- 258 people
- Sponsor
- Affiliated Hospital of Nantong University
Airway Inflammation
Woodsmoke Particulate + Prednisone
Deployment of military personnel has been associated with increased respiratory illness likely due, in part, to inhalation of unusual particulate matter (PM), such as from burn pits.
- Trial name
- Smokisone (NCT03861390)
- Testing
- 60 mg Prednisone
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Asthma
Phase II Study to Evaluate the Effect of AZD4604 on Airway Inflammation and Biomarkers in Adults With Asthma
The purpose of this study is to investigate the effect on airway inflammation and JAK1-associated signalling pathways of AZD4604 compared with placebo in participants with moderate-to-severe asthma.
- Trial name
- ARTEMISIA (NCT06435273)
- Testing
- AZD4604
- Where
- 18 sites in Canada, Denmark and 3 more
- Volunteers
- 36 people
- Sponsor
- AstraZeneca
Asthma; Eosinophilic
Dupilumab Efficacy on Bronchial Inflammation, Small Airways Disfunction and Mucous Secretion
Unicentric prospective real life study designed to analyse the efficacy of Dupilumab to reduce bronchial inflammation of asthma measured by inflammatory cell counts obtained in induced sputum and other related characteristics…
- Trial name
- DEBORA (NCT05787678)
- Testing
- Dupilumab
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau