Clinical trials: Airway Clearance Impairment
Airway Clearance Impairment
Comparisons of Two Airway Clearance Techniques
The goal of this clinical trial is to compare the effectiveness of two airway clearance techniques for patients with ventilator associated pneumonia.
- Trial name
- NCT06032871
- Testing
- high frequency chest wall oscillation, Chest physiotherapy
- Where
- 2 sites in Taiwan
- Volunteers
- 30 people
- Sponsor
- Hui-Ling Lin
Critically Ill, Ventilation Therapy; Complications
Consensus Statements on Airway Clearance Interventions in Intubated Critically Ill Patients--Protocol for a Delphi Study
Intubated critically ill patients are susceptible to secretion accumulation because of compromised airway clearance. Various airway clearance interventions are employed to prevent complication(s) arising from mucus retention.
- Conditions
- Critically Ill, Ventilation Therapy; Complications, Mucus Retention, Airway Clearance Impairment
- Trial name
- ACCorDingly (NCT06649734)
- Testing
- Delphi Study
- Where
- Netherlands
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Respiratory Failure, Neurological Disease
Procedures and Follow-up of Percutaneous Tracheostomy in Intensive Care Unit
Tracheostomy is worldwide performed in Intensive Care Unit (ICU). According to the current literature, indication for percutaneous tracheostomy (PDT) in ICU are: difficult prolonged weaning, prolonged mechanical ventilation, loss…
- Conditions
- Acute Respiratory Failure, Neurological Disease, Heart Failure
- Trial name
- NCT01792258
- Testing
- Percutaneous tracheostomy
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Genova
Bronchial Congestion, Airway Clearance Impairment
Bronchial Clearance Carried Out With a Mechanical In-exsufflator vs. a Manual Respiratory Physiotherapy Technique in Hospitalized Elderly People
Everywhere in the world, life expectancy is increasing. Currently, most individuals can expect to live up to 60 years and beyond. In all countries, the number and proportion of older adult in the population are rising.
- Trial name
- INEXPA2 (NCT06730217)
- Testing
- Intervention : mechanical insufflator, Control : standard care
- Where
- 4 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Clermont-Ferrand
Mechanically Ventilated Patients, Lung Compliance
Effects of Ventilator Hyperinflation Versus Vibrocompression in Mechanically Ventilated Patients
The aim of the current study is to compare the effects of ventilator hyperinflation and vibrocompression on lung compliance in mechanically ventilated patients.
- Conditions
- Mechanically Ventilated Patients, Lung Compliance, Airway Clearance Impairment
- Trial name
- NCT06791798
- Testing
- Ventilator Hyperinflation, Vibrocompression, Traditional Chest Physical Therapy Program
- Where
- Egypt
- Volunteers
- 81 people
- Sponsor
- Cairo University
Cystic Fibrosis, Motor Neuron Disease
MN4000 for Treatment of CF and MND Patients in the Home Setting
The study was a non-randomized open label pilot study. It was an observational design conducted at one (1) site in the US. All enrolled subjects received treatment with the MN4000.
- Conditions
- Cystic Fibrosis, Motor Neuron Disease, Airway Clearance Impairment
- Trial name
- NCT03797677
- Testing
- MN 4000
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Hill-Rom
Obstructive Sleep Apnea, Dementia
The Effect of OSA on Brain Waste Clearance
Recent ground-breaking research has shown that clearance of toxic neuro-metabolites from the brain including the proteins β-Amyloid (Aβ) and tau that form dementia causing plaques and tangles is markedly impaired when sleep is…
- Conditions
- Obstructive Sleep Apnea, Dementia, Cognitive Impairment
- Trial name
- NCT05606991
- Testing
- CPAP Withdrawal
- Where
- Australia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Woolcock Institute of Medical Research
Cystic Fibrosis, Airway Clearance Impairment
IPV vs CPT for Airway Clearance During CF Exacerbation
Intrapulmonary Percussive Ventilation (IPV) will show greater improvements in Forced Expiatory Volume in 1 second (FEV1) shorter duration of stay, and greater time to next pulmonary exacerbation in pediatric Cystic Fibrosis…
- Trial name
- NCT03261219
- Testing
- Intrapulmonary Percussive ventilation, Chest Physiotherapy Vest (Incourage)
- Sponsor
- University of Florida
Acute Respiratory Failure, Heart Failure
Tracheostomy in ICU With a Double Lumen Endotracheal Tube
Percutaneous tracheostomy in Intensive care unit (ICU) is performed with the use of flexible fiberoptic bronchoscope inside the conventional single lumen endotracheal tube owned by the patients.
- Conditions
- Acute Respiratory Failure, Heart Failure, Neurological Disease
- Trial name
- NCT01691222
- Testing
- Double lumen endotracheal tube tracheostomy
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- University of Genova
Ventilation Therapy; Complications, Airway Clearance Impairment
In-line Mechanical Insufflation-Exsufflation in the Management of Ventilated Patients
Catheter suction (CS), the standard method for airway secretion management during mechanical ventilation, is invasive and has significant hemodynamic and traumatic side effects.
- Trial name
- NCT05365620
- Testing
- Mechanical In-Line Inexsufflation, catheter suction
- Volunteers
- 120 people
- Sponsor
- Alyn Pediatric & Adolescent Rehabilitation Hospital
Airway Clearance Impairment, Intubating Conditions
Characteristics of Patients Intubated for Airway Protection in the Intensive Care Unit and Timing of Tracheostomy
Every year, approximately 10-15 patients are admitted to the general intensive care unit at our institution who have been intubated for airway protection for various reasons, the main ones being soft tissue infection of the…
- Trial name
- NCT07315477
- Testing
- early tracheostomy
- Where
- 2 sites in Israel
- Volunteers
- 200 people
- Sponsor
- Meir Medical Center
Bronchiectasis, Airway Clearance Impairment
Is a Single Daily Session Combining HS + Physio Sufficient to Obtain Long-term Clinical Benefits in Bronchiectasis?
The present study will aim to find out whether a home treatment in people with bronchiectasis consisting of a single daily session to facilitate expectoration (combining nebulization of hypertonic saline (HS) at 6% followed by…
- Trial name
- NCT04905992
- Testing
- Hypertonic saline at 6%, Airway clearance techniques (oscillating positive expiratory pressure therapy)
- Where
- 2 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Clínico Universitario Lozano Blesa
Amyotrophic Lateral Sclerosis, Chronic Respiratory Failure
Mechanical Insufflation in the Philadelphia Amyotrophic Lateral Sclerosis Cohort (MI-PALS) Study
The goal of this clinical trial is to learn how doing mechanical insufflation (MI) using a mechanical insufflator-exsufflator (MI-E) device affects breathing in early amyotrophic lateral sclerosis (ALS).
- Conditions
- Amyotrophic Lateral Sclerosis, Chronic Respiratory Failure, Airway Clearance Impairment, Neuromuscular Diseases
- Trial name
- MI-PALS (NCT06119087)
- Testing
- Mechanical insufflation
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Pennsylvania
Airway Clearance Impairment
Effects of Intrapulmonary Percussive Ventilator on Respiratory Function
The goal of this clinical trial is to prove the benefit of intrapulmonary percussive ventilator in healthy volunteers. The main questions are: How can intrapulmonary percussive improve lung function？ What is the subjective…
- Trial name
- NCT06000618
- Testing
- Intrapulmonary Percussive ventilator
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Airway Clearance Impairment
Outcome Comparisons of Vibratory Airway Clearance Devices
This pilot study aims to compare the ability of a higher oscillatory index device versus a lower oscillatory index device on airway secretion clearance and other clinically significant outcomes.
- Trial name
- NCT05873504
- Testing
- High Oscillatory Index Device, Low Oscillatory Index Device
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Rush University Medical Center
Mechanical Ventilation Complication, Diaphragm Issues
Effect of Lung Volume Recruitment Technique After Extubation
This study was conducted to investigate the effect of the LVR technique on cough ineffectiveness, to determine its benefit as a simple, safe, and inexpensive cough augmentation technique, and to determine how much the LVR method…
- Conditions
- Mechanical Ventilation Complication, Diaphragm Issues, Cough, Ineffective Airway Clearance
- Trial name
- NCT05128552
- Testing
- Lung volume recruitment technique, Traditional chest physiotherapy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Cystic Fibrosis in Children, Airway Clearance Impairment
Efficacy of Simeox Airway Clearance Therapy in Children With Cystic Fibrosis
Chest physiotherapy plays a crucial role in treatment of lung disease in cystic fibrosis (CF). New airway clearance techniques (ACTs) adapted to individual needs are still being sought to achieve the best effect of airway…
- Trial name
- NCT04084041
- Testing
- Simeox, CCPT
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Physio-Assist
Acute Respiratory Failure, Acute-on-chronic Respiratory Failure
VICOR Study-High Frequency Chest Wall Oscillations (HFCWO) in Patients With Acute Respiratory Failure and Hypersecretion
The study aims to evaluates if the treatment with HFCWO Via The Vest® Airway Clearance System, in addition to standard care in critically ill patients admitted in the Respiratory Intensive Care Unit for acute respiratory failure…
- Conditions
- Acute Respiratory Failure, Acute-on-chronic Respiratory Failure, Airway Clearance Impairment
- Trial name
- VICOR2 (NCT05751707)
- Testing
- High Frequency Chest Wall Oscillations via The Vest® Airway Clearance System
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Raffaele Scala
Neuromuscular Diseases, Children, Only
Mechanical Cough Augmentation in Children With NMD
The study investigates the prevalence and use of mechanical insufflation - exsufflation (MI-E) in children with Neuromuscular disorders (NMD) in Norway.
- Conditions
- Neuromuscular Diseases, Children, Only, Airway Clearance Impairment, Cough
- Trial name
- NCT03831568
- Where
- Norway
- Volunteers
- 72 people
- Sponsor
- Oslo University Hospital
Ineffective Airway Clearance, Respiratory Tract Hemorrhage
Visual Sputum Suctioning System Tests in Mechanically Ventilated Patients
BACKGROUND: The investigators developed a fiber-optic-guided endotracheal suction catheter (visual sputum suctioning system or VSSS), which the investigators previously tested in vitro and animals.
- Trial name
- NCT02116491
- Testing
- Visual Sputum Suctioning System
- Where
- China
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University