Clinical trials: Agitation
Restless Legs Syndrome, Willis-Ekbom Disease
Treatment of RLS/WED Symptoms Through Sensory Counter-stimulation
To evaluate, in a pilot fashion, efficacy and tolerability of electrical counter-stimulation using the Scrambler device in alleviating uncomfortable sensations and urge to move in patients with restless legs syndrome/Willis Ekbom…
- Trial name
- RLS/WED (NCT03249779)
- Testing
- Scrambler
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
General Anesthetics，Emergence Agitation
Advanced Analgesia on the Quality of Recovery After General Anesthesia in Elderly Patients
Recovery period of general anesthesia refers to the period from the end of anesthesia infusion to recovery of the patient after the operation.
- Trial name
- NCT05769530
- Testing
- Nalbuphine，dexmedetomidine
- Where
- 2 sites in China
- Volunteers
- 360 people
- Sponsor
- Lili Jia
Anesthesia, General
Maternal Voice on Anesthetic Emergence Period
Mother spend a large amount of time with their children. It is assumed that mother contributes to their neurological development not only with visual stimuli, but also with auditory stimuli.
- Trial name
- MatherVoice (NCT02860377)
- Testing
- recorded maternal voice, recorded stranger's voice
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Daegu Catholic University Medical Center
Psychomotor Agitation
Haloperidol vs. Valproate in Agitation
The aim of this study is to compare the efficacy of haloperidol and valproate in management of people with agitation in emergency department
- Trial name
- NCT01750541
- Testing
- Haloperidol, Valproate
- Where
- Iran
- Volunteers
- 56 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Agitation Aggression in Dementia
The Effect of Oxcarbazepine in the Treatment of Agitation / Aggression in Dementia (OBAD)
We intend to conduct a phase III b trial to verify Oxcarbazepine's effect in agitation and aggression in patients with dementia. We designed the study as a randomized, double-blind, placebo-controlled multi center trial.
- Trial name
- NCT00145691
- Testing
- Oxcarbazepine
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Sykehuset Innlandet HF
Bipolar I Disorder, Bipolar II Disorder
Assessment of Acute Psychomotor Agitation Measures Associated With Schizophrenia and Bipolar Disorder
This open-label study will utilize treatment with BXCL501 in order to assess the suitability of patient-and lay informant-assessed outcome measures for evaluation of severity of psychomotor agitation episodes in patients with…
- Conditions
- Bipolar I Disorder, Bipolar II Disorder, Schizophrenia, Schizoaffective Disorder
- Trial name
- NCT07116694
- Testing
- BXCL501 Sublingual Film
- Where
- 5 sites in United States
- Volunteers
- 33 people
- Sponsor
- BioXcel Therapeutics Inc
Delirium - Postoperative, Agitation
Responsive Nature-Driven Imagery to Reduce Delirium After Cardiac Surgery
The goal of this clinical trial is to learn if a novel device (MindfulGarden) is beneficial in a population of patients undergoing cardiac surgery.
- Conditions
- Delirium - Postoperative, Agitation, Anxiety, Cardiac Surgery Recovery
- Trial name
- RESPITE (NCT07051096)
- Testing
- A novel device developed providing nature-driven responsive imagery that responds to the patient's physiological to distract, engage, and de-escalate behaviours of delirium., Routine post-operative management and standard delirium reduction measures.
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Anxiety, Agitation
Family Videos and Virtual Reality in Intensive Care Patients
This randomized controlled trial was conducted to evaluate the effects of family videos and virtual reality-based nature videos on anxiety, agitation, pain, and vital signs in adult intensive care unit patients.
- Conditions
- Anxiety, Agitation, Pain, Physiological Parameters
- Trial name
- NCT07794696
- Testing
- Family Video.Participants watched a five-minute video prepared by their family members twice daily on the second and third days of intensive care.
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Sennur Kula Şahin
Healthy
Emergency Agitation in T&A
Sevoflurane has been used commonly in pediatric anesthesia since 1990. However, it has caused more emergency agitation (EA) that other inhalation agents and the incidence is up to 80%.
- Trial name
- NCT01152476
- Testing
- remifentanil, normal saline
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Seoul National University Bundang Hospital
Delirium, Sedation
Neurosteer Bedside Monitoring System
The purpose of this study is to evaluate the clinical utility of Neurosteer's brain monitoring platform for monitoring delirium, sedation, and agitation in intubated and sedated ICU patients.
- Conditions
- Delirium, Sedation, Agitation
- Trial name
- NCT06718764
- Testing
- Neurosteer's single-channel EEG monitoring device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Agitation, Alzheimer's Disease
Efficacy, Safety and Tolerability Study of AVP-923 (Dextromethorphan/Quinidine) for Treatment of Symptoms of Agitation in Participants With Alzheimer's Disease
The objectives of the study are to evaluate the safety, tolerability and efficacy of AVP-923 compared to placebo, for the treatment of symptoms of agitation in participants with Alzheimer's Disease (AD).
- Trial name
- NCT01584440
- Testing
- AVP-923-20, AVP-923-30
- Where
- 44 sites in United States
- Volunteers
- 220 people
- Sponsor
- Avanir Pharmaceuticals
Schizophrenia
A Study Comparing Rapid Acting Intramuscular Olanzapine and Placebo in Agitated Patients With Schizophrenia
The primary objectives of the study is to confirm if the efficacy of IM olanzapine in patients with schizophrenia is greater than IM placebo by comparing changes from baseline to 2 hours post first IM injection of agitation.
- Trial name
- NCT00640510
- Testing
- Rapid Acting Intramuscular Olanzapine, Isotonic sodium chloride solution
- Where
- 11 sites in Japan
- Volunteers
- 34 people
- Sponsor
- Eli Lilly and Company
DEMENTIA
Memantine for Agitation in Dementia
We plan to evaluate the use of memantine in Alzheimer's disease to control agitation in the acute situation i.e under 12 weeks
- Trial name
- MAGD (NCT00371059)
- Testing
- Memantine
- Where
- 2 sites in United Kingdom
- Volunteers
- 153 people
- Sponsor
- East Kent Hospitals University NHS Foundation Trust
Hip Osteoarthritis, Hip Arthroplasty Replacement
Virtual Reality for Intraoperative Anxiolysis and Postoperative Agitation in Elderely Hip Arthroplasty Patients
This study evaluates the effectiveness of Virtual Reality (VR) as a non-pharmacological intervention to reduce intraoperative anxiety and postoperative agitation in elderly patients undergoing elective hip arthroplasty under…
- Conditions
- Hip Osteoarthritis, Hip Arthroplasty Replacement, Emergence Delirium, Anesthesia, Emergence Agitation
- Trial name
- VR (NCT07705451)
- Testing
- immersive virtual reality, standard sedation
- Volunteers
- 40 people
- Sponsor
- Menoufia University
Dementia, Agitation
A Naturalistic Two-year Cohort Study of Agitation and Quality of Life in Care Homes
One third of the population, aged over 65, live and will die with dementia. Half of people with dementia experience symptoms of agitation every month.
- Trial name
- MARQUE2 (NCT02216396)
- Where
- United Kingdom
- Volunteers
- 1,734 people
- Sponsor
- University College, London
Emergence Delirium
The PREVENT AGITATION Trial II - Children ≤1 Year
Emergence agitation is a clinical condition in which the child experiences a variety of behavioural disturbances including crying, thrashing, and disorientation during early awakening from anaesthesia.
- Trial name
- NCT05091242
- Testing
- Clonidine, Sodium chloride
- Where
- 2 sites in Australia, Denmark
- Volunteers
- 336 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Restless Legs Syndrome
Sifrol (Pramipexole) Onset of Action and Impact: a 12-weeks Observational Study in Patients With Primary Restless Legs Syndrome
The objectives of the Post Market Surveillance (PMS) study are to evaluate the treatment effect of pramipexole on Restless Legs Syndrome (RLS) severity as measured by International Restless Legs Rating Scale and Global Clinical…
- Trial name
- NCT00721279
- Testing
- Sifrol® (pramipexole dihydrochloride)
- Where
- 127 sites in Austria
- Volunteers
- 549 people
- Sponsor
- Boehringer Ingelheim
Restless Legs Syndrome
A Study to Evaluate the Efficacy and Safety of Cabergoline Compared With Placebo for the Treatment of RLS
The purpose of this study is to evaluate the efficacy and safety of cabergoline compared with placebo on periodic leg movements (PLMS) arousl index and sleep efficiency in patients with RLS.
- Trial name
- NCT00627003
- Testing
- Cabergoline
- Volunteers
- 43 people
- Sponsor
- Pfizer
Restless Legs Syndrome
Alpha-lipoic Acid Combined With B Vitamins Shows Promise for Treating Restless Legs Syndrome
Investigating Tiobec® 400's efficacy in alleviating Restless Legs Syndrome symptoms sheds light on promising therapeutic avenues.
- Trial name
- NCT06324760
- Testing
- Alpha-lipoic acid combined with B vitamins
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Uriach Consumer Healthcare
Emergence Delirium
Effect of Intravenous Nalbuphine and Magnesium Sulfate on Emergence Agitation in Pediatric
Primary outcome: Measure The incidence of EA in children undergoing to hypospadias repair under general anesthesia is considered using Pediatric Anesthesia Emergence Delirium (PAED) scales.
- Trial name
- NCT06306040
- Testing
- Nalbuphine Versus Magnesium Sulfate
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Assiut University