Clinical trials: Aggressive Periodontitis, Generalized
Aggressive Periodontitis, Generalized
Subgingival Microbiota Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Periodontitis Patients
The investigators planed to observe the microbiome of an aggressive periodontitis patient, during mechanical treatment, surgery(if indicated) and implant placement.
- Trial name
- NCT03090282
- Testing
- mechanical treatment(mainly scaling and root planing), periodontal surgery(if indicated), implant placement.
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Peking University
Aggressive Periodontitis
Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis
The aim of this study is to assess the clinical outcomes of full-mouth ultrasonic debridement combined with clarithromycin or amoxicillin + metronidazole association for the treatment of generalized aggressive periodontitis…
- Trial name
- NCT02969928
- Testing
- Full-mouth ultrasonic debridement, Clarithromycin, Amoxicillin
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Generalized Aggressive Periodontitis
Amoxicillin and Metronidazole in Association With Non-surgical Therapy in Aggressive Periodontitis Treatment
This study is designed as a parallel, masked, randomized, placebo-controlled clinical trial to assess the clinical, microbiological, and immunological outcomes of scaling and root planning (SRP) or full-mouth ultrasonic…
- Trial name
- NCT03933501
- Testing
- amoxicillin and metronidazole
- Volunteers
- 48 people
- Sponsor
- University of Campinas, Brazil
Aggressive Periodontitis, Generalized, Periodontal Health
GCF HIF-1α, VEGF and TNF-α Levels in G-AgP Patients Before and After Periodontal Treatment.
Hypoxia-inducible angiogenic pathway involving hypoxia inducible factor-1 alpha (HIF-1α), vascular endothelial growth factor (VEGF) and tumour necrosis factor- alpha (TNF-α) may regulate the several biological processes related…
- Trial name
- NCT04020315
- Testing
- Non-surgically performed scaling and root planing
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Residual Disease, Aggressive Periodontitis
Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis
The aim of this randomized controlled clinical trial of superiority will be to evaluate the effect of 3 g of omega-3 polyunsaturated fatty acids and 100 mg of aspirin daily supplementation over a period of 180 days as adjunct to…
- Trial name
- NCT03093207
- Testing
- Open flap debridement, Omega-3 polyunsaturated fatty acids, Aspirin
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Aggressive Periodontitis
Effects of Er,Cr:YSGG, Diode Lasers on GCF Cytokines Levels
The aim of our study is to determine the interleukin-1βeta (IL-1β), interleukin-8 (IL-8) and tumor necrosis factor-αlfa (Tnf-α) levels in gingival crevicular fluid (GCF) and clinical periodontal parameters following the treatment…
- Trial name
- NCT03034824
- Testing
- SRP+940±15 nm diode laser, SRP+Er,Cr:YSGG laser, Scaling and root planing (SRP)-Control
- Volunteers
- 26 people
- Sponsor
- Yuzuncu Yil University
Generalized Aggressive Periodontitis
Metagenomic and Immune-inflammatory Analysis of Individuals With Generalized Aggressive Periodontitis and Their Descendants.
Generalized aggressive periodontitis (GAgP) is a multifactorial disease related to several aspects that influence its installation and progression.
- Trial name
- NCT03933514
- Testing
- Plaque control
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Generalized Aggressive Periodontitis
Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families.
Generalized aggressive periodontitis (GAP) is an inflammatory disease that causes the severe and rapid destruction of periodontal tissue.
- Trial name
- NCT03642353
- Testing
- Triclosan
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Generalized Aggressive Periodontitis, Aggressive Periodontitis
Alternative Antibiotic Regime in the Treatment of GAgP
The objective of this randomized clinical study was to evaluate the effect of systemic administration of moxifloxacin compared to amoxicillin plus metronidazole combined with non-surgical treatment in patients with generalized…
- Trial name
- NCT02223702
- Testing
- Amoxicillin, Metronidazole, Moxifloxacin
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Aggressive Periodontitis
Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis
The aim of this randomized controlled clinical trial of superiority will be to evaluate the effect of 3 g of omega-3 polyunsaturated fatty acids and 100 mg of aspirin daily supplementation over a period of 180 days as adjunct to…
- Trial name
- NCT03093246
- Testing
- Omega-3 polyunsaturated fatty acids, Aspirin, Full-mouth ultrasonic debridement
- Where
- Brazil
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Aggressive Periodontitis, Generalized
Comparison Between Surgical Access and Repeated Applications of APDT
The aim of this study will be to compare the approach of repeated applications of APDT versus surgical therapy for the treatment of residual pockets in generalized agressive periodontitis.
- Trial name
- NCT03140059
- Testing
- Open flap debridement, Repeated application of aPDT
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Generalized Aggressive Periodontitis
EMD for Treatment of Proximal Class-II Furcation Involvements
The aim of the present study is to evaluate the clinical response of proximal furcations treated with enamel matrix derivative proteins (EMD).
- Trial name
- OFD (NCT03320135)
- Testing
- Enamel matrix derivative proteins, Open Flap debridement
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Generalized Aggressive Periodontitis, Smoking
Effects of Smoking on Non-surgical Periodontal Therapy in Generalized Aggressive Periodontitis
Smoking is the major preventable risk factor in the initiation and progression of periodontal diseases. Periodontitis risk was found to be 3.9 times higher among smokers aged between 19-30 years and 2.8 times higher among smokers…
- Trial name
- NCT03512938
- Testing
- Non-surgical periodontal therapy
- Volunteers
- 27 people
- Sponsor
- Ege University
Aggressive Periodontitis
Clarithromycin as Adjuvant to Periodontal Debridement
To assess the periodontal clinical response and the possible adverse effects of the clarithromycin combined to periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis.
- Trial name
- NCT02829983
- Testing
- Clarithromycin, One-stage full-mouth ultrasonic debridement (FMUD)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Periodontitis, Aggressive, Periodontal Diseases
Efficacy of GBT vs SRP+US, in the Treatment of Severe Generalized Periodontitis.
The first step in the management of periodontal disease involves the non-surgical removal of the soft and hard bacterial deposits at all supra- and sub-gingival sites, especially into deep pockets, which can be carried on with…
- Conditions
- Periodontitis, Aggressive, Periodontal Diseases, Periodontitis
- Trial name
- ERISRP (NCT05112471)
- Testing
- Airflow, Perioflow and Erythritol powder and ultrasonic debridement, Ultrasonic debridement and curettes
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Generalized Aggressive Periodontitis, Chronic Periodontitis
Evaluation of Possible Genes in Periodontal Diseases by Genetic Methods
Generalized aggressive Periodontitis (GAgP) and chronic periodontitis (CP) are inflammatory diseases. Little is known about molecular changes and signaling cascade of host response.
- Trial name
- NCT04026828
- Testing
- Periodontitis Group
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Generalized Aggressive Periodontitis
Gene Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-based Microarray Analysis
In this study, the investigators evaluated molecular biomarkers which play a role in the development of generalized aggressive periodontitis (GAgP) using gingival tissue samples through omics-based whole-genome transcriptomic…
- Trial name
- NCT02327533
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Periodontal Diseases, Periodontitis
Interaction Between Immune Cells and Bacteria Associated With Periodontitis
This study evaluates the interaction between host immune cells and bacteria associated with periodontitis. It comprises biological material from donors with and without periodontal disease.
- Conditions
- Periodontal Diseases, Periodontitis, Aggressive Periodontitis, Immunologic Disease
- Trial name
- NCT03225950
- Testing
- In vitro stimulation of blood with periodontitis-associated- and control bacteria, Anti-CCP- and anti-P.g.-antibodies titers, Analysis of selected single nucleotide polymorphisms (SNPs)
- Where
- 2 sites in Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Aggressive Periodontitis, Generalized
is Generalized Aggressive Periodontitis an Endless Disease When Does it Stop
Background: Inquiring thoroughly and systematically for evidence supporting the mechanism, time span, onset, or ending events of generalized aggressive periodontitis.
- Trial name
- NCT06970691
- Testing
- panoramic radiograph
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- Rasha Wagih
Molar-incisor Pattern Grade C Periodontitis ( Localized Aggressive Periodontitis), Generalized Grade C Periodontitis (Generalized Aggressive Periodontitis)
Apoptosis Markers in Aggressive Periodontitis
The aim of the present trial is to assess the gingival crevicular fluid level of caspase-3 and apoptosis inducing factor (AIF) in Generalized versus Molar-incisor grade C periodontitis.
- Trial name
- NCT04984031
- Testing
- ELISA assessment of apoptosis markers in gingival crevicular fluid
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Asem Mohammed Kamel Ali